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In situ optical backpropagation training of diffractive optical neural networks

Photonics Research 2020年第8期8卷 940-953页

作者： TIANKUANG ZHOU lu FANG TAO YAN jiamin WU YIPENG LI JINGTAO FAN HUAQIANG WU XING LIN QIONGHAI DA Department of Automation Tsinghua UniversityBeijing 100084China Institute for Brain and Cognitive Science Tsinghua UniversityBejing 100084China Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen 518055China Bejing Innovation Center for Future Chip Tsinghua UniversityBejing 100084China Institute of Microelectronics Tsinghua UniversityBejjing 100084China Bejing National Research Center for Information Science and Technology Tsinghua UniversityBejing 100084China

Training an artificial neural network with backpropagation algorithms to perform advanced machine learning tasks requires an extensive computational *** paper proposes to implement the backpropagation algorithm optically for in situ training of both linear and nonlinear diffractive optical neural networlks,which enables the acceleration of training speed and improvement in energy efficiency on core computing *** demonstrate that the gradient of a loss function with respect to the weights of diffractive layers can be accurately calculated by measuring the forward and backward propagated optical fields based on light reciprocity and phase conjunction *** diffractive modulation weights are updated by programming a high-speed spatial light modulator to minimize the error between prediction and target output and perform inference tasks at the speed of *** numerically validate the effectiveness of our approach on simulated networks for various *** proposed in situ optical learning architecture achieves accuracy comparable to in silico training with an electronic computer on the tasks of object dlassification and matrix-vector multiplication,which further allows the diffractive optical neural network to adapt to system ***,the self-adaptive property of our approach facilitates the novel application of the network for all-optical imaging through scattering *** proposed approach paves the way for robust implementation of large-scale difractive neural networks to perform distinctive tasks all-optically.

关键词： process. weights backward

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基于D-loop序列的从江田鱼与野生鲤形态和遗传差异分析

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淡水渔业 2024年第5期54卷 51-58页

作者：陆俊杰何旭盟李志力张宵胡文静孙佳敏刘其根上海海洋大学农业农村部鱼类营养与环境生态研究中心上海201306 上海海洋大学上海市水产养殖工程技术研究中心上海201306 上海海洋大学农业农村部稻渔综合种养生态重点实验室上海201306

利用形态学测量方法和D-loop序列分析了解从江田鱼与都柳江野生鲤的形态和遗传差异分析。结果显示,体长/体宽特征存在极显著差异,野生鲤独有17个单倍型,其核苷酸多样性(Pi)和单倍型多样性(Hd)较从江田鱼更高。野生鲤与从江田鱼的Fst值... 详细信息

利用形态学测量方法和D-loop序列分析了解从江田鱼与都柳江野生鲤的形态和遗传差异分析。结果显示,体长/体宽特征存在极显著差异,野生鲤独有17个单倍型,其核苷酸多样性(Pi)和单倍型多样性(Hd)较从江田鱼更高。野生鲤与从江田鱼的Fst值达到了0.15以上有较高的遗传分化。单倍型网络图显示,从江田鱼和野生鲤存在明显的遗传分化。分子方差(AMOVA)分析表明,从江田鱼群体的主要的遗传变异来自于群体内部个体间(80.66%)。基因流分析表明从江田鱼群体间基因交流水平不高但与野生鲤基因交流较频繁。研究表明,从江田鱼可能来源于野生鲤,其地理分布相对独立且有特定养殖模式,但受到自然和人工选择,其种群遗传多样性降低,种质资源存在退化风险需要保护。

关键词：从江田鱼线粒体D-loop 遗传多样性遗传结构

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Co-Ni Electromagnetic Coupling in Hollow Mo_(2)C/NC Sphere for Enhancing Electromagnetic Wave Absorbing Performance

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Chinese Journal of Chemistry 2023年第1期41卷 64-74页

作者： Xiufang Yang Wenming Gao jiamin Chen Xing lu Dong Yang Yifan Kang Qi Liu Yuchang Qing Wenhuan Huang Key Laboratory of Chemical Additives for China National Light Industry College of Chemistry and Chemical EngineeringShaanxi University of Science and TechnologyXi'anShaanxi 710021China Northwest Institute of Mechanical and Electrical Engineering XianyangShaanxi 712099China State Key Laboratory of Solidification Processing School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi'anShaanxi 710072China

For enhancing the electromagnetic wave(EW)attenuation and adsorption,rational constructing and homogeneously distributing bimetallic electromagnetic coupling units in hollow structure is an effective way,but hard to ***,a CoNi-doped hybrid zeolite imidazole framework was synthesized as precursor,which was further converted into a hollow CoNi-bimetallic doped molyb-denum carbide sphere(H-CoNi@MoC/NC)through a two-step etching and calcination *** the loading amount of 15 wt%,a strong absorption of minimum reflection loss(RL_(min))of-60.05 dB at 7.2 GHz with the thickness of 3.1 mm and a wide effective ad-sorption bandwidth(EAB)of 3.52 GHz at the thickness of 2.5 mm were achieved,which was far beyond the reported MoC-based metallic *** crucial synergistic Co-Ni electromagnetic coupling effect in the composite was characterized,not only enhanc-ing the dipolar/interfacial polarization,but also promoting the impedance matching,displaying the optimized EW absorbing perfor-mance.

