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Effect of Flexible Back on Energy Absorption during Landing in Cats： A Biomechanical Investigation

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Journal of Bionic Engineering 2014年第4期11卷 506-516页

作者： Zhiqiang zhang jialing Yang Hui Yu Institute of Solid Mechanics Beo'ing University of Aeronautics and Astronautics Beijing 100191 P. R. China

Cats are characterized by their excellent landing ability. During the landing, they extend and bend their flexible backs. This study was undertaken to examine the effect of flexible back on impact attenuation. We collected kinematic and ground reaction force data from cats performing self-initiated jump down at different heights. Based on these measurements, the mechanical energy and elastic back energy were calculated. Further, we derived a beam model to predict back stiffness from the morphology of the vertebral spines. We found that cat could actively modulate the bending level of flexible back and the landing angle at different heights, making some kinetic energy be stored briefly as elastic strain energy in the back. This mechanism allows cat to reduce the kinetic energy dissipated by limbs and improve the efficiency of energy absorption. These results can provide bio- logical inspiration for the design of a flexible spine on a landing robot, and we anticipated their use in the energy absorption equipments for planetary exploration.

关键词： cat biomechanics landing flexible back energy absorption

Quantum search with prior knowledge

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Science China(Information Sciences) 2024年第9期67卷 321-329页

作者： Xiaoyu HE Xiaoming SUN jialing zhang State Key Lab of Processors Institute of Computing Technology Chinese Academy of Sciences School of Computer Science and Technology University of Chinese Academy of Sciences

The combination of contextual side information and search is a powerful paradigm in the scope of artificial intelligence. The prior knowledge enables the identification of possible solutions but may be imperfect. Contextual information can arise naturally, for example in game AI where prior knowledge is used to bias move decisions. In this work we investigate the problem of taking quantum advantage of contextual information, especially searching with prior knowledge. We propose a new generalization of Grover's search algorithm that achieves the optimal expected success probability of finding the solution if the number of queries is fixed. Experiments on small-scale quantum circuits verify the advantage of our algorithm. Since contextual information exists widely, our method has wide applications. We take game tree search as an example.

关键词： quantum computing quantum search quantum query algorithm prior knowledge

Gravity modelling of crustal architecture and heterogeneity in the Nansha Block,South China Sea

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Journal of Oceanology and Limnology 2023年第2期41卷 630-643页

作者： jialing zhang Zhaocai WU Chun-Feng LI Hailong LI Key Laboratory of Submarine Geoscience Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China Department of Marine Science Zhejiang UniversityZhoushan 316021China Sanya Institute Zhejiang UniversitySanya 572025China Laboratory of Marine Mineral Resources Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China Key Laboratory of Gas Hydrate Ministry of Natural ResourcesQingdao Institute of Marine GeologyQingdao 266071China

The stretched structure and heterogeneity of the crust of the Nansha Block,the southern continental margin of the South China Sea(SCS),are not well *** used published ocean bottom seismic(OBS)/multichannel reflection seismic(MCS)profiles across the Nansha Block to establish five two-dimensional crustal structure *** gravity modelling with magnetic anomaly inversion,we obtained the distribution of density and local magnetic susceptibility of the *** models show that the distribution of density and thickness of the upper crust in the Nansha Block is uneven,and the thick upper crust is prevalent in the regions close to the continent-ocean transition(COT)showing different *** interpreted Mesozoic granite blocks and Precambrian rigid basement reflects the heterogeneity in the material composition of the SCS continental *** on the thinning styles of different crustal layers,we suggest that the Nansha Block has a three-layer thinning *** uppermost pre-rift layer was deformed via brittle fractures,the upper crust was sheared by discrete shear zones,and the lower crust experienced ductile *** inherited pre-rift thermal regime,mechanical state,and material composition of the SCS continental margin affected the extensional structure of the crust.

关键词： Nansha Block crustal architecture gravity inversion crustal boudinage

Three-dimensional constrained gravity inversion of Moho depth and crustal structural characteristics at Mozambique continental margin

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Acta Oceanologica Sinica 2024年第2期43卷 120-129页

作者： Shihao Yang Zhaocai Wu Yinxia Fang Mingju Xu jialing zhang Fanlin Yang College of Geodesy and Geomatics Shandong University of Science and TechnologyQingdao 266590China Key Laboratory of Submarine Geoscience Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China School of Geomatics and Municipal Engineering Zhejiang University of Water Resources and Electric PowerHangzhou 310018China Ocean College Zhejiang UniversityZhoushan 316021China

