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Pathological significance of tRNA-derived small RNAs in neurological disorders

Neural Regeneration Research 2020年第2期15卷 212-221页

作者： Chuan Qin Pei-Pei Xu Xin Zhang Chao Zhang Chang-Bin Liu De-Gang Yang Feng Gao Ming-Liang Yang Liang-Jie Du jian-jun Li School of Rehabilitation Medicine Capital Medical UniversityBeijingChina China Rehabilitation Science Institute BeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Department of Spinal and Neural Functional Reconstruction China Rehabilitation Research CenterBeijingChina Beijing Key Laboratory of Neural Injury and Rehabilitation BeijingChina

Non-coding RNAs(ncRNAs) are a type of RNA that is not translated into proteins. Transfer RNAs(tRNAs), a type of ncRNA, are the second most abundant type of RNA in cells. Recent studies have shown that tRNAs can be cleaved into a heterogeneous population of ncRNAs with lengths of 18–40 nucleotides, known as tRNA-derived small RNAs(tsRNAs). There are two main types of tsRNA, based on their length and the number of cleavage sites that they contain: tRNA-derived fragments and tRNA-derived stress-induced RNAs. These RNA species were first considered to be byproducts of tRNA random cleavage. However, mounting evidence has demonstrated their critical functional roles as regulatory factors in the pathophysiological processes of various diseases, including neurological diseases. However, the underlying mechanisms by which tsRNAs affect specific cellular processes are largely unknown. Therefore, this study comprehensively summarizes the following points:(1) The biogenetics of tsRNA, including their discovery, classification, formation, and the roles of key enzymes.(2) The main biological functions of tsRNA, including its miRNA-like roles in gene expression regulation, protein translation regulation, regulation of various cellular activities, immune mediation, and response to stress.(3) The potential mechanisms of pathophysiological changes in neurological diseases that are regulated by tsRNA, including neurodegeneration and neurotrauma.(4) The identification of the functional diversity of tsRNA may provide valuable information regarding the physiological and pathophysiological mechanisms of neurological disorders, thus providing a new reference for the clinical treatment of neurological diseases. Research into tsRNAs in neurological diseases also has the following challenges: potential function and mechanism studies, how to accurately quantify expression, and the exact relationship between tsRNA and miRNA. These challenges require future research efforts.

关键词： epigenetics molecular biology neurological disorders review sequencing stress tRNA tRNA-derived fragments tRNA-derived small RNAs tRNA-derived stress-induced RNA

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Performance characterization of Ni60-WC coating on steel processed with supersonic laser deposition

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Defence Technology（防务技术） 2015年第1期11卷 35-47页

作者： Fang LUO Andrew COCKBURN Martin SPARKES Rocco LUPOI Zhi-jun CHEN William O'NEILL jian-hua YAO Rong LIU College of Zhijiang Zhejiang University of Technology Institute for Manufacturing Department of Engineering University of Cambridge Department of Mechanical & Manufacturing Engineering Trinity College Dublin College of Mechanical Engineering Zhejiang University of Technology Department of Mechanical & Aerospace Engineering Carleton University 1125 Colonel By Drive Ottawa Ontario K1S 5B6 Canada

Ni60-WC particles are used to improve the wear resistance of hard-facing steel due to their high hardness. An emerging technology that combines laser with cold spraying to deposit the hard-facing coatings is known as supersonic laser deposition. In this study, Ni60-WC is deposited on low-carbon steel using SLD. The microstructure and performance of the coatings are investigated through SEM, optical microscopy, EDS, XRD, microhardness and pin-on-disc wear tests. The experimental results of the coating processed with the optimal parameters are compared to those of the coating deposited using laser cladding.

