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Chinese Medical Journal 2024年第8期137卷 1006-1008页

作者： Chuchu Huang Mengping Mao Yiran Peng Ben Wang Yuxuan Deng Hongfu Xie dan jian Department of Dermatology Xiangya HospitalCentral South UniversityChangshaHunan 410008China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China Hunan Key Laboratory of Aging Biology Xiangya HospitalCentral South UniversityChangshaHunan 410008China Department of Dermatology and Allergy and Christine Kühne-Center for Allergy Research and EducationUniversity Hospital of BonnD-53127BonnGermany

To the Editor:Acne vulgaris is a prevalent skin disorder affecting both physical and psychosocial health.[1]Although photodynamic therapy(PDT)exists for moderate-to-severe acne,due to its adverse reactions,we are still looking forward to a novel therapeutic option with fewer side ***,radiofrequency has been used to treat moderate acne.[2]In this study,we aimed to evaluate the efcacy and safety of moderate-to-severe acne treatment based on a single microneedle with radiofrequency(MRF)*** during three consecutive sessions through a prospective,randomized,and controlled trial study.

关键词： needle prospective randomized

基于卷积神经网络算法的金华地区高山气象观测站逐时气温预报订正

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山地学报 2024年第2期42卷 278-286页

作者：郜庆林简单金华市气象局兰溪市气象局

受地貌和气候条件影响，智能网格气温预报产品的预报结果，在复杂地形山区易出现误差。通过人工订正关键点降低误差，存在较大主观性，预报精度有限，难以满足精细化气象服务需求。神经网络算法能够大幅提升预报精度，然而这种方法在气... 详细信息

受地貌和气候条件影响，智能网格气温预报产品的预报结果，在复杂地形山区易出现误差。通过人工订正关键点降低误差，存在较大主观性，预报精度有限，难以满足精细化气象服务需求。神经网络算法能够大幅提升预报精度，然而这种方法在气温逐时波动小的平原地区应用较多，在气温波动大的山区鲜有应用。本文以浙江金华山区为研究区域，基于浙江省智能网格温度预报产品以及同时段高山气象观测站逐时气温观测数据，采用卷积神经网络算法，实现关键点气温逐时预报订正。研究结果表明：(1)小时尺度上，订正后各站点的气温均方根误差均显著减小，由订正前3℃～7℃减小至订正后2℃～3℃,订正后的预测结果更加准确，订正效果符合预期。(2)月尺度上，相较智能网格原始气温预报数据，该模型预报结果准确率也明显提升，订正后月平均气温准确率提高了33.18%～46.86%,其中准确率6月最高。(3)相较人工订正的方式，该模型对山地气温预报的订正能力更稳定，模型的两项关键指标(平均绝对误差和2℃预报准确率)均接近或超过同时段浙江省天气预报质量检验平台气温业务指标。该研究结果满足金华地区高山气象观测站对于气温预报产品的业务可用性需求，可为精细化山区气象服务提供数据支撑。

关键词：卷积神经网络高山气象观测站精细气温订正预报智能网格金华

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基于嵌套剖分的位姿图分层优化算法

计算机应用研究 2024年第6期41卷 1916-1920页

作者：简单魏国亮蔡洁王耀磊上海理工大学理学院上海200093 上海理工大学管理学院上海200093

位姿图优化(pose graph optimization,PGO)是一种在同时定位与地图构建(simultaneous localization and mapping,SLAM)后端优化中常用的高维非凸优化算法,通常建模成极大似然估计。由于目前的PGO算法优化大规模大噪声数据集时很难在保... 详细信息

位姿图优化(pose graph optimization,PGO)是一种在同时定位与地图构建(simultaneous localization and mapping,SLAM)后端优化中常用的高维非凸优化算法,通常建模成极大似然估计。由于目前的PGO算法优化大规模大噪声数据集时很难在保证精度的同时提升速度,所以提出了一种基于嵌套剖分的位姿图分层优化算法。该算法首先建立不同距离度量的χ2检验模型,进而剔除异常值点。然后利用嵌套剖分算法将位姿图分割成一组子图,再从这些子图中提取出一个表示原SLAM问题的抽象拓扑的骨架图,从而优化该骨架图,完成初始化。最后在模拟和真实的位姿图数据集上进行实验评估,结果表明该算法在不影响精度的情况下,可以提高算法的计算速度,具有可伸缩性。

关键词：位姿图优化嵌套剖分噪声 χ2检验最大似然估计

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兰溪市负氧离子浓度特征与气象因素关系研究

四川环境 2024年第2期43卷 7-13页

作者：简单金杨方鹤鸣韦丹清兰溪市气象局浙江兰溪321100 金东区气象局浙江金华321015

利用兰溪市负氧离子监测数据及同期的气象环境观测资料,分析兰溪市负氧离子浓度变化特征、影响负氧离子浓度的主要气象环境因子,建立预报模型。结果表明,兰溪市负氧离子浓度具有明显的日变化特征,夜里至清晨时段较高,白天到傍晚时段较... 详细信息

