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脑深部电刺激对帕金森病患者步态灵活性和稳定性的远期影响

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中华神经医学杂志 2024年第7期23卷 676-683页

作者：郑爽梁思泉于洋吴静超李海涛程元元巫嘉陵天津医科大学神经内外科及神经康复临床学院天津300070 天津市环湖医院神经外科天津300350 天津市环湖医院康复医学科天津300350 天津市环湖医院神经内科天津300350

目的探讨帕金森病(PD)患者接受脑深部电刺激(DBS)治疗2年后步态灵活性和稳定性的变化。方法选取天津市环湖医院神经外科自2019年10月至2021年11月采用DBS治疗的20例PD患者为研究对象,术前(药物关期)、术后2年(药物关期、药物开期)采用... 详细信息

目的探讨帕金森病(PD)患者接受脑深部电刺激(DBS)治疗2年后步态灵活性和稳定性的变化。方法选取天津市环湖医院神经外科自2019年10月至2021年11月采用DBS治疗的20例PD患者为研究对象,术前(药物关期)、术后2年(药物关期、药物开期)采用国际帕金森病和运动障碍协会统一帕金森病评定量表第三部分(MDS-UPDRS-Ⅲ)评估PD患者的运动症状;术前(药物开期)、术后2年(药物开期)采用简易精神状态检查量表(MMSE)和蒙特利尔认知评估量表(MoCA)评估PD患者的认知,采用39项帕金森病生活质量调查表(PDQ-39)评估PD患者的生活质量;术前(药物关期)、术后2年(药物关期、药物开期)采用三维步态分析仪记录患者在仪器化站立行走测试(ISAW)中的步态参数,比较患者手术前后运动症状评分、认知和生活质量评分、步态灵活性和稳定性的差异。结果(1)术前药物关期、术后药物关期、术后药物开期患者的MDS-UPDRS-Ⅲ评分[(45.30±12.57)分、(24.95±10.74)分、(15.80±7.19)分]依次降低,差异均有统计学意义(P<0.05)。(2)与术前比较,术后2年PD患者每日左旋多巴等效剂量(LEDD)较少[(711.84±343.99)mg/d vs.(549.30±301.08)mg/d],PDQ-39总分较低[47.00(30.00,64.00)分vs.13.50(7.75,27.00)分]、PDQ-39中问题9"对跌倒的担心程度"评分较低[2.00(0.00,3.00)分vs.0.00(0.00,1.75)分]均较低,差异均有统计学意义(P<0.05)。(3)与术前药物关期比较,术后药物开期PD患者手臂摆动速度增加,差异有统计学意义(P<0.05)。与术前药物关期比较,术后药物关期、术后药物开期PD患者手臂摆动范围增加,差异均有统计学意义(P<0.05)。与术前药物关期比较,术后药物关期、术后药物开期PD患者转弯速度增加,差异均有统计学意义(P<0.05)。与术前药物关期比较,术后药物关期PD患者转弯持续时间降低,差异均有统计学意义(P<0.05)。与术前药物关期比较,术后药物关期、术后药物开期PD患者躯干水平面运动范围增加,差异均有统计学意义(P<0.05)。与术前药物关期比较,术后药物开期PD患者腰部矢状面、躯干冠状面、躯干矢状面运动范围均增加,差异均有统计学意义(P<0.05)。与术前药物关期比较,术后药物开期PD患者的平均速度、均方根加速度增加,差异有统计学意义(P<0.05)。与术前药物关期比较,术后药物关期PD患者的摆动频率降低,差异有统计学意义(P<0.05)。结论PD患者接受DBS治疗后2年步态仍有显著改善,步态的灵活性、动态与静态稳定性均增强。

关键词：帕金森病脑深部电刺激步态灵活性稳定性

Cobalt atoms dispersed on hierarchical carbon nitride support as the cathode electrocatalyst for high-performance lithium-polysulfide batteries

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Science Bulletin 2019年第24期64卷 1875-1880页

作者： jialing wu Junmei Chen Yang Huang Kun Feng Jun Deng Wei Huang Yunling wu Jun Zhong Yanguang Li Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Soochow University

