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重视早发性肝内胆管癌的研究

临床肝胆病杂志 2025年第12期40卷 2345-2350页

作者：覃德龙陈家璐唐玥李宗龙汤朝晖全志伟上海交通大学医学院附属新华医院普通外科上海 200092

肝内胆管癌（ICC）是一种高度恶性的胆道肿瘤，其中早发性ICC（EOICC）是指确诊年龄≤50岁的ICC，但通常具有更晚的临床分期、更显著的生物学侵袭性。目前EOICC的发病率正在迅速增长，但其研究仍处于早期阶段。现有的研究表明EOICC具有... 详细信息

肝内胆管癌（ICC）是一种高度恶性的胆道肿瘤，其中早发性ICC（EOICC）是指确诊年龄≤50岁的ICC，但通常具有更晚的临床分期、更显著的生物学侵袭性。目前EOICC的发病率正在迅速增长，但其研究仍处于早期阶段。现有的研究表明EOICC具有与晚发ICC显著不同的流行病学、临床和分子学特征。因此，重视EOICC高危因素及发病机制等方面的研究对于EOICC的早识别、早诊断以及针对性治疗具有重要意义。由于EOICC患者年龄较轻、身体状况较佳，可耐受风险更大的医疗干预措施，采取更积极的个体化诊疗方案，因此患者可能获得与晚发ICC相似甚至更好的生存预后。然而，EOICC的分子学特征与ICC显著不同，现有的靶向药物可能不适用于EOICC患者，晚期EOICC患者系统治疗面临巨大挑战。EOICC的临床和基础研究整体滞后，需要进一步深入阐明EOICC的人群特征及其发病因素，进而推动建立适合EOICC群体的预防及诊疗规范。

关键词：胆管上皮癌早发性肿瘤流行病学体征和症状基因表达谱

Enhancing the electrochemical performance of Na metal anodes via local eutectic melting in porous Al-Cu alloy hosts

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Nano Research 2024年第7期17卷 6111-6118页

作者： Tao Hu Qiang Wu cheng Wang jialu chen Fu Su Zibo chen Yizhou Wang Jianyu chen Yanwen Ma Jin Zhao State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced Materials(IAM) Nanjing University of Posts&Telecommunications9 Wenyuan RoadNanjing 210023China Materials Science and Engineering King Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia Suzhou Vocational Institute of Industrial Technology 1 Zhineng AvenueSuzhou International Education ParkSuzhou 215104China

Sodium(Na)metal batteries(SMBs)have emerged as promising alternatives to lithium metal batteries for large-scale energy storage applications,owing to their cost-effectiveness,abundance,and favorable redox ***,the practical implementation of SMBs faces several challenges associated with the Na metal anode,including the formation of dendrites,low Coulombic efficiency,and capacity ***,we propose a novel approach to enhance the electrochemical performance of Na metal anodes through a porous Al-Cu alloy host(PAC)fabricated by a local eutectic melting *** local eutectic melting facilitates the development of a conductive network,offering mechanical support,and the porous structure provides abundant channels for the diffusion of Na ions and accommodates volume fluctuations in the Na metal during charge–discharge ***,the PAC exhibits a high average Coulombic efficiency of 99.8%at 1 mA·cm^(−2)for 1 mAh·cm^(−2)and a low voltage polarization of 19 mV during 500 *** study provides valuable insight into the design and fabrication of highperformance Na metal anodes,which hold significant promise for the advancements of next-generation energy storage systems.

关键词： Na metal anode porous Al-Cu alloy porous current collector local eutectic melting

Experimental investigations on the fluid flow mechanism in porous media of enhanced oil recovery by alkli/surfactant/polymer flooding

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Science China(Technological Sciences) 2005年第4期48卷 454-467页

作者： WANG jialu SHEN Pingping chen Yongzhong ZHANG Zubo JIA Xu TIAN Yuling Research Institute of Petroleum Exploration and Development Beijing 100083 China Research Institute of Petroleum Exploration and Development Beijing 100083 China Research Institute of Petroleum Exploration and Development Beijing 100083 China Research Institute of Petroleum Exploration and Development Beijing 100083 China Research Institute of Petroleum Exploration and Development Beijing 100083 China Research Institute of Petroleum Exploration and Development Beijing 100083 China

