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Metabolic basis of solute carrier transporters in treatment of type 2 diabetes mellitus

Acta Pharmaceutica Sinica B 2024年第2期14卷 437-454页

作者： jiamei Le Yilong Chen Wei Yang Ligong Chen Jianping Ye Shanghai Key Laboratory of Molecular Imaging Zhoupu HospitalShanghai University of Medicine and Health SciencesShanghai 201318China School of Health Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China Metabolic Disease Research Center Zhengzhou Central Hospital Affiliated to Zhengzhou UniversityZhengzhou 450007China School of Pharmaceutical Sciences Tsinghua UniversityBeijing 100084China Research Center for Basic Medicine Academy of Medical SciencesZhengzhou UniversityZhengzhou 450052China

Solute carriers(SLCs) constitute the largest superfamily of membrane transporter *** transporters, present in various SLC families, play a vital role in energy metabolism by facilitating the transport of diverse substances, including glucose, fatty acids, amino acids, nucleotides, and *** actively participate in the regulation of glucose metabolism at various steps, such as glucose uptake(e.g., SLC2A4/GLUT4), glucose reabsorption(e.g., SLC5A2/SGLT2), thermogenesis(e.g., SLC25A7/UCP-1), and ATP production(e.g., SLC25A4/ANT1 and SLC25A5/ANT2). The activities of these transporters contribute to the pathogenesis of type 2 diabetes mellitus(T2DM). Notably, SLC5A2 has emerged as a valid drug target for T2DM due to its role in renal glucose reabsorption, leading to groundbreaking advancements in diabetes drug discovery. Alongside SLC5A2, multiple families of SLC transporters involved in the regulation of glucose homeostasis hold potential applications for T2DM therapy. SLCs also impact drug metabolism of diabetic medicines through gene polymorphisms, such as rosiglitazone(SLCO1B1/OATP1B1) and metformin(SLC22A1-3/OCT1-3 and SLC47A1, 2/MATE1, 2). By consolidating insights into the biological activities and clinical relevance of SLC transporters in T2DM, this review offers a comprehensive update on their roles in controlling glucose metabolism as potential drug targets.

关键词： Solute carriers(SLCs) Energ ymetabolism ATP production Type 2 diabetes mellitus(T2DM) Glucose homeostasis Polymorphisms

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Remote loading paclitaxel-doxorubicin prodrug into liposomes for cancer combination therapy

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Acta Pharmaceutica Sinica B 2020年第9期10卷 1730-1740页

作者： Jiang Yu Yingli wang Shuang Zhou Jinbo Li jiamei wang Dongxu Chi Xue wang Guimei Lin Zhonggui He Yongjun wang Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China Department of Pharmaceutics Shenyang Pharmaceutical UniversityShenyang 110016China School of Pharmaceutical Science Shandong UniversityJinan 250012China

The combination of paclitaxel(PTX)and doxorubicin(DOX)has been widely used in the ***,it remains unsatisfied due to the generation of severe ***,we have successfully synthesized a prodrug PTX-S-DOX(PSD).The prodrug displayed comparable in vitro cytotoxicity compared with the mixture of free PTX and ***,we speculated that it could be promising to improve the anti-cancer effect and reduce adverse effects by improving the pharmacokinetics behavior of PSD and enhancing tumor *** to the fact that copper ions(Cu2+)could coordinate with the anthracene nucleus of DOX,we speculate that the prodrug PSD could be actively loaded into liposomes by Cu2+***,we designed a remote loading liposomal formulation of PSD(PSD LPs)for combination *** prepared PSD LPs displayed extended blood circulation,improved tumor accumulation,and more significant anti-tumor efficacy compared with PSD ***,PSD LPs exhibited reduced cardiotoxicity and kidney damage compared with the physical mixture of Taxol and Doxil,indicating better ***,this novel nano-platform provides a strategy to deliver doxorubicin with other poorly soluble antineoplastic drugs for combination therapy with high efficacy and low toxicity.

