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Chinese Chemical Letters 2005年第12期16卷 1590-1592页

作者： sheng jian zhang zhang Gao LE Ningbo Institute of Technology Zhejiang University Ningbo 315100 Department of Applied Chemistry East China Institute of Technology Fuzhou 344000

Reaction of alkanones with 1-butyl-3-methylimidazolium tribromide （[Bmim]Br3） under solvent-free conditions, selectively gave the corresponding ct-bromoalkanones with excellent yields.

关键词： Alkanone ionic liquid [Bmim]Br3

Interactive Web service choice-making based on extended QoS model

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2006年第4期7卷 483-492页

作者： MOU Yu-jie CAO jian zhang Shen-sheng zhang jian-hong CIT Lab Department of Computer Science ＆ Technology Shanghai Jiao Tong University Shanghai 200030 China

Quality of Service (QoS) is a key factor in Web service advertising, choosing and runtime monitoring. Web service QoS is multi-faceted, fuzzy and dynamic. Current researches focus on implementation level performance assurance, ignoring domain specific or application level metrics which are also very important to service users. Industry Web service standards lack QoS expression. The support for QoS based service choice-making is very limited. We proposed an extended Web service QoS model based on configurable fuzzy synthetic evaluation system. Web service QoS is evaluated dynamically according to the service context. A QoS requirement description model is also given for service QoS requirement definition. An interactive Web service choice-making process is described, which takes QoS as a key factor when choosing from functionally equivalent services.

关键词： Quality of Service (QoS) Web service Choice-making Fuzzy synthetic evaluation

Securing offshore resources development:A mathematical investigation into gas leakage in long-distance flexible pipes

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Petroleum Science 2024年第4期21卷 2734-2744页

作者： Xiang-An Lu Liang-Liang jiang jian-sheng zhang Min-Gui Wang Guangling College of Yangzhou University Yangzhou225131JiangsuChina Department of Chemical and Petroleum Engineering University of CalgaryCalgaryT2N 1N4AlbertaCanada Department of Energy and Power Engineering Tsinghua UniversityBeijing100084China

Gas flexible pipes are critical multi-layered equipment for offshore oil and gas *** high pressure conditions,small molecular components of natural gas dissolve into the polymer inner liner of the flexible pipes and further diffuse into the annular space,incurring annular pressure build-up and/or production of acidic environment,which poses serious challenges to the structure and integrity of the flexible *** permeation in pipes is a complex phenomenon governed by various factors such as internal pressure and temperature,annular structure,external *** a long-distance gas flexible pipe,moreover,gas permeation exhibits non-uniform features,and the gas permeated into the annular space flows along the metal *** assess the complex gas transport behavior in long-distance gas flexible pipes,a mathematical model is established in this paper considering the multiphase flow phenomena inside the flexible pipes,the diffusion of gas in the inner liner,and the gas seepage in the annular space under varying permeable properties of the *** addition,the effect of a variable temperature is accounted.A numerical calculation method is accordingly constructed to solve the coupling mathematical *** annular permeability was shown to significantly influence the distribution of annular *** permeability increases,the annular pressure tends to become more uniform,and the annular pressure at the wellhead rises more *** annular pressure relief followed by shut-in,the pressure increase follows a convex *** simulating the pressure recovery pattern after pressure relief and comparing it with test results,we deduce that the annular permeability lies between 123 and 512 m *** results help shed light upon assessing the annular pressure in long distance gas flexible pipes and thus ensure the security of gas transport in the emerging development of offshore resources.

