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mini-Jet Controlled Turbulent Round Air Jet

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Chinese Physics Letters 2011年第12期28卷 171-174页

作者： DU Cheng mi jian-Chun ZHOU Yu ZHAN Jie Department of Energy&Resources Engineering College of EngineeringPeking UniversityBeijing 100871 Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong Key Laboratory of Manufacture and Test Techniques for Automobile Parts Chongqing University of TechnologyChongqing 400054

We report an investigation of the active control of a round air jet by multiple radial blowing *** Reynolds number based on the jet exit velocity and diameter is *** is found that once the continuous mini-jets are replaced with pulsed ones,the centerline velocity decay rate K can be greatly increased as the pulsing frequency of mini−jets approaches the natural vortex frequency of the main *** example,the K value is amplified by more than 50%with two(or four)pulsed mini-jets blowing,compared with the continuous mini-jets at the same ratio of the mass flow rate of the mini-jets to that of the main jet.

关键词： vortex decay Turbulent

Theoretical Interpretation of Conformation Variations of Polydimethylsiloxane Induced by Nanoparticles

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Chinese Journal of Polymer Science 2018年第4期36卷 505-513页

作者： Zhao-Yang Wei Nan-Ying Ning ming Tian Li-Qun Zhang jian-Guo mi State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical Technology Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology

There has been controversy as to whether the addition of nanoparticles to a polymer melt causes perturbed chain structure of polymers. In this work, the chain conformations of polydimethylsiloxane（PDMS） with addition of polyhedral oligomeric silsesquioxane（POSS） nanoparticles have been studied using a classical density functional approach. Under the strong interactions of POSS-PDMS, the radius of gyration of PDMS in the nanocomposites can either increase or decline depending on particle loading. After adding nanoparticles with larger size or weaker interactions, both the increasing and the declining amplitudes can be largely suppressed. The results provide a deep understanding of chain conformation in polymer nanocomposites.

关键词： Chain conformation Radius of gyration Polymer nanocomposites Density functional theory

Large eddy simulations of a triangular jet and its counterpart through a chamber

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Chinese Physics B 2020年第6期29卷 265-273页

作者： Xiu Xiao Guo-Chang Wang min-Yi Xu jian-Chun mi Marine Engineering College Dalian Maritime UniversityDalian 116026China College of Engineering Peking UniversityBeijing 100871China

A free triangular jet(TJ1)and its counterpart initially passing a short circular chamber(TJ2)are numerically modeled using large eddy simulation(LES).This paper compares the near-field characteristics of the two jets in *** enable some necessary experimental validations,the LES conditions of TJ1 and TJ2 are taken to be identical to those measured by Xu et al.(*** Phys.561176(2013))and England et al.(***.4869(2010)),*** LES predictions are found to agree well with those *** is demonstrated that a strong swirl occurs near the chamber inlet plane for the TJ2 *** the center of the swirl,there is a cluster of three sink foci,where each focus is aligned midway between the original triangular *** the vortex skeleton constructed from the time-averaged flow field,the vortices arising from the foci are helically twisted around the core of the *** the flow passes through the chamber,the foci merge to form a closed-loop“bifurcation line”,which separates the inward swirling flow and the outward oscillating *** global oscillation is regarded as a source node near the centerline of the *** the chamber is removed for a“free”jet,i.e.,TJ1,a cluster of three pairs of counter-rotating foci is produced and the net swirl circulation is zero,so the overall oscillation of the jet does not occur.

关键词： turbulent triangular jet large eddy simulation

Key Factors in Determining the Magnitude of Vorticity in Turbulent Plane Wakes

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Chinese Physics Letters 2010年第2期27卷 145-148页

作者：米建春 R.A.Antonia College of Energy & Power Engineering Changsha University of Science and Technology Changsha 410004 State Key Laboratory for Turbulence and Complex Systems College of Engineering Peking University Beijing 100871 Discipline of Mechanical Engineering University of Newcastle NSW 2308 Australia

We examine the effects of local turbulence Reynolds number Rλ and inflow conditions on the magnitude of vorticity in plane turbulent wakes. Measurements of the spanwise component （ω3） of the fluctuating vorticity vector ω = ω1i ＋ ω2j ＋ ω3k （here the subscripts 1, 2 and 3 denote the streamwise, lateral and spanwise directions, respectively） are made in turbulent wakes of a screen and a circular cylinder. Lateral distributions of ω3＊（normalized） in general depend on both Rλ and inflow conditions. In the developing region, as the downstream distance x1 increases, ω3＊ increases significantly in the screen wake but decreases slightly in the cylinder wake. Far downstream in the self-preserving region, ω3＊ increases linearly with Rλ while it no longer varies with x1 and depends weakly on the influence of inflow conditions. Our analysis suggests that these findings from the measurement of ω3＊ should apply for the magnitude of ω.