关键词： Combination therapy Nanoparticles Paclitaxel-doxorubicin prodrug Remote loading liposomes Prodrug Safety

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基于脊背特征的发动机低转速特性扩展方法

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北京航空航天大学学报 2023年第9期49卷 2351-2360页

作者：王佳美郭迎清于华锋西北工业大学动力与能源学院西安710072

旋转部件在高空低转速时,其工作状态受来流的吹动作用可能会发生变化,此时压气机处在特殊的“搅拌机”或“涡轮”工作状态,使得发动机的动态计算中效率插值出现不连续的问题。为解决此问题,采用美国国家航空航天局(NASA)和通用电气公司(... 详细信息

旋转部件在高空低转速时,其工作状态受来流的吹动作用可能会发生变化,此时压气机处在特殊的“搅拌机”或“涡轮”工作状态,使得发动机的动态计算中效率插值出现不连续的问题。为解决此问题,采用美国国家航空航天局(NASA)和通用电气公司(GE)联合开发的针对旋转部件特性转化的脊背特征方法,通过分析低转速下旋转部件脊背特征及非脊背特征的变化趋势,提出基于脊背特征的旋转部件低转速范围特性的扩展方法,并有效规避了效率特性在低转速下插值的失效。以某型军用涡扇发动机为例,计算其处于不同飞行条件下的发动机风车工作状况,结果表明:所提方法能够反映出低转速下压气机压比小于1的特殊工作状态,且不同飞行条件下的风车特性计算合理。

关键词：低转速效率不连续脊背点非脊背点风车

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Teaching Reform of Basic Medicine Curriculum by Integrating the Perspective of Curriculum Civics and Politics in the Context of Healthy China

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Journal of Contemporary Educational Research 2024年第4期8卷 132-137页

作者： jiamei Wu Baxin wang Tianrong Xing Yanan Su Lei Liu School of Basic Medical Sciences Jiamusi UniversityJiamusi 154002Heilongjiang ProvinceChina Baicheng Medical College Baicheng 137000Jilin ProvinceChina The First Hospital Attached to Jiamusi University Jiamusi 154002 Heilongjiang ProvinceChina

Basic medicine is the foundation of basic knowledge of medical science,life science,and natural science,and is the basis for training medical *** can help students correctly understand the relationship between disease and health,and is of great significance under the perspective of the Healthy China ***,there are still some deficiencies in the current teaching,and insufficient attention has been paid to civics and ***,it is necessary to carry out curriculum reform in order to enable students to better understand medical knowledge and master medical skills,to ensure the development of medical education,and to play an important role in basic *** study combines the necessity of curriculum reform under the perspective of civics and politics and puts forward a teaching reform strategy suitable for the development of contemporary medicine to provide a direction for the educational development of basic medicine.

关键词： Healthy China Curriculum civics and politics Basic medicine

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Rate of Correct Use of Folic Acid Supplementation Among Pregnant Women—Beijing Municipality,China,2017–2019

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China CDC weekly 2021年第37期3卷 783-787页

作者： Qinfeng Song Jing Wei jiamei wang Le Zhang Xiaohong Liu Yali Zhang Nan Li Zhiwen Li Institute of Reproductive and Child Health Peking University/Key Laboratory of Reproductive HealthNational Health Commission of the People’s Republic of ChinaBeijingChina Department of Epidemiology and Biostatistics School of Public HealthPeking UniversityBeijingChina Cancer Center of Shanxi Bethune Hospital Shanxi Academy of Medical ScienceTaiyuanShanxiChina Haidian Maternal and Child Health Hospital BeijingChina.

Summary What is already known on this topic?Neural tube defects can be effectively prevented by folic acid ***,compliance with the recommendations for supplementation is still low in *** is added by this report?This study investigated the rate of correct use of folic acid supplementation and its risk factors among pregnant women in Beijing.

