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化工自动化及仪表 2011年第8期38卷 951-953,1031页

作者：丛建平大庆中蓝石化有限公司黑龙江大庆163713

对丙烯管道冷却系统进行分析,提出了丙烯塔在一定条件下的最优恒压设计方案。

关键词：丙烯塔风机变频器电机控制

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管道壁面散热对瓦斯爆炸传播特性影响的研究

中国矿业大学学报 2009年第1期38卷 1-4页

作者：林柏泉菅从光张辉中国矿业大学安全工程学院江苏徐州221116 中国矿业大学机电工程学院江苏徐州221008 平煤集团河南平顶山467000 中国矿业大学徐海学院江苏徐州221008

在实验室对几何尺寸为80 mm×80 mm的爆炸钢质管道进行了研究,通过在内壁加贴绝热材料,采用高精度动态数据采集分析系统,测量爆炸过程中的火焰、爆炸波参数,研究了瓦斯爆炸过程中壁面散热对火焰传播速度、爆炸波超压峰值及爆炸波波速的... 详细信息

在实验室对几何尺寸为80 mm×80 mm的爆炸钢质管道进行了研究,通过在内壁加贴绝热材料,采用高精度动态数据采集分析系统,测量爆炸过程中的火焰、爆炸波参数,研究了瓦斯爆炸过程中壁面散热对火焰传播速度、爆炸波超压峰值及爆炸波波速的影响.结果表明:壁面散热条件对瓦斯爆炸传播特性影响非常明显,内贴绝热材料管道的火焰传播速度和爆炸波超压值、波速均比光滑管道有大幅提高,并可诱导激波的产生,其原因是管道内贴绝热材料后,壁面散热大幅减小.减少的热量一部分通过导热、扩散向未燃气体传递,一部分通过膨胀做功使爆炸波强度增大,两者均使火焰传播速度、爆炸波强度增加.从爆炸能量特征及能量守恒的角度进行了理论分析,实验结论与理论分析相吻合.

关键词：壁面散热瓦斯爆炸火焰传播速度超压

中药活性成分对卵巢癌的直接作用机制研究进展

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中国中西医结合杂志 2005年第12期25卷 1140-1144页

作者：郭方徐丛剑复旦大学附属妇产科医院上海200011

卵巢癌在女性生殖器官恶性肿瘤中的发生率及病死率均较高,传统的治疗手段包括手术治疗、化学药物治疗(化疗)、放射线治疗及上述治疗方式的联合应用。近年来发现我国传统中药成分如金雀黄素、薏苡仁、植物固醇类、姜黄素、五羟黄酮、人... 详细信息

卵巢癌在女性生殖器官恶性肿瘤中的发生率及病死率均较高,传统的治疗手段包括手术治疗、化学药物治疗(化疗)、放射线治疗及上述治疗方式的联合应用。近年来发现我国传统中药成分如金雀黄素、薏苡仁、植物固醇类、姜黄素、五羟黄酮、人参皂苷等可在体内和(或)体外发挥对卵巢癌细胞的抑制增殖、诱导凋亡、增加对化疗药物的敏感性等抗癌作用。其作用机制涉及到抑制细胞代谢关键酶活性、影响细胞基因表达、抗氧化、抑制肿瘤新生血管形成等方面,其作为卵巢癌的一种辅助治疗手段,有着广阔的临床应用前景。

关键词：卵巢癌中药作用机制

Mechanism of pachymic acid in the treatment of gastric cancer based on network pharmacology and experimental verification