利用兰溪市负氧离子监测数据及同期的气象环境观测资料,分析兰溪市负氧离子浓度变化特征、影响负氧离子浓度的主要气象环境因子,建立预报模型。结果表明,兰溪市负氧离子浓度具有明显的日变化特征,夜里至清晨时段较高,白天到傍晚时段较低。负氧离子浓度存在季节差异,春季呈“V”型;秋、冬季呈“W”型曲线,秋季的变化幅度没有冬季大,整体变化平缓;夏季呈波峰波谷交替出现,相较于其他季节更为复杂。降雨对负氧离子浓度影响很大,小时雨强和负氧离子浓度呈显著正相关关系;小时雨强达大雨以上对负氧离子浓度的影响最大;负氧离子浓度峰值出现在雨量峰值的前一个时次,有较好的对应关系。通过建立负氧离子浓度预报模型,实现定量化预报,对丰富旅游气象服务产品具有参考价值。

关键词：负氧离子浓度变化特征气象环境因子预报模型

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基于HUVEC细胞膜色谱的莱菔子中抗血管性疾病活性成分筛选及验证

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药物分析杂志 2024年第6期44卷 929-937页

作者：李华妮刘长河菅单单陈胜虎葛文静张雪侠河南省中西医结合医院河南省中医药研究院郑州450004 河南省中药制剂工程技术研究中心郑州450004 河南大学药学院开封475004

目的:构建人脐静脉细胞膜色谱(HUVEC/CMC)模型,并将其应用于莱菔子中抗血管性疾病活性成分的快速筛选。方法:采用HUVEC/CMC模型二维在线联用HPLC-ESI IT TOF MS系统对莱菔子活性成分进行分离、筛选和鉴定,并将筛选的活性成分进一步作用... 详细信息

目的:构建人脐静脉细胞膜色谱(HUVEC/CMC)模型,并将其应用于莱菔子中抗血管性疾病活性成分的快速筛选。方法:采用HUVEC/CMC模型二维在线联用HPLC-ESI IT TOF MS系统对莱菔子活性成分进行分离、筛选和鉴定,并将筛选的活性成分进一步作用于氧化低密度脂蛋白(ox-LDL)诱导的HUVEC,验证其保护作用。结果:利用所建立的方法从莱菔子中共筛选出2个保留组分,通过与对照品比对,鉴定出1个成分为芥子酸。与模型组比较,芥子酸低、中、高预处理组细胞存活率显著增加,细胞中ICAM-1和VCAM-1的含量下降,并呈剂量依赖性;Bcl-2蛋白表达水平下降、Bax蛋白表达升高,具有统计学意义(P<0.05)。结论:构建的HUVEC/CMC在线联用HPLC-ESI IT TOF MS系统可用于快速筛选复杂中药体系中活性成分,为细胞膜色谱的应用和莱菔子的开发提供了参考。

关键词：莱菔子细胞膜色谱芥子酸人脐静脉内皮细胞

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黑茶活性成分及健康功效研究进展

湖南城市学院学报（自然科学版） 2024年第4期33卷 67-72页

作者：刘湛军蹇丹李滔滔刘石泉湖南城市学院材料与化学工程学院/黑茶金花湖南省重点实验室湖南益阳413000

茶的活性成分及其健康功效一直是国内外茶学界研究的热点问题。黑茶是一种典型的微生物后发酵茶,研究表明黑茶在渥堆发酵过程中产生的生物碱、黄酮类化合物、游离氨基酸、多肽、多酚、色素、茶多糖等生物活性成分具有独特的药理活性与... 详细信息

茶的活性成分及其健康功效一直是国内外茶学界研究的热点问题。黑茶是一种典型的微生物后发酵茶,研究表明黑茶在渥堆发酵过程中产生的生物碱、黄酮类化合物、游离氨基酸、多肽、多酚、色素、茶多糖等生物活性成分具有独特的药理活性与健康功效。基于此,文章综述了黑茶中几种主要生物活性成分及其健康功效的最新研究进展,旨在为探究黑茶中功能性成分的具体作用机制,以及为茶叶功能成分利用、新产品开发等提供新的科学依据。

关键词：黑茶生物活性健康功效

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“大思政课”实践教学现状及体系构建研究

鄂州大学学报 2024年第1期31卷 62-63页

作者：陈洁琼邓娜李翠翠蹇丹贵州省体育运动学校贵州贵阳550002

“大思政课”是现代教育体系中思政工作的内在主线,是党和国家教育事业发展的必然要求。“大思政课”符合思想政治教育工作的发展规律,是思政教育的系统性创新。推进“大思政课”开发,需要紧跟时代发展,提高对“大思政课”的思想价值认... 详细信息

“大思政课”是现代教育体系中思政工作的内在主线,是党和国家教育事业发展的必然要求。“大思政课”符合思想政治教育工作的发展规律,是思政教育的系统性创新。推进“大思政课”开发,需要紧跟时代发展,提高对“大思政课”的思想价值认同,在此基础上将专业课程和思政教学有机融合,改进教学方法,完善评价机制,切实增强思政教育工作实效,全面落实立德树人的根本育人目标。