关键词： Electromagnetic wave absorbing materials Hollow structure Hybrid zeolite imidazolate frameworks Microwave absorption Electromagnetic coupling

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Wearable membranes from zirconium-oxo clusters cross-linked polymer networks for ultrafast chemical warfare agents decontamination

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Chinese Chemical Letters 2022年第6期33卷 3241-3244页

作者： Litao Ma jiamin Xie Xiaoshan Yan Zhiwei Fan Heguo Li Lin lu Likun Chen Yi Xin Panchao Yin South China Advanced Institute for Soft Matter Science and Technology&State Key Laboratory of luminescent Materials and Devices University of Technology Guangzhou 510641China State Key Laboratory of NBC Protection for Civilian Research Institution of Chemical DefenseBeijing 100191China

The urgent need for immediate personal protection against chemical warfare agents(CWAs)spurs the requirement on robust and highly efficient catalytic systems that can be conveniently integrated to wearable ***,as a new concept for CWA decontamination catalyst design,sub-nanoscale,catalytically active zirconium-oxo molecular clusters are covalently integrated in flexible polymer network as crosslinkers for the full exposure of catalytic sites as well as robust framework *** obtained membrane catalysts exhibit high swelling ratio with aqueous content as 84 wt%and therefore,demonstrate quasi-homogeneous catalytic activity toward the rapid hydrolysis of both CWA,soman(GD)(t_(1/2)=5.0 min)and CWA simulant,methyl paraoxon(DMNP)(t_(1/2)=8.9 min).Meanwhile,due to the covalent nature of cross-linkages and the high flexibility of polymer strands,the membranes possess promising mechanical strength and toughness that can stand the impact of high gas pressures and show high permeation for both CO_(2)and O_(2),enabling their extended applications in the field of collective/personal protective materials with body comfort.

关键词： Molecular clusters Chemical warfare agents Catalysis Polymer nanocomposites Wearable devices

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多囊卵巢综合征患者血清特异性LncRNA表达谱研究

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浙江医学 2020年第8期42卷 798-801,I0002页

作者：吴镔莎余宁卢佳敏李小青周怡池万凌屹谢迟迟张娟文郑若姮杭州医学院临床医学院 310053 杭州医学院妇产科教研室 310053 浙江省中西医结合医院生殖医学科浙江大学医学院附属第一医院检验科浙江大学医学院附属第一医院生殖医学科

目的探讨多囊卵巢综合征(PCOS)患者血清特异性长链非编码核糖核酸(LncRNA)表达谱及下游mRNA通路。方法建立PCOS患者(PCOS组,50例)和健康人群(对照组,50例)队列,随机选取各3例,采用单色微阵列基因表达分析流程进行表达谱检测,并辅以热图... 详细信息

目的探讨多囊卵巢综合征(PCOS)患者血清特异性长链非编码核糖核酸(LncRNA)表达谱及下游mRNA通路。方法建立PCOS患者(PCOS组,50例)和健康人群(对照组,50例)队列,随机选取各3例,采用单色微阵列基因表达分析流程进行表达谱检测,并辅以热图分析、实时定量逆转录-聚合酶链反应(qRT-PCR)验证和下游mRNA的基因本体注释(GO)富集分析。结果PCOS患者血清中分别有351、217种显著上调和下调的LncRNA(符合变化系数≥2.0,P<0.05);进一步聚类分析发现,包含显著上调的11种LncRNA和显著下调的8种LncRNA的数据集可以成功区分PCOS患者和健康人群。qRT-PCR成功验证其中16种LncRNA具有相同显著变化。GO富集分析发现,这些LncRNA调控的mRNA功能范围包括细胞活化/生长/周期、基因及表观遗传学负调控等方面。结论 PCOS患者血清特异性LncRNA表达谱可为疾病的非侵入性诊断提供分子生物学标志物。

关键词：多囊卵巢综合征长链非编码核糖核酸表达谱

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Characteristics of oral methicillin-resistant Staphylococcus epidermidis isolated from dental plaque

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International Journal of Oral Science 2020年第2期12卷 152-161页