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 30-50页

作者： Yu-Hua Du jian-Jun Zhao Xia Li Shi-cong Huang Na Ning Guo-Qing Chen Yi Yang Yi Nan Ling Yuan College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Ningxia Chinese Medicine Research Center Manufacturing LaboratoryYinchuan 750004Ningxia Hui Autonomous RegionChina College of Foundation Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Key Laboratory of Ningxia Minority Medicine Modernization Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Pachymic acid(PA)is derived from Poria *** has a variety of pharmacological and inhibitory effects on various ***,the mechanism of action of PA in gastric cancer(GC)remains *** To investigate the mechanism of PA in treating GC via the combination of network pharmacology and experimental *** The GeneCards and OMIM databases were used to derive the GC targets,while the Pharm Mapper database provided the PA *** the STRING database,a protein-protein interaction network was constructed and core targets were *** analyses of Gene Ontology,Kyoto Encyclopedia of Genes and Genomes(KEGG),and gene set enrichment analysis were conducted,and molecular docking and clinical correlation analyses were performed on the core ***,the network pharmacology findings were validated through in vitro cell assays,encompassing assessments of cell viability,apoptosis,cell cycle,cloning,and western blot *** According to network pharmacology analysis,the core targets were screened,and the PI3K/AKT signaling pathway is likely to be the mechanism by which PA effectively treats GC,according to KEGG enrichment *** experimental findings showed that PA could control PI3K/AKT signaling to prevent GC cell proliferation,induce apoptosis,and pause the cell *** Network pharmacology demonstrated that PA could treat GC by controlling a variety of signaling pathways and acting on a variety of *** has also been supported by in vitro cell studies,which serve as benchmarks for further research.

关键词： Pachymic acid Gastric cancer Network pharmacology Enrichment analysis Cell proliferation

UWLPIPE:Ultra-wide Bandwidth Low-frequency Pulsar Data Processing Pipeline

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Research in Astronomy and Astrophysics 2024年第7期24卷 145-157页

作者： Ya-Zhou Zhang Hai-Long Zhang Jie Wang jian Li Xin-Chen Ye Shuang-Qiang Wang Xu Du Han Wu Ting Zhang Shao-cong Guo Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China National Astronomical Data Center Beijing 100101China Southeast University Nanjing 211189China

For real-time processing of ultra-wide bandwidth low-frequency pulsar baseband data,we designed and implemented an ultra-wide bandwidth low-frequency pulsar data processing pipeline(UWLPIPE)based on the shared ringbuffer and GPU parallel *** runs on the GPU cluster and can simultaneously receive multiple 128 MHz dual-polarization VDIF data packets preprocessed by the front-end *** aligning the dual-polarization data,multiple 128M subband data are packaged into PSRDADA baseband data or multi-channel coherent dispersion filterbank data,and multiple subband filterbank data can be spliced into wideband data after time *** used the Nanshan 26 m radio telescope with the L-band receiver at964~1732 MHz to observe multiple ***,we processed the data using DSPSR software,and the results showed that each subband could correctly fold out the pulse profile,and the wideband pulse profile accumulated by multiple subbands could be correctly aligned.

关键词： (stars)pulsars general-methods data analysis-techniques miscellaneous

各向异性弹黏塑性模型在ABAQUS中的研发

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岩土力学 2012年第4期33卷 1240-1246页

作者：钦亚洲李宁许建聪同济大学岩土及地下工程教育部重点实验室上海200092 同济大学地下建筑与工程系上海200092

通过将Perzyna过应力理论与临界状态理论相结合,并引入Wheeler旋转硬化法则,提出一个能描述土体初始各向异性及应力诱发各向异性的三维弹黏塑性本构模型。模型考虑流变发生的下限,在三维应力空间,模型存在形状相似的静屈服面及动态加载... 详细信息

通过将Perzyna过应力理论与临界状态理论相结合,并引入Wheeler旋转硬化法则,提出一个能描述土体初始各向异性及应力诱发各向异性的三维弹黏塑性本构模型。模型考虑流变发生的下限,在三维应力空间,模型存在形状相似的静屈服面及动态加载面。采用缩放形式的幂函数。本构模型数值算法采用回映算法,借助ABAQUS软件UMAT子程序接口实现。并通过对三轴不排水蠕变试验的模拟,确定合适的积分步长。此后,分别对三轴不排水蠕变试验及常应变率三轴不排水剪切试验进行了模拟。模拟中通过设置不同参数值,可将模型退化为各向同性模型,并对这两种模拟结果进行了比较。模拟结果表明:(1)对于三轴不排水蠕变,在低剪应力水平下,各向同性模型和各向异性模型模拟的结果相差不大,而在高剪应力水平下,各向异性模型模拟结果更接近试验结果;(2)对于常应变率加载试验的模拟,模型合理反映了土体不排水强度随着加载速率的增大而增大现象。

