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1例CAV1基因缺陷致家族性部分脂肪营养不良症的病例报道

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中国优生与遗传杂志 2024年第5期32卷 1018-1020页

作者：高育健黄志恒程佳敏康倩红贵港市人民医院儿童诊疗中心广西贵港537100 国家儿童医学中心上海201100 上海复旦大学附属儿科医院消化内科上海201100

目的报道1例CAV1基因c.396del(***133Alafs*6)发生移码变异导致家族性部分脂肪营养不良症。方法对1例严重营养不良症患儿及家系进行全外显子组测序,并结合文献对其基因型和表型进行分析。结果患儿,女,2岁,体重增长缓慢,全身皮下脂肪菲薄... 详细信息

目的报道1例CAV1基因c.396del(***133Alafs*6)发生移码变异导致家族性部分脂肪营养不良症。方法对1例严重营养不良症患儿及家系进行全外显子组测序,并结合文献对其基因型和表型进行分析。结果患儿,女,2岁,体重增长缓慢,全身皮下脂肪菲薄,三角形面容,小颌畸形。全外显子组测序提示CAV1基因c.396del(***133Alafs*6)发生移码变异,该位点突变为未有报道的新检测到的突变,本病诊断为CAV1基因相关家族性部分脂肪营养不良症7型。结论本研究有助于提高临床医生对家族性部分脂肪营养不良症的早期诊断和合并症的管理。

关键词： CAV1基因家族性脂肪营养不良症

抗原提呈细胞亚群预测肝癌患者的免疫治疗疗效研究

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解放军医学院学报 2024年第4期45卷 370-376页

作者：高舒玥程家敏赵飞宇千年松解放军医学院北京100853 解放军总医院第五医学中心肝病医学部北京100853 解放军总医院第八医学中心呼吸学部胸部肿瘤科北京100853 解放军总医院海南医院肿瘤内科海南三亚572000

背景原发性肝细胞癌(hepatocellular carcinoma,HCC)患者中免疫治疗应用广泛,但需寻找有效的疗效预测标志物,以此提供个体化和精准化的治疗。目的探讨抗原提呈细胞(antigen presenting cell,APC)亚群与HCC患者免疫治疗的疗效关系。方法... 详细信息

背景原发性肝细胞癌(hepatocellular carcinoma,HCC)患者中免疫治疗应用广泛,但需寻找有效的疗效预测标志物,以此提供个体化和精准化的治疗。目的探讨抗原提呈细胞(antigen presenting cell,APC)亚群与HCC患者免疫治疗的疗效关系。方法前瞻性纳入2022年5月—2023年9月在解放军总医院第五医学中心初次接受免疫治疗的中晚期HCC患者,通过流式细胞仪检测免疫治疗前的B细胞/淋巴细胞(B/LYM)、巨噬细胞/所有核细胞(MA/TNC)和树突细胞/所有核细胞(DC/TNC)的比值。根据均值将患者分为高水平组和低水平组,并比较两组间无进展生存期(progression free survival,PFS),并通过Cox分析影响PFS的因素。最后利用ROC曲线预测疾病控制的效能。结果共纳入84例患者,中位年龄为57岁;男性58例,女性26例。APC亚群基线数据:B/LYM均值为16.54%±6.27%,MA/TNC均值为9.14%±2.87%,DC/TNC均值为0.051%±0.021%。Kaplan-Meier生存分析和Cox回归分析显示B/LYM高值组的mPFS显著高于低值组(5.90个月vs 5.50个月,P=0.019;HR=0.588,95%CI:0.358~0.966),MA/TNC低值组的mPFS显著高于高值组(7.20个月vs 5.40个月,P=0.034;HR=0.617,95%CI:0.374~1.019),DC/TNC高值组的mPFS显著高于低值组(6.30个月vs 5.50个月,P=0.026;HR=0.615,95%CI:0.378~0.955)。且高水平的MA/TNC是疾病进展的独立危险因素,高水平的DC/TNC、B/LYM是疾病进展的保护因素。基线B/LYM、MA/TNC、DC/TNC对HCC患者接受2周期治疗后的疾病控制情况而言,具有较好的预测效能,且联合应用时效能进一步提高,AUC分别为0.685、0.723、0.745、0.865。结论高DC/TNC、B/LYM水平和低MA/TNC水平的HCC患者,可能更容易从免疫治疗中获益。

