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Effect of titanium microalloying on microstructure and mechanical properties of vanadium microalloyed steels for hot forging

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Journal of Iron and Steel Research International 2022年第2期29卷 295-306页

作者： Fan Zhao Guo-ning He Ya-zheng liu Zhi-hao Zhang jian-xin Xie Beijing Laboratory of Metallic Materials and Processing for Modern Transportation Institute for Advanced Materials and TechnologyUniversity of Science and Technology BeijingBeijing100083China State Key Laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan430074HubeiChina School of Materials Science and Engineering University of Science and Technology BeijingBeijing100083China

Effect of titanium microalloying on the microstructure and mechanical properties of vanadium microalloyed steels for hot forging was *** microalloying improves the mechanical properties mainly through refining the austenite *** the heating temperature is in the range of 1050–1300℃,the austenite grain diameter is decreased from 77–133 to 26–68μm by titanium *** the decrease in austenite grain diameter,the final microstructure is refined significantly,and the high misorientation boundaries are *** the steel is heated at 1200℃(the common hot forging temperature)and cooled slowly,titanium microalloying decreases the yield strength from 548.4 to 519.4 MPa,and the tensile strength decreases from 842.7 to 808.7 ***,the elongation increases from 19.0%to 21.4%,and the impact energy increases from 9.8 to 38.2 J.V–Ti steel has a better combination of strength,plasticity and toughness than V *** addition,the nucleation of intragranular ferrite idiomorphs is promoted by titanium microalloying,which may have a beneficial effect on the property of steels with coarse microstructure caused by the critical deformation in hot die forging.

关键词： Titanium microalloying Microalloyed steel Microstructure Mechanical property Intragranular ferrite

KTI-RNN:Recognition of Heart Failure from Clinical Notes

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Tsinghua Science and Technology 2023年第1期28卷 117-130页

作者： Dengao Li Huiting Ma Wenjing Li Baofeng Zhao Jumin Zhao Yi liu jian Fu College of Data Science Taiyuan University of TechnologyJinzhong 030600China Department of Statistics and Applied Probability University of CaliforniaSanta BarbaraCA 93106USA College of Mining Engineering Taiyuan University of TechnologyTaiyuan 030024China College of Information and Computer Taiyuan University of TechnologyJinzhong 030600China

Although deep learning methods have recently attracted considerable attention in the medical field,analyzing large-scale electronic health record data is still a difficult *** particular,the accurate recognition of heart failure is a key technology for doctors to make reasonable treatment *** study uses data from the Medical Information Mart for Intensive Care *** with structured data,unstructured data contain abundant patient ***,this type of data has unsatisfactory characteristics,e.g.,many colloquial vocabularies and sparse *** solve these problems,we propose the KTI-RNN model for unstructured data *** proposed model overcomes sparse content and obtains good classification *** term frequency-inverse word frequency(TF-IWF)model is used to extract the keyword *** latent dirichlet allocation(LDA)model is adopted to extract the topic word *** models enable the expansion of the medical record text ***,we embed the global attention mechanism and gating mechanism between the bidirectional recurrent neural network(BiRNN)model and the output *** call it gated-attention-BiRNN(GA-BiRNN)and use it to identify heart failure from extensive medical *** show that the F 1 score of the proposed KTI-RNN model is 85.57%,and the accuracy rate of the proposed KTI-RNN model is 85.59%.

关键词： heart failure diagnosis text classification deep learning

Xenopus GLP-1-based glycopeptides as dual glucagon-like peptide 1 receptor/glucagon receptor agonists with improved in vivo stability for treating diabetes and obesity

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Chinese Journal of Natural Medicines 2022年第11期20卷 863-872页

作者： LI Qiang YANG Qimeng HAN Jing liu Xiaohan FU Junjie YIN jian Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan UniversityWuxi 214122China School of Chemistry and Materials Science Jiangsu Normal UniversityXuzhou 221116China Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor Ministry of EducationGuangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency TumorGuangxi Medical UniversityNanning 530021China

Peptide dual agonists toward both glucagon-like peptide 1 receptor(GLP-1R)and glucagon receptor(GCGR)are emerging as novel therapeutics for the treatment of type 2 diabetes mellitus(T2DM)patients with *** previous work identified a Xenopus GLP-1-based dual GLP-1R/GCGR agonist termed xGLP/GCG-13,which showed decent hypoglycemic and body weight lowering ***,the clinical utility of xGLP/GCG-13 is limited due to its short in vivo *** by the fact that O-GlcNAcylation of intracellular proteins leads to increased stability of secreted proteins,we rationally designed a panel of O-GlcNAcylated xGLP/GCG-13 analogs as potential long-acting GLP-1R/GCGR dual *** of the synthesized glycopeptides 1f was found to be equipotent to xGLP/GCG-13 in cell-based receptor activation *** expected,O-GlcNAcylation effectively improved the stability of xGLP/GCG-13 in ***,chronic administration of 1f potently induced body weight loss and hypoglycemic effects,improved glucose tolerance,and normalized lipid metabolism and adiposity in both db/db and diet induced obesity(DIO)mice *** results supported the hypothesis that glycosylation is a useful strategy for improving the in vivo stability of GLP-1-based peptides and promoted the development of dual GLP-1R/GCGR agonists as antidiabetic/antiobesity drugs.