The fluid flow mechanism in porous media of enhanced oil recovery by Alkli/ Surfactant/Polymer (ASP) flooding is investigated by measuring production performance, pressure distribution and saturation distribution through installing differential pressure transducers and saturation measuring probes in a physical model of vertical heterogeneous reservoir. The fluid flow variation in porous media is the main reason of enhanced oil recovery of ASP flooding. The pressure field and saturation field are nonlinearly coupled together and the interaction between them results in the fluid flow variation in the reservoir. In a vertical heterogeneous reservoir, the ASP agents initially flow in the high permeability layers because the resistance in the high permeability layer is increased under the physical and chemical action of adsorption, retention and emulsion. ASP flooding displaces out not only the residual oil in the high permeability layer, but also the remaining oil in the low and the middle permeability layers by increasing swept volume and displacing efficiency.

关键词： ASP flooding, vertical heterogeneous reservoir, enhanced oil recovery, fluid flow mechanism in porous media.

Lateral Hypothalamus Calcium/Calmodulin-Dependent Protein Kinase IIα Neurons Encode Novelty-Seeking Signals to Promote Predatory Eating

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Research 2022年第4期2022卷 657-675页

作者： Na Tan Jiaying Shi Lingyu Xu Yanrong Zheng Xia Wang Nanxi Lai Zhuowen Fang jialu chen Yi Wang Zhong chen Institute of Pharmacology and Toxicology College of Pharmaceutical SciencesZhejiang UniversityHangzhouChina Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhouChina

Predatory hunting is an innate appetite-driven and evolutionarily conserved behavior essential for animal survival, integrating sequential behaviors including searching, pursuit, attack, retrieval, and ultimately consumption. Nevertheless, neural circuits underlying hunting behavior with different features remain largely unexplored. Here, we deciphered a novel function of lateral hypothalamus (LH) calcium/calmodulin-dependent protein kinase II α (CaMKIIα^(+)) neurons in hunting behavior and uncovered upstream/downstream circuit basis. LH CaMKIIα^(+) neurons bidirectionally modulate novelty-seeking behavior, predatory attack, and eating in hunting behavior. LH CaMKIIα^(+) neurons integrate hunting-related novelty-seeking information from the medial preoptic area (MPOA) and project to the ventral periaqueductal gray (vPAG) to promote predatory eating. Our results demonstrate that LH CaMKIIα^(+) neurons are the key hub that integrate MPOA-conveyed novelty-seeking signals and encode predatory eating in hunting behavior, which enriched the neuronal substrate of hunting behavior.

关键词： seeking integrate integrating

Analysis of Factors Influencing Second-hand Housing Prices in Beijing based on Hierarchical Linear Model

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Journal of Landscape Research 2021年第4期13卷 37-41,46页

作者： chen jialu School of Urban Planning and Design Peking UniversityShenzhenGuangdong 518055China

In recent years,housing prices have attracted widespread attention,and the fluctuation of housing prices is due to a combination of many *** addition to the characteristics of the house itself,the price of a house is also affected by other factors,such as the community in which the house is *** article used Beijing’s 2017 second-hand housing transaction data (based on second-hand housing transaction records on ***),introduced a hierarchical linear model,and employed Stata software to analyze from different *** is intended to find the correlation between housing prices and different levels of characteristics,so to pin down the factors that affect prices of the second-hand housing.

关键词： Second-hand Housing Housing Price Hierarchical Linear Model Beijing

Research on the Marketing Strategy of Online Education - Taking New Oriental as an Example

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Journal of Management Science & Engineering Research 2019年第2期2卷 13-22页

作者： jialu chen Yingxiao Han An Li Hebei University BaodingHebei071000China

In recent years,with the development of society and the progress of science and technology,online learning has penetrated into people’s daily life,and people’s demand for high-quality curriculum products is more and more *** a macro perspective,the continuous growth of national financial investment in education,the continuous upgrading of China’s consumption structure,the development of 5G technology and the popularization of AI intelligence make online teaching less *** online education industry is showing an explosive growth *** and more online education institutions are listed for financing,and the market value is ***,in 2019,except for GSX,the latest online learning platforms such as New Oriental,Speak English Fluently and Sunlands,have been in a state of *** of these agencies seize the market by increasing advertising investment,but at the same time,they also bring huge marketing costs,which affect the financial performance of the *** the enhancement of Matthew effect,largescale educational institutions occupy a large market through free classes and low-price classes,while small and medium-sized institutions with weak capital strength are often unable to afford high sales costs,facing the risk of capital chain *** new Oriental online as an example,this paper analyzes the problems existing in the marketing strategies of online education *** also puts forward suggestions on four aspects,which are target market,differentiated value,marketing mix and marketing mode,so as to make sure that online education institutions can control marketing expenses and achieve profits by improving course quality,expanding marketing channels and implementing precise positioning.