Mozambique's continental margin in East Africa was formed during the break-off stage of the east and west Gondwana lands. Studying the geological structure and division of continent-ocean boundary(COB) in Mozambique's continental margin is considered of great significance to rebuild Gondwana land and understand its movement mode. Along these lines, in this work, the initial Moho was fit using the known Moho depth from reflection seismic profiles, and a 3D multi-point constrained gravity inversion was carried out. Thus, highaccuracy Moho depth and crustal thickness in the study area were acquired. According to the crustal structure distribution based on the inversion results, the continental crust at the narrowest position of the Mozambique Channel was detected. According to the analysis of the crustal thickness, the Mozambique ridge is generally oceanic crust and the COB of the whole Mozambique continental margin is divided.

关键词： 3D constrained gravity inversion continent-ocean boundary Mozambique continental margin Moho depth

New Strategy for Further Improving the Detection Sensitivity of Direct Analysis in Real Time-Mass Spectrometry

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Journal of Analysis and Testing 2017年第1期1卷 17-22页

作者： Ze Li jialing zhang Yiwei zhang Yu Bai Huwei Liu Institute of Analytical Chemistry College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China State Key Laboratory of Petroleum Pollution Control CNPC Research Institute of Safety and Environmental TechnologyBeijing 102206China

Ambient mass spectrometry facilitates surface detection under ambient conditions and has quickly found its applications in various ***,the sensitivity of AMS methods is usually not as good as that of encapsulated ion sources due to less efficient ion *** this work,a briefly machined external ion funnel(threepole electrostatic lens)was adopted and installed between direct analysis in real time and the mass spectrometer inlet to increase detection *** investigation with SIMION version 8.0 was employed to calculate electric fields and to simulate the trajectories of charged particles in the electric *** the geometrical parameters of the ion funnel and the electric parameters were studied to obtain the optimal ion focusing results,which demonstrated the ion funnel equipment would greatly improve the ion transmission *** equipment showed good prospect in direct analysis in real time-mass spectrometry analysis in the future.

关键词： Ambient mass spectrometry Direct analysis in real time-mass spectrometry Ion focusing Sensitivity

See the color,see the seed:GmW1 as a visual reporter for transgene and genome editing in soybean

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The Crop Journal 2023年第1期11卷 311-315页

作者： Li Chen Shan Yuan Yupeng Cai Weiwei Yao Qiang Su Yingying Chen jialing zhang Wensheng Hou National Center for Transgenic Research in Plants Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China Ministry of Agriculture Key Laboratory of Soybean Biology(Beijing) Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081China

A fast and efficient recognition method of transgenic lines will greatly improve detection efficiency and reduce *** this study,we successfully identified the transgenic soybean plants by the *** isolated a GmW1 gene encoding a flavonoid 3'5'-hydroxylase from a soybean cultivar ZH42(purple flower).We found that purple flowers occurred in the overexpression lines in the Jack and Williams 82 backgrounds(white flower).All plants with purple flowers were positive,and this trait seems stably inherited in the *** have also obtained the editing plants,which were classified into three types according to the different flower colors *** analyzed the phenotype and the homozygous types of the T_*** also found that a correspondence between flower color and stem *** study provides a visible color reporter on soybean *** can be quickly and early to identify the transgenic soybean plants by stem color of seedlings,which substantially reduces the amount of labor and cost.

关键词： Soybean GmW1 Color Transgenic lines Genome editing

Characterization of cancer genomic heterogeneity by next-generation sequencing advances precision medicine in cancer treatment

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Precision Clinical Medicine 2018年第1期1卷 29-48页

作者： jialing zhang Stephan Stanislaw Späth Sadie L.Marjani Wengeng zhang Xinghua Pan Department of Genetics Yale School of MedicineYale UniversityNew HavenCT USA University of Tibingen TibingenGermany Department of Biology Central Connecticut State UniversityNew BritainCTUSA Precision Medicine Key Laboratory of Sichuan Province&Precision Medicine Center West China HospitalSichuan UniversityChengduSichuanChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesSouthem Medical University Guangdong Provincial Key Laboratory of Single Cell Technology and Application GuangzhouGuangdong ProvinceChina

Cancer is a heterogeneous disease with unique genomic and phenotypic features that differ between individual patients and even among individual tumor *** recent years,large-scale genomic studies and new next-generation sequencing technologies have uncovered more scientifc details about tumor heterogeneity,with significant implications for the choice of specific molecular biomarkers and clinical decision making Genomic heterogeneity signifcantly contributes to the generation of a diverse cell population during tumor development and progression,representing a determining factor for variation in tumor treatment *** has been considered a prominent contributor to therapeutic failure,and increases the likelihood of resistance to future therapies in most common *** understanding of molecular heterogeneity in cancer is a fundamental component of precision oncology,enabling the identification of genomic alteration of key genes and pathways that can be targeted ***,we review the emerging knowledge of tumor genomics and heterogeneity,as well as potential implications for precision medicine in cancer treatment and new therapeutic *** analysis and interpretation of the TCGA database was included.