关键词： Offshore resources development Transport security Long-distance flexible pipes Gas leakage Heat and mass transfer model Finite difference calculation

Ligustrazine alleviates acute renal injury in a rat model of acute necrotizing pancreatitis

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World Journal of Gastroenterology 2006年第47期12卷 7705-7709页

作者： jian-Xin zhang sheng-Chun Dang jian-Guo Qu Xue-QingWang Department of General Surgery the Affiliated Hospital of Jiangsu University Zhenjiang 212001 Jiangsu Province China

AIM: To evaluate the effect of ligustrazine, a traditional Chinese medicine, on renal injury in a rat model of acute necrotizing pancreatitis (ANP). METHODS: A total of 192 rats were randomly divided into three groups: control (C group), ANP without treatment (P group), and ANP treated with ligustrazine (T group). Each group was further divided into 0.5, 2, 6, 12 h subgroups. All rats were anesthetized with an intraperitoneal injection of sodium pentobarbital. Sodium taurocholate was infused through the pancreatic membrane to induce ANP. T group was infused sodium taurocholate as above, and 0.6% ligustrazine was then administered via the femoral vein. Serum urea nitrogen (BUN) and creatinine (Cr) concentrations were measured for the evaluation of renal function. The effects of ligustrazine on the severity of renal injury were assessed by renal function, TXA2/PGI2 and histopathological changes. Renal blood flow was determined by the radioactive microsphere technique (RMT).RESULTS: Compared with control group, the renal blood flow in P group was decreased significantly. Serious renal and pancreatic damages were found in P group, the BUN and Cr levels were elevated significantly, and the ratio of TXA2 to PGI2 was increased at 2, 6 and 12 h. Compared with P group, the blood flow of kidney was elevated significantly at 6 and 12 h after induction of ANP, the renal and pancreatic damages were attenuated, and the BUN and Cr levels were decreased significantly, and the ratio of TXA2 to PGI2 was decreased at 6 and 12 h in T ***: Microcirculatory disorder (MCD) is an important factor for renal injury in ANP. Ligustrazine can ameliorate the condition of MCD and the damage of pancreas and kidney.

关键词： Pancreatitis Microcirculation Ligustrazine Renal injury

Preventive effect of tetramethylpyrazine on intestinal mucosal injury in rats with acute necrotizing pancreatitis

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World Journal of Gastroenterology 2006年第39期12卷 6386-6390页

作者： jian-Xin zhang sheng-Chun Dang jian-Guo Qu Xue-Qing Wang Department of General Surgery the Affiliated Hospital of Jiangsu University Zhenjiang 212001 Jiangsu Province China

AIM： To evaluate the role of microcirculatory disorder （MCD） and the therapeutic effectiveness ;of tetramethylpyrazine （TMP） on intestinal mucosa injury in rats with acute necrotizing pancreatitis （ANP）.METHODS： A total of 192 Sprague-Dawley rats were randomly divided into three groups： normal control group （C group）, ANP group not treated with TMP （P group）, ANP group treated with TMP （T group）. An ANP model was induced by injection of 50 g/L sodium taurocholate under the pancreatic membrane （4 mL/kg）. C group received isovolumetric injection of 9 g/L physiological saline solution using the same method. T group received injection of TMP （10 mL/kg） via portal vein. Radioactive biomicrosphere technique was used to measure the blood flow at 0.5, 2, 6 and 12 h after the induction of ANP. Samples of pancreas, distal ileum were collected to observe pathological changes using a validated histology score. Intestinal tissues were also used for examination of myeloperoxidase （MPO） expressed intraceUularly in azurophilic granules of neutrophils.RESULTS： The blood flow was significantly lower in P group than in C group （P 〈 0.01）. The pathological changes were aggravated significantly in P group. The longer the time, the severer the pathological changes. The intestinal MPO activities were significantly higher in P group than in C group （P 〈 0.01）. The blood flow of intestine was significantly higher in T group than in P group after 2 h （P 〈 0.01）. The pathological changes were alleviated significantly in T group. MPO activities were significantly lower in T group than in P group （P 〈 0.01 or P 〈 0.05）. There was a negative correlation between intestinal blood flow and MPO activity （r = -0.981, P 〈 0.01） as well as between intestinal blood flow and pathologic scores （r = -0.922, P 〈 0.05）.CONCLUSION： MCD is an important factor for intestinal injury in ANP. TMP can ameliorate the condition of MCD and the damage to pancreas and intestine.

