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The relationship between body mass index and incident diabetes mellitus in Chinese aged population: a cohort study

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The relationship between body mass index and incident diabet...

氢气吸入对2型糖尿病大鼠代谢水平的影响研究

中国营养学会第十五届全国营养科学大会

作者： Molian Tang Yiquan Zhou jialu wang Yanping Wan Renying Xu Department of Clinical Nutrition Ren Ji Hospital School of Medicine Shanghai Jiao Tong University

Previous studies reported that aged population with overweight had a lower mortality after cardiovascular diseases attack, indicating being thinner might not be better. However, the debate is ongoing what is optimal range of body mass index(BMI) for aged population. We aimed to predict the association between BMI and the prediction of incident diabetes mellitus(DM) in Chinese elderly people. Methods 6,911 Chinese elderly people(4,110 men and 2,801 women, aged 71±6.0 years) were included in this cohort study. BMI was measured at baseline(Jan 1 st. 2014 to Dec 31 st. 2014). All the participants were further classified into six groups: < 18.5 kg/m, 18.5 to < 22.5 kg/m, 22.5 to < 25.0 kg/m, 25.0 to < 27.5 kg/m, 27.5 to < 30.0 kg/m, and ≥30.0 kg/m. Fasting blood glucose(FBG) and glycated hemoglobin A1 c(HbA1c) were annually measured during follow-up(Jan 1 st. 2015-May 31 st. 2019). DM was confirmed if either FBG ≥7.0 mmol/L or HbA1c ≥6.5%. We used the Cox proportional hazards regression model to evaluate the association between BMI and the prediction of incident DM. Results Comparing individuals with a BMI range of 18.5-22.5 kg/m(reference), the hazards ratio for incident DM was 2.13(95%CI: 1.54～2.95), 2.14(95%CI:1.53～3.00), 3.17(95%CI: 2.19～4.59), 3.15(95%CI: 1.94～5.09), and 3.14(95%CI: 1.94～5.09) for the group with a BMI range of 22.5 to <25.0 kg/m, 25.0 to <27.5 kg/m, 27.5 to <30.0 kg/m, and ≥30.0 kg/m after adjusting baseline age, sex, blood pressure, lipid profiles, and eGFR. Conclusion High BMI was associated with high risk of developing DM in Chinese aged population. Thus, it is optimal for aged population to maintain their body weight within a reasonable range to prevent chronic diseases.

关键词： Body mass index（BMI） diabetes mellitus（DM） aged population people

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中国社区医师 2024年第9期40卷 11-13页

作者：杨梦鸿杜智郁王嘉璐李文垚临潼康复疗养中心疗养三科陕西西安710600

目的:研究氢气吸入对2型糖尿病大鼠代谢水平的影响。方法:选取48只健康雄性SD大鼠作为研究对象,随机分为正常对照组(NC组,n=16)、糖尿病模型组(DM组,n=16)、糖尿病氢气吸入干预组(DM+HI组,n=16)。制备相应模型并进行干预,比较三组血糖... 详细信息

目的:研究氢气吸入对2型糖尿病大鼠代谢水平的影响。方法:选取48只健康雄性SD大鼠作为研究对象,随机分为正常对照组(NC组,n=16)、糖尿病模型组(DM组,n=16)、糖尿病氢气吸入干预组(DM+HI组,n=16)。制备相应模型并进行干预,比较三组血糖水平、血脂水平及胰腺病理变化。结果:DM组、DM+HI组空腹血糖、随机血糖、糖化血红蛋白水平均高于NC组,DM+HI组空腹血糖、随机血糖、糖化血红蛋白水平低于DM组,差异有统计学意义(P<0.05)。DM组、DM+HI组总胆固醇、甘油三酯、低密度脂蛋白胆固醇水平高于NC组,高密度脂蛋白胆固醇水平低于NC组,DM+HI组总胆固醇、甘油三酯、低密度脂蛋白胆固醇水平低于DM组,高密度脂蛋白胆固醇水平高于DM组,差异有统计学意义(P<0.05)。DM+HI组存在胰腺组织及胰岛形态结构异常,胰岛结构与周围组织损害较轻,无细胞空泡变性。结论:氢气吸入可改善2型糖尿病大鼠的血糖、血脂指标,减轻胰腺组织损害,具有一定研究价值。