关键词：抗原提呈细胞肿瘤免疫微环境肝癌疗效预测标志物免疫治疗

Enantioselective Reductive Cross-Coupling of Aryl/Alkenyl Bromides with Benzylic Chlorides via Photoredox/Biimidazoline Nickel Dual Catalysis

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Chinese Journal of Chemistry 2022年第9期40卷 1033-1038页

作者： Tongtong Li Xiaokai cheng jiamin Lu Huifeng Wang Qun Fang Zhan Lu Department of Chemistry Zhejiang University 866 Yuhangtang roadHangzhouZhejiang 310058China College of Chemistry ZhengzhouUniversityZhengzhouHenan 450001China Hangzhou Innovation Center Zhejang UniversityHangzhouZhejiang 311200China

The asymmetric reductive arylation and alkenylation of benzylic chloride under photoredox/nickel dual catalysis using chiral bimidazoline(Bilm)ligand is reported to access 1,1-diaryl alkanes and aryl allylic compounds with good yield as well as stereo-and *** protocol uses more commercially available and less expensive C(sp^(2))-Br as the electrophile coupling partner.A primary result using alkenyl chloride and alkyl chloride is also *** functional groups are tolerated and the applications of this method are investigated by late-stage functionalization and gram-scale reaction.

关键词： Cross-coupling Photocatalysis Enantioselectivity Stereoselectivity Bimidazoline

维普期刊数据库评论

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论平装胶订质量管理制度

印刷世界 2004年第2期9卷 30-30页

作者：程佳敏湖北省咸宁市鄂南新华印务有限公司

近年来,随着胶订自动生产线和无线胶订工艺的大量应用,使单机生产变成联机生产,使过去行之有效的自检、互检、专职检有了很大的改变,退书率开始上升.为了适应发展的需求,装订质量管理制度应作相应改变.

关键词：平装胶订质量管理制度印后加工工艺制度内部签样制度抽样检查制度印刷企业

T细胞免疫球蛋白和黏蛋白结构域3及其单抗在肿瘤中的临床应用现状

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实用临床医药杂志 2023年第24期27卷 132-137页

作者：高舒玥赵飞宇范润佳程家敏千年松解放军医学院北京100853 中国人民解放军总医院第五医学中心肝病医学部北京100853 中国人民解放军总医院第八医学中心呼吸与危重症医学部北京100853 解放军总医院海南医院肿瘤内科海南三亚572000

T细胞免疫球蛋白和黏蛋白结构域3(Tim-3)是TIM家族中的一员,广泛表达于各种细胞表面,可以参与自身免疫、感染和癌症等疾病的发生发展。临床试验发现联合阻断Tim-3和程序性死亡蛋白-1(PD-1)可提高晚期癌症患者的抗癌免疫反应水平,消退肿... 详细信息

T细胞免疫球蛋白和黏蛋白结构域3(Tim-3)是TIM家族中的一员,广泛表达于各种细胞表面,可以参与自身免疫、感染和癌症等疾病的发生发展。临床试验发现联合阻断Tim-3和程序性死亡蛋白-1(PD-1)可提高晚期癌症患者的抗癌免疫反应水平,消退肿瘤。本文就Tim-3的基本生物学结构、相应配体和其在肿瘤微环境中的作用进行综述,以及总结正在进行的药物临床试验,这些数据表明Tim-3可以作为一个具有潜在意义的免疫检查点受体应用于未来抗肿瘤治疗中。

关键词： T细胞免疫球蛋白和黏蛋白结构域3 肿瘤免疫微环境免疫抑制性受体肿瘤预后标志物临床应用

Uniform Convergence Analysis of the Discontinuous Galerkin Method on Layer-Adapted Meshes for Singularly Perturbed Problem

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Wuhan University Journal of Natural Sciences 2023年第5期28卷 411-420页

作者： SHI jiamin LU Zhongshu ZHANG Luyi LU Sunjia cheng Yao School of Mathematical Sciences Suzhou University of Science and TechnologySuzhou 215009JiangsuChina

This paper concerns a discontinuous Galerkin(DG)method for a one-dimensional singularly perturbed problem which possesses essential characteristic of second order convection-diffusion problem after some simple *** derive an optimal convergence of the DG method for eight layer-adapted meshes in a general *** convergence rate is valid independent of the small ***,we establish a sharper L^(2)-error estimate if the true solution has a special regular *** experiments are also given.

