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Distribution of pathogenic bacteria and antimicrobial sensitivity of eye infections in Suzhou

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 700-706页

作者： li Zhang Hai-Zhang You Guo-Hui Wang Wei xu jian-Shan li Qing-liang Zhao Shu Du Department of Hospital-Acquired Infection Control Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina Department of Administrative Office Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina Department of Clinical Laboratory Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina Department of Pharmacy Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina Department of Corneal and Lacrimal Passage Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina Department of Fundus Diseases and Ocular Trauma Lixiang Eye Hospital of Soochow UniversitySuzhou 215021Jiangsu ProvinceChina

AIM:To investigate the types of bacteria in patients with eye infections in Suzhou and their drug resistance to commonly used antibacterial ***:The clinical data of 155 patients were retrospectively collected in this study,and the pathogenic bacteria species and drug resistance of each pathogenic bacteria were ***:Among the 155 patients(age from 12 to 87 years old,with an average age of 57,99 males and 56 females)with eye infections(160 eyes:74 in the left eye,76 in the right eye and 5 in both eyes,all of which were exogenous),71(45.81%)strains were gram-positive bacteria,23(14.84%)strains were gram-negative bacteria and 61(39.35%)strains were ***-positive bacteria were highly resistant to penicillin and erythromycin(78.87%and 46.48%respectively),but least resistant to vancomycin at ***-negative bacteria were highly resistant to cefoxitin and compound sulfamethoxazole(100%and 95.65%respectively),but least resistant to meropenem at *** of the resistance of gram-positive and gram-negative bacteria to some drugs revealed statistically significant differences(Plications caused by eye infections.

关键词： eye infection pathogenic bacteria drug resistance antimicrobial sensitivity test

Molecular Chain Flexibility and Dielectric Loss at High-Frequency:Impact of Ester Bond Arrangement in Poly(ester imide)s

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Chinese Journal of Polymer Science 2024年第8期42卷 1122-1133页

作者： Ya-Dong li Hong li Lu-Kun Feng Feng Bao Ming-liang Wang Cai-Zhen Zhu Zhao-Hui Zheng Xiao-Bin Ding jian xu Chengdu Institute of Organic Chemistry Chinese Academy of SciencesChengdu 610041China University of Chinese Academy of Sciences Beijing 100081China Institute of Low-Dimensional Materials Genome Initiative College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060China

The evolution of high-frequency communication has accentuated the significance of controlling dielectric properties in polymer ***,it has been theorized that rigid molecular chains lead to lower dielectric ***,the validity of this proposition at high frequencies remains *** scrutinize the correlation between chain flexibility and dielectric properties,we synthesized six poly(ester imide)s(PEIs)with systematically varied molecular chain flexibilities by modifying the ester's substitution on the aromatic *** introduction of ester bonds bestowed all PEI films with a low dielectric dissipation factor(D_(f)),ranging from 0.0021 to 0.0038 at 10 GHz in dry *** dry D_(f)displayed a pattern consistent with volume polarizability(P/V).Unexpectedly,PI-mmm-T,featu ring the most flexible molecular chain,exhibited the lowest dielectric loss under both dry(0.0021@10 GHz)and hygroscopic(0.0029@10 GHz)***,the observed increase in D_(f)after humidity absorption suggests that the high dielectric loss of PEI in applications may be attributed to its hygroscopic *** simulations and characterization of the aggregation structure revealed that the smaller cavities within flexible molecular chains,after close stacking,impede the entry of water *** sacrificing high-temperature resistance,the precursor exhibited enhanced solubility properties and could be processed into high-quality *** research unveils new insights into the relationship between flexibility and highfrequency dielectric loss,offering innovative perspectives on synthesizing aromatic polymers with exceptional dielectric properties.