关键词： New oriental Online course Marketing strategy Matthew effect

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纳米孔测序技术在核酸修饰检测中的应用

高等学校化学学报 2023年第3期44卷 119-129页

作者：陈佳璐黄硕南京大学化学化工学院生命分析化学国家重点实验室南京210023 南京大学化学和生物医药创新研究院南京210023

DNA和RNA上广泛存在着多种化学修饰.这些核酸修饰参与基因表达的调控,影响生长发育等生理过程,并可能会引发癌症等疾病.对核酸修饰的精准识别与定位有助于理解其功能机制,帮助相关疾病的诊断与治疗.纳米孔测序是一种新兴的单分子测序技... 详细信息

DNA和RNA上广泛存在着多种化学修饰.这些核酸修饰参与基因表达的调控,影响生长发育等生理过程,并可能会引发癌症等疾病.对核酸修饰的精准识别与定位有助于理解其功能机制,帮助相关疾病的诊断与治疗.纳米孔测序是一种新兴的单分子测序技术,可以根据修饰碱基与天然碱基之间阻孔信号的差异实现核酸序列中多种修饰的同时检测,是目前检测核酸修饰最直接的方法.本文简要介绍了纳米孔测序技术的发展和原理以及识别核酸修饰的算法工具,总结了纳米孔测序技术在核酸修饰检测中的应用,并对其发展前景进行了展望.

关键词：纳米孔测序 MinION测序仪核酸修饰碱基识别

Growth mechanisms of Ag and Cu nanodendrites via Galvanic replacement reactions

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Progress in Natural Science:Materials International 2021年第1期31卷 141-151页

作者： jialu chen Jemima J.Davies Alister S.Goodfellow Sarah M.D.Hall Helena G.Lancaster Xinyu Liu Cameron J.Rhodes Wuzong Zhou School of Chemistry University of St Andrews

Dendritic silver and copper crystals were produced via Galvanic replacement reactions on zinc and aluminum plates, respectively. The growth orientations of these metals were determined using electron microscopy. The results showed that a fast crystal growth associated with a high concentration of metal cations led to kinetically controlled growth along the axes of the cubic close-packed structures. However, a slow growth rate resulted in thermodynamically controlled growth along the [111] axis. The crystal growth was not found to rely upon the direct deposition of metal cations at crystallographic sites on crystal facets, but instead, hydrated metal cations deposited on the crystal surface to form an amorphous coating layer, followed by the reduction of metal cations and crystallization at the crystal/coating interface. Twin defects and stacking faults were often observed across the whole particle and commonly observed1/3{422} diffraction spots were explained by stacking faults rather than by the possible presence of any superstructures. The present work offers evidences to claim that both the crystal growth rate and Coulomb interaction between negatively charged crystal surface and metal cations play an important role in the formation of metal dendrites in replacement reactions.

关键词： Silver nanodendrite Copper nanodendrite Electron microscopy Stacking fault Crystal growth

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拟建高大建筑对邻近建筑整体风荷载的影响

同济大学学报（自然科学版） 2019年第7期47卷 897-905页

作者：陈嘉路全涌顾明同济大学土木工程防灾国家重点实验室

基于一栋既有高层建筑的刚性模型测压风洞试验,讨论了邻近更高大的拟建超高层建筑及周边其他建筑对其整体风荷载的干扰效应.试验结果表明,当拟建超高层建筑处在上游时,遮挡效应一般会减小下游既有建筑的顺风向气动力平均值,但尾流旋涡... 详细信息

基于一栋既有高层建筑的刚性模型测压风洞试验,讨论了邻近更高大的拟建超高层建筑及周边其他建筑对其整体风荷载的干扰效应.试验结果表明,当拟建超高层建筑处在上游时,遮挡效应一般会减小下游既有建筑的顺风向气动力平均值,但尾流旋涡脱落现象会导致下游既有建筑的横风向风荷载峰值显著增大,这可能使得下游既有建筑的原始结构设计偏于危险.

关键词：整体风荷载干扰效应超高层建筑旋涡脱落