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Two New Bisabolane Sesquiterpenes from Ligularia Thyrsoidea

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Chemical Research in Chinese Universities 1999年第1期15卷 69-71页

作者： liao jian-chun YANG Li JIA Zhong-jian Department of Chemistry National Laboratory of Applied ChemistryLanzhou UniversityLanzhou730000

ＩｎＣｈｉｎａ，ｍｏｒｅｔｈａｎ２０Ｌｉｇｕｌａｒｉａｓｐｅｃｉｅｓ（Ｃｏｍｐｏｓｉｔａｅ）ｈａｖｅｂｅｅｎｕｓｅｄｆｏｒｆｏｌｋｍｅｄｉｃｉｎｅｓｗｉｔｈａｎｔｉｂｉｏｔｉｃ，ａｎｔｉｐｈｌｏｇｉｓｔｉｃａｎｄａｎ... 详细信息

ＩｎＣｈｉｎａ，ｍｏｒｅｔｈａｎ２０Ｌｉｇｕｌａｒｉａｓｐｅｃｉｅｓ（Ｃｏｍｐｏｓｉｔａｅ）ｈａｖｅｂｅｅｎｕｓｅｄｆｏｒｆｏｌｋｍｅｄｉｃｉｎｅｓｗｉｔｈａｎｔｉｂｉｏｔｉｃ，ａｎｔｉｐｈｌｏｇｉｓｔｉｃａｎｄａｎｔｉｔｕｍｏｒａｃｔｉｖｉｔｉｅｓ...

关键词： Ligularia thyrsoidea Bisabolane Sesquiterpene 2D NMR

Discrete micropayment protocol based on master-slave payword chain

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The Journal of China Universities of Posts and Telecommunications 2007年第1期14卷 58-60,84页

作者： FAN Li-min liao jian-xin State Key Laboratory of Net Studying and Switching Technology Beijing University of Posts and Telecommunications Beijing 100876 China

Using the idea of Payword, the new concept of master-slave payword chain （MSPC） is proposed in this article. MSPC consists of one master payword chain and one slave payword chain. On the basis of MSPC, a new micropayment protocol called discrete micropayment protocol （DMP）, is presented in this article. DMP consists of three sub-protocols： registration, payment, and settlement. Both part fairness and non-unit-wise payment can be provided by DMP.

关键词： payword micropayment fairness unit-wise payment

Pd-catalyzed asymmetric carbonyl alkynylation:Synthesis of axial chiral ynones

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Chinese Chemical Letters 2024年第6期35卷 293-297页

作者： Long Jin jian Han Dongmei Fang Min Wang jian liao Natural Products Research Center Chengdu Institute of BiologyChinese Academy of SciencesChengdu 610041China College of Chemical Engineering Sichuan UniversityChengdu 610065China University of Chinese Academy of Sciences Beijing 100049China

Ynones are important skeletons in bioactive molecules and valuable building blocks for organic synthesis,thus great efforts have been devoted to their ***,introducing prochiral substrates to construct ynones bearing a chiral framework is unrealized to ***,we reported the first example of Pd/SOP-catalyzed asymmetric carbonylative alkynylation via a non-classical carbonylative Sonogashiratype approach(acyl-Pd(Ⅱ)species generated from nucleophiles).By using cyclic diaryliodonium salts as prochiral substrates,various axial chiral ynones with good functional group tolerance(39 examples),satisfied yields(71%-96%)and excellent enantioselectivities(generally 94%-99%ee)were *** of bioactive compounds,scale-up experiment and useful transformations were also conducted to demonstrate the utility of this process.