关键词： Genomics heterogeneity next generation sequencing cancer treatment precision medicine

Regulator of G protein signaling 20 contributes to radioresistance of non-small cell lung cancer cells by suppressing pyroptosis

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Radiation Medicine and Protection 2024年第3期5卷 178-184页

作者： jialing zhang Zhaoyan Jiang Xinglong Liu Xiaoya Jin Yan Pan Yang Bai Jianghong zhang Chunlin Shao Institute of Radiation Medicine Shanghai Medical CollegeFudan UniversityShanghai200032China

Objective:To investigate the potential role of the regulator of G protein signaling 20(RGS20)in radioresistance of non-small cell lung cancer(NSCLC).Methods:A total of 35 lung adenocarcinoma(LUAD)patients from The Cancer Genome Atlas(TCGA),who un-derwent radiotherapy,were enrolled and divided into radiosensitive(n=16)and radioresistant(n=19)groups based on clinical *** expression and prognosis of RGS20 were analyzed by Gene Expression Profiling Interactive Analysis(GEPIA)database.A radioresistant cell line(A549R)was constructed by irradiating A549 cells with 6 Gy X-rays for 10 *** survival was measured by colony formation *** regulatory effect of RGS20 on pyroptosis were verified by LDH release and Western blot assay,and the underlying mech-anism was investigated by transfecting RGS20 siRNA and applying a GSDMD ***:A total of 2,181 differentially expressed genes(DEGs)were identified by analyzing the data of radio-sensitive and radioresistant individuals from the TCGA-LUAD *** DEGs were enriched in G alpha(z)signalling events analyzed by Reactome ***20 exhibited significant upregulation among the DEGs,and its higher expression predicted poor prognosis in LUAD *** vitro,the expression of RGS20 protein was increased by irradiation in A549 cells,whereas it remained at much high levels in A549R cells regardless of *** irradiation,the expressions of pyroptosis-related proteins were significantly increased in A549 cells(P<0.05),with no significant changes were observed in A549R *** with LDC7559 significantly reduced LDH release(P<0.01)and improved the survival rate of irradiated A549 cells(P<0.01).Furthermore,knockdown of RGS20 gene in A549R cells significantly increased LDH release(P<0.001)and enhanced radiosensitivity(P<0.01),while LDC7559 administration reversed LDH release(P<0.01)and radiation-induced cell death increased by siRGS20(P<0.05).Meantime,the increased expression le

关键词： NSCLC Radioresistance RGS20 Pyroptosis

变工况下混合噪声字典和迁移子空间学习的滚动轴承故障诊断方法

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振动与冲击 2022年第18期41卷 176-183页

作者：张嘉玲武吉梅西安文理学院机械与材料工程学院西安710065 西安理工大学机械与精密仪器工程学院西安710048 西安理工大学印刷包装与数字媒体学院西安710054

滚动轴承在实际运行中受到复杂的工作环境影响,采集的振动信号无法满足独立同分布的条件。同时,振动信号混有大量的噪声和无关信息,直接影响诊断轴承故障的能力。因此,提出一种变工况下混合噪声字典和迁移子空间学习的滚动轴承故障诊断... 详细信息

滚动轴承在实际运行中受到复杂的工作环境影响,采集的振动信号无法满足独立同分布的条件。同时,振动信号混有大量的噪声和无关信息,直接影响诊断轴承故障的能力。因此,提出一种变工况下混合噪声字典和迁移子空间学习的滚动轴承故障诊断方法。首先,通过建立混合噪声字典学习模型,剔除无关信息分量对字典学习的干扰。然后,构建迁移子空间模型,将稀疏化的信号迁移到一个公共子空间中,通过联合分布适配方法和减少源域分类误差来降低两个域的分布差异。最后,通过交替方向乘子方法进行优化求解。实验结果表明,所提出的方法在复杂的可变工况下能够准确地识别滚动轴承故障类型。

关键词：滚动轴承故障诊断字典学习迁移子空间学习