作者： Boyu Tang Tao Gong Yujia Cui Lingyun Wang Chao He Miao lu jiamin Chen Meiling Jing Anqi Zhang Yuqing Li State Key Laboratory of Oral Diseases&National Clinical Research Center for Oral Diseases&West China Hospital of Stomatology Sichuan UniversityChengduChina Division of Infectious Diseases Boston Children’s HospitalHarvard Medical SchoolBostonMAUSA Department of Laboratory Medicine West China HospitalSichuan UniversityChengduChina

The oral microbial community is widely regarded as a latent reservoir of antibiotic resistance genes. This study assessed the molecular epidemiology, susceptibility profile, and resistance mechanisms of 35 methicillin-resistant Staphylococcus epidermidis(MRSE) strains isolated from the dental plaque of a healthy human population. Broth microdilution minimum inhibitory concentrations(MICs) revealed that all the isolates were nonsusceptible to oxacillin and penicillin G. Most of them were also resistant to trimethoprim(65.7%) and erythromycin(54.3%). The resistance to multiple antibiotics was found to be largely due to the acquisition of plasmid-borne genes. The mec A and dfr A genes were found in all the isolates, mostly dfr G(80%), aac A-aph D(20%), aad D(28.6%), aph A3(22.9%), msr A(5.7%), and the erm C gene(14.3%). Classical mutational mechanisms found in these isolates were mainly efflux pumps such as qac A(31.4%), qac C(25.7%), tet K(17.1%), and nor A(8.6%). Multilocus sequence type analysis revealed that sequence type 59(ST59) strains comprised 71.43% of the typed isolates, and the e BURST algorithm clustered STs into the clonal complex 2-II(CC2-II). The staphyloccoccal cassette chromosome mec(SCCmec) type results showed that 25(71.43%) were assigned to type IV. Moreover, 88.66% of the isolates were found to harbor six or more biofilm-associated genes. The aap, atl E, embp, sdr F, and IS256 genes were detected in all 35 isolates. This research demonstrates that biofilm-positive multipleantibiotic-resistant ST59-SCCmec IV S. epidermidis strains exist in the dental plaque of healthy people and may be a potential risk for the transmission of antibiotic resistance.

关键词： epidemiology resistant reservoir

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《急救广生集》学术思想探析

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中国中医急症 2022年第11期31卷 2018-2019,2033页

作者：李嘉彤邵旭鹏谢娜陆佳敏魏久翔吴玉坤范开亮山东中医药大学山东济南250355 山东中医药大学附属医院山东济南250014

《急救广生集》共十卷,为清末程鹏程辑录,嘉庆年间刊行。本书包括内、外、妇、儿、骨等多种疾病证治,治法崇尚经典、博采众长,尊古而不泥古,具备多方面学术价值。

关键词：《急救广生集》外治法学术思想

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基于响应面法优化高效液相色谱法检测凉茶颗粒中7种绿原酸及其类似物的微波辅助萃取条件

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理化检验（化学分册） 2024年第2期60卷 161-170页

作者：陆剑华陈其钊王桂华高裕锋陈嘉敏韩秋珍黄可静李颖茵广东省科学院生物与医学工程研究所(国家糖业质量检验检测中心) 广州510316

在采用高效液相色谱法测定时,以凉茶颗粒样品中7种绿原酸及其类似物总含量为响应值,通过单因素法和响应面法,优化了萃取溶剂甲醇溶液的体积分数(因素A)、萃取时间(因素B)、萃取温度(因素C)和料液比[样品用量和提取溶剂体积的比值,单位g:... 详细信息

在采用高效液相色谱法测定时,以凉茶颗粒样品中7种绿原酸及其类似物总含量为响应值,通过单因素法和响应面法,优化了萃取溶剂甲醇溶液的体积分数(因素A)、萃取时间(因素B)、萃取温度(因素C)和料液比[样品用量和提取溶剂体积的比值,单位g:mL,因素D]等微波辅助萃取条件。取1.00 g凉茶颗粒样品,加入20 mL 70%(体积分数,下同)甲醇溶液,涡旋溶解1 min,置于微波萃取仪中,于80℃萃取2.0 min。萃取液过0.22μm滤膜,滤液按照色谱条件测定。在色谱分析中,以ZORBAX Eclipse Plus C_(18)色谱柱为固定相,不同体积比的0.1%(体积分数)磷酸溶液和甲醇的混合溶液为流动相进行梯度洗脱分离,采用二极管阵列检测器在325 nm波长下检测。结果显示:采用Box-Behnken中心组合设计,通过四因素三水平试验建立了二次多项回归模型,其中A2,B2对7种目标物总含量的影响极显著,AD,D2影响显著,且交互因素的影响和等高线、响应面所得的一致;在优化的微波辅助萃取条件下,7种目标物的总测定值为32.98 mg·kg^(-1),是预测值(41.10 mg·kg^(-1))的80.3%,说明回归模型的可靠性较高;7种目标物的质量浓度均在0.01~4.0 mg·L^(-1)内和峰面积呈线性关系,检出限(3S/N)为0.12~0.60 mg·kg^(-1);按标准加入法进行回收试验,7种目标物的回收率为97.5%~105%,测定值的相对标准偏差(n=6)为1.4%~6.9%。

