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Solving the transient response of the randomly excited dry friction system via piecewise RBF neural networks

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Science China(Technological Sciences) 2023年第5期66卷 1408-1416页

作者： qian jiamin CHEN LinCong SUN JianQiao College of Civil Engineering Huaqiao UniversityXiamen361021China Key Laboratory for Intelligent Infrastructure and Monitoring of Fujian Province Huaqiao UniversityXiamen361021China Department of Mechanical Engineering School of EngineeringUniversity of CaliforniaMercedCA95343USA

Over the years,practical importance and interesting dynamical features have caused a growing interest in dry friction ***,an effective approach to capture the non-smooth transition behavior of such systems is still ***,we propose a piecewise radial basis function neural network(RBFNN)strategy to solve the transient response of the randomly excited dry friction *** the established framework,the transient probability density function of the dry friction system is expressed in a piecewise *** segment of the solution is expressed by the sum of a series of Gaussian activation functions with time-dependent *** time dependent weights are solved by minimizing the loss function,which involves the residual of the Fokker-Planck-Kolmogorov equations and constraint *** avoid the singularity of the initial condition being a Dirac delta function,a short-time Gaussian approximation strategy is presented to solve the initiating time-dependent *** on some numerical results,the proposed scheme effectively ***,a comparison with other existing methods reveals that the proposed scheme can completely capture the nonlinear characteristic of the dry friction system stochastic response more ***,we can easily extend the proposed method to other types of non-smooth systems with piecewise response ***,the semi-analytical solution provides a valuable reference for system optimization.

关键词： dry friction system transient response semi-analytical solution piecewise RBF neural networks

Random vibration of hysteretic systems under Poisson white noise excitations

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Applied Mathematics and Mechanics(English Edition) 2023年第2期44卷 207-220页

作者： Lincong CHEN Zi YUAN jiamin qian J.Q.SUN College of Civil Engineering Huaqiao UniversityXiamen 361021Fujian ProvinceChina Key Laboratory for Intelligent Infrastructure and Monitoring of Fujian Province Xiamen 361021Fujian ProvinceChina Department of Mechanical Engineering School of EngineeringUniversity of CaliforniaMercedCA 95343U.S.A.

Hysteresis widely exists in civil structures,and dissipates the mechanical energy of *** on the random vibration of hysteretic systems,however,is still insufficient,particularly when the excitation is *** this paper,the radial basis function(RBF)neural network(RBF-NN)method is adopted as a numerical method to investigate the random vibration of the Bouc-Wen hysteretic system under the Poisson white noise *** solution to the reduced generalized Fokker-PlanckKolmogorov(GFPK)equation is expressed in terms of the RBF-NNs with the Gaussian activation functions,whose weights are determined by minimizing the loss function of the reduced GFPK equation residual and constraint associated with the normalization condition.A steel fiber reinforced ceramsite concrete(SFRCC)column loaded by the Poisson white noise is studied as an example to illustrate the solution *** effects of several important parameters of both the system and the excitation on the stochastic response are evaluated,and the obtained results are compared with those obtained by the Monte Carlo simulations(MCSs).The numerical results show that the RBF-NN method can accurately predict the stationary response with a considerable high computational efficiency.

关键词： random vibration Bouc-Wen hysteresis system non-Gaussian excitation Poisson white noise excitation radial basis function(RBF)neural network(RBF-NN)

Optimization for vibro-impact nonlinear energy sink under randomexcitation

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Theoretical & Applied Mechanics Letters 2022年第5期12卷 322-325页

作者： jiamin qian Lincong Chen College of Civil Engineering Huaqiao UniversityXiamen 361021China Key Laboratory for Intelligent Infrastructure and Monitoring of Fujian Province Huaqiao UniversityJimei Avenue 668XiamenFujian361021China

As a promising vibration control device, the vibro-impact nonlinear energy sink (VI-NES) gathered extensively attention in recent years. However, general optimization procedures have not been available forthe design of VI-NES subjected to random excitations. To this end, this paper constitutes a research effortto address this gap. Specifically, the approximate analytical solution of the system stochastic responseis obtained in conjunction with non-smooth conversion and stochastic averaging methodology. Takingadvantages of this approximate solution, the variance of the system is defined and easily minimized tocalculate the optimal parameters for VI-NES. In addition, the results computed by this way fairly correlatewith direct numeric simulations.