关键词： China. Pregnant defects

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Al和Mg元素对吉帕级熔敷金属组织和力学性能的影响

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焊接学报 2022年第12期43卷 20-26,I0004页

作者：栾宗锋邸新杰利成宁王佳美天津大学天津300350

针对吉帕级熔敷金属韧性不足的现状,设计了4组焊丝,研究了Al,Mg元素对金属粉芯焊丝熔敷金属组织和力学性能的影响.采用扫描电子显微镜对熔敷金属的显微组织进行了表征,通过力学性能测试表征了熔敷金属的力学性能.结果表明,熔敷金属主要... 详细信息

针对吉帕级熔敷金属韧性不足的现状,设计了4组焊丝,研究了Al,Mg元素对金属粉芯焊丝熔敷金属组织和力学性能的影响.采用扫描电子显微镜对熔敷金属的显微组织进行了表征,通过力学性能测试表征了熔敷金属的力学性能.结果表明,熔敷金属主要由马氏体、贝氏体构成.随着熔敷金属中Al,Mg元素的添加量由0Al-0Mg增加至0.3Al-0.9Mg,其氧含量由0.030 8%降为0.014 3%,聚合贝氏体含量减少,板条马氏体含量增加.夹杂物由传统的以Fe,Al,Si,Mn等元素的氧化物转变为以Al,Mg氧化物为主的球形细小夹杂物(MgO·Al2O3).0.3Al-0.9Mg组与0Al-0Mg组相比较,夹杂物的平均尺寸降低了0.13μm,抗拉强度增加了152 MPa,冲击吸收能量增加了11 J (-20℃).

关键词：吉帕级熔敷金属 Al和Mg联合脱氧马氏体氧化物夹杂

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The Application of Embodied Cognitive Linguistics in the English Translation of Two-Part Allegorical Saying—An Analysis of Examples From A Dream of Red Mansions

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Sino-US English Teaching 2024年第7期21卷 337-342页

作者： HE jiamei ZOU Jianling University of Shanghai for Science and Technology ShanghaiChina

As a kind of widely circulated folk language,two-part allegorical saying(“xiehouyu”)carries the wisdom of the Chinese people and is characterized with humor and vivid *** the two English translation versions of A Dream of Red Mansions as examples,this paper analyzes the English translation of two-part allegorical saying based on the core principle of Embodied Cognitive Linguistics(ECL),“Reality-Cognition-Language”,and explores how the English translation of two-part allegorical saying reflects the three dimensions of ECL.

关键词： two-part allegorical saying A Dream in Red Mansions Embodied Cognitive Linguistics translation

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中国含油气盆地富氦天然气藏氦气富集模式

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天然气工业 2022年第7期42卷 125-134页

作者：秦胜飞李济远王佳美陶刚王晓锋中国石油勘探开发研究院中国矿业大学(北京) 西北大学地质系

氦气由于其化学惰性、分子量小、低沸点、强渗透性、高导热性等特点,广泛用于航空航天、低温超导、医疗以及高科技领域,是一种不可替代的战略性稀缺资源。但关于氦气如何在天然气藏中富集的研究较为薄弱。为此,在探讨富氦气藏划分标准... 详细信息

氦气由于其化学惰性、分子量小、低沸点、强渗透性、高导热性等特点,广泛用于航空航天、低温超导、医疗以及高科技领域,是一种不可替代的战略性稀缺资源。但关于氦气如何在天然气藏中富集的研究较为薄弱。为此,在探讨富氦气藏划分标准的基础上,系统剖析了典型富氦气藏氦气成因、来源及富集过程,重点突出了主力氦源对富氦气藏的贡献,并提出了中国含油气盆地富氦气藏氦气富集模式。研究结果表明:①针对中国不同含油气盆地建立了壳源富氦和壳幔混合富氦2大类,6种氦气富集模式;②富氦气藏具有供氦多元、富集模式多样的特征;无论哪种氦气富集模式,都离不开主氦源对气藏的贡献;③中西部盆地富氦气藏中的氦气以壳源氦为主,富集模式包括古老地层水沿断层上移释氦、天然气沿古老储集层运移过程中富氦、页岩气富氦模式。④东部盆地富氦气藏中氦气为壳幔混合成因,富集模式包括以烃类气为主的气藏富氦模式、以二氧化碳为主的气藏富氦模式、以氮气为主的气藏富氦模式。结论认为,中国含油气盆地富氦气藏氦气富集模式的建立,可为氦气富集规律和富集主控因素的研究提供参考和借鉴,同时,该认识对氦气有利勘探区带评价具有重要意义。

