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Crystal Structure of 1-Methyl-5-phenylhydantoin

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Chinese Journal of Structural Chemistry 2000年第4期19卷 249-252页

作者： QIU Li Hua * (Department of Chemistry, Suzhou Medical College, Suzhou, 215007) [WT4”BZ]ge jian Feng zhang De Chun ZOU jian Ping (Department of Chemistry, Suzhou University, Suzhou, 215006) 苏州医学院江苏苏州 2 1 50 0 7 苏州大学江苏苏州 2 1 50 0 6

The title compound (C 10H 10N 2O 2 , M r =190.20), 1 methyl 5 phenylhydantoin (1 methyl 5 phenyl 2, 4 imidazolidinedione) was synthesized by the reaction of 2 hydroxy 2 methylthio acetophenone ( α benzoyl hemithioacetal) with methylurea in slightly acidic medium. The crystal was crystallized in the orthorhombic system, space group Pbca with parameters a=18.077(5), b=14.386(2), c=7.035(1), Z=8, V=1829(1) 3, D c =1.381 g/cm 3, μ (Mo Kα )=0.99cm -1, F(000)=800, R=0.040, R w =0.050 for 1395 observed reflections [ I>3σ(I )]. It consists of a planar benzene ring and an imidazole ring, whose dihedral angle is 96.32°. In the title crystal, the glide c related molecules ( x, 1/2-y, -1/2+z ) form chains, which are further related by the screw axis ( 1-x, 1/2+y, 1/2-z ), forming networks along the bc plane. The networks are centrosymmetrically packed (1- x, -y, -z).

关键词： crystal structure 1 methyl 5 phenylhydantoin bioelectric activity.

Advances in the application of action learning in nursing practice

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Chinese Nursing Research 2016年第3期3卷 101-104页

作者： Er-Huan Han Yan zhang jian-ge zhang Bei-Lei Lin School of Nursing Zhengzhou University

In this paper, we elucidate the concept and characteristics of action learning as well as summarize the re？exivity, cooperativeness, and subjectivity of this approach. Furthermore, we describe the effects and limitations of action learning when applied in nursing management, nursing education, and clinical practice, among various ？elds.

关键词： Action learning Nursing practice Re?exivity Cooperativeness Subjectivity

Macrophage-mimetic liposome adsorbing endotoxins for sepsis treatment

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Macrophage-mimetic liposome adsorbing endotoxins for sepsis ...

2018年第十二届中国药物制剂大会

作者：姜礼贤 Ruixiang Li jian’ge zhang Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine

OBJECTIVE. Sepsis is a systemic inflammatory response syndrome mainly caused by bacterial infections. Severe sepsis may induce damage to organs and subsequent septic shock, which has become the leading cause of death in ICU patients worldwide. The common treatment for bacterial infections and sepsis is far from satisfaction. To develop a novel therapy for sepsis is urgently needed. Endotoxins, also refers to lipopolysaccharide（LPS）, have been regarded as the most important pathogenic factor in Gram-negative bacterial sepsis. Inspired by the intrinsic LPS-binding capacity of macrophage, a macrophage-mimetic liposome（M-Lipo） was developed for LPS neutralization. METHODS. The macrophage-mimetic liposome was designed under a hybrid concept. Firstly, macrophage-derived micro vesicles（MMV） were isolated from RAW264.7 cells by chemical stimulation, serving as membrane source. Then, the natural MMV was fused with artificial liposome by an extrusion method to prepare hybrid M-Lipo. Representative proteins of M-Lipo were detected using SDS-PAge and Western blotting. The in vivo circulation of PEGylated M-Lipo was measured. The neutralization of LPS by M-Lipo was determined. And the therapeutic effect of M-Lipo was observed in LPS-infected cells. Finally, the survivals of sepsis-bearing mice after M-Lipo injection were observed. RESULTS. The result showed the M-Lipo had similar surface protein of macrophages, indicating MLipo could specifically bind LPS just like macrophages. As the pharmacokinetics experiment presented, MLipo showed 16% retention in blood and 382% more than the natural MMV at 12 h, indicating the combination of natural MMV and artificial lipid could integrate their advantages, which presumably could promote the elimination of LPS in vivo. The in vitro neutralization assay showed a neutralization capacity of 50 ng LPS per mg of M-Lipo. And M-Lipo significantly reduced LPS-induced inflammatory factor levels and i NOs levels. In a mouse LPS sensitive model, trea