关键词：大思政课课程思政构建

Three-dimensional cell-based strategies for liver regeneration

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BIOCELL 2024年第7期48卷 1023-1036页

作者： dan GUO XI XIA jian YANG Liver Transplant Center Transplant CenterWest China HospitalSichuan UniversityChengdu610041China Frontiers Medical Center Tianfu Jincheng LaboratoryChengdu610212China

Liver regeneration and the development of effective therapies for liver failure remain formidable challenges in modern *** recent years,the utilization of 3D cell-based strategies has emerged as a promising approach for addressing these urgent clinical *** review provides a thorough analysis of the application of 3D cell-based approaches to liver regeneration and their potential impact on patients with end-stage liver ***,we discuss various 3D culture models that incorporate hepatocytes and stem cells to restore liver function and ameliorate the consequences of liver ***,we explored the challenges in transitioning these innovative strategies from preclinical studies to clinical *** collective insights presented herein highlight the signiﬁcance of 3D cell-based strategies as a transformative paradigm for liver regeneration and improved patient care.

关键词： Three-Dimensional Liver regeneration Organoids Stem cells Cell therapy

Nanostructured lubricant additives for titanium alloy:Lubrication by the solid-liquid interface with Coulomb repulsion

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Friction 2024年第7期12卷 1564-1579页

作者： Linlin DUAN dan JIA jian LI jianfang LIU Haitao DUAN State Key Laboratory of Special Surface Protection Materials and Application Technology Wuhan Research Institute of Materials ProtectionWuhan 430030China Hubei Longzhong Laboratory Xiangyang 441000China College of Life Science and Technology Wuhan Polytechnic UniversityWuhan 430030China

In this work,the advantage of Coulomb repulsion in the intermolecular forces experienced by molecules on the solid–liquid nanosized contact interface is taken,and the superior friction-reducing property of Cu_(3)(PO_(4))2·3H_(2)O(CuP)oil-based additives has been confirmed for titanium ***-dimensional(3D)CuP nanoflowers(CuP-Fs)with a strong capillary absorption effect are prepared to achieve the homogeneous mixing of solid CuP and lubricating *** by CuP-Fs additives for titanium alloy,friction coefficient(COF)can be reduced by 73.68%,and wear rate(WR)reduced by 99.69%.It is demonstrated that the extraordinary friction-reducing property is due to the repulsive solid–liquid interface with low viscous shear force originating from Coulomb repulsion between polar water molecules in CuP and non-polar oil ***,any steric hindrance or connection between this repulsive solid–liquid interface will trigger the adhesion and increase the viscous shear force,for example,dispersant,hydrogen bondings,and shaky adsorbed water ***,the lamellar thickness of CuP and the molecular size of lubricant both have a great influence on tribological *** the lubrication mechanism based on interface Coulomb repulsion is proposed that may help broaden the scope of the exploration in low-friction nanomaterial design and new lubricant systems.

关键词： lubrication nanomaterial additive solid-liquid interface wear

Impact of stage-specific limb function exercises guided by a selfmanagement education model on arteriovenous fistula maturation status

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World Journal of Clinical Cases 2024年第14期12卷 2316-2323页

作者： Yi Li Li-Jun Huang jian-Wen Hou dan-dan Hu Department of Nursing The People's Hospital of Jianyang CityJianyang 641400Sichuan ProvinceChina Department of Nephrology The People's Hospital of Jianyang CityJianyang 641400Sichuan ProvinceChina Department of Head and Neck Surgery Zhejiang Cancer HospitalHangzhou 310000Zhejiang ProvinceChina School of Nursing Shangqiu Institute of TechnologyShangqiu 476005Henan ProvinceChina

BACKGROUND The exercise of limb function is the most economical and safe method to promote the maturation of arteriovenous fistula(AVF).However,due to the lack of a uni-fied exercise standard in China,many patients have insufficient awareness of the importance of AVF,leading to poor effectiveness of limb function *** self-management education model can effectively promote patients to take pro-active health-related *** study focuses on the characteristics of patients during the peri-AVF period and conducts a phased limb function exercise under the guidance of the self-management education model to observe changes in fac-tors such as the maturity of *** To assess the impact of stage-specific limb function exercises,directed by a self-management education model,on the maturation status of *** This study is a randomized controlled trial involving 74 patients with forearm AVFs from the Nephrology Department of a tertiary hospital in Sichuan Province,*** were randomly divided into an observation group and a control group using a random number table *** observation group underwent tailored stage-specific limb func-tion exercises,informed by a self-management education model which took into account the unique features of AVF at various stages,in conjunction with routine ***,the control group was given standard limb function exercises along with routine *** assessment involves the maturity of AVFs post-intervention,post-operative complications,and the self-management level of the fistula in both groups *** were conducted using SPSS version *** data were represented by frequency and percentage and subjected to chi-square test *** data adhering to a normal distribution were presented as mean±*** independent samples t-test was utilized for inter-group comparisons,while the paired t-test was used for intra-group *** measurement data not fitting a normal distr

关键词： Self-management Education model Stage-specific Limb function exercises Arteriovenous fistula Maturation status