Lithium-sulfur batteries are promising candidates for next-generation energy storage but are confronted with several challenges. One of the possible solutions is to design proper cathode electrocatalysts to accelerate the redox interconversion of solvated polysulfide intermediates. Herein, we report cobalt atoms dispersed on hierarchical carbon nitride support as an effective cathode electrocatalyst for lithium-polysulfide batteries. The electrocatalyst material is prepared from the simple reaction between melamine and cyanuric acid in the presence of Co^2+, followed by the Ar annealing. The product has a unique hierarchical structure consisting of many thin and porous C3 N4 nanosheets finely dispersed with Co atoms. The atomic dispersion of Co species is confirmed by X-ray absorption *** measurements reveal that it can promote the interconversion of polysulfides. As a result,batteries using this cathode electrocatalyst achieve large capacity($1400 mAh/g at 1.6 mA/cm^2), good rate performance($800 mAh/g at 12.8 mA/cm^2) and impressive cycling stability under different current densities and different sulfur loadings.

关键词： Li-polysulfide battery Cathode electrocatalyst Carbon nitride Cobalt single atom

特发性正常颅压脑积水患者与帕金森病患者步态障碍对比研究

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中华老年医学杂志 2024年第7期43卷 846-850页

作者：朱志中侯玮佳虞舒然程元元梁思泉于洋巫嘉陵天津市环湖医院康复医学科天津300350 天津市环湖医院神经外科天津300350 天津市环湖医院神经康复科天津300350

目的对比特发性正常压力脑积水(iNPH)患者与帕金森病(PD)患者步态障碍的特征。方法纳入2020年1月至2020年12月于天津市环湖医院就诊的iNPH患者16例、PD患者20例,健康成年人23例,对一般临床资料和步态评估结果进行回顾性分析。采用美国Mo... 详细信息

目的对比特发性正常压力脑积水(iNPH)患者与帕金森病(PD)患者步态障碍的特征。方法纳入2020年1月至2020年12月于天津市环湖医院就诊的iNPH患者16例、PD患者20例,健康成年人23例,对一般临床资料和步态评估结果进行回顾性分析。采用美国Mobility LabTM APDM Opal型可穿戴式步态测试系统进行步态分析。结果iNPH组患者年龄(68.81±8.73)岁,PD组患者年龄(65.05±10.15)岁,正常对照组年龄(59.96±6.20)岁。iNPH组与PD组年龄差异无统计学意义(P>0.05),但较健康对照组年龄更大(t=3.71,P<0.05)。iNPH组病程为(22.94±23.19)个月,较PD组(92.60±53.70)个月更短(t=5.23,P<0.05)。iNPH组简易精神状态评价量表(MMSE)得分(17.13±7.08)分、蒙特利尔认知评估量表(MoCA)得分(11.75±5.43)分,评分低于PD组[(24.17±4.73)分,t=3.45,P<0.05、(21.29±5.82)分,t=4.86,P<0.05]和对照组[(26.70±1.61)分,t=5.31,P<0.05、(22.78±3.30)分,t=7.89,P<0.05]。iNPH组足廓清[右(1.65±0.76)cm]和双侧足离地角[左(20.59±6.11)°、右(20.78±6.88)°]较PD组足廓清[右(2.56±1.30)cm],双侧足离地角[左(28.43±6.36)°、右(28.12±7.49)°]减小(t=3.74、3.02,均P<0.05)。与对照组比较,iNPH患者的所有步态参数均差异有统计学意义(均P<0.05)。结论iNPH患者的步态障碍明显,与PD患者比较,呈现出更明显的步态障碍。可穿戴式步态分析系统可以准确评估iNPH患者的步态障碍,可以应用于该疾病的步态评估及康复方案制定。

关键词：脑积水,正常压力帕金森病步态分析

上海市高职护生的职业认同状况及其影响因素分析

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中华医学教育探索杂志 2024年第3期23卷 359-364页

作者：马兰张美琴吴佳玲郁晶上海东海职业技术学院护理学院上海200241 重庆医科大学附属第二医院医务处重庆400010

目的了解上海高职护生的职业认同现状,并探讨其相关影响因素。方法采用整群抽样方法,选取上海市某高职院校2019级护理高职护生308名作为研究对象。采用一般资料调查问卷、护生职业认同问卷、斯坦福隐性缺勤量表、情绪智力量表、工作场... 详细信息