关键词： Glucagon-like peptide-1 Glucagon Diabetes Obesity O-GlcNAcylation

Texture Evolution and Dynamic Recrystallization of Zr-1Sn-0.3Nb-0.3Fe-0.1Cr Alloy During Hot Rolling

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Acta Metallurgica Sinica(English Letters) 2020年第2期33卷 215-224页

作者： jian Xun Gaoyong Lin Huiqun liu Siyu Zhao Jing Chen Xun Dai Ruiqian Zhang School of Materials Science and Engineering Central South UniversityChangsha 410083China Key Lab of Nonferrous Materials Ministry of EducationCentral South UniversityChangsha 410083China Science and Technology on Reactor Fuel and Materials Laboratory Nuclear Power Institute of ChinaChengdu 610213China

In the present work,the sheets of Zr-1Sn-0.3Nb-0.3Fe-0.1Cr alloy were hot rolled with different reductions(10%,30%,50%,and 60%) at 1023 K and 1073 *** micro structure evolutions including grain micro structure,texture,and dislocation were investigated,using electron backscattering diffraction and transmission electron *** results showed that dislocation slip,twinning,and dynamic recrystallization(DRX) were the main deformation *** was found to be promoted by larger reduction and higher rolling *** predominant texture formed during hot rolling was basal //ND,whose intensity reached peak value after 30% reduction hot *** the intensity of DRX texture //ND and//ND increased with increasing reduction and *** study provided an effective way to tailor the texture and microstructure of the alloy,for optimizing process parameters.

关键词： Zr–1Sn–0.3Nb–0.3Fe–0.1Cr alloy Hot rolling Texture evolution Recrystallization

Gene expression and MR diffusion-weighted imaging after chemoembolization in rabbit liver VX-2 tumor model

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World Journal of Gastroenterology 2008年第36期14卷 5557-5563页

作者： You-Hong Yuan En-Hua Xiao jian-Bin liu Zhong He Ke Jin Cong Ma Jun Xiang jian-Hua Xiao Wei-jian Chen Department of Radiology Hunan Province People's Hospital Changsha 410005 HtmanProvince China Departmentof Radiology the Second Xiang-Ya Hospital Central SouthUniversity Changsha 410005 Hunan Province China Department of Pathology HunanProvince Children's Hospital Changsha 410005 HunanProvince China Department of Epidemiology Center forDisease Control of Hunan Province Changsha 410005 HunanProvince China

AIM: To investigate the dynamic characteristics and the correlation between PCNA, Bax, nm23, E-cadherin expression and apparent diffusion coefficient (ADC) on MR diffusion-weighted imaging (DWI) after chemoembolization in rabbit liver VX-2 tumor model. METHODS: Forty New Zealand rabbit liver VX-2 tumor models were included in the study. DWI was carried out periodically after chemoembolization. All VX-2 tumor samples in each group were examined by histopathology and Strept Avidin-Biotin Complex (SABC) immunohistochemical staining. RESULTS: The PCNA expression index in VX-2 tumors was higher than in the normal parenchyma around the tumor (P < 0.001). Nm23, Bax or E-caderin expression index in VX-2 tumors were lower than in the normal parenchyma around the tumor (all P < 0.001). PCNAand nm23 expression in the VX-2 tumor periphery first increased and then decreased (P < 0.001 and P = 0.03, respectively), while the expression of Bax and E-cadherin before and after chemoembolization was insignificant. When b-value was 100 s/mm2, there was a linear correlation between PCNA expression and ADC in the area of VX-2 tumor periphery (P < 0.001), and PCNA expression in VX-2 tumor periphery influenced the ADC. CONCLUSION: The potential of VX-2 tumor infiltrating and metastasizing decreases, while its ability to proliferate increases for a short time after chemoembolization. To some degree, the ADC value indirectly reflects the proliferation of VX-2 tumor cells.

关键词： Rabbit liver VX-2 tumor Chemoembolization Diffusion-weighted imaging Gene expression

Amyloid cross-seeding between Ab and hIAPP in relation to the pathogenesis of Alzheimer and type 2 diabetes

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Chinese Journal of Chemical Engineering 2021年第2期34卷 225-235页

作者： Yanxian Zhang Yijing Tang Dong Zhang Yonglan liu jian He Yung Chang Jie Zheng Department of Chemical Biomolecularand Corrosion EngineeringThe University of AkronOHUSA Department of Chemical Engineering R&D Center for Membrane TechnologyChung Yuan Christian UniversityTaoyuanTaiwanChina

Amyloid cross-seeding of different amyloid proteins is considered as a highly possible mechanism for exacerbating the transmissible pathogenesis of protein misfolding disease(PMDs)and for explaining a molecular link between different PMDs,including Alzheimer disease(AD)and type 2 diabetes(T2D),AD and Parkinson disease(PD),and AD and prion *** them,AD and T2D are the most prevalent PMDs,affecting millions of people globally,while Ab and hIAPP are the causative peptides responsible for AD and T2D,*** clinical and epidemiological evidences lead to a hypothesis that the cross-seeding of Ab and hIAPP is more biologically responsible for a pathological link between AD and *** this review,we particularly focus on(i)the most recent and important findings of amyloid cross-seeding between Ab and hIAPP from in vitro,in vivo,and in silico studies,(ii)a mechanistic role of structural compatibility and sequence similarity of amyloid proteins(beyond Ab and hIAPP)in amyloid cross-seeding,and(iii)several current challenges and future research directions in this lessstudied *** of amyloid cross-seeding hopefully provides some mechanistic understanding of amyloidogenesis and inspires more efforts for the better design of next-generation drugs/strategies to treat different PMDs simultaneously.