关键词： Fluid dynamics

CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies

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Frontiers of Medicine 2021年第6期15卷 783-804页

作者： jian-Qing mi Jie Xu jianfeng Zhou Weili Zhao Zhu Chen J.Joseph Melenhorst Saijuan Chen State Key Laboratory of Medical Genomics Shanghai Institute of HaematologyNational Research Centre for Translational MedicineRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200025China Department of Pathology&Laboratory Medicine University of PennsylvaniaPhiladelphiaPA19104USA Immunotherapy Research Centre for Hematologic Diseases of Hubei Province Department of HaematologyTongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

The current standard of care in hematological malignancies has brought considerable clinical benefits to ***,important bottlenecks still limit optimal achievements following a current medical *** genetic complexity of the diseases and the heterogeneity of tumor clones cause difficulty in ensuring long-term efficacy of conventional treatments for most hematological ***,new treatment strategies are necessary to improve clinical *** antigen receptor T-cell(CAR T)immunotherapy opens a new path for targeted therapy of hematological *** this review,through a representative case study,we summarize the current experience of CAR T-cell therapy,the management of common side effects,the causative mechanisms of therapy resistance,and new strategies to improve the efficacy of CAR T-cell therapy.

关键词： CAR T cells hematological malignancies review

A mimetic peptide of α2,6-sialyllactose promotes neuritogenesis

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Neural Regeneration Research 2020年第6期15卷 1058-1065页

作者： Shuang-Xi Chen Jia-Hui He Yong-jian mi Hui-Fan Shen Melitta Schachner Wei-jiang Zhao Center for Neuroscience Shantou University Medical CollegeShantouGuangdong ProvinceChina Department of Neurology The First Affiliated Hospital of University of South ChinaHengyangHunan ProvinceChina Department of Neurology Chongqing Qijiang Renmin HospitalChongqingChina Keck Center for Collaborative Neuroscience and Department of Cell Biology and Neuroscience Rutgers UniversityPiscatawayNJUSA

Oxidative stress contributes to the pathogenesis of neurodegenerative *** the aim to find reagents that reduce oxidative stress,a phage display library was screened for peptides mimicking a2,6-sialyllactose(6'-SL),which is known to beneficially influence neural *** Sambucus nigra lectin,which specifically binds to 6'-SL,we screened a phage display library and found a peptide comprising identical sequences of 12 amino *** peptide,reverse peptide and scrambled peptide were tested for inhibition of 6'-SL binding to the ***,lectin binding to 6'-SL was inhibited by the most frequently identified mimetic peptide,but not by the reverse or scrambled peptides,showing that this peptide mimics 6'-***,mimetic peptide,but not the reverse or scrambled peptides,increased viability and expression of neural cell adhesion molecule L1 in SK-N-SH human neuroblastoma cells,and promoted survival and neurite outgrowth of cultured mouse cerebellar granule neurons challenged by H_20_2-induced oxidative *** combined results indicate that the 6'-SL mimetic peptide promotes neuronal survival and neuritogenesis,thus raising hopes for the treatment of neurodegenerative *** study was approved by the Medical Ethics Committee of Shantou University Medical College,China(approval *** 2014-004)on February 20,2014.

关键词： central nervous system cerebellar granule neurons mimetic peptide neural cell adhesion molecule L1 neuritogenesis neurodegenerative disease neuronal survival oxidative stress phage display Sambucus nigra lectin α2,6-sialyllactose

IRF4 and IRF8 expression are associated with clinical phenotype and clinico-hematological response to hydroxyurea in essential thrombocythemia

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Frontiers of Medicine 2022年第3期16卷 403-415页

作者： Xiao Huang Tingting Ma Yongmei Zhu Bo Jiao Shanhe Yu Kankan Wang jian-Qing mi Ruibao Ren Shanghai Institute of Hematology State Key Laboratory for Medical GenomicsCollaborative Innovation Center of HematologyNational Research Center for translational Medicine(Shanghai)Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China

The morbidity and mortality of myeloproliferative neoplasms(MPNs)are primarily caused by arterial and venous complications,progression to myelofibrosis,and transformation to acute ***,identifying molecular-based biomarkers for risk stratification of patients with MPNs remains a *** have previously shown that interferon regulatory factor-8(IRF8)and IRF4 serve as tumor suppressors in myeloid *** this study,we evaluated the expression of IRF4 and IRF8 and the JAK2V617F mutant allele burden in patients with *** with decreased IRF4 expression were correlated with a more developed MPN phenotype in myelofibrosis(MF)and secondary AML(sAML)transformed from MPNs versus essential thrombocythemia(ET).Negative correlations between the JAK2V617F allele burden and the expression of IRF8(Pmia vera *** response(CR),partial response(PR),and no response(NR)were observed in 67.5%,10%,and 22.5%of ET patients treated with hydroxyurea(HU),respectively,in 12 *** 3 months,patients in the CR group showed high IRF4 and IRF8 expression compared with patients in the PR and NR *** the 12-month therapy period,low IRF4 and IRF8 expression were independently associated with the unfavorable response to HU and high WBC *** data indicate that the expression of IRF4 and IRF8 was associated with the MPN phenotype,which may serve as biomarkers for the response to HU in ET.