关键词： Ni60-WC Supersonic laser deposition Laser cladding Microstructure Wear

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Enterogenous infection of Candida albicans in immunocompromised rats under severe acute pancreatitis

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World Journal of Emergency Medicine 2016年第4期7卷 294-299页

作者： Xiang-wang Zhao Lei Yan Dan Xu Yu-hui Cui Chun-hui Yang Yan-jun Zhou jian-guo Tang Department of Intensive Care Unit Shandong Cancer HospitalShandong UniversityJinan 250117China Department of Emergency Medicine Zhongshan HospitalFudan UniversityShanghai 200032China Department of Trauma-Emergency&Critical Care Medicine Shanghai Fifth People's HospitalFudan University Shanghai 200240China Division of Swine Infectious Diseases Shanghai Veterinary Research InstituteCAASShanghai 200240China

BACKGROUND:Opportunistic infection of Candida albicans(***) has become a serious problem in immunocompromised *** study aimed to explore the mechanism of enterogenous infection of *** in immunocompromised rats under severe acute pancreatitis(SAP).METHODS:Sprague Dawley(SD) rats(n=100) were randomly assigned into 5 groups as the following:blank group,cyclophosphamide+ceftriaxone+SAP group,cyclophosphamide+ceftriaxone group,cyclophosphamide+SAP group,and cyclophosphamide *** rats were sacrificed at 5and 10 days,and their jejunum,colon,mesenteric lymph nodes,pancreas,intestinal content,and blood were quickly collected to detect ***.A region of the 25 S rRNA gene was chosen and amplified by polymerase chain reaction(PCR) to differentiate *** *** amplified products were further sequenced and compared to judge their ***:Compared with the Cyclophosphamide group,the combination of immunosuppressants and broad-spectrum antibiotics significantly increased the colonization of *** in intestine in 5 and 10 *** SAP stress did not increase the opportunistic infection of *** PCR products of *** isolates all belonged to the genotype A family,and sequence alignment showed that the amplified fragments were ***:The damage of immune system and broad-spectrum antimicrobial agents are important risk factors for opportunistic fungal *** tract is an important source for genotype-A *** to translocate and invade into bloodstream.

关键词： Candida albicans Immunosuppression Severe acute pancreatitis Genotype

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An updated classification for the hyper-diverse genus Corydalis(Papaveraceae: Fumarioideae)based on phylogenomic and morphological evidence

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植物学报:英文版 2023年第9期65卷 2138-2156页

作者： jun‐Tong Chen Magnus Lidén Xian‐Han Huang Liang Zhang Xin‐jian Zhang Tian‐Hui Kuang Jacob BLandis Dong Wang Tao Deng Hang Sun CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China Evolutionary Biology Centre Systematic BiologyUppsala UniversityUppsala 75236Sweden School of Integrative Plant Science Section of Plant Biology and the L.H.Bailey HortoriumCornell UniversityIthacaNew York 14853USA BTI Computational Biology Center Boyce Thompson InstituteIthacaNew York 14853USA School of Life Sciences Central China Normal UniversityWuhan 430079China

The genus Corydalis, with ca. 530 species, has long been considered taxonomically challenging because of its great variability. Previous molecular analyses,based on a few molecular markers and incomplete taxonomic sampling, were clearly inadequate to delimit sections and subgenera. We have performed phylogenetic analyses of Corydalis and related taxa,using 65 shared protein-coding plastid genes from313 accessions(including 280 samples of ca. 226species of Corydalis) and 152 universal low-copy nuclear genes from 296 accessions(including 271samples of Corydalis) covering all 42 previously recognized sections and five independent “series”.Phylogenetic trees were inferred using Bayesian Inference and Maximum Likelihood. Eight selected morphological characters were estimated using ancestral state reconstructions. Results include:(i) of the three subgenera of Corydalis, two are fully supported by both the plastid and nuclear data;the third,subg. Cremnocapnos, is weakly supported by plastid DNA only, whereas in the nuclear data the two included sections form successive outgroups to the rest of the genus;(ii) among all 42 sections and five“series”, 25 sections and one “series” are resolved as monophyletic in both data sets;(iii) the common ancestor of Corydalis is likely to be a perennial plant with a taproot, yellow flowers with a short saccate spur, linear fruits with recurved fruiting pedicels, and seeds with elaiosomes;(iv) we provide a new classification of Corydalis with four subgenera(of which subg. Bipapillatae is here newly described), 39 sections, 16 of which are consistent with the previous classification, 16 sections have been recircumscribed, one section has been reinstated and six new sections are established. Characters associated with lifespan, underground structures, floral spur, fruit and elaiosomes are important for the recognition of subgenera and sections. These new phylogenetic analyses combined with ancestral character reconstructions uncovered previo