目的了解上海高职护生的职业认同现状,并探讨其相关影响因素。方法采用整群抽样方法,选取上海市某高职院校2019级护理高职护生308名作为研究对象。采用一般资料调查问卷、护生职业认同问卷、斯坦福隐性缺勤量表、情绪智力量表、工作场所社会资本量表和护士心理资本问卷对这308名实习期的高职护生进行问卷调查。运用SPSS 22.0软件进行描述性分析、独立样本t检验、单因素方差分析、Pearson相关分析和多元线性回归分析。结果高职护生的职业认同总分为(64.93±12.83),隐性缺勤总分为(15.91±4.40),情绪智力总分为(80.57±15.52),社会资本总分为(32.38±6.33),心理资本总分为(95.47±18.63)。职业认同总分与隐性缺勤总分呈负相关(r=-0.282,P<0.01),与情绪智力总分呈正相关(r=0.712,P<0.01),与社会资本总分呈正相关(r=0.659,P<0.01),与心理资本总分呈正相关(r=0.681,P<0.01)。多元线性回归分析显示,个人兴趣、情绪智力和心理资本均对职业认同产生影响,这3个因素都进入了职业认同的回归方程。结论上海高职护生的职业认同状况处于中等水平,个人兴趣、情绪智力和心理资本是主要影响因素。

关键词：高职护生职业认同影响因素调查研究

Color doppler ultrasound in the application of breast intraductal papilloma

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The Chinese-German Journal of Clinical Oncology 2013年第5期12卷 224-227页

作者： jialing wu Guang Yang Jian Shi Department of Ultrasonography The First Affilliated Hospital of Dalian Medical University

Objective:The aim of this study was to evaluate the application value of high-frequency color Doppler ultrasound in the diagnosis of intraductal papilloma (IDP). Methods:A retrospective analysis of 64 IDP cases was done, the pathology proven by surgery with 89 lesions. According to the ultrasonic performance, the lesions were divided into different types and the solid focal were evaluated according to the classification BI-RADS-US standard. Results:There were 47 patients corresponds with the 64 cases of surgical pathology, the accuracy was 73.4%, according to the ultrasonic performance could be divided into two types, named catheter type and solid type, catheter diagnostic accuracy was 22/25 (88%), compared the morphological features of the solid type, grouped according to their size (≥ 2 cm or < 2 cm lesions), discovered there was no statistically significant difference between the benign and malignant lesions by BI-RADS-US grading standard. Conclusion:Two-dimensional ultrasound and Color Doppler flow imaging (CDFI) can make a definite diagnosis and positioning for IDP, but there are still some limitations to differentiate the benign and malignant, it need to pay more attention to the clinical application of substantive IDP and improve the understanding, provide more relevant information for clinic, the focal will be earlier treated to reduce the possibility of malignant happened change.

关键词： ultrasound BI-RADS-US grading intraductal papilloma

Value of contrast-enhanced ultrasound in diagnosis of focal liver lesions

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The Chinese-German Journal of Clinical Oncology 2008年第3期7卷 125-127页

作者： jialing wu Guang Yang Xiaoqin Qian Rui Hou Department of Ultrasonography the First Affilliated Hospital Dalian Medical University Dalian 116011 China

Objective： By observing the pattern of the focal liver lesions （FLL） in different phases by real time contrast-enhanced ultrasound （CEUS）, compared to enhanced CT, investigate the value of CEUS in diagnosing focal liver lesions. Meth. ods： 35 patients with unconfirmed focal liver lesions were studied by contrast agent SonoVue and Technos DU 8 produced by Esaote company. Results： Among the 14 cases of hepatocellular carcinoma （HCC）, 10 were typical, presented with early artery enhancement and immediate wash-out. The enhancement patterns of 6 livers metastasis were diverse, including peripheral or entire degree enhancement. The wash-out time in malignant tumors was eadier than other focal liver lesions （P 〈 0.05）, appeared as hypoechoic in the portal phase or parenchyma phase. The 6 cases of hemangioma were enhanced centripetally nodular in artery phase and washed out after several minutes. The patterns of different lesions were similar compared to contrast-enhanced CT, without significant statistic differences. Conclusion： The contrast enhanced ultrasound technique can significantly improved the value of diagnosing focal liver lesions.

关键词： ultrasonography, contrast agent focal liver lesions

Value of high-frequency ultrasonography with virtual touch tissue quantification in diagnosis of breast pure mucinous carcinomas

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The Chinese-German Journal of Clinical Oncology 2012年第8期11卷 445-448页

作者： Jian Shi Guang Yang jialing wu Wenlin Xu Department of Ultrasound The First Affiliated Hospital Dalian Medical University Dalian 116011 China

Objective The aim of our study was to analyze the characters of breast pure mucinous carcinomas on highfrequency ultrasonography with virtual touch tissue quantification (VTQ).

