检索结果-南通市图书馆

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

多场景森林火灾灭火直升机调度策略

综合运输 2024年第3期46卷 103-108页

作者：宋洋程嘉敏中国民航大学经济与管理学院天津300300 中国民航大学交通科学与工程学院天津300300

为制定森林灭火直升机在不同灾情下的灭火出动策略,通过建立多目标优化函数并基于遗传算法和灰狼算法对直升机调度优化问题进行了研究。针对单着火点、多着火点情况下的三种火情,以总灭火时间最短及总成本最小作为优化目标,建立调度模型... 详细信息

为制定森林灭火直升机在不同灾情下的灭火出动策略,通过建立多目标优化函数并基于遗传算法和灰狼算法对直升机调度优化问题进行了研究。针对单着火点、多着火点情况下的三种火情,以总灭火时间最短及总成本最小作为优化目标,建立调度模型;将备选机型的灭火数据和火灾数据引入遗传算法和灰狼算法中,寻找最优机队组合方案并对目标函数进行解算,借助Matlab程序获得运算结果和最优出动机队配置及调度方案。实例分析表明,加入对实时火情变化的计算和机队组合的筛选,优化算法在达到火灾损失最小、灭火成本最低的同时给出最优的直升机调度方案。

关键词：森林火灾机型选择直升机调度灭火策略灰狼算法

Improving Knowledge Graph Completion Using Soft Rules and Adversarial Learning

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Electronics 2021年第4期30卷 623-633页

作者： TANG Caifang RAO Yuan YU Hualei SUN Ling cheng jiamin WANG Yutian Xi'an Key Laboratory of Social Intelligence and Complexity Data Processing School of Software EngineeringXi'an Jiaotong University Shaanxi Joint Key Laboratory for Artifact Intelligence School of Software EngineeringXi'an Jiaotong University School of Software Engineering Xi'an Jiaotong University

Knowledge graph is a useful resources and tools for describing entities and relationships in natural language processing tasks. However, the existing knowledge graph are incomplete. Therefore, knowledge graph completion technology has become a research hotspot in the field of artificial intelligence, but the traditional knowledge graph embedding method does not fully take into account the role of logic rules and the effect of false negative samples on knowledge *** on the logic rules of knowledge and the role of adversarial learning in knowledge embedding, we proposes a model to improve the completion of knowledge graph:soft Rules and graph adversarial learning(RUGA). Firstly,the traditional knowledge graph embedding model is trained as generator and discriminator by using adversarial learning method, and high-quality negative samples are obtained. Then these negative samples and the existing positive samples together constitute the label triple in the injection rule model. The whole model will benefit from both high-quality samples and logical rules. In addition,we evaluated the performance of link prediction task and triple classification task on Freebase and Yago datasets respectively. Finally, the experimental results show that the model can effectively improve the effect of knowledge graph completion.

关键词： Knowledge graph Knowledge embedding Knowledge graph completion Adversarial learning

Geochemistry and geochronology of multi-generation garnet:New insights on the genesis and fluid evolution of prograde skarn formation

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Geoscience Frontiers 2023年第1期14卷 360-371页

作者： Gaobin Chu Huayong Chen Shitao Zhang Yu Zhang jiamin cheng CAS Key Laboratory of Mineralogy and Metallogeny Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China CAS Center for Excellence in Deep Earth Science Guangzhou 510640China Guangdong Provincial Key Laboratory of Mineral Physics and Materials Guangzhou 510640China State Key Laboratory of Continental Dynamics Department of GeologyNorthwest UniversityXi'an 710069China Key Laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitor Central South UniversityChangsha 410083China University of Chinese Academy of Sciences Beijing 100049China

Origin of garnet in skarn(magmatic ***)and the prograde skarn fluid evolution are still *** generations of garnet(Grt1,Grt2)were identified at the Tongshankou deposit:Grt1 is anisotropic with oscillatory zoning and resorbed boundary,whilst Grt2 grew around Grt1 and formed oscillatory ***-situ LA-ICP-MS U-Pb dating of Grt1 and Grt2 yielded a lower intercept^(206)Pb/^(238)U age of 142.4±2.8 Ma(n=57;MSWD=1.16)and 142.3±9.6 Ma(n=60;MSWD=1.06),respectively,coeval with the ore formation and ore-related granodiorite *** Eu anomaly,non-CHARAC Y/Ho value and low TiO_(2)content,together with the mineral assemblages indicate that both Grtl and Grt2 have a hydrothermal *** existence of melt and melt-fluid inclusions in Grt1,together with similar LREE-enriched patterns to the granodiorite,further indicate that Grt1 may have formed in the magmatic-hydrothermal *** U contents and LREE-enriched patterns of Grt1 indicate that fluid I is mildly acidic pH and low fO_(2).The inner gray Grt2 rims(Grt2A)is HREE-enriched with low U contents,indicating that fluid II has nearly neutral pH and high fO_(2).The wider Y/Ho range and LREE-enriched patterns of the outer light-gray Grt2 rims(Grt2B)show that the evolved magmatic fluidⅡhad mixed with an external fluid,characterized by being mildly acidic pH and with high fO_(2)·Our results suggest that the prograde skarn-forming fluids can be multistage at Tongshankou,and the mixing of meteoric water may have been prominent in the prograde skarn stage.