关键词： character evolution Corydalis genome skimming Papaveraceae phylogeny

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丝瓜新品种‘衡亮1号’的选育

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湖南生态科学学报 2024年第1期11卷 25-30页

作者：旷碧峰余席茂胡国平刘阳华谭建军李健生蒋可湖南省衡阳市蔬菜研究所湖南衡阳421005 湖南省衡阳市科技创新工作站湖南衡阳421005 湖南省衡阳市德丰源种业有限责任公司专家工作站湖南衡阳421005

【目的】本研究旨在介绍‘衡亮1号’丝瓜,一种经过精心培育的优良自交系品种,具有耐热、耐湿和高产特性,适合在长江流域广泛种植。【方法】通过株内定向培育和多代单株选育,从株洲白丝瓜的变异单株中获得了‘衡亮1号’丝瓜。对该品种的... 详细信息

【目的】本研究旨在介绍‘衡亮1号’丝瓜,一种经过精心培育的优良自交系品种,具有耐热、耐湿和高产特性,适合在长江流域广泛种植。【方法】通过株内定向培育和多代单株选育,从株洲白丝瓜的变异单株中获得了‘衡亮1号’丝瓜。对该品种的生长特性、产量、品质等方面进行了详细观察和评估。【结果】‘衡亮1号’丝瓜为早熟品种,单瓜重量控制在0.48~0.61kg,果实纵径为26.0~27.2cm,呈现出短棒圆筒形的优美形态。果皮白绿油亮,果肉洁白如玉。全期产量高达2781.3kg/667m^(2),口感清香,品质卓越。【结论】‘衡亮1号’丝瓜是一种具有优良特性的瓜类蔬菜品种,适合在长江流域的广大地区进行大面积种植。其高产、优质的特点将为农业生产提供有力支持,满足市场需求。

关键词：白丝瓜新品种 ‘衡亮1号’ 特征特性栽培技术

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茶多酚在医药和食品领域的应用研究进展

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食品安全质量检测学报 2024年第17期15卷 176-184页

作者：葛天睿黄雪君张娜陈小强沙如意毛建卫湖北工业大学生命科学与健康工程学院武汉430068 浙江科技大学生物与化学工程学院杭州310000

茶多酚具有抗氧化、抗菌、抗癌和抗肥胖活性,因此研究者们将其应用在医药和食品领域。在医药领域研究中,茶多酚和姜黄素等药物具有多种活性,但易受环境影响而降解。研究人员利用递送系统保护易降解药物,提高其生物利用度。在医药领域的... 详细信息

茶多酚具有抗氧化、抗菌、抗癌和抗肥胖活性,因此研究者们将其应用在医药和食品领域。在医药领域研究中,茶多酚和姜黄素等药物具有多种活性,但易受环境影响而降解。研究人员利用递送系统保护易降解药物,提高其生物利用度。在医药领域的其他方面,茶多酚与蛋白、多糖等结合用于制作新的防晒产品和药品,用于护肤、抗过敏、抗致病菌、维持口腔健康和调节脂质代谢。在食品领域研究中,茶多酚主要与多糖、蛋白等结合,通过分子间的相互作用改善食品的感官品质、延长食品储存期、制作食品包装材料和抑制美拉德反应产物。本文综述了茶多酚在医药和食品领域上的应用研究,为茶多酚在医药和食品上的深入研究提供参考。

关键词：茶多酚生物利用度医药食品

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有氧八段锦联合踏车运动训练对慢性阻塞性肺疾病合并慢性心力衰竭的干预效果

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心血管康复医学杂志 2024年第4期33卷 395-401页

