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Chinese Chemical Letters 2008年第9期19卷 1059-1062页

作者： jian fei ding Zhang Feng Qin Xue Kuan Li Guo Fu Wang jian Guo Wang State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy of Sciences P.O. Box 165 Taiyuan 030001 China Graduate School of the Chinese Academy of Sciences Beijing 100049 China

The dehydrogenation of isobutane （IB） to produce isobutene coupled with reverse water gas shift in the presence of carbon dioxide was investigated over the catalyst Cr2O3 supported on active carbon （Cr2O3/AC）. The results illustrated that isobutane conversion and isobutene yield can be enhanced through the reaction coupling in the presence of carbon dioxide. Moreover, carbon dioxide can partially eliminate carbonaceous deposition on the catalyst and keep the active phase （Cr2O3）, which are then helpful to alleviate the catalyst deactivation.

关键词： Dehydrogenation Isobutane Carbon dioxide Isobutene Reaction coupling Cr2O3/AC

嵌入量子点的介观Aharonov-Bohm环的基态与持续电流

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物理学报 2003年第2期52卷 468-472页

作者：叶剑斐叶飞丁国辉上海交通大学物理系上海200030

对嵌入量子点的介观金属环进行了研究 .在二级微扰变分近似下得出了其基态能量表达式和基态持续电流表达式 ,并在库仑排斥势趋于无穷大的假设下 ,得到了系统Kondo温度及持续电流的数值计算结果 .并且将它们与一级微扰变分近似所得结果... 详细信息

对嵌入量子点的介观金属环进行了研究 .在二级微扰变分近似下得出了其基态能量表达式和基态持续电流表达式 ,并在库仑排斥势趋于无穷大的假设下 ,得到了系统Kondo温度及持续电流的数值计算结果 .并且将它们与一级微扰变分近似所得结果进行了对比 ,指出了它们之间存在的差异 ,对于这一系统二级微扰变分近似将给出更好的数值计算结果 .

关键词：量子点 Kondo效应持续电流变分法介观金属环

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia Yang Qian-Ru He fei ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

Revolutionizing solid-state single-photon sources with multifunctional metalenses

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Light(Science & Applications) 2024年第1期13卷 8-9页

作者： fei ding Centre for Nano Optics University of Southern DenmarkCampusvej 55Odense MDK-5230Denmark

Ultrathin multifunctional metalenses are demonstrated to control the multiple degrees of freedom of a single-photon source in hexagonal boron nitride.

关键词： hexagonal boron state

Quantum dots get a bright upgrade

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Light(Science & Applications) 2024年第11期13卷 2438-2440页

作者： fei ding Institut für Festkörperphysik Leibniz Universität HannoverAppelstraße 230167 HannoverGermany

Developing a bright,deterministic source of entangled photon pairs has been an outstanding scientific and technological *** quantum dots are a promising candidate for this task.A new device combining a circular Bragg resonator and a piezoelectric actuator achieves high brightness and entanglement fidelity simultaneously,overcoming previous *** breakthrough enhances quantum dot applications in entanglement-based quantum communication protocols.

关键词： quantum breakthrough piezoelectric

Role of oxygen vacancy inducer for graphene in graphene-containing anodes

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Frontiers of Chemical Science and Engineering 2023年第3期17卷 326-333页

作者： fei Wang jian Mao College of Materials Science and Engineering Sichuan UniversityChengdu 610065China

Currently,graphene is only considered as a conductive additive and expansion inhibitor in oxides/graphene composite *** this study,a new graphene role(oxygen vacancy inducer)in graphene/oxides composites anodes,which are treated at high-temperature,is proposed and verified using experiments and density functional theory *** high-temperature processing,graphene forms carbon vacancies due to increased thermal vibration,and the carbon vacancies capture oxygen atoms,facilitating the formation of oxygen vacancies in ***,the induced oxygen vacancy concentrations can be regulated by sintering temperatures,and the behavior is unaffected by oxide crystal structures(crystalline and amorphous)and morphology(size and shape).According to density functional theory calculations and electrochemical measurements,the oxygen vacancies enhance the lithiumion storage *** findings can result in a better understanding of graphene’s roles in graphene/oxide composite anodes,and provide a new method for designing high-performance oxide anodes.

关键词： oxide oxygen vacancy graphene anode density functional theory calculation

Induction of multi-epitope-specific antibodies against HIV-1 by multi-epitope-vaccines

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Chinese Science Bulletin 2001年第22期46卷 1859-1864页

作者： ding jian HE fei LU Yun XIAO Yi CHEN Yinghua Laboratory of Immunology Research Center for Medical Science and Department of BiologyTsinghua UniversityProtein Science Laboratory of Ministry of Education of ChinaBeijing 100084China

Some neutralizing antibodies against HIV-1 envelope proteins were highly effective to inhibit the infection of different strains in vitro, and existed in the infected individuals with very low levels. We suggested multi-epi-tope-vaccine as a new strategy to increase levels of neutralizing antibodies and the abilities against HIV mutation in vivo. Two candidate multi-epitope-vaccines induced antibodies with predefined multi-epitope-specificity in rhesus macaque. These antibodies recognized corresponding neutralizing epitopes on epitope-peptides, gp41 peptides, V3 loop peptide, rsgp41 and rgp120. Besides, three candidate epi-tope-vaccines in combination (another kind of multi-epitope-vaccines) showed similar potency to induce predefined multiple immune responses in rabbits. These results suggest thatmulti-epitope-vaccines may be a new strategy to induce multi-antiviral activities against HIV-1 infection and mutations.

关键词： HIV-1 multi-epitope-vaccine neutralizing epitope.