关键词： Multi-generation garnet Mineral chemistry LA-ICP-MS U-Pb dating Fluid evolution Prograde skarn

经动脉化疗栓塞术单用及联合靶向药物治疗中期肝癌的肝功能变化及预后比较

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

解放军医学院学报 2024年第3期45卷 230-238页

作者：王沫萱程家敏千年松解放军医学院北京100853 解放军总医院第五医学中心肝病医学部肝病科北京100039 解放军总医院第八医学中心呼吸与危重症医学部胸部肿瘤科北京100091

背景经动脉化疗栓塞术(transcatheter arterial chemoembolization,TACE)和酪氨酸激酶抑制剂(tyrosine kinase inhibitors,TKI)是原发性肝细胞癌(hepatocellular carcinoma,HCC)治疗的常用手段,然而关于TACE与TACE-TKI对中期HCC术后肝功能的影响及预后差异的临床研究仍缺乏。目的比较TACE与TACE-TKI(索拉非尼或仑伐替尼)治疗中期HCC的短期肝功能变化、并发症、生存情况[无进展生存期(progression free survival,PFS)]及其关联因素。方法收集2010年6月—2023年1月规律就诊于解放军总医院第五医学中心肝脏肿瘤科的中期HCC患者149例,依据治疗方法将其分为TACE组和TACE-TKI组,研究随访至2023年6月,对首次TACE治疗前、治疗后48 h、治疗后2个月的肝功能、术后并发症及生存预后进行分析。结果149例患者中,TACE组97例,TACE-TKI组52例(索拉非尼组27例,仑伐替尼组25例)。两组基线特征差异无统计学意义(P>0.05)。术后48 h TACE-TKI组肝功能不全占比高于TACE组(42.3%vs21.6%,P=0.008);白细胞、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、总胆红素均较术前升高(P2次(HR=2.104,95%CI:1.359~3.259,P=0.001)、单用TACE治疗方案(HR=0.598,95%CI:0.380~0.942,P=0.027)患者的PFS更长。结论相比于TACE,TACE-TKI治疗中期肝细胞癌时,发生肝功能不全和术后并发症的概率更高。对于接受TACE或TACE-TKI治疗的中期肝细胞癌患者,甲胎蛋白>647 ng/mL、TACE次数≤2次、天冬氨酸氨基转移酶>31μ/L、凝血酶原活动度>93%、使用TACETKI方案在一定范围内与更差的PFS存在相关性。

关键词：中期肝细胞癌经动脉化疗栓塞术索拉非尼仑伐替尼肝功能术后并发症

1例CAV1基因缺陷致家族性部分脂肪营养不良症的病例报道

在线全文

学校读者我要写书评

暂无评论

中国优生与遗传杂志 2024年第5期32卷 1018-1020页

作者：高育健黄志恒程佳敏康倩红贵港市人民医院儿童诊疗中心广西贵港537100 国家儿童医学中心上海201100 上海复旦大学附属儿科医院消化内科上海201100

目的报道1例CAV1基因c.396del(***133Alafs*6)发生移码变异导致家族性部分脂肪营养不良症。方法对1例严重营养不良症患儿及家系进行全外显子组测序,并结合文献对其基因型和表型进行分析。结果患儿,女,2岁,体重增长缓慢,全身皮下脂肪菲薄... 详细信息

目的报道1例CAV1基因c.396del(***133Alafs*6)发生移码变异导致家族性部分脂肪营养不良症。方法对1例严重营养不良症患儿及家系进行全外显子组测序,并结合文献对其基因型和表型进行分析。结果患儿,女,2岁,体重增长缓慢,全身皮下脂肪菲薄,三角形面容,小颌畸形。全外显子组测序提示CAV1基因c.396del(***133Alafs*6)发生移码变异,该位点突变为未有报道的新检测到的突变,本病诊断为CAV1基因相关家族性部分脂肪营养不良症7型。结论本研究有助于提高临床医生对家族性部分脂肪营养不良症的早期诊断和合并症的管理。