作者：杨爱萍尹枭孟吴君华郭建英徐维国绵阳市中心医院呼吸与危重症医学科四川绵阳621000

目的:观察有氧八段锦联合踏车运动训练对慢性阻塞性肺疾病(COPD)合并慢性心力衰竭(CHF)的干预效果。方法:纳入2019年1月至2021年6月间绵阳市中心医院收治的COPD合并CHF患者180例,根据随机数字表法均分为对照组(基础治疗及干预)和试验组... 详细信息

目的:观察有氧八段锦联合踏车运动训练对慢性阻塞性肺疾病(COPD)合并慢性心力衰竭(CHF)的干预效果。方法:纳入2019年1月至2021年6月间绵阳市中心医院收治的COPD合并CHF患者180例,根据随机数字表法均分为对照组(基础治疗及干预)和试验组(在对照组基础上给予有氧八段锦联合踏车运动训练),两组均干预12周。比较两组干预前、4周、8周和12周后的慢阻肺评估测试量表(CAT)评分、左心室射血分数(LVEF)、左心室收缩末期容积(LVESV)和左心室舒张末期容积(LVEDV)、改良呼吸困难指数(mMRC)和明尼苏达心力衰竭生活质量问卷(MLHFQ)评分。结果:干预12周期间,两组CAT评分、LVESV、LVEDV、mMRC及MLHFQ评分呈逐渐降低趋势,LVEF呈逐渐升高趋势(P<0.05或<0.01)。与对照组相比,干预12周后试验组CAT评分[(17.47±3.96)分比(13.36±3.42)分]、LVEDV[(139.44±7.12)ml比(131.74±6.47)ml]、LVESV[(81.84±8.54)ml比(74.29±9.18)ml]、mMRC评分[(1.67±0.47)分比(1.42±0.50)分]和MLHFQ各维度分及总分[(40.07±6.86)分比(32.54±6.61)分]均显著降低,LVEF[(41.29±4.76)%比(44.56±4.42)%]显著升高,P均<0.001。结论:在基础治疗上增加有氧八段锦联合踏车运动训练,可显著改善COPD合并CHF患者的心肺功能,缓解呼吸困难并提高生活质量,值得推广。

关键词：心力衰竭肺疾病,慢性阻塞性运动疗法

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基于PSCAD/EMTDC的高压电缆护套沿线过电压计算分析

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电工电气 2024年第10期 31-36,72页

作者：叶昊亮杨勇曹俊平王少华何坚林浩凡张帅国网浙江省电力有限公司电力科学研究院浙江杭州310014 杭州意能电力技术有限公司浙江杭州310014

近年来高压电缆护层保护器击穿烧毁故障频出,为优化电缆接地系统设计并为保护器选型提供参考,利用电磁暂态仿真软件PSCAD/EMTDC建立电力电缆线路模型。结合实际工程中长电缆线路各类接地方式,对单相接地故障期间不同电缆长度、接地电阻... 详细信息

近年来高压电缆护层保护器击穿烧毁故障频出,为优化电缆接地系统设计并为保护器选型提供参考,利用电磁暂态仿真软件PSCAD/EMTDC建立电力电缆线路模型。结合实际工程中长电缆线路各类接地方式,对单相接地故障期间不同电缆长度、接地电阻、敷设回流缆的护套沿线过电压变化规律进行研究。研究结果表明,电缆末端单相接地故障后,220 kV交叉互联电缆护套沿线过电压水平在2~8 kV;对交叉互联混合单端/中间接地方式,护套连接处存在地电位升高特性,严重时达16 kV;敷设回流缆对单端接地方式电缆护套过电压抑制效果明显,利于保护器选型。

关键词：高压电缆金属护套交叉互联过电压回流缆保护器接地电阻

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术前CT在诊断非小细胞肺癌脏层胸膜浸润中的应用价值

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中国中西医结合影像学杂志 2024年第1期22卷 72-79页

作者：杨扬王健杨光钊茅国群徐文杰刘珺杨昭李伟谢宗玉蚌埠医学院第一附属医院放射科安徽蚌埠233004 浙江省立同德医院放射科浙江杭州310012 浙江中医药大学第二临床医学院浙江杭州310053 浙江省立同德医院病理科浙江杭州310012 安徽省呼吸系统疾病(肿瘤)临床医学研究中心安徽蚌埠233004