关键词： Vibration control Vibro-impact NES Stochastic averaging Optimization

Josephin domain containing 2(JOSD2)promotes lung cancer by inhibiting LKB1(Liver kinase B1)activity

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Signal Transduction and Targeted Therapy 2024年第2期9卷 693-708页

作者： Tao Yuan Chenming Zeng Jiawei Liu Chenxi Zhao Fujing Ge Yuekang Li Meijia qian jiamin Du Weihua Wang Yonghao Li Yue Liu Xiaoyang Dai Jianya Zhou Xueqin Chen Shenglin Ma Hong Zhu Qiaojun He Bo Yang Institute of Pharmacology&Toxicology Zhejiang Province Key Laboratory of Anti-Cancer Drug ResearchCollege of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Innovation Institute for Artificial Intelligence in Medicine Zhejiang UniversityHangzhou 311199China Ministry of Education Key Laboratory of Chinese Medicinal Plants Resource from Lingnan Research Center of Medicinal Plants Resource Science and EngineeringGuangzhou University of Chinese MedicineGuangzhou 510006China Center for Drug Safety Evaluation and Research of Zhejiang University Hangzhou 310058China Department of Respiratory Disease Thoracic Disease CenterThe First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310006China Department of Oncology Hangzhou Cancer HospitalHangzhou 310002China Cancer Center of Zhejiang University HangzhouChina Engineering Research Center of Innovative Anticancer Drugs Ministry of EducationHangzhouChina

Non-small cell lung cancer(NSCLC)ranks as one of the leading causes of cancer-related deaths *** the prominence and effectiveness of kinase-target therapies in NSCLC treatment,these drugs are suitable for and beneficial to a mere~30%of NSCLC ***,the need for novel strategies addressing NSCLC remains ***(DUBs),a group of diverse enzymes with well-defined catalytic sites that are frequently overactivated in cancers and associated with tumorigenesis and regarded as promising therapeutic ***,the mechanisms by which DUBs promote NSCLC remain poorly *** a global analysis of the 97 DUBs’contribution to NSCLC survival possibilities using The Cancer Genome Atlas(TCGA)database,we found that high expression of Josephin Domain-containing protein 2(JOSD2)predicted the poor prognosis of *** of JOSD2 significantly impeded NSCLC growth in both cell/patient-derived xenografts in ***,we found that JOSD2 restricts the kinase activity of LKB1,an important tumor suppressor generally inactivated in NSCLC,by removing K6-linked polyubiquitination,an action vital for maintaining the integrity of the LKB1-STRAD-MO25 ***,we identified the first small-molecule inhibitor of JOSD2,and observed that its pharmacological inhibition significantly arrested NSCLC proliferation in vitro/in *** findings highlight the vital role of JOSD2 in hindering LKB1 activity,underscoring the therapeutic potential of targeting JOSD2 in NSCLC,especially in those with inactivated LKB1,and presenting its inhibitors as a promising strategy for NSCLC treatment.

关键词： LKB1 inhibiting removing

AUTOSAR多核MCU数据一致性方案研究

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上海汽车 2022年第6期 39-43页

作者：钱贾敏联合汽车电子有限公司上海201206

随着半导体技术的发展,多核MCU在汽车控制器中的应用越来越多,然而将在单核系统上开发的应用软件向多核系统上移植一直是个难题,尤其是多核访问数据的一致性问题。文章首先介绍了多核MCU数据访问的一致性问题,并详细描述了在AUTOSAR中... 详细信息

随着半导体技术的发展,多核MCU在汽车控制器中的应用越来越多,然而将在单核系统上开发的应用软件向多核系统上移植一直是个难题,尤其是多核访问数据的一致性问题。文章首先介绍了多核MCU数据访问的一致性问题,并详细描述了在AUTOSAR中确保数据一致性的几种机制;比较了这几种机制在单核软件移植到多核系统过程中应用的成本和效果,指出了Sender/Receiver隐性访问机制在移植成本和性能方面所具备的优势。

关键词：多核 AUTOSAR 操作系统

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拉伸伸长率对压力袜压力及压力分布的影响

针织工业 2022年第6期 16-19页

作者：钱佳敏孙玉钗苏州大学纺织与服装工程学院江苏苏州215006

为了使医疗压力袜的压力及压力分布满足不同腿型患者的需求,选取中筒压力袜为试验样品,研究拉伸伸长率对压力袜压力及压力分布的影响。结果表明,测量点处的压力受到各部段拉伸伸长率的共同影响,且压力袜压力与拉伸伸长率呈显著线性相关... 详细信息