关键词：含油气盆地富氦气藏氦气氦源富集模式有利勘探区

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Combination losartan with hyaluronic acid modified diethyldithiocarbamate loaded hollow copper sulfide nanoparticles for the treatment of breast cancer and metastasis

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Chinese Chemical Letters 2024年第3期35卷 406-414页

作者： Haili Hu Weiwei Zhang Lei Lei Fan Tong Huilin Zhang Yiwei Zhang Wenqin Yang Yilu Tang Ruyi Lin Xue Xia jiamei Li Shiyong Song Huile Gao Key Laboratory of Drug Targeting and Drug Delivery Systems West China School of PharmacySichuan UniversityChengdu 610041China School of Pharmacy Henan UniversityKaifeng 475004China Department of Public Health Chengdu Medical CollegeChengdu 610500China

The application of photothermal therapy(PTT)is greatly limited by the low accumulation of photothermal agents,uneven photothermal distribution,and heat endurance of cancer *** still,despite PTT enhances immunogenicity,the anti-tumor immune efficacy is still unsatisfactory due to the inefficient immunogenic cell death(ICD)induction and poor infiltration of immune *** solve the above problems of PTT,we developed hyaluronic acid(HA)modified hollow copper sulfide nanoparticles encapsulating diethyldithiocarbamate(DDTC)to construct a breast tumor targeting and near infrared(NIR)photo-responsive drug delivery system(D-HCuS@HA),which further combined with losartan to improve the accumulation and penetration in the tumor *** irradiation,D-HCuS@HA realized enhanced PTT and released cytotoxic Cu(DDTC)_(2)to eliminate heat endurance tumor cells,thereby enhancing antitumor effect and inducing effective ***,the combination with losartan could remodel the tumor microenvironment,allowing more T cells to infiltrate into the tumor,and significantly inhibiting the occurrence and development of metastatic *** vitro/vivo results revealed the great potential of D-HCuS@HA combined with losartan,which provides a new paradigm for anti-tumor and anti-metastases.

关键词： Targeted drug delivery system Hollow copper sulfide nanoparticles Photothermal therapy Hyaluronic acid Breast cancer Anti-metastasis

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Genetic variation of Porphyra yezoensis by using AFLP1

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Acta Oceanologica Sinica 2003年第3期22卷 453-457页

作者： Rui Yang, Biqian Liu, Qijun Luo, Yajun wang, jiamei Bao Marine Biotechnology Institution, Ningbo University,Ningbo 315211,China.E-mail:yangrui @ *** Marine Biotechnology Institution Ningbo University Ningbo 315211 China

Genetic variation of 11 lines of Porphyra yezoensis from the coastline of Kagoshima of Japan, Qingdao, Nantong, Putuo and Nanji Islands of China were studied by using amplified fragment length polymorphism (AFLP). 778 bands were obtained with AFLP analysis of 16 primer combinations, among which 15 were unique, about 98.07% were polymorphic. The AFLP data showed that the closest genetic distance was 0 - 180 between two Kagoshima samples, and the farthest one was 0.397 between Kagoshima No. 1 and Nantong No - 9 line. The genetic distance showed that the variation was within the inner species scope. Neighbor-joining cluster and UPGMA cluster indicated that samples from Kagoshima and Qingdao were with high similarity and either with the samples of Nantong, Putuo and Nanji Islands. P. yezoensis in China shared high genetic diversity, and the genetic distance showed positive correlation with the geographic distance.

关键词： Porphyra yezoensis AFLP genetic variation

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