关键词： 5G communications Poly(ester imide)s Molecular chain flexibility Dielectric properties Humidity absorption

3-Epi-betulinic acid 3-O-β-D-glucopyranoside(eBAG)induces autophagy by activation of AMP-activated protein kinase in hepatocellular carcinoma

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Food Science and Human Wellness 2024年第3期13卷 1453-1464页

作者： Mengjie liu xuqiang liu Kaiyue He Yongping jian Yujia li Jinrong Guo Jingyu Yang Zhixiang xu Wenyi Kang School of life Sciences Henan UniversityKaifeng 475004China National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Joint International Research Laboratory of Food&Medicine Resource Function Kaifeng 475004China Shenzhen Research Institute of Henan University Shenzhen 518000China

3-Epi-betulinic acid 3-O-β-D-glucopyranoside(eBAG)is a pentacyclic triterpene mainly distributed in food and medicinal plants,which exhibits various pharmacological ***,whether these functions are attributed to eBAG or additional components in these plants remain ***,we report that eBAG exerted an inhibitory activity against hepatocellular carcinoma and esophageal cancer *** induced non-apoptotic cell death in hepatocellular carcinoma *** eBAG-induced cell death was inhibited by knock-down of autophagy related gene(ATG)5 and ATG7,by administration of 3-methyladenine,a selective autophagy inhibitor that suppresses phosphoinositide 3-kinase(PI3K),and by chloroquine,a classic autophagy flux *** demonstrated that eBAG induced an autophagy-mediated cell *** of eBAG mimicked cellular bioenergetics depletion leading to the reduction of intracellular ATP,activation of AMP-activated protein kinase(AMPK),and inhibition of ***-treatment with compound C,an AMPK inhibitor,abrogated cell death induced by *** further validated the anti-tumor effect of eBAG in the murine xenograft model of hepatocellular carcinoma and found that eBAG treatment promoted the induction of autophagy and reduction of tumor growth in *** a functional food ingredient,eBAG is a potential therapeutic agent for the treatment of hepatocellular carcinoma and esophageal cancer.

关键词： eBAG Autophagy ATP AMPK Hepatocellular carcinoma

A Novel Anti-Collision Algorithm for Large Scale of UHF RFID Tags Access Systems

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Computers, Materials & Continua 2024年第7期80卷 897-912页

作者： xu Zhang Yi He Haiwen Yi Yulu Zhang Yuan li Shuai Ma Gui li Zhiyuan Zhao Yue liu Junyang liu Guangjun Wen jian li School of Information and Communication Engineering/Yibin Institute University of Electronic Science and Technology of ChinaChengdu611731China Department of IoT Technology Research China Mobile Research InstituteBeijing100053China The 10th Research Institute of China Electronics Technology Group Corporation Chengdu611731China College of Information and Communication National University of Defense TechnologyWuhan430019China

When the radio frequency identification(RFID)system inventories multiple tags,the recognition rate will be seriously affected due to *** on the existing dynamic frame slotted Aloha(DFSA)algorithm,a sub-frame observation and cyclic redundancy check(CRC)grouping combined dynamic framed slotted Aloha(SUBF-CGDFSA)algorithm is *** algorithm combines the precise estimation method of the quantity of large-scale tags,the large-scale tags grouping mechanism based on CRC pseudo-randomcharacteristics,and the Aloha anti-collision optimization mechanism based on sub-frame *** grouping tags and sequentially identifying themwithin subframes,it accurately estimates the number of remaining tags and optimizes frame length accordingly to improve efficiency in large-scale RFID *** outcomes demonstrate that this proposed algorithmcan effectively break through the system throughput bottleneck of 36.8%,which is up to 30%higher than the existing DFSA standard scheme,and has more significant advantages,which is suitable for application in largescale RFID tags scenarios.

关键词： Radio frequency identification anti-collision tags grouping dynamic framed slotted Aloha

Estimation-free spatial-domain image reconstruction of structured illumination microscopy

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Journal of Innovative Optical Health Sciences 2024年第2期17卷 45-58页

作者： Xiaoyan li shijie Tu Yile Sun Yubing Han Xiang Hao Cuifang kuang xu liu State Key Laboratory of Extreme Photonics and Instrumentation College of Optical Science and Engineering Zhejiang University Hangzhou 310027P.R.China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 311200 P.R.China Collaborative Innovation Center of Extreme Optics Shanxi University TaiyuanShanxi 030006P.R.China A dvanced Biomedical Imaging Facility-Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology WuhanHubei 430074P.R.China