关键词： Pd-catalyzed Axial chiral ynones Cyclic diaryliodonium High-valent palladium catalyzed Asymmetric carbonyl alkynylation

Laparoscopic radical prostatectomy： oncological and functional results of 126 patients with a minimum 3-year follow-up at a single Chinese institute

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Asian Journal of Andrology 2009年第5期11卷 548-556,I0001,I0002页

作者： Xin Gao jian-Hua Zhou liao-Yuan Li jian-Guang Qiu Xiao-Yong Pu Department of Urology The Third Affiliated Hospital Sun Yat-Sen University Guangzhou 510630 China

In this study we evaluate the oncological and functional results of the largest cohort of patients in China treated by laparoscopic radical prostatectomy （LRP） and with at least 3 years of follow-up. 126 inconsecutive patients （range 56-78 years, median 62.5） who had an LRP were retrospectively analyzed. The mean prostate specific antigen level and Gleason score was 13.4 ng mL^-1 and 6.4, respectively. Twenty-seven patients had unilateral or bilateral nerve preservation and 29 had pelvic lymphadenectomy. Multivariate analysis was used to adjust for differences in clinical and pathological features when comparing the risk for biochemical progression-free survival （bPFS）. Urinary continence was assessed by incontinence questionnaire and erectile function by the Sexual Health Inventory for Men score. The mean operative duration was 250 min and blood loss 354 mL. Five patients received blood transfusion and nine had complications, including rectal injury （two）, ureteral injury （one）, active bleeding （one）, bladder neck stenosis （two）, paralytic ileus （one）, subcutaneous hematoma （one） and port-site hernia （one）. The overall positive surgical margin rate was 20.6% and correlated with pathological stage and Gleason score respectively （P = 0.03, P 〈 0.001 respectively）. All patients had 〉 3 years of follow-up （range 3-6.75 years, mean 4.6, median 4.75）. At 3 years of follow-up, the overall survival rate was 100% and the bPFS was 81.0% in all patients; 124 patients （98.4%） were continent; 22 of 27 patients （81.5%） who underwent nerve preservation retained erectile function. Our series confirms that LRP is an effective, safe and precise technique at Chinese institution.

关键词： complication follow-up laparoscopic surgery prostate cancer prostatectomy survival

Proliferating cell nuclear antigen clamp associated factor,a potential proto-oncogene with increased expression in malignant gastrointestinal tumors

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World Journal of Gastrointestinal Oncology 2021年第10期13卷 1425-1439页

作者： Li-Juan Liu jian-Ming liao Fan Zhu State Key Laboratory of Virology and Hubei Province Key Laboratory of Allergy&Immunology Department of Medical MicrobiologySchool of MedicineWuhan UniversityWuhan 430071Hubei ProvinceChina Department of Neurosurgery Renmin HospitalWuhan UniversityWuhan 430060Hubei ProvinceChina

Gastrointestinal(GI)cancers,including malignancies in the gastrointestinal tract and accessory organs of digestion,represent the leading cause of death worldwide due to the poor prognosis of most GI *** investigation into the potential molecular targets of prediction,diagnosis,prognosis,and therapy in GI cancers is urgently *** cell nuclear antigen(PCNA)clamp associated factor(PCLAF),which plays an essential role in cell proliferation,apoptosis,and cell cycle regulation by binding to PCNA,is a potential molecular target of GI cancers as it contributes to a series of malignant properties,including tumorigenesis,epithelial-mesenchymal transition,migration,and ***,PCLAF is an underlying plasma prediction target in colorectal cancer and liver *** addition to GI cancers,PCLAF is also involved in other types of cancers and autoimmune *** pivotal pathways,including the Rb/E2F pathway,NF-κB pathway,and p53-p21 cascade,are implicated in PCLAF-mediated *** also contributes to some diseases through dysregulation of the p53 pathway,WNT signal pathway,MEK/ERK pathway,and PI3K/AKT/mTOR signal *** review mainly describes in detail the role of PCLAF in physiological status and GI *** signaling pathways involved in PCLAF are also *** of the interaction of PCLAF/PCNA or the expression of PCLAF might be potential biological therapeutic strategies for GI cancers.