关键词： Acute necrotizing pancreatitis Microcirculation Tetramethylpyrazine Intestinal mucosal injury

Rectal gastrointestinal stromal tumors:Imaging features with clinical and pathological correlation

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World Journal of Gastroenterology 2013年第20期19卷 3108-3116页

作者： Zhao-Xia jiang sheng-jian zhang Wei-Jun Peng Bao-Hua Yu Department of Radiology Fudan University Shanghai Cancer Center Department of Oncology Shanghai Medical CollegeFudan University Department of Pathology Fudan University Shanghai Cancer Center

AIM:To investigate computed tomography(CT) and magnetic resonance imaging(MRI) manifestations of rectal gastrointestinal stromal tumors(GISTs) in order to enhance the recognition of these rare ***:Fourteen patients with pathologically proven rectal GISTs were retrospectively *** histories were retrospectively reviewed for patient age,gender,presenting symptoms,endoscopic investigations,operation notes and pathologic *** tumors were evaluated for CD117,CD34 expression,and the tumors were stratified according to current criteria of the National Institutes of Health(NIH).In all cases the first pre-operation imaging findings(CT and MRI,n = 3;MRI only,n = 8;CT only,n = 3) were analyzed by two experienced radiologists by consensus,which include:tumor size,shape,CT density(hypodense,isodense and hyperdense),MRI signal intensity(hypointense,isointense and hyperintense),epicenter(intraluminal or extraluminal),margin(well-defined or ill-defined),internal component(presence of calcifications,necrosis,hemorrhage or ulceration),pattern and degree of enhancement,invasion into adjacent *** review of the radiologic studies,clinical and pathological findings were correlated with radiological ***:The patients,13 men and 1 woman,were aged 31-62 years(mean = 51.5 ± 10.7 years).The most common initial presentation was hematochezia(n = 6).The mean tumor diameter was 5.68 ± 2.64 cm(range 1.5-11.2 cm).Eight lesions were round or oval,and 6 lesions were *** lesions were welldefined and 3 had ill-defined *** tumors were extraluminal and 4 were *** density and MR signal intensity of the solid component of the lesions were similar to that of muscle on unenhanced CT(n = 6) and T1-weighted images(n = 11),and hyperintense on T2-weighted MR *** was detected in 2 *** intravenous injection of contrast media,3 lesions had mild enhancement and 11 lesions had moderate ***

关键词： Gastrointestinal stromal tumors Rectum Computed tomography Magnetic resonance imaging

Ligustrazine alleviates acute lung injury in a rat model of acute necrotizing pancreatitis

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Hepatobiliary & Pancreatic Diseases International 2006年第4期5卷 605-609页

作者： jian-Xin zhang and sheng-Chun Dang Department of General Surgery, Affiliated Hospital of jiangsu University, Zhenjiang 212001, China Department of General Surgery Affiliated Hospital of Jiangsu University Zhenjiang 212001 China. zhangjx@***

BACKGROUND: Acute necrotizing pancreatitis leads to a systemic inflammatory response characterized by widespread leukocyte activation and, as a consequence, distant lung injury. The aim of this study was to evaluate the effect of ligustrazine, extracted from Ligusticum wallichii a traditional Chinese medicine, on lung injury in a rat model of acute necrotizing pancreatitis (ANP). METHODS: A total of 192 rats were randomly divided into three groups: control (C group); ANP without treatment (P group); and ANP treated with ligustrazine (T group). Each group was further divided into 0.5, 2, 6 and 12 hours subgroups. All rats were anesthetized with an intraperitoneal injection of sodium pentobarbital. Sodium taurocholate was infused through the pancreatic membrane to induce ANP. For the T group, sodium taurocholate was infused as above, then 0.6% ligustrazine was administered via the femoral vein. The effects of ligustrazine on the severity of lung injury were assessed by lung wet/dry weight ratio, myeloperoxidase (MPO) activity and histopathological changes. Pulmonary blood flow was determined by the radioactive microsphere technique (RMT). RESULTS: The blood flow in the P group was significantly lower than that of the C group, while the blood flow in the T group was significantly higher than that of the P group but showed no significant difference from the C group. Compared with C group, the lung wet/dry ratios in both the P and T groups were significantly increased, but there was no significant difference between them. The MPO activity in the P group was greatly increased over that of the C group. In the T group, although the MPO activity was also higher than in the C group, it much less increased than in the P group. Moreover, the difference between P and T groups was significant after 0.5 to 12 hours. After induction of the ANP model, the pancreas showed mild edema and congestion; the longer the time, the more severe this became. The pulmonary pathological changes w

