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圆锥面拟合的太赫兹发散角精密测量研究

计量学报 2024年第1期45卷 24-29页

作者：黎雅恬方波邬佳璐方灿蔡晋辉中国计量大学计量测试工程学院浙江杭州330018

针对太赫兹(THz)光束发散角精密测量问题,以单频连续波太赫兹源为研究对象,搭建了基于圆锥面拟合的太赫兹发散角测量装置。通过研究太赫兹光束的传播模式,分析其在空间上的光强分布特性,提出将太赫兹输出光束在远场范围内视作圆锥曲面,... 详细信息

针对太赫兹(THz)光束发散角精密测量问题,以单频连续波太赫兹源为研究对象,搭建了基于圆锥面拟合的太赫兹发散角测量装置。通过研究太赫兹光束的传播模式,分析其在空间上的光强分布特性,提出将太赫兹输出光束在远场范围内视作圆锥曲面,利用太赫兹探测器采集光斑图像,根据图像的边缘点坐标构建圆锥曲面,借助间接平差对边缘点数据做预处理并进行参数迭代与圆锥面拟合计算出光束发散角数值。结果表明,被测100 GHz的太赫兹源发散角为2.73°,相对扩展不确定度为3.8%(k=2)。

关键词：发散角测量太赫兹光束圆锥面拟合太赫兹探测器不确定度评定

数智时代技能人才数字素养能力现状与提升对策

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中国人事科学 2024年第1期 46-55页

作者：吴画斌吴佳璐陈如意金伟林浙江财经大学东方学院南京大学

数字素养能力是各类技能人才适应数智时代需求的迫切需要。技能人才数字素养能力要求技能人才必须兼具岗位所需专业知识和技术以及利用数字化工具进行数据获取、分析、处理、创新的能力,并在工作实践中能够创新融合两种能力进行实际操... 详细信息

数字素养能力是各类技能人才适应数智时代需求的迫切需要。技能人才数字素养能力要求技能人才必须兼具岗位所需专业知识和技术以及利用数字化工具进行数据获取、分析、处理、创新的能力,并在工作实践中能够创新融合两种能力进行实际操作。目前,我国技能人才数字素养能力相对不足,面临数字素养框架尚未构建、培养体系不完善、培养资源分布不均、产业数字人才不足等问题。全面提升技能人才数字素养能力,应立足国情,借鉴国内外经验,构建中国特色数字素养框架,加强顶层设计,完善统筹规划;完善公众意见反馈体系,形成“因材施教”培养方案;拓展资金、课程、人才资源合流渠道,完善数字素养培训体系;打通企校合作培训体系,培育数字高端人才,为技能人才数字素养能力提升提供动力。

关键词：数智时代技能人才数字素养能力数字创新能力

MF-SuP-pK_(a): Multi-fidelity modeling with subgraph pooling mechanism for pK_(a) prediction

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药学学报:英文版 2023年第6期13卷 2572-2584页

作者： jialu wu Yue Wan Zhenxing wu Shengyu Zhang Dongsheng Cao Chang-Yu Hsieh Tingjun Hou Innovation Institute for Artificial Intelligence in Medicine of Zhejiang University College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China CarbonSilicon AI Technology Co. Ltd.Hangzhou 310018China Tencent Quantum Laboratory TencentShenzhen 518057China Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410004China

Acid-base dissociation constant(pK_(a)) is a key physicochemical parameter in chemical science, especially in organic synthesis and drug discovery. Current methodologies for pK_(a) prediction still suffer from limited applicability domain and lack of chemical insight. Here we present MF-SuP-pK_(a)(multi-fidelity modeling with subgraph pooling for pK_(a) prediction), a novel pK_(a) prediction model that utilizes subgraph pooling, multi-fidelity learning and data augmentation. In our model, a knowledgeaware subgraph pooling strategy was designed to capture the local and global environments around the ionization sites for micro-pK_(a) prediction. To overcome the scarcity of accurate pK_(a) data, lowfidelity data(computational pK_(a)) was used to fit the high-fidelity data(experimental pK_(a)) through transfer learning. The final MF-SuP-pK_(a) model was constructed by pre-training on the augmented ChEMBL data set and fine-tuning on the DataWarrior data set. Extensive evaluation on the DataWarrior data set and three benchmark data sets shows that MF-SuP-pK_(a) achieves superior performances to the state-of-theart pK_(a) prediction models while requires much less high-fidelity training data. Compared with Attentive FP, MF-SuP-pK_(a) achieves 23.83% and 20.12% improvement in terms of mean absolute error(MAE) on the acidic and basic sets, respectively.