关键词：各向异性弹黏塑性模型回映算法 ABAQUS软件 UMAT子程序

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降雨诱发浅层滑坡稳定性的计算模型研究

岩土力学 2012年第5期33卷 1485-1490页

作者：李宁许建聪钦亚洲同济大学岩土及地下工程教育部重点实验室上海200092 同济大学地下建筑与工程系上海200092

我国是一个滑坡灾害频发的国家,众多事实表明:降雨是影响边坡稳定性,导致边坡失稳的最主要和最普遍的环境因素,是浅层滑坡的触发因素。为了更好地对降雨诱发浅层滑坡进行研究,采用非饱和土VG模型与改进的Green-Ampt入渗模型对Mein-Larso... 详细信息

我国是一个滑坡灾害频发的国家,众多事实表明:降雨是影响边坡稳定性,导致边坡失稳的最主要和最普遍的环境因素,是浅层滑坡的触发因素。为了更好地对降雨诱发浅层滑坡进行研究,采用非饱和土VG模型与改进的Green-Ampt入渗模型对Mein-Larson降雨入渗模型进行改进,并结合无限边坡提出了一个降雨诱发浅层滑坡的简化计算模型。与以往提出的简化计算模型相比,该模型既考虑了坡面倾斜的影响,又考虑了非饱和土的特性,并可用于两种降雨形式下的边坡浅层稳定性估算,具有更广的应用范围。通过与有限元得到的结果进行比较可得:在不同降雨条件下,该计算模型得到的各项结果与数值解是接近的,安全系数计算结果是偏于安全的,因此,可将该计算模型用于降雨诱发浅层滑坡的近似估算;该计算模型公式简单,便于计算,计算效率较高。

关键词：降雨入渗模型无限边坡非饱和土浅层滑坡

Biochemical and Morphological Changes in the Lenses of Selenium and/or Vitamin E Deficient Rats

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Biomedical and Environmental Sciences 1994年第2期7卷 109-115页

作者： CAI QIU-YIN CHEN XIAO-SHU ZHU LIAN-ZHEN XUE AN-NA LI WEN-XIAN WANG SHU-QIN PIAO jian-HUA LI JIE SUN CUN-PU WU KE AND cong jian-BO(Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, 29 Nan Wet Road, Beijing 100050, Chin Institute of Nutrition and Food Hygiene Chinese Academy of Preventive Medicine Beijing.

The activities of glutathione peroxidase (GSH-Px), glutathione reductase (GSSG-R),superoalde dismutase (SOD) and the contents of malondialdehyde (MDA) and free radicals were measured, and the morphological changes were observed in the lens of control rats, selenium-deficient (SeD) and/or vitamin E deficient (VED) rats. The activities of GSH-Px in the lens of SeD rats decreased significantly. The GSH-Px activities of lens were positively related to erythrocytes selenium level. There was a free radical at g = 2.0015 in the rat lens of all groupe, but the content of free radicals in the lens of SeD group was significantly higher than that of the control group. The free radical content of lens was negatively related to erythrocytes selenium level, as well as the GSH-Px activities in the lens. In vitro, ultraviolet radiation caused the generation of another kind of free radical (g = 2.0097) in the lens of all groups, but the amount of the free radical in the lens of the SeD group was also significantly higher than that of the control group. The activities of SoD and GSSG-R in VED rat lens were significantly decreased. The amount of MDA in the lens of SeD and/or VED rats were significantly increased. The results showed that the decrease of antioaldative capability in the lenses of SeD and/or VED rats accelerated the lipid peroxidation and generation of free radicals. Although only early morphological changes in SeD and/or VED rat lens were observed, it is considered that selenium and vitamin E deficiency may be involved in the occurrence of cataract

关键词： Res GSH Biochemical and Morphological Changes in the Lenses of Selenium and/or Vitamin E Deficient Rats

Geometrical characteristic investigation of the Baihetan irregular columnar jointed basalt and corresponding numerical reconstruction method

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Journal of Central South University 2022年第2期29卷 455-469页

作者： ZHANG jian-cong jianG Quan FENG Guang-liang LI Shao-jun PEI Shu-feng HE Ben-guo State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines Northeastern UniversityShenyang 110819China

