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XELOX方案联合腹腔热灌注化疗对结直肠癌手术患者预后的影响

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临床医学工程 2024年第8期31卷 971-972页

作者：李铁民高佳美姚冠航苗景玉洛阳市第三人民医院普外科河南洛阳471000

目的探讨XELOX方案联合腹腔热灌注化疗(HIPEC)对结直肠癌(CRC)手术患者预后的影响。方法72例CRC患者随机分为两组。在根治术后,对照组给予XELOX方案化疗,观察组给予XELOX方案化疗联合HIPEC。比较两组的临床疗效、生存情况和不良反应。... 详细信息

目的探讨XELOX方案联合腹腔热灌注化疗(HIPEC)对结直肠癌(CRC)手术患者预后的影响。方法72例CRC患者随机分为两组。在根治术后,对照组给予XELOX方案化疗,观察组给予XELOX方案化疗联合HIPEC。比较两组的临床疗效、生存情况和不良反应。结果化疗后,观察组的治疗总有效率、6个月无病生存率均高于对照组(P0.05)。结论XELOX方案联合HIPEC可提高CRC患者的临床疗效,改善患者短期预后,但可能会增加患者的不良反应.

关键词： XELOX方案腹腔热灌注化疗结直肠癌预后

Genotype analysis of rotaviruses isolated from children during a phase III clinical trial with the hexavalent rotavirus vaccine in China

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Virologica Sinica 2023年第6期38卷 889-899页

作者： Wenqi Zou Qingchuan Yu Yan Liu Qingliang Li Hong Chen jiamei gao Chen Shi Ying Wang Wei Chen Xuan Bai Biao Yang Jiuwei Zhang Ben Dong Bo Ruan Liuyifan Zhou Gelin Xu Zhongyu Hu Xiaoming Yang National Engineering Technology Research Center for Combined Vaccines Wuhan Institute of Biological Products Co.LtdWuhan430207China National Institutes for Food and Drug Control Beijing100050China China National Biotec Group Beijing100024China

The oral hexavalent live human-bovine reassortant rotavirus vaccine(RV6)developed by Wuhan Institute of Biological Products Co.,Ltd(WIBP)has finished a randomized,placebo-controlled phase III clinical trial in four provinces of China in *** trail demonstrated that RV6 has a high vaccine efficacy against the prevalent strains and is safe for use in *** the phase III clinical trial(2019–2021),200 rotavirus-positive fecal samples from children with RV gastroenteritis(RVGE)were further *** reverse transcription-polymerase chain reaction and high-throughput sequencing,VP7 and VP4 sequences were obtained and their genetic characteristics,as well as the differences in antigenic epitopes of VP7,were analyzed in *** rotavirus genotypes were *** predominant rotavirus genotype was G9P[8](77.0%),followed by prevalent strains G8P[8](8.0%),G3P[8](3.5%),G3P[9](1.5%),G1P[8](1.0%),G2P[4](1.0%),and G4P[6](1.0%).The amino acid sequence identities of G1,G2,G3,G4,G8,and G9 genotypes of isolates compared to the vaccine strains were 98.8%,98.2%–99.7%,88.4%–99.4%,98.2%,94.2%–100%,and 93.9%–100%,***,the vaccine strains exhibited high similarity in amino acid sequence,with only minor differences in antigenic epitopes compared to the Chinese endemic *** supports the potential application of the vaccine in preventing diseases caused by rotaviruses.

关键词： Rotavirus(RV) Hexavalent rotavirus vaccine Epidemiology Sequence analysis

Combination losartan with hyaluronic acid modified diethyldithiocarbamate loaded hollow copper sulfide nanoparticles for the treatment of breast cancer and metastasis

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Chinese Chemical Letters 2024年第3期35卷 406-414页

作者： Haili Hu Weiwei Zhang Lei Lei Fan Tong Huilin Zhang Yiwei Zhang Wenqin Yang Yilu Tang Ruyi Lin Xue Xia jiamei Li Shiyong Song Huile gao Key Laboratory of Drug Targeting and Drug Delivery Systems West China School of PharmacySichuan UniversityChengdu 610041China School of Pharmacy Henan UniversityKaifeng 475004China Department of Public Health Chengdu Medical CollegeChengdu 610500China

The application of photothermal therapy(PTT)is greatly limited by the low accumulation of photothermal agents,uneven photothermal distribution,and heat endurance of cancer *** still,despite PTT enhances immunogenicity,the anti-tumor immune efficacy is still unsatisfactory due to the inefficient immunogenic cell death(ICD)induction and poor infiltration of immune *** solve the above problems of PTT,we developed hyaluronic acid(HA)modified hollow copper sulfide nanoparticles encapsulating diethyldithiocarbamate(DDTC)to construct a breast tumor targeting and near infrared(NIR)photo-responsive drug delivery system(D-HCuS@HA),which further combined with losartan to improve the accumulation and penetration in the tumor *** irradiation,D-HCuS@HA realized enhanced PTT and released cytotoxic Cu(DDTC)_(2)to eliminate heat endurance tumor cells,thereby enhancing antitumor effect and inducing effective ***,the combination with losartan could remodel the tumor microenvironment,allowing more T cells to infiltrate into the tumor,and significantly inhibiting the occurrence and development of metastatic *** vitro/vivo results revealed the great potential of D-HCuS@HA combined with losartan,which provides a new paradigm for anti-tumor and anti-metastases.

关键词： Targeted drug delivery system Hollow copper sulfide nanoparticles Photothermal therapy Hyaluronic acid Breast cancer Anti-metastasis

全长粘结型锚杆支护后围岩应力和位移的线弹性分析

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长沙矿山研究院季刊 1989年第3期9卷 55-64页

作者：高家美顿志林焦作矿业学院

本文将文献〔4〕所得围岩作用于全长粘结型锚杆的剪力均分于锚杆微段的围岩体积内,并假设原岩应力处于二向等压条件下,推导出圆形井巷在全长粘结型锚杆支护后围岩中应力和位移的表达式,然后对所得结果进行了分析讨论。

关键词：围岩应力位移弹性分析锚杆支护

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腈纶含油率检验方法对比

合成纤维工业 2006年第3期29卷 64-65页

作者：高佳梅陈莹玮秦皇岛奥莱特腈纶有限公司河北秦皇岛066003

使用索氏萃取法、红外光谱分析法、紫外分光光度法对腈纶短纤维含油率进行了测定,对其结果进行了假设检验分析,并比较了3种方法。结果表明:3种方法测定3．20 dtex×102 mm,6．00 dtex×102 mm, 2．78 dtex×64 mm腈纶短纤维的含油率分别... 详细信息

使用索氏萃取法、红外光谱分析法、紫外分光光度法对腈纶短纤维含油率进行了测定,对其结果进行了假设检验分析,并比较了3种方法。结果表明:3种方法测定3．20 dtex×102 mm,6．00 dtex×102 mm, 2．78 dtex×64 mm腈纶短纤维的含油率分别为0．358％-0．365％,0．534％～0．550％,0．401％～0．410％; 假设检验分析表明,3种方法均接受假设,其检验水平一致;3种方法各有特点,在进行含油率测试时,可根据条件和需要,合理选择分析方法。

关键词：聚丙烯腈纤维含油率红外光谱分析法索氏萃取法紫外分光光度法