关键词： CAV1基因家族性脂肪营养不良症

抗原提呈细胞亚群预测肝癌患者的免疫治疗疗效研究

在线全文

学校读者我要写书评

暂无评论

解放军医学院学报 2024年第4期45卷 370-376页

作者：高舒玥程家敏赵飞宇千年松解放军医学院北京100853 解放军总医院第五医学中心肝病医学部北京100853 解放军总医院第八医学中心呼吸学部胸部肿瘤科北京100853 解放军总医院海南医院肿瘤内科海南三亚572000

背景原发性肝细胞癌(hepatocellular carcinoma,HCC)患者中免疫治疗应用广泛,但需寻找有效的疗效预测标志物,以此提供个体化和精准化的治疗。目的探讨抗原提呈细胞(antigen presenting cell,APC)亚群与HCC患者免疫治疗的疗效关系。方法... 详细信息

背景原发性肝细胞癌(hepatocellular carcinoma,HCC)患者中免疫治疗应用广泛,但需寻找有效的疗效预测标志物,以此提供个体化和精准化的治疗。目的探讨抗原提呈细胞(antigen presenting cell,APC)亚群与HCC患者免疫治疗的疗效关系。方法前瞻性纳入2022年5月—2023年9月在解放军总医院第五医学中心初次接受免疫治疗的中晚期HCC患者,通过流式细胞仪检测免疫治疗前的B细胞/淋巴细胞(B/LYM)、巨噬细胞/所有核细胞(MA/TNC)和树突细胞/所有核细胞(DC/TNC)的比值。根据均值将患者分为高水平组和低水平组,并比较两组间无进展生存期(progression free survival,PFS),并通过Cox分析影响PFS的因素。最后利用ROC曲线预测疾病控制的效能。结果共纳入84例患者,中位年龄为57岁;男性58例,女性26例。APC亚群基线数据:B/LYM均值为16.54%±6.27%,MA/TNC均值为9.14%±2.87%,DC/TNC均值为0.051%±0.021%。Kaplan-Meier生存分析和Cox回归分析显示B/LYM高值组的mPFS显著高于低值组(5.90个月vs 5.50个月,P=0.019;HR=0.588,95%CI:0.358~0.966),MA/TNC低值组的mPFS显著高于高值组(7.20个月vs 5.40个月,P=0.034;HR=0.617,95%CI:0.374~1.019),DC/TNC高值组的mPFS显著高于低值组(6.30个月vs 5.50个月,P=0.026;HR=0.615,95%CI:0.378~0.955)。且高水平的MA/TNC是疾病进展的独立危险因素,高水平的DC/TNC、B/LYM是疾病进展的保护因素。基线B/LYM、MA/TNC、DC/TNC对HCC患者接受2周期治疗后的疾病控制情况而言,具有较好的预测效能,且联合应用时效能进一步提高,AUC分别为0.685、0.723、0.745、0.865。结论高DC/TNC、B/LYM水平和低MA/TNC水平的HCC患者,可能更容易从免疫治疗中获益。

关键词：抗原提呈细胞肿瘤免疫微环境肝癌疗效预测标志物免疫治疗

The advanced development of molecular targeted therapy for hepatocellular carcinoma

在线全文

学校读者我要写书评

暂无评论

Cancer Biology & Medicine 2022年第6期19卷 802-817页

作者： Tao Yan Lingxiang Yu Ning Zhang Caiyun Peng Guodong Su Yi Jing Linzhi Zhang Tong Wu jiamin cheng Qian Guo Xiaoliang Shi Yinying Lu Comprehensive Liver Cancer Center the 5th Medical Center of Chinese PLA General HospitalBeijing 100039China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510515China The Second Department of Hepatobiliary Surgery Senior Department of Hepatologythe 5th Medical Center of Chinese PLA General HospitalBeijing 100039China Shanghai OrigiMed Co. Ltd.Shanghai 201112China National Clinical Medical Research Center for Infectious Diseases the 5th Medical Center of Chinese PLA General HospitalBeijing 100039China

