检索结果-南通市图书馆

Exploring the interconnectivity of biomimetic hierarchical porous Mg scaffolds for bone tissue engineering:Effects of pore size distribution on mechanical properties,degradation behavior and cell migration ability

引用

Journal of Magnesium and Alloys 2021年第6期9卷 1954-1966页

作者： Gaozhi Jia Hua Huang jialin niu Chenxin Chen Jian Weng Fei Yu Deli Wang Bin Kang Tianbing Wang Guangyin Yuan Hui Zeng Department of Bone&Joint Surgery Peking University Shenzhen HospitalShenzhen Peking University-The Hong Kong University of Science and Technology Medical CenterShenzhen 518036China National Engineering Research Center of Light Alloy Net Forming&State Key Laboratory of Metal Matrix Composite Shanghai Jiao Tong UniversityShanghai 200240China Beijing Key Laboratory of Civil Aircraft Structures and Composite Materials Beijing Aircraft Technology Research Institute of COMACBeijing 102211China National&Local Joint Engineering Research Center of Orthopaedic Biomaterials Peking University Shenzhen HospitalShenzhen 518036China Department of Orthopaedics Peking University People's HospitalBeijing 100044China

Interconnectivity is the key characteristic of bone tissue engineering scaffold modulating cell migration,blood vessels invasion and transport of nutrient and ***,efforts and understanding of the interconnectivity of porous Mg is limited due to the diverse architectures of pore struts and pore size distribution of Mg scaffold *** this work,biomimetic hierarchical porous Mg scaffolds with tailored interconnectivity as well as pore size distribution were prepared by template replication of infiltration *** scaffold with better interconnectivity showed lower mechanical *** interconnected pores would enhance the interconnectivity of the whole scaffold and reduce the change of ion concentration,pH value and osmolality of the degradation microenvironment due to the lower specific surface ***,the degradation rates of five tested Mg scaffolds were no different because of the same geometry of strut *** cell culture and evaluation of cell density at both sides of four typical Mg scaffolds indicated that cell migration through hierarchical porous Mg scaffolds could be enhanced by not only bigger interconnected pore size but also larger main pore *** summary,design of interconnectivity in terms of pore size distribution could regulate mechanical strength,microenvironment in cell culture condition and cell migration potential,and beyond that it shows great potential for personalized therapy which could facilitate the regeneration process.

关键词： Bone tissue engineering Porous Mg scaffold Interconnectivity Pore size distribution Cell migration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Research and development strategy for biodegradable magnesium-based vascular stents:a review

引用

Biomaterials Translational 2021年第3期2卷 236-247页

作者： jialin niu Hua Huang Jia Pei Zhaohui Jin Shaokang Guan Guangyin Yuan National Engineering Research Center of Light Alloy Net Forming and Key State Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghaiChina School of Materials Science and Engineering Zhengzhou UniversityZhengzhouHenan ProvinceChina

Magnesium alloys are an ideal material for biodegradable vascular stents,which can be completely absorbed in the human body,and have good biosafety and mechanical ***,the rapid corrosion rate and excessive localized corrosion,as well as challenges in the preparation and processing of microtubes for stents,are restricting the clinical application of magnesium-based vascular *** the present work we will give an overview of the recent progresses on biodegradable magnesium based vascular stents including magnesium alloy design,high-precision microtubes processing,stent shape optimisation and functional coating *** particular,the Triune Principle in biodegradable magnesium alloy design is proposed based on our research experience,which requires three key aspects to be considered when designing new biodegradable magnesium alloys for vascular stents application,*** and biosafety,mechanical properties,and *** review hopes to inspire the future studies on the design and development of biodegradable magnesium alloy-based vascular stents.

关键词： biodegradable magnesium alloy vascular stents functional coatings synthesis high-precision microtubes processing magnesium alloy design stent shape optimisation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Concerting magnesium implant degradation facilitates local chemotherapy in tumor-associated bone defect

引用

Bioactive Materials 2024年第10期40卷 445-459页

作者： Qingqing Guan Tu Hu Lei Zhang Mengjiao Yu jialin niu Zhiguang Ding Pei Yu Guangyin Yuan Zhiquan An Jia Pei National Engineering Research Center of Light Alloy Net Forming Center of Hydrogen Science&State Key Laboratory of Metal Matrix CompositeSchool of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai200240China Department of Orthopedics Shanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai Jiao Tong UniversityShanghai200233China Department of Orthopedics Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghai200025China Institute of Medical Robotics&National Engineering Research Center for Advanced Magnetic Resonance Technologies for Diagnosis and Therapy Shanghai Jiao Tong UniversityShanghai200240China