Structured illumination microscopy(SIM)achieves super-resolution(SR)by modulating the high-frequency information of the sample into the passband of the optical system and subsequent image *** traditional Wiener-filtering-based reconstruction algorithm operates in the Fourier domain,it requires prior knowledge of the sinusoidal illumination patterns which makes the time-consuming procedure of parameter estimation to raw datasets necessary,besides,the parameter estimation is sensitive to noise or aberration-induced pattern distortion which leads to reconstruction ***,we propose a spatial-domain image reconstruction method that does not require parameter estimation but calculates patterns from raw datasets,and a reconstructed image can be obtained just by calculating the spatial covariance of differential calculated patterns and differential filtered datasets(the notch filtering operation is performed to the raw datasets for attenuating and compensating the optical transfer function(OTF)).Experiments on reconstructing raw datasets including nonbiological,biological,and simulated samples demonstrate that our method has SR capability,high reconstruction speed,and high robustness to aberration and noise.

关键词： Structured illumination microscopy image reconstruction spatial domain digital micromirror device(DMD)

Anesthesia,Anesthetics,and Postoperative Cognitive Dysfunction in Elderly Patients

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Current Medical Science 2024年第2期44卷 291-297页

作者： Hong-yu ZHU jian-li YAN Min ZHANG Tian-yun xu Chen CHEN Zhi-lin WU Department of Anesthesiology Linhe District People's HospitalBayannur 015000China Department of Neurosurgery Xinzhou District People's HospitalWuhan 430408China Department of Anesthesiology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Postoperative cognitive dysfunction(POCD)remains a major issue that worsens the prognosis of elderly surgery *** article reviews the current research on the effect of different anesthesia methods and commonly utilized anesthetics on the incidence of POCD in elderly patients,aiming to provide an understanding of the underlying mechanisms contributing to this condition and facilitate the development of more reasonable anesthesia protocols,ultimately reducing the incidence of POCD in elderly surgery patients.

关键词： anesthesia anesthetics postoperative cognitive dysfunction elderly patients

Salidroside Ameliorates Lung Injury Induced by PM_(2.5) by Regulating SIRT1-PGC-1αin Mice

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Biomedical and Environmental Sciences 2024年第4期37卷 367-376页

作者： li Xiao Hong liU Yu Mei SHAN Hui TAN Jin Feng ZHOU jian SONG Yuan Jin li Si Qi liU Chen xu Dong Qun YU li li Wan Wei School of Public Health Shandong Second Medical UniversityWeifang 261053ShandongChina Key Laboratory of Health Inspection and Quarantine Weifang 261053ShandongChina Weifang Environmental Monitoring Station Weifang 261042ShandongChina Department of Orthopedics The 80th Army Hospital of PLAWeifang 261000ShandongChina Environment and Health Related Product Safety Institute of Chinese Center for Disease Control and Prevention Beijing 100021China School of Basic Medicine Shandong Second Medical UniversityWeifang 261053ShandongChina

Objective This study aimed to clarify the intervention effect of salidroside(SAL)on lung injury caused by PM_(2.5) in mice and illuminate the function of SIRT1-PGC-1ɑ*** Specific pathogen-free(SPF)grade male C57BL/6 mice were randomly assigned to the following groups:control group,SAL group,PM_(2.5) group,SAL+PM_(2.5) *** the first day,SAL was given by gavage,and on the second day,PM_(2.5) suspension was given by intratracheal *** whole experiment consist of a total of 10 cycles,lasting 20 *** the end of treatment,blood samples and lung tissues were collected and *** of pathological changes in lung tissue using inverted microscopy and transmission electron *** expression of inflammatory,antioxidants,apoptosis,and SIRT1-PGC-1ɑproteins were detected by Western *** Exposure to PM_(2.5) leads to obvious morphological and pathologica changes in the lung of ***_(2.5) caused a decline in levels of antioxidant-related enzymes and protein expressions of HO-1,Nrf2,SOD2,SIRT1 and PGC-1ɑ,and an increase in the protein expressions of IL-6,IL-1β,Bax,caspase-9 and cleaved ***,SAL reversed the aforementioned changes caused by PM_(2.5) by activating the SIRT1-PGC-1α *** SAL can activate SIRT1-PGC-1ɑ to ameliorate PM2.5-induced lung injury.