Hepatocellular carcinoma(HCC),one of the most common malignant tumors in China,severely threatens the life and health of *** recent years,precision medicine,clinical diagnoses,treatments,and innovative research have led to important breakthroughs in HCC *** discovery of new biomarkers and the promotion of liquid biopsy technologies have greatly facilitated the early diagnosis and treatment of *** in targeted therapy and immunotherapy has provided more choices for precise HCC *** technologies,such as genomics,transcriptomics,and metabolomics,have enabled deeper understanding of the occurrence and development mechanisms,heterogeneity,and genetic mutation characteristics of *** continued promotion and accurate typing of HCC,accurate guidance of treatment,and accurate prognostication have provided more treatment opportunities and prolonged survival timelines for patients with *** HCC research providing an in-depth understanding of the biological characteristics of HCC will be translated into accurate clinical practices for the diagnosis and treatment of HCC.

关键词： Hepatocellular carci no ma precision medicine liquid biopsy targeted therapy immunotherapy

Thylakoid engineered M2 macrophage for sonodynamic effect promoted cell therapy of early atherosclerosis

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第4期17卷 2919-2928页

作者： Guanghao Wu Changwen Mu Qianru Zhao Yao Lei Ran cheng Weidong Nie jiamin Qu Yuping Dong Ruili Yang Haiyan Xie State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesChemical Biology CenterPeking UniversityBeijing 100191China School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081China School of Life Science Beijing Institute of TechnologyBeijing 100081China School of Stomatology Peking UniversityBeijing 100081China

Atherosclerosis is the most common cause of cardiovascular diseases that contribute to the major morbidity worldwide,but still lacking of effective treatment ***,a hybrid cell is constructed for the sonodynamic effect promoted cell therapy of early atherosclerosis by fusing M2 macrophages with thylakoid(TK)*** systemic administration,the obtained TK-M2 actively accumulates in the early atherosclerotic plaques,wherein M2 macrophages relieve the cholesterol accumulation and the inflammation in the foam ***,the TK membranes decorated on the M2 macrophages exhibit both type I and type II sonodynamic effects under ultrasound(US)activation,inducing the direct apoptosis of foam *** cooperation of M2 and TK leads to significant outcome in eliminating atherosclerotic plaques without obvious side-effects,providing a new avenue for atherosclerosis treatment.

关键词： atherosclerosis thylakoid ultrasound M2 macrophage

血清高迁移率族蛋白B1、人β防御素2与腺病毒肺炎患儿闭塞性细支气管炎发生的关系

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

山东医药 2024年第7期64卷 38-41页

作者：程佳敏谭志军蒙勇球梁宙赵玉莲郑凤丽贵港市人民医院(广西医科大学第八附属医院)儿科广西贵港537100

目的探讨血清高迁移率族蛋白B1(HMGB1)、人β防御素2(hBD-2)与腺病毒肺炎(AP)患儿闭塞性细支气管炎(BO)发生的关系。方法选取193例AP患儿,根据出院3个月后是否发生BO将AP患儿分为BO组58例和非BO组135例。收集两组临床资料并用酶联免疫... 详细信息

目的探讨血清高迁移率族蛋白B1(HMGB1)、人β防御素2(hBD-2)与腺病毒肺炎(AP)患儿闭塞性细支气管炎(BO)发生的关系。方法选取193例AP患儿,根据出院3个月后是否发生BO将AP患儿分为BO组58例和非BO组135例。收集两组临床资料并用酶联免疫吸附试验检测血清HMGB1、hBD-2,用单因素及多因素Logistic回归分析AP患儿发生BO的影响因素,以受试者工作特征(ROC)曲线分析血清HMGB1、hBD-2对AP患儿发生BO的预测价值。结果BO组月龄小于非BO组,热程长于非BO组,低氧血症、机械通气发生比例及血液白细胞计数、血小板计数、C反应蛋白、降钙素原、HMGB1、hBD-2高于非BO组(P均<0.05)。多因素Logistic回归分析显示,低氧血症、机械通气和HMGB1、hBD-2升高为AP患儿发生BO的独立危险因素(P均<0.05)。ROC曲线分析显示,血清HMGB1、hBD-2联合应用预测AP患儿发生BO的曲线下面积为0.818,与血清HMGB1、hBD-2单独预测的曲线下面积(0.739、0.726)比较差异有统计学意义(P均<0.05)。结论血清HMGB1、hBD-2水平升高是AP患儿发生BO的危险因素,二者联合检测对AP患儿发生BO的预测价值较高。

关键词：腺病毒肺炎闭塞性细支气管炎高迁移率族蛋白B1 人β防御素2