关键词： Macrophage-mimetic liposome hybrid LPS sepsis

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一种三维PET图像盲恢复方法

上海交通大学学报 2009年第7期43卷 1167-1171页

作者：张剑戈王成章鲁上海交通大学基础医学院上海200025

为提高三维采集模式下正电子发射计算机断层(PET)图像的质量,提出了一种图像自动盲恢复的方法,从降质后的PET图像一维频域信号中估计出Levy分布的参数,使用点扩展函数的估计值恢复PET图像.实验结果表明,该方法增强了PET图像的结构细节,... 详细信息

为提高三维采集模式下正电子发射计算机断层(PET)图像的质量,提出了一种图像自动盲恢复的方法,从降质后的PET图像一维频域信号中估计出Levy分布的参数,使用点扩展函数的估计值恢复PET图像.实验结果表明,该方法增强了PET图像的结构细节,明显改善了图像的视觉效果.

关键词：图像恢复正电子发射计算机断层图像 Levy分布

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后腹腔镜重复肾上位半肾切除术疗效观察

中国内镜杂志 2010年第10期16卷 1020-1023页

作者：葛建章陈湘中南大学湘雅医院泌尿外科湖南长沙410008

目的回顾性比较后腹腔镜重复肾上位半肾切除术与开放重复肾上位半肾切除术的临床疗效,探讨后腹腔镜重复肾上位半肾切除术的临床应用价值。方法回顾性分析后腹腔镜上位半肾切除术患者30例(后腹腔镜组)及开放上位半肾切除术32例(开放组)... 详细信息

目的回顾性比较后腹腔镜重复肾上位半肾切除术与开放重复肾上位半肾切除术的临床疗效,探讨后腹腔镜重复肾上位半肾切除术的临床应用价值。方法回顾性分析后腹腔镜上位半肾切除术患者30例(后腹腔镜组)及开放上位半肾切除术32例(开放组)术中、术后及随访指标,对其结果进行统计学分析。结果两组比较在手术时间、主要并发症及次要并发症发生率方面无显著性差异(P>0.05);两组在手术切口长度、术中估计失血量、术后肛门排气时间、术后静脉应用抗生素时间、术后止痛药应用例数、术后体温恢复正常时间、术后留置引流管时间、术后下床活动时间、术后住院时间方面有显著性差异(P<0.05)。腹腔镜组早期手术时间长于开放手术组,后期短于开放手术组;腹腔镜组手术时间随手术例数的增加有一定的下降趋势。结论与传统开放手术相比,后腹腔镜下重复肾上位半肾切除术能达到开放手术的临床疗效,且具有创伤小、术后恢复快的优势;后腹腔镜重复肾上位半肾切除术虽然手术操作难度大,但随着术者操作经验的积累,手术时间逐渐缩短。

关键词：重复肾后腹腔镜上位半肾切除术

Transcatheter closure of coronary artery fistula in children

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Chinese Medical Journal 2010年第7期123卷 822-826页

作者： XU Liang XU Zhong-ying jianG Shi-liang ZHENG Hong ZHAO Shi-hua LING jian zhang ge-jun WU Wen-hui LI Shi-guo HU Hai-bo Department of Radiology Peking Union Medical College Chinese Academy of Medical Sciences Cardiovascular Institute & Fu Wai Hospital Beijing 100037 China