关键词： PM_(2.5) Salidroside Oxidative stress Inflammation Apoptosis SIRT1-PGC-1α

Effects of Ta content on microstructure and oxidation behavior of AlCoCrFeNiYTa_(x)high entropy alloy

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Rare Metals 2024年第9期43卷 4462-4475页

作者： Cang Gu Jun-Hao Hu jian-Bo Song Cheng xu Ming-Yu Hu Yu-xuan Zhang jiang Tian Chao li Jing Feng Faculty of Materials Science and Engineering Kunming University of Science and TechnologyKunming 650093China Department of Physics Hong Kong Baptist UniversityHong Kong 999077China

The oxidation behavior of the Al CoCrFeNiYTa_(x)high entropy alloy(HEA)doped with different Ta contents at 1100℃is *** this study,different reasons for the spallation of the oxide scales of HEAs without/with excessive Ta addition after 1000 h of oxidation are discussed,and the most suitable Ta doping content for this HEA is explored,in which the HEA exhibits both an exceptionally low oxidation rate,and the formation of oxide scales composed of intact a-Al_(2)O_(3).Meanwhile,it is found that the addition of Ta can effectively inhibit the phase transition of β phase,which makes the surface of the oxide scale *** combining our experimental results with Wagner–Hauffe theory,the influence of Ta drag effect on oxide scale growth is explained,which provides some theoretical guidance for the subsequent design of AlCoCrFeNi HEAs,and can lead to the development of thermal barrier coatings at higher service temperature.

关键词： High-entropy alloy Al_(2)O_(3)scales Oxidation Elements diffusion

Leptin-mediated suppression of lipoprotein lipase cleavage enhances lipid uptake and facilitates lymph node metastasis in gastric cancer

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Cancer Communications 2024年第8期44卷 855-878页

作者： jian Xiao Shuqing Cao Jiawei Wang Pengyu li Quan Cheng Xinyi Zhou Jiacheng Dong Yuan li Xinyu Zhao Zekuan xu li Yang Department of General Surgery The First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsuP.R.China

Background:Lymph node metastasis(LNM)is the primary mode of metastasis in gastric cancer(GC).However,the precise mechanisms underlying this process remain *** cells necessitate lipid metabolic reprogramming to facilitate metastasis,yet the role of lipoprotein lipase(LPL),a pivotal enzyme involved in exogenous lipid uptake,remains uncertain in tumor ***,the aim of this study was to investigate the presence of lipid metabolic reprogramming during LNM of GC as well as the role of LPL in this ***:Intracellular lipid levels were quantified using oil red O staining,BODIPY 493/503 staining,and flow *** analysis was employed to identify alterations in intracellular lipid composition following LPL *** expression levels were assessed through immunohistochemistry,Western blotting,and enzyme-linked immunosorbent *** mouse popliteal LNM model was utilized to investigate differences in *** and mass spectrometry were employed to examine protein *** vitro phosphorylation assays and Phos-tag sodium dodecyl-sulfate polyacrylamide gel electrophoresis assays were conducted to detect angiopoietin-like protein 4(ANGPTL4)***:We identified that an elevated intracellular lipid level represents a crucial characteristic of node-positive(N+)GC and further demonstrated that a high-fat diet can expedite *** was found to be significantly overexpressed in N+GC tissues and shown to facilitate LNM by mediating dietary lipid uptake within GC ***,an obesity-related hormone,intercepted the effect exerted by ANGPTL4/Furin on LPL *** leptin binding to the leptin receptor could induce the activation of inositol-requiring enzyme-1(IRE1)kinase,leading to the phosphorylation of ANGPTL4 at the serine 30 residue and subsequently reducing its binding affinity with ***,our research revealed that LPL disrupted lipid homeostasis by elevating intrace

关键词： angiopoietin-like protein 4 leptin lipoprotein lipase lymph node metastasis prostaglandin E2