关键词： pK_(a)prediction Graph neural network Subgraph pooling Multi-fidelity learning Data augmentation

Identifying Comprehensive Genomic Alterations and Potential Neoantigens for Cervical Cancer Immunotherapy in a Cohort of Chinese Squamous Cell Carcinoma of the Cervix

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Biomedical and Environmental Sciences 2024年第6期37卷 565-580页

作者： Meng wu jialu Zhou Zhe Zhang Yuanguang Meng School of Medicine Nankai UniversityTianjin 300071China Department of Obstetrics and Gynecology The First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Obstetrics and Gynecology Chinese PLA Medical SchoolBeijing 100853China Department of Obstetrics and Gynecology The Seventh Medical Center of Chinese PLA General HospitalBeijing 100700China

Objective Genomic alterations and potential neoantigens for cervical cancer immunotherapy were identified in a cohort of Chinese patients with cervical squamous cell carcinoma(CSCC).Methods Whole-exome sequencing was used to identify genomic alterations and potential neoantigens for CSCC *** Sequencing was performed to analyze neoantigen *** Systematic bioinformatics analysis showed that C>T/G>A transitions/transversions were dominant in *** mutations were the most frequent types of somatic mutation in the coding sequence *** signature analysis detected signature 2,signature 6,and signature 7 in CSCC ***3CA,FBXW7,and BICRA were identified as potential driver genes,with BICRA as a newly reported *** variation profiling identified 4,960 potential neoantigens,of which 114 were listed in two neoantigen-related *** The present findings contribute to our understanding of the genomic characteristics of CSCC and provide a foundation for the development of new biotechnology methods for individualized immunotherapy in CSCC.

关键词： Cervical squamous cell carcinoma Genome alteration Neoantigens Immunotherapy

德阳市2023年6—9月VOCs源分布与臭氧形成

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环境影响评价 2024年第3期46卷 89-96页

作者：王春艳吴加禄关垚高韦韦四川省德阳生态环境监测中心站四川德阳618000 河北先河环保科技股份有限公司河北石家庄051000

对德阳市2023年6—9月臭氧及其前体物质NO_(2)、VOCs的气象条件和监测数据进行了分析,6—9月德阳VOCs平均浓度为39.52 ppbv。臭氧浓度的日时间序列变化呈单峰型分布,在16∶00—18∶00时达到峰值。此次臭氧重污染基本伴有高温、低湿、低... 详细信息

对德阳市2023年6—9月臭氧及其前体物质NO_(2)、VOCs的气象条件和监测数据进行了分析,6—9月德阳VOCs平均浓度为39.52 ppbv。臭氧浓度的日时间序列变化呈单峰型分布,在16∶00—18∶00时达到峰值。此次臭氧重污染基本伴有高温、低湿、低风速等气象条件。采用正矩阵分解(PMF)受体模型进行VOCs源解析。移动源、固定燃烧源和工艺过程源是VOCs的主要来源,对VOCs的贡献率分别为21.00%、17.40%和14.96%。臭氧生成潜势(OFP)值表明,主要活性物质为OVOCs和烯烃,以丙醛和乙烯为代表。

关键词： VOCs 臭氧生成潜势源解析臭氧

Enhancing the electrochemical performance of Na metal anodes via local eutectic melting in porous Al-Cu alloy hosts

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Nano Research 2024年第7期17卷 6111-6118页

作者： Tao Hu Qiang wu Cheng Wang jialu Chen Fu Su Zibo Chen Yizhou Wang Jianyu Chen Yanwen Ma Jin Zhao State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials(IAM) Nanjing University of Posts&Telecommunications9 Wenyuan RoadNanjing 210023China Materials Science and Engineering King Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia Suzhou Vocational Institute of Industrial Technology 1 Zhineng AvenueSuzhou International Education ParkSuzhou 215104China

Sodium(Na)metal batteries(SMBs)have emerged as promising alternatives to lithium metal batteries for large-scale energy storage applications,owing to their cost-effectiveness,abundance,and favorable redox ***,the practical implementation of SMBs faces several challenges associated with the Na metal anode,including the formation of dendrites,low Coulombic efficiency,and capacity ***,we propose a novel approach to enhance the electrochemical performance of Na metal anodes through a porous Al-Cu alloy host(PAC)fabricated by a local eutectic melting *** local eutectic melting facilitates the development of a conductive network,offering mechanical support,and the porous structure provides abundant channels for the diffusion of Na ions and accommodates volume fluctuations in the Na metal during charge–discharge ***,the PAC exhibits a high average Coulombic efficiency of 99.8%at 1 mA·cm^(−2)for 1 mAh·cm^(−2)and a low voltage polarization of 19 mV during 500 *** study provides valuable insight into the design and fabrication of highperformance Na metal anodes,which hold significant promise for the advancements of next-generation energy storage systems.