关键词： Amyloid peptide Amyloid aggregation Amyloid cross-seeding Amyloid-b hIAPP Protein misfolding

Composition and processing of direct-quench hot rolled steels with ultrahigh strength exceeding GPa

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Journal of Iron and Steel Research International 2021年第6期28卷 703-712页

作者： Qian Zhang Da Ren Zhi-pu liu Chen-chong Wang jian Huang Wei Xu State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819LiaoningChina Benxi Iron and Steel Group Co. Ltd.Benxi 117002LiaoningChina

The design of high-strength steel has long been discussed in the field of metal structural *** further increase the strength of common high-strength steel and further decrease the cost for production,three direct-quench hot rolled steels were designed and *** rolling and coiling processes were set based on continuous cooling transformation *** addition,the effect of the coiling temperature on the tensile properties was discussed to further guide the optimization of the *** was found that compared with granular bainite,lower bainite probably has more advantages for both the strength and low temperature impact toughness of direct-quench hot rolled *** a process of tailoring the morphology of bainite and controlling the grain boundary precipitation,the newly designed direct-quench hot rolled steels showed greatly improved strength and acceptable ductility/toughness compared with traditional quenched and tempered steels.

关键词： High-strength steel Direct-quench hot rolling Bainite morphology Precipitation Mechanical property

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原料种类对合成羟基磷灰石粉体的影响

中国陶瓷 2024年第3期60卷 12-16页

作者：郑恩涛冯果江峰吴丽丹王辉刘健敏景德镇陶瓷大学材料科学与工程学院景德镇333000 景德镇欧神诺陶瓷有限公司景德镇333000 景德镇陶瓷大学国家日用及建筑陶瓷工程技术研究中心景德镇333000

以无水醋酸作为非水溶剂,采用非水沉淀法合成羟基磷灰石粉体。借助XRD、SEM、BET等测试表征手段,系统研究了钙源、磷源、反应条件和前驱体混合液浓度对羟基磷灰石合成效果的影响。结果表明:最优钙源和磷源分别为乙酸钙和磷酸氢二钠,在... 详细信息

以无水醋酸作为非水溶剂,采用非水沉淀法合成羟基磷灰石粉体。借助XRD、SEM、BET等测试表征手段,系统研究了钙源、磷源、反应条件和前驱体混合液浓度对羟基磷灰石合成效果的影响。结果表明:最优钙源和磷源分别为乙酸钙和磷酸氢二钠,在前驱体混合液浓度为0.5 mol/L时,非水沉淀法低温制备出棒状羟基磷灰石,样品的比表面积为39.1 m^(2)/g,从而拓宽了非水工艺的应用,为制备陶瓷粉体提供了一个新的参考方向。

关键词：羟基磷灰石非水沉淀法低温制备

Effects of rebinding rate and asymmetry in unbinding rate on cargo transport by multiple kinesin motors

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Communications in Theoretical Physics 2021年第1期73卷 106-116页

作者： Yao Wang Yu-Ying liu jian Liang Peng-Ye Wang Ping Xie College of Engineering and College of Science China Agricultural UniversityBeijing 100083China Key Laboratory of Soft Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

Many intracellular transports are performed by multiple molecular motors in a cooperative ***,we use stochastic simulations to study the cooperative transport by multiple kinesin motors,focusing mainly on effects of the form of unbinding rate versus force and the rebinding rate of single motors on the cooperative *** consider two forms of the unbinding *** is the symmetric form with respect to the force direction,which is obtained according to Kramers *** other is the asymmetric form,which is obtained from the prior studies for the single kinesin *** the asymmetric form the simulated results of both velocity and run length of the cooperative transport by two identical motors and those by a kinesin-1 motor and a kinesin-2 motor are in quantitative agreement with the available experimental data,whereas with the symmetric form the simulated results are inconsistent with the experimental *** the cooperative transport by a faster motor and a much slower motor,the asymmetric form can give both larger velocity and longer run length than the symmetric form,giving an explanation for why kinesin adopts the asymmetric form of the unbinding rate rather than the symmetric *** the cooperative transport by two identical motors,while the velocity is nearly independent of the rebinding rate,the run length increases linearly with the rebinding *** the cooperative transport by two different motors,the increase of the rebinding rate of one motor also enhances the run length of the cooperative *** dynamics of transport by N(N=3,4,5,6,7 and 8)motors is also studied.

关键词： molecular motors collective transport kinesin