关键词： pancreatitis microcirculation ligustrazine lung injury

Protective effect of clodronate-containing liposomes on intestinal mucosal injury in rats with severe acute pancreatitis

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Hepatobiliary & Pancreatic Diseases International 2011年第5期10卷 544-551页

作者： jian-Xin zhang, sheng-Chun Dang, Kai Yin and De-Li jiang Department of General Surgery, Affiliated Hospital of jiangsu University, Zhenjiang 212001, China School of Chemistry and Chemical Engineering of jiangsu University, Zhenjiang 212013, China Department of General Surgery Affiliated Hospital of Jiangsu University Zhenjiang 212001 China School of Chemistry and Chemical Engineering of jiangsu University Zhenjiang212013 China

BACKGROUND: Severe acute pancreatitis (SAP) can result in intestinal mucosal injury. This study aimed to demonstrate the protective effect of clodronate-containing liposomes on intestinal mucosal injury in rats with SAP. METHODS: Liposomes containing clodronate or phosphate buffered saline (PBS) were prepared by the thin-film method SAP models were prepared by a uniform injection of sodium taurocholate (2 mL/kg body weight) into the subcapsular space of the pancreas. Sprague-Dawley rats were randomly divided into a control group (C group), a SAP plus PBS-containing liposomes group (P group) and a SAP plus clodronate-containing liposomes group (T group). At 2 and 6 hours after the establishment of SAP models, 2 mL blood samples were taken from the superior mesenteric vein to measure the contents of serum TNF-α and IL-12. Pathological changes in the intestine and pancreas were observed using hematoxylin and eosin staining, while apoptosis was detected using TUNEL staining. In addition, the macrophage markers cluster of differentiation 68 (CD68) in the intestinal tissue was assessed with immunohistochemistry. RESULTS: At the two time points, the levels of TNF-α and IL-12 in the P group were higher than those in the C group (P<0.05) Compared with the P group, the levels of TNF-α and IL-12 decreased in the T group (P<0.05). The pathological scores of the intestinal mucosa and pancreas in the T group were lower than those of the P group. In the T group, large numbers of TUNEL-positive cells were observed, but none or few in the C and P groups. The number of CD68-positive macrophages decreased in the T ***: Clodronate-containing liposomes have prote- ctive effects against intestinal mucosal injury in rats with SAP. The blockade of macrophages may provide a novel therapeutic strategy in SAP.

关键词： pancreatitis clodronate disodium macrophage intestinal mucosal injury

One-year clinical outcome of interventionalist-versus patient-transfer strategies for primary percutaneous coronary intervention in patients with acute ST-segment elevation myocardial infarction: results from the REVERSE-STEMI study

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One-year clinical outcome of interventionalist-versus patien...

Assessment of the relation between IVUS measurements and clinical outcome in elderly patients after sirolimus-eluting stent implantation for de novo coronary lesions

中华医学会第十五次全国心血管病学大会

作者： Qi zhang Rui Yan zhang jian sheng zhang jian Hu Zhen Kun Yang Wei Feng Shen Department of Cardiology Rui Jin Hospital Shanghai Jiaotong University School of Medicine

Background Traditional reperfusion options for patients with acute ST-segment elevation myocardial infarction (STEMI) presenting to non-primary percutaneous coronary intervention (PPCI)-capable hospitals generally include onsite fibrinolytics or emergency transfer for PPCI. A third option, involving interventionalist transfer, was examined in the REVERSE-STEMI study.

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Assessment of the relation between IVUS measurements and cli...