关键词： Na metal anode porous Al-Cu alloy porous current collector local eutectic melting

Self-fueling ferroptosis-inducing microreactors based on p H-responsive Lipiodol Pickering emulsions enable transarterial ferro-embolization therapy

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National Science Review 2024年第1期11卷 74-85页

作者： Chunjie Wang Lei Zhang Zhijuan Yang Dongxu Zhao Zheng Deng jialu Xu Yumin wu Yu Hao Ziliang Dong Liangzhu Feng Zhuang Liu Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices Soochow University Center of Interventional Radiology & Vascular Surgery Department of Radiology Zhongda Hospital Medical School Southeast University Department of Interventional Radiology The First Afflliated Hospital of Soochow University

Lipiodol chemotherapeutic emulsions remain one of the main choices for the treatment of unresectable hepatocellular carcinoma(HCC) via transarterial chemoembolization(TACE). However, the limited stability of Lipiodol chemotherapeutic emulsions would lead to rapid drug diffusion, which would reduce the therapeutic benefit and cause systemic toxicity of administrated chemotherapeutics. Therefore, the development of enhanced Lipiodol-based formulations is of great significance to enable effective and safe TACE treatment. Herein, a stable water-in-oil Lipiodol Pickering emulsion(LPE) stabilized by pH-dissociable calcium carbonate nanoparticles and hemin is prepared and utilized for efficient encapsulation of lipoxygenase(LOX). The obtained LOX-loaded CaCO3&hemin-stabilized LPE(LHCa-LPE) showing greatly improved emulsion stability could work as a pH-responsive and self-fueling microreactor to convert polyunsaturated fatty acids(PUFAs), a main component of Lipiodol, to cytotoxic lipid radicals through the cascading catalytic reaction driven by LOX and hemin, thus inducing ferroptosis of cancer cells. As a result, such LHCa-LPE upon transcatheter embolization can effectively suppress the progression of orthotopic N1S1 HCC in rats. This study highlights a concise strategy to prepare pH-responsive and stable LPE-based self-fueling microreactors, which could serve as bifunctional embolic and ferroptosis-inducing agents to enable proof-of-concept transarterial ferro-embolization therapy of HCC.

关键词： CaCO3 nanoparticles Pickering emulsion ferroptosis lipid peroxidation transarterial ferro-embolization

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论白居易与韦应物诗歌惭愧表现之异同

中国韵文学刊 2023年第1期37卷 25-34页

作者：吴嘉璐西华大学文学与新闻传播学院四川成都610039

白居易诗表现惭愧情绪的高频次,在中国古典诗人中极其少见。以时代相近、同样多表现惭愧之情的韦应物诗作对比,二者不论进退,在仕途上都多有惭于为官、愧对民众的真诚论调。不同的是,白居易表达惭愧之情的场域不限于仕途,对自己的外貌... 详细信息

白居易诗表现惭愧情绪的高频次,在中国古典诗人中极其少见。以时代相近、同样多表现惭愧之情的韦应物诗作对比,二者不论进退,在仕途上都多有惭于为官、愧对民众的真诚论调。不同的是,白居易表达惭愧之情的场域不限于仕途,对自己的外貌、亲属乃至优裕的生活,都有愧悔的表达,其广度远远大于韦应物;而韦应物所表现的惭愧甚至达到“忏悔”的程度,其深度又远大于白居易。造成二者迥异的惭愧情绪表达的原因,在于其出身、性格与人生经历存在较大的差异。

关键词：白居易韦应物惭愧

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论苏轼对白居易咏茶诗的承变

重庆交通大学学报（社会科学版） 2023年第1期23卷 97-105页

作者：吴嘉璐西华大学文学与新闻传播学院成都610039

同样经历贬谪、从挫折中寻求超脱之道、追求素朴闲适的生活,苏轼将白居易视作自己的精神导师之一。白、苏二人都爱茶,苏之咏茶诗继承了白诗的表现内容及艺术特色。苏接受白将茶与酒并言比较的写法,认为茶是闲适生活的象征,并改造白种植... 详细信息

同样经历贬谪、从挫折中寻求超脱之道、追求素朴闲适的生活,苏轼将白居易视作自己的精神导师之一。白、苏二人都爱茶,苏之咏茶诗继承了白诗的表现内容及艺术特色。苏接受白将茶与酒并言比较的写法,认为茶是闲适生活的象征,并改造白种植松树及其他植物的诗作为种茶诗,表现自己的政治追求。相较白诗,苏之咏茶诗丰富了茶作为文学意象的艺术内涵:突出咏茶诗的动态性,用更细致的语言绘茶,将茶与诗人自我的关系紧密化。

关键词：苏轼白居易咏茶诗承变

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