关键词：凉茶颗粒绿原酸响应面法微波辅助萃取法高效液相色谱法

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Mirror-enhanced scanning light-field microscopy for long-term high-speed 3D imaging with isotropic resolution

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Light(Science & Applications) 2021年第12期10卷 2369-2379页

作者： Bo Xiong Tianyi Zhu Yuhan Xiang Xiaopeng Li Jinqiang Yu Zheng Jiang Yihan Niu Dong Jiang Xu Zhang lu Fang jiamin Wu Qionghai Dai Department of Automation Tsinghua UniversityBeijing 100084China Institute for Brain and Cognitive Sciences Tsinghua UniversityBeijing 100084China Beijing Laboratory of Brain and Cognitive Intelligence Beijing Municipal Education CommissionBeijing 100084China State Key Laboratory of Membrane Biology Tsinghua University-Peking University Joint Centre for Life SciencesBeijing Frontier Research Center for Biological StructureSchool of Life SciencesTsinghua UniversityBeijing 100084China Beijing Institute of Collaborative Innovation Beijing 100094China Department of Electronic Engineering Tsinghua UniversityBeijing 100084China

Various biological behaviors can only be observed in 3D at high speed over the long term with low ***-field microscopy(LFM)provides an elegant compact solution to record 3D information in a tomographic manner simultaneously,which can facilitate high photon ***,LFM still suffers from the missing-cone problem,leading to degraded axial resolution and ringing effects after ***,we propose a mirrorenhanced scanning LFM(MiSLFM)to achieve long-term high-speed 3D imaging at super-resolved axial resolution with a single objective,by fully exploiting the extended depth of field of LFM with a tilted mirror placed below *** establish the unique capabilities of MiSLFM,we performed extensive experiments,we observed various organelle interactions and intercellular interactions in different types of photosensitive cells under extremely low light ***,we demonstrated that superior axial resolution facilitates more robust blood cell tracking in zebrafish larvae at high speed.

关键词： resolution mirror field

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纳米晶合金粉芯的超重力渗流制备及磁性能

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材料科学与工艺 2024年第1期32卷 34-41页

作者：王佳敏甘章华朱昭峰吴传栋鲁越辉丁景楠省部共建耐火材料与冶金国家重点实验室(武汉科技大学) 武汉430081 江苏奥玛德新材料科技有限公司江苏盐城224000

为了探索粉芯的新制备工艺,以Fe_(73.5)Cu_(1)Nb_(3)Si1_(3.5)B_(9)纳米晶合金铁芯为原料,使用机械破碎法制粉,并采用超重力渗流工艺制备了7种不同粒度配比的纳米晶合金粉芯,借助SEM、XRD、VSM分别对纳米晶粉末的形貌、结构和磁性能进... 详细信息

为了探索粉芯的新制备工艺,以Fe_(73.5)Cu_(1)Nb_(3)Si1_(3.5)B_(9)纳米晶合金铁芯为原料,使用机械破碎法制粉,并采用超重力渗流工艺制备了7种不同粒度配比的纳米晶合金粉芯,借助SEM、XRD、VSM分别对纳米晶粉末的形貌、结构和磁性能进行了表征,研究了粉末粒度配比对纳米晶合金粉芯的形貌、密度、有效磁导率、损耗及品质因数的影响。结果表明,机械破碎法制得的粉末虽带尖角,但矫顽力低,利用超重力渗流工艺制备的粉芯其粉末表面基本被树脂完全包覆。同时,通过适当的粉末粒度匹配,发现性能最佳粉芯的粉末粒度配比为:100~200目占60%,200~400目占20%,400~1000目占20%。该种粉芯的密度为4.46 g∕cm^(3),在100~3000 kHz频率范围内有效磁导率比较稳定,且在3000 kHz时为28.2。当设定磁感应强度为20 mT,频率为500 kHz时,其损耗为99.1 W/kg。另外,根据实验结果可知,该工艺能够制备出频率在MHz以上具有较低损耗的粉芯。

关键词： Fe_(73.5)Cu_(1)Nb_(3)Si1_(3.5)B_(9)纳米晶合金粉芯超重力渗流粒度配比有效磁导率粉芯损耗

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