为了使医疗压力袜的压力及压力分布满足不同腿型患者的需求,选取中筒压力袜为试验样品,研究拉伸伸长率对压力袜压力及压力分布的影响。结果表明,测量点处的压力受到各部段拉伸伸长率的共同影响,且压力袜压力与拉伸伸长率呈显著线性相关关系。改变拉伸伸长率,压力分布发生变化,甚至出现逆梯度压力分布现象,不符合人体需求。在挑选压力袜时可根据自身腿部特征,并结合压力袜拉伸伸长率与压力及压力分布之间的关系来挑选符合自身需求的压力袜型号,得到积极的治疗效果。

关键词：压力袜压力压力分布拉伸伸长率

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扩张型心肌病动物模型及治疗的研究进展

浙江大学学报(农业与生命科学版) 2024年第1期50卷 1-11页

作者：金佳敏巩倩庄乐南浙江大学动物科学学院

扩张型心肌病（dilated cardiomyopathy, DCM）是一类以一侧或双侧心室扩张和收缩功能障碍为特征的心血管疾病，发病原因包括遗传性的基因突变及多种继发因素。人类DCM动物模型涉及小鼠、大鼠、斑马鱼、猪等多种实验动物，一般通过基因... 详细信息

扩张型心肌病（dilated cardiomyopathy, DCM）是一类以一侧或双侧心室扩张和收缩功能障碍为特征的心血管疾病，发病原因包括遗传性的基因突变及多种继发因素。人类DCM动物模型涉及小鼠、大鼠、斑马鱼、猪等多种实验动物，一般通过基因编辑、药物诱导、自身免疫缺陷诱导、病毒感染等方法构建。借助DCM动物模型，研究者对该病的致病机制和治疗靶点进行了深入的研究。本文简述了人类DCM的病理特征、临床症状和流行病学特征，对近年来DCM动物模型的种类和构建方法进行了综述，并对优化造模方法与推动治疗研究提出了新的展望。基于DCM动物模型的治疗研究可以帮助我们更好地理解DCM的发生机制，为开发新的治疗方法提供依据。

关键词：扩张型心肌病疾病动物模型生物治疗基因编辑

来源：博看期刊

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高校网络意识形态阵地建设与管理

无锡职业技术学院学报 2022年第1期21卷 89-92页

作者：钱佳敏王爱祥冉育彭常州工学院航空与机械工程学院/飞行学院江苏常州213022

在如今的互联网时代,为维护网络意识形态安全、筑牢意识形态阵地,也为了培养堪当复兴大任的时代新人,高校必须进一步加强网络意识形态阵地的建设和管理。当前高校网络意识形态工作仍然面临实效性低、主导性差、吸引力弱和信息监控技术... 详细信息

在如今的互联网时代,为维护网络意识形态安全、筑牢意识形态阵地,也为了培养堪当复兴大任的时代新人,高校必须进一步加强网络意识形态阵地的建设和管理。当前高校网络意识形态工作仍然面临实效性低、主导性差、吸引力弱和信息监控技术落后的挑战。对此,高校要在网络安全管理、全员全程参与、工作队伍建设和网络管理技术方面下功夫,紧握网络意识形态工作的领导权、主动权和话语权,坚决筑牢高校网络意识形态阵地。

关键词：高校网络意识形态管理

铁路起重机箱型伸缩臂设计的多目标模糊优化模型

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中国铁道科学 2011年第5期32卷 135-139页

作者：杨帆于兰峰里超曹晔钱佳敏西南交通大学机械工程学院机械工程研究所四川成都610031

以N1002G型铁路起重机箱形伸缩臂设计为例,以箱形伸缩臂的截面几何参数为设计变量,以箱形伸缩臂的结构重量、整体稳定性这2个相互制约的要求为目标函数,以强度、刚度、局部稳定性和几何限制为模糊约束条件,建立铁路起重机箱形伸缩臂设... 详细信息

以N1002G型铁路起重机箱形伸缩臂设计为例,以箱形伸缩臂的截面几何参数为设计变量,以箱形伸缩臂的结构重量、整体稳定性这2个相互制约的要求为目标函数,以强度、刚度、局部稳定性和几何限制为模糊约束条件,建立铁路起重机箱形伸缩臂设计的多目标模糊优化模型。应用最优水平截集法,将该多目标模糊优化模型转化为多目标普通优化模型,并应用遗传算法NSGA-Ⅱ求解。实例验证表明:采用建立的模型和求解算法,可以得到目标空间下的Pareto解;结构重量和整体稳定性是此消彼长的关系,设计者可以根据需要,选择合适的结构重量和整体稳定性作为设计方案。

关键词：铁路起重机箱形伸缩臂伸缩臂设计结构重量整体稳定性