关键词：氢气吸入 2型糖尿病代谢指标血糖血脂

The short and long-term effect of polystyrene nanoplastics on nitrifying sludge at high nitrite concentrations

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Journal of Environmental Sciences 2024年第1期135卷 222-231页

作者： Xiaolong wang jialu Huang Zhiqiang Qi Ruiqin Kang Chao Du Da Li School of Chemical and Environmental Engineering Anyang Institute of TechnologyAnyang 455000China Henan Licheng Environmental Technology Co. Ltd.Anyang 455000China State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin 150090China

The effect of nanoplastics(NPs)on nitrite oxidation bacteria(NOB)community in treating high-strength wastewater remains unclear,which seriously affects the stability of nitrogen removal process.In this study,highly active nitrifying sludge was enriched and exposed to 50nm polystyrene NPs(PS-NPs)for short-term(1,100,500,and 1000 mg/L,1.5 hr)and long-term(1,10,100 mg/L,40 days)at high nitrite concentration.In contrast to previous studies,our results showed that the exposures to PS-NPs had little effect on nitrifying performances.After long-term exposure,the protein/polysaccharide ratios in extracellular polymeric substances(EPS)were positively correlated with PS-NPs concentrations(0.78–0.99).The produced reactive oxygen species(ROS)were gradually removed,and PS-NPs higher than 10 mg/L caused damage to membrane integrity.Long-term exposure for 40 days increased the community diversity and caused significant differences between the control and exposed communities.The control group were dominated by Nitrobacter and Exiguobacterium,while the exposure group was dominated by Bacillus,Mycobacterium,and Nitrospira.A noticeable shift in the NOB community from Nitrobacter(26.5%to 3.4%)to Nitrospira(1.61%to 14.27%)was observed.A KEGG analysis indicated a decrease in cell growth and death,cell motility and energy metabolism.It appeared that NOB could adapt to PS-NPs stress through enhanced secretion and removal of oxidative damage.Overall,this study provided new insights into the response mechanism of NOB to PS-NPs exposure.

关键词： Nanoplastics Nitrifying activity Extracellular polymeric substance(EPS) Exposure Community analysis

CBL联合翻转课堂教学模式在感染科临床带教中的应用研究

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中国卫生产业 2024年第2期21卷 16-19页

作者：李春杨王佳露席德扬叶黎离徐州医科大学附属医院感染性疾病科江苏徐州221000 徐州医科大学附属医院儿科江苏徐州221000

目的探究案例教学法(Case-Based Learning,CBL)联合翻转课堂教学模式在感染科本科生临床实习教学中的应用效果。方法选取2021年12月—2022年12月于徐州医科大学附属医院感染科实习的116名医学生作为研究对象,以随机数表法分为两组,每组5... 详细信息

目的探究案例教学法(Case-Based Learning,CBL)联合翻转课堂教学模式在感染科本科生临床实习教学中的应用效果。方法选取2021年12月—2022年12月于徐州医科大学附属医院感染科实习的116名医学生作为研究对象,以随机数表法分为两组,每组58名。研究组采用CBL联合翻转课堂教学,对照组实施传统临床带教模式。对比两组教学效果。结果研究组理论考核、临床技能操作考核评分均优于对照组,差异有统计学意义(P均<0.05);研究组病历书写、疾病诊断、临床常规操作评分高于对照组,差异有统计学意义(P均<0.05);研究组的在学习兴趣、知识掌握、师生互动、案例分析能力和实操能力等临床带教的满意度评分均高于对照组,差异有统计学意义(P均<0.05)。结论CBL与翻转课堂联合应用于感染科临床实习教学,能够有效提高感染科临床实习教学质量,增强学生的理论基础和实践操作能力。

关键词：感染科案例教学法翻转课堂临床教学

基于网络药理学和分子对接探讨羌活胜湿汤治疗颈椎病的作用机制

维普期刊数据库博看期刊评论

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光明中医 2024年第1期39卷 67-71页

作者：王嘉璐李熠王东杰陈建锋陈洪波湖北中医药大学湖北武汉430061 湖北中医药大学针灸骨伤学院湖北武汉430061 湖北省中医院骨科湖北武汉430061

目的运用网络药理学和分子对接技术分析羌活胜湿汤治疗颈椎病的作用机制。方法从TCMSP数据库查找羌活胜湿汤的有效活性成分及对应靶点;从Genecards、OMIM、DisGeNET数据库获取颈椎病的相关靶点,利用Cytoscape 3.9.1构建“中药-活性成分... 详细信息