Background Transcatheter closure of coronary artery fistula （CAF） has emerged as a successful alternative to surgery. We described our experiences in 10 children patients who were accepted for transcatheter closure of CAF. Methods Ten children were 3-10 years old （seven males） with CAF who underwent percutaneous transcatheter closure between October 1995 and April 2008. Sites of origin of these fistulas were： right coronary artery in seven, left anterior descending coronary artery in two, and left circumflex coronary artery in one patient. Drainage sites of these fistulas were： right atrium in seven, right ventricle in two and left ventricle in one patient. All of these fistulas were congenital and had only one orificium *** A Cook coil was used in four patients and an Amplatzer patent ductus arteriosus （PDA） occluder was used in six patients. Checking the angiogram after the procedure revealed complete occlusion in nine patients （90%） and minimal residual flow in one （10%） patient. Technical success was achieved in all patients. Follow-up studies at short term showed complete abolition of shunt in all patients with no evidence of recanalization leading to recurrence of shunt. Conclusions Transcatheter therapy using either Cook coil or Amplatzer PDA occluder is suggested to be a safe and effective method of occlusion. The midterm outcome of the intervention for CAF is satisfactory.

关键词： coronary artery fistula transcatheter occlusion Cook coil Amplatzer patent ductus arteriosus occluder

Dielectric-ion-conductive ZnNb2O6 layer enabling rapid desolvation and diffusion for dendrite-free Zn metal batteries

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Journal of Energy Chemistry 2025年第1期100卷 693-701页

作者： Haifeng Yang jian Wang Panpan zhang Xiaomin Cheng Qinghua Guan Jing Dong Bixian Chen Lujie Jia Jing zhang Yongzheng zhang Yunjian Liu Hongzhen Lin School of Materials Science and Engineering Jiangsu University i-Lab & CAS Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Helmholtz Institute Ulm (HIU) Karlsruhe Institute of Technology (KIT) School of Materials Science and Engineering Xi'an University of Technology State Key Laboratory of Chemical Engineering East China University of Science and Technology

Rechargeable aqueous zinc-metal batteries （AZMBs） are promising candidates for large-scale energy storage systems due to their low cost and high ***,their performance and sustainability are significantly hindered by the sluggish desolvation kinetics at the electrode/electrolyte interface and the corresponding hydrogen evolution reaction where active water molecules tightly participate in the Zn（H2O）62+solvation ***,learnt from self-generated solid electrolyte interphase （SEI） in anodes,the dielectric but ion-conductive zinc niobate nanoparticles artificial layer is constructed on metallic Zn surface （ZNB@Zn）,acting as a rapid desolvation *** zincophilic and dielectric-conductive properties of ZNB layer accelerate interfacial desolvation/diffusion and suppress surface corrosion or dendrite formation,achieving uniform Zn plating/stripping behavior,as confirmed by electronic/optical microscopies and interface spectroscopical measurements together with theoretical ***,the as-prepared ZNB@Zn electrode exhibits excellent cycling stability of over 2000 h and robust reversibility （99.54%） even under high current density and depth of discharge ***,the assembled ZNB@Zn-based full cell displays high capacity-retention rate of 80.21%after 3000 cycles at 5 A g-1and outstanding rate performance up to 10 A *** large-areal pouch cell is stabilized for hundreds of cycles,highlighting the bright prospects of the dielectric but ion-conductive layer in further application of AZMBs.

关键词： Zn metal battery Dielectric artificial layer Rapid ion diffusion Zincophilic diffusion Active water inhibition

Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

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Neural Regeneration Research 2025年第8期20卷 2153-2168页

作者： Xinyu You Lin Niu Jiafeng Fu Shining ge jiangwei Shi Yanjun zhang Pengwei Zhuang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry

Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

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Neural Regeneration Research 2025年第1期20卷 93-106页

作者： Yujie Yang Xinyi Li Jiaying Lu Jingjie ge Mingjia Chen Ruixin Yao Mei Tian jian Wang Fengtao Liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET Center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest *** conducted a thorough literature search using reputable databases such as PubMed and Web of *** criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting ***,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo *** validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic *** summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2