关键词： layer-adapted meshes singularly perturbed problem uniform convergence discontinuous Galerkin method

24 h continuous observation of sodium layer over Wuhan by lidar

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Science China(Physics,Mechanics & Astronomy) 2007年第3期50卷 287-293页

作者： cheng XueWu GONG ShunSheng LI FaQuan DAI Yang SONG Juan WANG jiamin LI FengYan State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsChinese Academy of SciencesWuhan 430071China

Based on the dual-wavelength lidar we have developed, the 24 h continuous ob- servation has been realized in its sodium channel by using Faraday atomic filter technology and other relevant technologies. This will facilitate the continuous ob- servation of the sodium layer and the relevant upper atmosphere over Wuhan. A result of about 50 h observation indicates that the daytime column density of so- dium layer over Wuhan is slightly increased compared to that during the nighttime, and the characteristics of the sporadic sodium layer occurring during the daytime are compared with that during the nighttime.

关键词： lidar 24 h continuous observation sodium layer Faraday atomic filter

Melting mechanisms of Pt-based multimetallic spherical nanoparticles by molecular dynamics simulation

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Rare Metals 2023年第2期42卷 406-417页

作者： Chun-Yu cheng Yuan-Yuan Guo Yi-Ming Zou Amanda jiamin Ong Alfred ling Yoong Tok Shuzhou Li School of Materials Science and Engineering Nanyang Technological UniversitySingapore639798Singapore

The melting mechanisms of Pt-based multimetallic nanoparticles(NPs)are important to help determine their optimal melting *** understand the melting and coalescence behaviors of heterogeneous NPs(Pd-Pt NPs)with various sizes and compositions,molecular dynamics(MD)simulation was *** MD results for larger Pd-Pt NPs with an effective diameter of4.6-7.8 nm show that PtPd alloy can form at Pd/Pt interface before Pd NP melted completely,while for Pt-core/Pdshell NP and Pd-core/Pt-shell NP,PtPd alloy formed only after Pd portion melted *** smaller Pd-Pt NPs with an effective diameter of 2.5-4.0 nm,PdPt alloy is not formed until both Pd and Pt NPs melted ***,the coalescence process of Pd-Pt NPs depends on the melting temperature of Pt NP when Pt composition is higher than 20 at%.Furthermore,the melting mechanisms of Pd/Pt/Ir trimetallic NPs are investigated.A two-step melting process occurs in Pd-Pt-Ir NPs and Ir-core/Ptshell/Pd-shell NP,and the melting sequence of Pd-core/Ptshell/Ir-shell NP and Pt-core/Pd-shell/Ir-shell NP is different from Pd/Pt bimetallic NPs.

关键词： Molecular dynamics(MD) Melting mechanism Pt-based Multimetallic Heterogeneous structure

Thylakoid engineered M2 macrophage for sonodynamic effect promoted cell therapy of early atherosclerosis

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Nano Research 2024年第4期17卷 2919-2928页

作者： Guanghao Wu Changwen Mu Qianru Zhao Yao Lei Ran cheng Weidong Nie jiamin Qu Yuping Dong Ruili Yang Haiyan Xie State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesChemical Biology CenterPeking UniversityBeijing 100191China School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China School of Life Science Beijing Institute of TechnologyBeijing 100081China School of Stomatology Peking UniversityBeijing 100081China

Atherosclerosis is the most common cause of cardiovascular diseases that contribute to the major morbidity worldwide,but still lacking of effective treatment ***,a hybrid cell is constructed for the sonodynamic effect promoted cell therapy of early atherosclerosis by fusing M2 macrophages with thylakoid(TK)*** systemic administration,the obtained TK-M2 actively accumulates in the early atherosclerotic plaques,wherein M2 macrophages relieve the cholesterol accumulation and the inflammation in the foam ***,the TK membranes decorated on the M2 macrophages exhibit both type I and type II sonodynamic effects under ultrasound(US)activation,inducing the direct apoptosis of foam *** cooperation of M2 and TK leads to significant outcome in eliminating atherosclerotic plaques without obvious side-effects,providing a new avenue for atherosclerosis treatment.

关键词： atherosclerosis thylakoid ultrasound M2 macrophage