Papillary thyroid microcarcinoma with contralateral lymphatic skip metastasis and breast cancer: A case report

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World Journal of Clinical Cases 2022年第11期10卷 3609-3614页

作者： Min ding Ya-Hui Kong jian-Hua Gu Rong-Li Xie jian fei Department of General Surgery Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Department of General Surgery Shanghai Changhang HospitalShanghai 200122China Department of General Surgery Shanghai Ruijin Rehabilitation HospitalShanghai 200023China Department of General Surgery Ruijin Hospital Luwan BranchShanghai Jiao Tong University School of MedicineShanghai 200020China

BACKGROUND The recognized pattern of cervical lymph node metastasis(CLNM)of papillary thyroid carcinoma involves a stepwise *** lymph node skip metastasis is very *** addition,the patient in our case report also suffered from a breast carcinoma accompanied by left supraclavicular lymphadenopathy,which made it difficult to distinguish the origin of the *** on this case,we recommended that more detailed physical and imaging examinations are needed for patients with uncommon cervical lymphatic metastasis of primary *** SUMMARY A 53-year-old women was admitted to the hospital for a neck mass in the left cervical region that had existed for 2 *** neck mass was suspected to be an enlarged lateral LN originating from papillary thyroid microcarcinoma of the contralateral thyroid lobe,according to ultrasound and ultrasound-guided fine needle aspiration *** patient underwent total thyroidectomy and radical cervical LN *** pathology confirmed the diagnosis of papillary thyroid microcarcinoma with contralateral lymphatic skip ***,a breast cancer was discovered 4 mo later,which was accompanied by ipsilateral supraclavicular LN *** accepted neoadjuvant chemotherapy and subsequent left modified radical mastectomy for *** patient is currently receiving postoperative radiotherapy,and no local recurrence was observed in the 6-mo follow-up after *** present a rare case of papillary thyroid microcarcinoma with contralateral lymphatic skipmetastasis and breast cancer with supraclavicular lymphatic metastasis.

关键词： Thyroid cancer Papillary Breast neoplasms Lymphatic metastasis Skip metastasis Contralateral metastasis Case report

Tall Buildings with Dynamic Facade Under Winds

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Engineering 2020年第12期6卷 1443-1453页

作者： fei ding Ahsan Kareem NatHaz Modeling Laboratory University of Notre DameNotre DameIN 46556USA

Burgeoning growth of tall buildings in urban areas around the world is placing new demands on their performance under *** involves selection of the building form that minimizes wind loads and structural topologies that efficiently transfer *** practice is to search for optimal shapes,but this limits buildings with static or fixed *** shape tailoring that consists of modifying the external form of the building has shown great promise in reducing wind loads and associated structural motions as reflected in the design of Taipei 101 and Burj *** these buildings,corner modifications of the cross-section and tapering along the height are *** appealing alternative is to design a building that can adapt its form to the changing complex wind environment in urban areas with clusters of tall buildings,i.e.,by implementing a dynamic *** leap beyond the static shape optimization,autonomous dynamic morphing of the building shape is advanced in this study,which is implemented through a cyber–physical system that fuses together sensing,computing,actuating,and engineering *** approach will permit a building to intelligently morph its profile to minimize the source of dynamic wind load excitation,and holds the promise of revolutionizing tall buildings from conventional static to dynamic facades by taking advantage of the burgeoning advances in computational design.

关键词： Tall buildings Aerodynamic shape tailoring Autonomous morphing Cyber-physical system Computational design Surrogate modeling Machine learning

Deciphering fungal metabolon coupling tandem inverse-electrondemand Diels-Alder reaction and semipinacol rearrangement for the biosynthesis of spiro polycyclic alkaloids

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Science China Chemistry 2025年第01期 288-296页

作者： Shuai Liu Wen-Qiang Xu Ying-Tong Di Man-Cheng Tang ding-Kang Chen Ming-Ming Cao Yao-Wen Chang Hong-Yu Tang Chun-Mao Yuan Jun-Bo Yang Zhi-Li Zuo Han Guo Zi-fei Xu Ying Zeng Yun-Dong Wu Xiao-jiang Hao Key Laboratory of Phytochemistry and Natural Medicines (Chinese Academy of Sciences) Kunming Institute of Botany Chinese Academy of Sciences University of Chinese Academy of Sciences Lab of Computational Chemistry and Drug Design State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate School Shenzhen Bay Laboratory State Key Laboratory of Microbial Metabolism School of Life Sciences & Biotechnology Shanghai Jiao Tong University State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Molecular Biology Experimental Center Germplasm Bank of Wild Species in Southwest China Kunming Institute of Botany Chinese Academy of Sciences Yunnan Key Laboratory for Wild Plant Resources Kunming Institute of Botany Chinese Academy of Sciences Research Unit of Chemical Biology of Natural Anti-Virus Products Chinese Academy of Medical Sciences

In the intricate process of natural product biosynthesis, a metabolon can enhance metabolic flux by associating sequential enzymes. A fungal metabolon, comprising of flavin-dependent monooxygenase Spe F and P450 monooxygenase Spe G, is identified in the biosynthesis of spiro polycyclic alkaloids(+)-notoamide B and its diastereomer(+)-versicolamide B. Using notoamide E as a substance, Spe F/Spe G metabolon can control the stereoselectivity of its 2,3-epoxidation, followed by hydrogen atom ion at C-17 to generate reactive epoxide tau-m A with dienyl iminium unit. Subsequently,(+)-notoamide B and(+)-versicolamide B are produced via tandem nonenzymatic inverse-electron-demand Diels-Alder reaction and semipinacol rearrangement. This provides the first example of metabolon in the biosynthesis of spiro-prenylated indole alkaloids.

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