关键词： Proliferating cell nuclear antigen Proliferating cell nuclear antigen clamp associated factor Transcript variant Gastrointestinal cancers Signal pathway Biological therapeutic

Use of liquid crystal to study the interactions of alkyl polyglycosides with gelatin and bovine serum albumin

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Chinese Chemical Letters 2016年第6期27卷 852-856页

作者： Zhi-jian liao Si-Nan Du Yang Luo Fang Zuo jian-Bin Luo College of Chemistry & Environment Protection Engineering Southwest University for Nationalities

In this study, liquid crystal（LC） was used to study the interactions of alkyl polyglycosides（APG） with gelatin and bovine serum albumin（BSA） at the LC-aqueous interface. The LC easily undergo an orientational transition from a homeotropic to a planar state after proteins were in contact to the LCaqueous interface decorated with APG, thus inducing an optical change from dark to bright. The optical image analysis reveals that the rearrangement rate of APG monolayer is tightly dependent on the concentration and chemical structure of the protein of interest. For example, the rearrangement rate of APG monolayer increases with an increasing gelatin concentration. We also find that the chemical structure of the proteins has a significant impact on the difference in the growth behavior of bright domains in LC.

关键词： Liquid crystal Alkyl polyglycoside Optical image Orientational transition

An efficient Approach to Modify the Catalyst Activity for the Hydrogenation of Nitrobenzene

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Chinese Chemical Letters 2001年第9期12卷 817-820页

作者： Wei Min MO Bo Shun WAN Shi jian liao Dalian Institute of Chemical Physics Chinese Academy of SciencesDalian 116023 College of Chemical Engineering Zhejiang University of TechnologyHangzhou 310014

The addition of a suitable amount of PPh3 to PdCl2 or PdCl2(PhCN)(2) in situ can considerably increase the catalytic activity in the hydrogenation of nitrobenzene, while the catalytic activities of PdCl2 (reduced)+PPh3, PdCl2(PPh3)(2) and Pd(PPh3)(4) are very poor. The poisoning of catalyst by mercury indicates that the catalytically active species are composed of Pd(0) colloidal particles. Transmission electron micrographs show that the size of nanometric Pd(0) particles of PdCl2 with PPh3 added in situ is smaller than that of PhCl2(PPh3) or PdCl2 (reduced)+PPh3. A synergic effect of bimetallic catalysts such as PdCl2+nPPh(3)+NiCl2 (n= 0.5, 1) and PdCl2(PhCN)(2)+PPh3+FeCl3 gives rise to a further increase in the catalytic activity.

关键词： Bimetallic catalyst synergic effect catalytic hydrogenation palladium

Pretreatment of Polymer-Supported Pd-Co and Its Catalytic Activity

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Chinese Chemical Letters 2000年第8期11卷 743-744页

作者： Yan GAO Shi jian liao Fu Dong WANG Yue GAO Xi Gao jian Department of Polymer Science&Materials Dalian University of TechnologyDalian 116012 Dalian Institute of Chemical Physics The Chinese Academy of SciencesDalian 116023

Various pretreatments of poly (N-vinyl-2-pyrrolidone) (PVP) protected palladium-cobalt system result in different catalytic activities in the hydrodechlorination of chlorobenzene.

关键词： pretreatment polymer supported Pd-Co catalytic activity

Fractal Growth of Giant Amphiphiles in Langmuir-Blodgett Films

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Chinese Journal of Polymer Science 2022年第6期40卷 556-566页

作者： Wei-Jie Wang Xian Xu Yu Shao jian-Wen liao Han-Xin jian Bing Xue Shu-Guang Yang State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Center for Advanced Low-dimension MaterialsCollege of Materials Science and EngineeringDonghua UniversityShanghai 201620China Beijing National Laboratory for Molecular Sciences Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationCenter for Soft Matter Science and EngineeringCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

Fractal structures have attracted considerable scientific interest,and fractal geometry is an effective tool to study the complicated structure and dynamic processes,such as dilation symmetry of disorder structure,percolation,gelation,and metal-insulator ***,we summarized our findings of fractal growth of giant amphiphiles in Langmuir-Blodgett(LB)*** amphiphiles composed of polyhedral oligomeric silsesquioxanes(POSS)derivatives and poly(ethylene oxide)(PEO),with structural diversities of POSS head modification,POSS head number,PEO chain length,are precisely *** effect of molecular structures and operation parameters on the fractal growth patterns are discussed,in addition,other fractal growth patterns in LB films and in Langmuir films are included,aiming to understand the basic molecular principle of fractal growth in LB system.

关键词： Fractal growth Langmuir-Blodgett(LB)film Langmuir film Giant amphiphiles Poly(ethylene oxide)(PEO)crystallization