关键词： breast pure mucinous carcinoma ultrasonography virtual touch tissue quantification

糖尿病肾病患者肠道菌群生态特点与胃肠道功能障碍的关联性研究

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中华消化病与影像杂志（电子版） 2024年第5期14卷 453-458页

作者：邱岭朱旭丽浦坚邢苗苗吴佳玲无锡市锡山人民医院肾内科江苏省214000 鄂托克前旗人民医院内蒙古自治区016200

目的分析糖尿病肾病(DKD)患者肠道菌群生态特点,并探究肠道菌群生态特点与患者胃肠道功能障碍的关联性。方法选取无锡市锡山人民医院2021年3月至2023年3月收治的150例DKD患者,纳入DKD组,并选取同期2型糖尿病(T2DM)患者80例,纳入T2DM组... 详细信息

目的分析糖尿病肾病(DKD)患者肠道菌群生态特点,并探究肠道菌群生态特点与患者胃肠道功能障碍的关联性。方法选取无锡市锡山人民医院2021年3月至2023年3月收治的150例DKD患者,纳入DKD组,并选取同期2型糖尿病(T2DM)患者80例,纳入T2DM组。采集患者新鲜粪便样本,行16sRNA检测,比较2组肠道菌群组成、丰度和多样性差异。按照DKD组患者胃肠道功能障碍症状是否存在,将其分别纳入有功能障碍组、无功能障碍组,对比2亚组患者肠道菌群特点,分析DKD及胃肠道功能障碍与肠道菌群生态特点的关联。结果α多样性分析提示,DKD组Chao指数明显高于T2DM组,Shannon指数明显低于T2DM组,差异均有统计学意义(P<0.05)。β多样性主成分分析提示,DKD组、T2DM组肠道菌群结构存在差异性(P<0.05)。门水平上,DKD组厚壁菌门相对丰度较低,变形菌门相对丰度较高;在属水平上,DKD组在大肠志贺菌属相对丰度增加,布劳特菌属、拟杆菌相对丰度降低。150例DKD患者中,103例(68.67%)合并胃肠道功能障碍症状。在厚壁菌门相对丰度水平方面比较,有功能障碍组低于T2DM组和无功能障碍组。在变形菌门相对丰度水平方面,有功能障碍组高于T2DM组和无功能障碍组(P<0.01)。有功能障碍组在厚壁菌门与超敏C反应蛋白、白介素-6呈现正相关,而变形菌门与超敏C反应蛋白、白介素-6呈现负相关(P<0.05)。结论DKD患者致病性菌群多样性和丰度增加、有益菌多样性和丰度减少。DKD患者发生胃肠道功能障碍可能与厚壁菌门相对丰度降低,变形菌门相对丰度升高有关。

关键词：糖尿病肾病肠道菌群胃肠道功能障碍

Three-dimensional constrained gravity inversion of Moho depth and crustal structural characteristics at Mozambique continental margin

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Acta Oceanologica Sinica 2024年第2期43卷 120-129页

作者： Shihao Yang Zhaocai wu Yinxia Fang Mingju Xu jialing Zhang Fanlin Yang College of Geodesy and Geomatics Shandong University of Science and TechnologyQingdao 266590China Key Laboratory of Submarine Geoscience Second Institute of OceanographyMinistry of Natural ResourcesHangzhou 310012China School of Geomatics and Municipal Engineering Zhejiang University of Water Resources and Electric PowerHangzhou 310018China Ocean College Zhejiang UniversityZhoushan 316021China

Mozambique's continental margin in East Africa was formed during the break-off stage of the east and west Gondwana lands. Studying the geological structure and division of continent-ocean boundary(COB) in Mozambique's continental margin is considered of great significance to rebuild Gondwana land and understand its movement mode. Along these lines, in this work, the initial Moho was fit using the known Moho depth from reflection seismic profiles, and a 3D multi-point constrained gravity inversion was carried out. Thus, highaccuracy Moho depth and crustal thickness in the study area were acquired. According to the crustal structure distribution based on the inversion results, the continental crust at the narrowest position of the Mozambique Channel was detected. According to the analysis of the crustal thickness, the Mozambique ridge is generally oceanic crust and the COB of the whole Mozambique continental margin is divided.

关键词： 3D constrained gravity inversion continent-ocean boundary Mozambique continental margin Moho depth