关键词： myeloproliferative neoplasms IRF4 IRF8 hydroxyurea essential thrombocythemia

Early visual function outcomes of topography-guided FS-LASIK and SmiLE in treatment of myopia and myopic astigmatism

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International Journal of Ophthalmology(English edition) 2021年第3期14卷 423-429页

作者： Lin-Juan Yang Xuan Liu Sheng-jian mi Le Sun Meng-Xin Chen Department of Ophthalmology the First Affliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina

AIM: To compare the quality outcomes of vision at early phase after topography-guided femtosecond laser-assisted in situ keratomileusis(FS-LASIK-CV) and small incision lenticule extraction(SmiLE) in treatment of myopia and myopic ***: Retrospective comparative analysis of 49 patients that underwent FS-LASIK(n=23) or SmiLE(n=26) procedure for myopia and myopic astigmatism between April and September in 2019. Pre-and postoperative uncorrected visual acuity(UCVA), spherical equivalent refraction(SEQ), cylindrical refraction, contrast sensitivity function(CSF), and corneal higher-order aberrations(HOAs) were evaluated. Independent t-test was used for inter-group comparison, while repeated measures ANOVA was used to analyze changes at different time points. RESULTS: In both groups, 100% of the eyes obtained a UCVA of 20/20 or better at 1 wk, 1, and 3 mo postoperatively. At 1 d and 3 mo postoperatively, UCVA was better in FS-LASIKCV group than in SmiLE group. At 1 wk postoperatively, SEQ was lower in SmiLE group than in FS-LASIK-CV group(P=0.006). At 3 mo postoperatively, the SEQ reached target refraction in both groups. The residual astigmatism was reduced in both groups without intergroup difference(P>0.05). At 3 mo postoperatively, the spherical aberration and coma under 6 mm pupil size were higher than preoperative levels in both groups(PmiLE group(PmiLE demonstrate to be safe, effective, and predictable in treatment of myopia and myopic

关键词： corneal topography femtosecond laser laser-assisted in-situ keratomileusis small incision lenticule extraction quality of vision contrast sensitivity

Location and expression of neurotrophin-3 and its receptor in the brain of human embryos during early development

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Neural Regeneration Research 2008年第12期3卷 1277-1280页

作者： jian Li Yongjie mi Dajun Ma Department of Human Anatomy Histology and Embryology Chengdu Medical College Chengdu 610083 Sichuan Province China

BACKGROUND： Cell culture in vitro trials have demonstrated that neurotrophin-3 （NT-3） can enhance the survival of sensory neurons and sympathetic neurons, and can also support embryo-derived motor neurons. This effect is dependent on nerve growth factor on the surface of cells. Understanding the role of NT-3 and its receptor in the early development of human embryonic brains will help to investigate the correlation between early survival of nerve cells and the microenvironment of neural regeneration. OBJECTIVE： To observe the proliferation of cerebral neurons in the development of human embryonic brain, and to investigate the location, expression and distribution of NT-3 and its receptor TrkC during human brain development. DESIGN, TIME AND SETTING： An observation study on cells was performed in the Department of ttuman Anatomy, Histology and Embryology, Chengdu Medical College in September 2007. MATERIALS： Fifteen specimens of flesh human embryo, aged 6 weeks, were used in this study. METHODS： The proliferation of cerebral neurons was detected using proliferating cell nuclear antigen, and the immunocytochemistry ABC technique was applied to observe the location, expression and distribution of NT-3 and its receptor TrkC in the brain of the human embryo. MAIN OUTCOME MEASURES： Location, expression and distribution of NT-3 and its receptor in the brain of the human embryo. RESULTS： In the early period （aged 6 weeks） of human embryonic development, proliferating cell nuclear antigen-positive reactive substances were mainly observed in the nucleus of the forebrain ventricular zone and subventricular zone, and the intensity was stronger in the subventricular zone than the forebrain ventricle. NT-3 positive reactive substance was mainly distributed in the cytoblastema of the forebrain neuroepithelial layer and nerve cell process, while TrkC was mainly distributed in the cell membrane of the forebrain ventricular zone and subventricular zone. During embryonic development,

关键词： neurotrophin-3 TrkC human embryo brain development