目的:探讨术前CT在诊断非小细胞肺癌(NSCLC)脏层胸膜浸润(VPI)中的应用价值。方法:回顾性纳入489例经手术病理证实的NSCLC患者的资料,按收集时间分为训练集362例和验证集127例,2个数据集根据弹力纤维染色结果各分为VPI组和无VPI组。训... 详细信息

目的:探讨术前CT在诊断非小细胞肺癌(NSCLC)脏层胸膜浸润(VPI)中的应用价值。方法:回顾性纳入489例经手术病理证实的NSCLC患者的资料,按收集时间分为训练集362例和验证集127例,2个数据集根据弹力纤维染色结果各分为VPI组和无VPI组。训练集中,VPI组57例,无VPI组305例;验证集中,VPI组15例,无VPI组112例。总结VPI组和无VPI组病理特征、临床资料及CT征象,通过单因素分析和二元logistic回归分析,筛选出VPI的独立风险因素并构建联合模型;采用ROC曲线比较各模型的诊断效能。结果:在训练集中,VPI组与无VPI组在结节类型、空气支气管征、胸膜接触类型、实性接触长度、长径、短径、最小CT值(CT_(min)值)和平均CT值(CT_(mean)值)之间差异均有统计学意义(均P0.05)。结论:实性接触长度和胸膜接触类型可作为鉴别VPI的独立风险因素,可为临床术前决策提供影像学依据。

关键词：肺肿瘤脏层胸膜浸润癌非小细胞肺体层摄影术 X线计算机

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Identification of survival-associated biomarkers based on three datasets by bioinformatics analysis in gastric cancer

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World Journal of Clinical Cases 2023年第20期11卷 4763-4787页

作者： Long-Kuan Yin Hua-Yan Yuan jian-jun Liu Xiu-Lian Xu Wei Wang Xiang-Yu Bai Pan Wang Department of Gastrointestinal Surgery Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Sichuan Key Laboratory of Medical Imaging North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

BACKGROUND Gastric cancer(GC)is one of the most common malignant tumors with poor prognosis in terms of advanced ***,the survival-associated biomarkers for GC remains *** To investigate the potential biomarkers of the prognosis of patients with GC,so as to provide new methods and strategies for the treatment of *** RNA sequencing data from The Cancer Genome Atlas(TCGA)database of STAD tumors,and microarray data from Gene Expression Omnibus(GEO)database(GSE19826,GSE79973 and GSE29998)were *** differentially expressed genes(DEGs)between GC patients and health people were picked out using R software(x644.1.3).The intersections were underwent between the above obtained co-expression of differential genes(co-DEGs)and the DEGs of GC from Gene Expression Profiling Interactive Analysis database,and Gene Ontology(GO)analysis,Kyoto Encyclopedia of Gene and Genome(KEGG)pathway analysis,Gene Set Enrichment Analysis(GSEA),Protein-protein Interaction(PPI)analysis and Kaplan-Meier Plotter survival analysis were performed on these *** Immunohistochemistry(IHC)database of Human Protein Atlas(HPA),we verified the candidate Hub *** With DEGs analysis,there were 334 co-DEGs,including 133 up-regulated genes and 201 down-regulated *** enrichment analysis showed that the co-DEGs were involved in biological process,cell composition and molecular function *** enrichment analysis suggested the co-DEGs pathways were mainly enriched in ECM-receptor interaction,protein digestion and absorption pathways,*** pathway analysis showed that co-DEGs mainly concentrated in cell cycle progression,mitotic cell cycle and cell cycle pathways,*** analysis showed 84 nodes and 654 edges for the *** survival analysis illustrated 11 Hub genes with notable significance for prognosis of patients were ***,using IHC database of HPA,we confirmed the above candidate Hub genes,and 10 Hub genes that associated with prognos

关键词： Gastric cancer Survival-associated biomarkers Bioinformatics analysis Hub genes

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