目的运用网络药理学和分子对接技术分析羌活胜湿汤治疗颈椎病的作用机制。方法从TCMSP数据库查找羌活胜湿汤的有效活性成分及对应靶点;从Genecards、OMIM、DisGeNET数据库获取颈椎病的相关靶点,利用Cytoscape 3.9.1构建“中药-活性成分-靶点”网络图,通过STRING数据库建立蛋白相互作用关系。通过Metascape数据库对潜在作用靶点进行GO和KEGG富集分析,最后使用AutoDock、PyMOL进行分子对接验证。结果共得到羌活胜湿汤活性成分169个,相关靶点205个;颈椎病靶点680个,潜在作用靶点55个。GO分析得到生物过程1041条,细胞组成37条,分子功能81条,KEGG分析得到信号通路147条。分子对接结果表明,主要活性成分与关键靶点间有较强结合活性。结论羌活胜湿汤通过多成分、多靶点、多通路治疗颈椎病。

关键词：项痹颈椎病羌活胜湿汤网络药理学分子对接

Preventive effects of Bifidobacterium lactis Probio-M8 on ovalbumin-induced food allergy in mice

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Food Science and Human Wellness 2024年第4期13卷 2346-2352页

作者： jialu Shi Yan Xu Cheng Liu Shizhi wang Jin wang Vijaya Raghavan Key Laboratory of Environmental Medicine and Engineering Ministry of Educationand Department of Nutrition and Food HygieneSchool of Public HealthSoutheast UniversityNanjing 210009China Department of Bioresource Engineering Faculty of Agricultural and Environmental SciencesMcGill UniversitySainte-Anne-de-BellevueQC H9X3V9Canada

Food allergy is a significant public health concern globally.Certain probiotics have been found to enhance food allergy by regulating immune-microbe interactions in animal models and patients.However,the effects of Bifidobacterium lactis Probio-M8 on food allergy have not been thoroughly investigated.The present study examined the anti-allergic properties of Probio-M8,particularly in relation to immune response and gut microbiota composition.Results demonstrate that oral administration of Probio-M8 effectively mitigated the allergy symptoms triggered by ovalbumin(OVA)by ameliorating the morphological damage in the jejunum,reducing OVA-specific IgE and histamine levels in the serum,and suppressing Th2 cytokines(interleukin(IL)4 and IL-13)while increasing Th1 cytokines(interferon(IFN)γ)and regulatory T(Treg)cytokines(IL-10 and transforming growth factor(TGF)β1)in the culture supernatants of splenic cells.Furthermore,Probio-M8 effectively altered the diversity and composition of gut microbiota,particularly the relative abundances of Akkermansia_muciniphila in OVA-induced mice.Compared to the OVA group,the Probio-M8 group showed a decrease in the relative abundance of Akkermansia_muciniphila.In conclusion,Probio-M8 demonstrates the potential to alleviate food allergy by regulating the Th1/Th2 response and modulating gut microbiota,thereby offering a novel therapeutic strategy for patients with food allergy.

关键词： Food allergy Bifidobacterium lactis Probio-M8 T cell immune response Gut microbiota

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老年人主观认知下降影响因素的路径分析

护理研究 2024年第2期38卷 216-223页

作者：王嘉璐徐林燕赵磊姚远杨灏栋许丽娟叶丽慧张莎莉林家玲丽水学院医学院浙江323000

目的:调查老年人主观认知下降(SCD)现状,分析其影响因素及作用路径。方法:于2022年7月—11月采用两阶段整群抽样法抽取浙江省8个社区或乡镇的1004名老年人作为研究对象,采用一般资料调查问卷、SCD⁃Q21、微营养评定法简表(MNA⁃SF)、简版... 详细信息