Columnar jointed rock mass with unique geometric and geological properties is one spectacular example of geometrical order in *** joints are generally accepted to be formed by spatially uniform volume contraction during *** this paper,substantial field work was performed to study the geological characteristics of irregular columnar jointed basalt on the left bank dam foundation in the Baihetan Hydropower Station,where the columnar jointed rock mass is extensively exposed due to *** quantitative measurements of the sizing of polygonal crack pattern of columnar joints and assessment of their degree of irregularity were *** the irregularity of polygonal crack pattern,a modified Voronoi polygon(MVP)method was developed to model the special polygonal crack pattern of columnar *** new polygonal pattern obtained by the MVP method consists of a large number of irregular polygons,of which the degree of irregularity is consistent with the field measurement *** method can reproduce the rapid evolution from an initial ideal regular hexagonal pattern to a final actual irregular polygonal pattern as the degree of irregularity *** compression tests of columnar jointed rock mass with different irregularity show that the geometric irregularity has a great influence on its mechanical *** numerical construction method provides a reliable way to reconstruct columnar joint structure with specific polygonal crack pattern,which is consistent with onsite columnar jointed basalt.

关键词： columnar jointed basalt geometrical characteristics degree of irregularity numerical construction modified Voronoi polygon method

A nomogram predicting the recurrence of hepatocellular carcinoma in patients after laparoscopic hepatectomy

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Cancer Communications 2019年第1期39卷 499-509页

作者： Yang-Xun Pan jian-cong Chen Ai-Ping Fang Xiao-Hui Wang Jin-Bin Chen Jun-Cheng Wang Wei He Yi-Zhen Fu Li Xu Min-Shan Chen Yao-Jun Zhang Qi-Jiong Li Zhong-Guo Zhou State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060GuangdongP.R.China Department of Liver Surgery Sun Yat-sen University Cancer Center651 Dongfeng Road EastGuangzhou 510060GuangdongP.R.China Department of Public Health Sun Yat-sen UniversityGuangzhou 510080GuangdongP.R.China Department of Molecular Medicine California Campus The Scripps Research Institute10550North Torrey Pines RoadLa JollaCA 92037USA

Background:Patients with hepatocellular carcinoma(HCC)undergoing surgical resection still have a high 5-year recurrence rate(~60%).With the development of laparoscopic hepatectomy(LH),few studies have compared the efficacy between LH and traditional surgical approach on *** objective of this study was to establish a nomo-gram to evaluate the risk of recurrence in HCC patients who underwent ***:The clinical data of 432 patients,pathologically diagnosed with HCC,underwent LH as initial treatment and had surgical margin>1 cm were *** significance of their clinicopathological features to recurrence-free survival(RFS)was assessed,based on which a nomogram was constructed using a training cohort(n=324)and was internally validated using a temporal validation cohort(n=108).Results:Hepatitis B surface antigen(hazard ratio[HR],1.838;P=0.044),tumor number(HR,1.774;P=0.003),tumor thrombus(HR,2.356;P=0.003),cancer cell differentiation(HR,0.745;P=0.080),and microvascular tumor invasion(HR,1.673;P=0.007)were found to be independent risk factors for RFS in the training cohort,and were used for con-structing the *** C-index for RFS prediction in the training cohort using the nomogram was 0.786,which was higher than that of the 8th edition of the American Joint Committee on Cancer TNM classification(C-index,0.698)and the Barcelona Clinic Liver Cancer staging system(C-index,0.632).A high consistency between the nomogram prediction and actual observation was also demonstrated by a calibration *** improved predictive benefit in RFS and higher threshold probability of the nomogram were determined by receiver operating characteristic curve analysis,which was also confirmed in the validation cohort compared to other ***:We constructed and validated a nomogram able to quantify the risk of recurrence after initial LH for HCC patients,which can be clinically implemented in assisting the planification of individual postoperative surveil-lance

关键词： Hepatocellular carcinoma Laparoscopic hepatectomy Recurrence Nomogram American Joint Committee on Cancer TNM classification Barcelona Clinic Liver Cancer staging system Hepatitis B surface antigen Tumor thrombus Tumor invasion