目的:调查老年人主观认知下降(SCD)现状,分析其影响因素及作用路径。方法:于2022年7月—11月采用两阶段整群抽样法抽取浙江省8个社区或乡镇的1004名老年人作为研究对象,采用一般资料调查问卷、SCD⁃Q21、微营养评定法简表(MNA⁃SF)、简版老年抑郁量表(GDS⁃15)、老年抑郁量表的3项分量表(GDS⁃3A)、国际体力活动问卷(IPAQ⁃SF)对老年人进行调查,分析老年人SCD影响因素及作用路径。结果:老年人SCD⁃Q21总分为7.50(3.50,11.50)分,听力状况、看远处状况、看近处状况、用药种数、受教育程度、疼痛程度、淡漠状况、抑郁状况、高血压、是否握力下降是老年人SCD的影响因素(P<0.05),其中,淡漠状况(0.245)、听力状况(-0.184)、看近处状况(-0.138)是效应较高的影响因素,淡漠状况和抑郁状况是老年人SCD的中介因素。结论:老年人主观认知水平有待进一步提高,其受多因素、多路径影响,淡漠状况和抑郁状况对SCD具有中介作用。

关键词：老年人主观认知下降(SCD) 影响因素路径分析认知功能护理

A food-grade and senescent cell-targeted fisetin delivery system based on whey protein isolate-galactooligosaccharides Maillard conjugate

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Food Science and Human Wellness 2024年第2期13卷 688-697页

作者： Shuai Hou Chutong Lai Yukun Song Haitao wang jialu Ni Mingqian Tan Academy of Food Interdisciplinary Science School of Food Science and TechnologyDalian Polytechnic UniversityDalian 116034China Institute of Cancer Stem Cell Cancer CenterDalian Medical UniversityDalian 116044China National Engineering Research Center of Seafood Dalian Polytechnic UniversityDalian 116034China Collaborative Innovation Center of Seafood Deep Processing Dalian Polytechnic UniversityDalian 116034China

Cellular senescence is the results of aging and age-related diseases,and the development of anti-aging methods may improve health and extend longevity.The natural flavonol fisetin has been shown to antagonize senescence in vitro and increases longevity in vivo,but has poor water solubility and limited bioavailability.In this study,a food-grade and senescent cell-targeted delivery system for fisetin was developed based on whey protein isolate-galactooligosaccharides(WPI-GOS)Maillard conjugate,which could recognize senescence associatedβ-galactosidase in senescent cells.The fisetin nanoparticles possessed a high encapsulation efficiency,excellent dispersibility in water,good storage stability and well biocompatibility.Moreover,they could effectively accumulate and retain in senescent cells with excellent senescent cell-targeting efficacy,and inhibit the oxidative stress-induced cellular senescence in vitro.Thus,this novel nanoparticle system based on WPI-GOS Maillard conjugate showed promise to deliver hydrophobic bioactive ingredients like fisetin to senescent cells to improve their bioavailability and anti-senescence effect.

关键词： Fisetin Nanoparticle Cellular senescence Targeted delivery

Experimental study of chemical concentration variation of ASP flooding

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Science China(Technological Sciences) 2009年第7期52卷 1882-1890页

作者： wang jialu YUAN ShiYi SHI FaShun JIA Xu Research Institute of Petroleum Exploration and Development Beijing 100083China PetroChina Limited Company Beijing 100011China

A physical modeling system of long slim tube was established. Several pressure measuring and sampling points were laid out at different positions along the tube. Through real-time measurements of pressures and chemical concentrations at different points, the mass transfer and chemical concentration of ASP flooding in porous media are studied. The concentration of chemicals declines gradually during the fluid flow from the inlet to the outlet of the model. The concentration increases in the front edge of the slug faster than the concentration decreases in the rear edge of the slug. The concentration variation of the chemicals is an asymmetrical and offset process. The order of motion velocities of the chemicals from fast to slow is polymer, alkali and surfactant. The motion lag and comprehensive diffusion are strong in the vicinity of the inlet, the motion velocities of the chemicals are high, the difference of flow velocities among the three chemicals is significant and the chromatographic separation of the chemicals is obvious. In the area near the outlet, the comprehensive diffusion and motion lag become weak, the concentrations of the chemicals decrease, the motion velocities of the chemicals are slow, the difference among the motion velocities of the chemicals becomes small, the chromatographic separation is not obvious, the adsorption and retention of chemicals gradually increase as the chemical slug moves further along the tube, the adsorption and retention of polymer is the most serious.

关键词： ASP flooding concentration of chemicals motion velocity chromatographic separation adsorption and retention