Effective management of malignant tumor-induced bone defects remains challenging due to severe systemic side effects,substantial tumor recurrence,and long-lasting bone reconstruction post tumor *** and its alloys have recently emerged in clinics as orthopedics implantable metals but mostly restricted to mechanical ***,by deposition of calcium-based bilayer coating on the surface,a Mg-based composite implant platform is developed with tailored degradation characteristics,simultaneously integrated with chemotherapeutic(Taxol)loading *** delicate modulation of Mg degradation occurring in aqueous environment is observed to play dual roles,not only in eliciting desirable osteoinductivity,but allows for modification of tumor microenvironment(TME)owing to the continuous release of degradation ***,the sustainable H2 evolution and Ca2+from the implant is distinguished to cooperate with local Taxol delivery to achieve superior antineoplastic activity through activating Cyt-c pathway to induce mitochondrial dysfunction,which in turn leads to significant tumor-growth inhibition in *** addition,the local chemotherapeutic delivery of the implant minimizes toxicity and side effects,but markedly fosters osteogenesis and bone repair with appropriate structure degradation in rat femoral defect *** together,a promising intraosseous administration strategy with biodegradable Mg-based implants to facilitate tumor-associated bone defect is proposed.

关键词： Tumor-associated bone defect Biodegradable magnesium-based implant Multifunctional composite coating Bone regeneration Local tumor therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biocompatibility of Mg-Nd-Zn-Zr alloy with rabbit blood

引用

Chinese Science Bulletin 2013年第23期58卷 2903-2908页

作者： WANG YongPing OUYANG YuanMing HE YaoHua CHEN DaoYun JIANG Yao MAO Lin niu jialin ZHANG Jian YUAN GuangYin Department of Orthopaedics First Hospital of Lanzhou University Department of Orthopaedics Sixth People's Hospital of Shanghai Jiao Tong University National Engineering Research Center of Light Alloys Net Forming School of Materials Science and Engineering Shanghai Jiao Tong University

In this study, in vitro blood biocompatibility of Mg-Nd-Zn-Zr (JDBM) alloy was investigated to determine its suitability as a degradable medical biomaterial. Blood biocompatibility was assessed by blood cell aggregation, platelet adhesion, and protein adsorption. A titanium alloy was used as control. The results showed that the JDBM alloy did not induce significant blood cell aggregation, platelet adhesion, and protein adsorption comparison with the titanium alloy (P>0.05). Our data indicate that the JDBM alloy has excellent in vitro blood compatibility, and thus can be considered as a potential degradable biomaterial for medical applications with respect to hemocompatibility.

关键词：生物相容性钛合金血液相容性血小板粘附蛋白质吸附钕镁生物材料

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

可降解医用镁合金在骨修复应用中的研究进展

引用

金属学报 2017年第10期53卷 1168-1180页

作者：袁广银牛佳林上海交通大学轻合金精密成型国家工程研究中心和金属基复合材料国家重点实验室上海200240 沪创医疗科技(上海)有限公司上海200232

镁合金可在人体内完全降解,其弹性模量与人皮质骨接近,可有效避免应力遮挡效应,且具有较高的机械强度和良好的骨诱导性,因此镁合金作为骨修复材料具有很好的应用潜力,并受到广泛研究。本文对可降解医用镁合金材料在骨修复领域的研究进... 详细信息

镁合金可在人体内完全降解,其弹性模量与人皮质骨接近,可有效避免应力遮挡效应,且具有较高的机械强度和良好的骨诱导性,因此镁合金作为骨修复材料具有很好的应用潜力,并受到广泛研究。本文对可降解医用镁合金材料在骨修复领域的研究进行了总结,分别从镁合金骨修复材料的优势,发展历史,存在的问题与挑战,近几年的研究进展等几个方面进行了阐述。文章最后介绍了上海交通大学轻合金精密成型国家工程研究中心团队在骨修复用镁合金方面的最新研究成果,以及为推动我国可降解医用镁合金的产业化进程方面所做的工作。

关键词：可降解医用镁合金骨修复生物降解性能生物相容性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

In vitro degradation and biocompatibility of Mg-Nd-Zn-Zr alloy

引用

Chinese Science Bulletin 2012年第32期57卷 2163-2170页

作者： WANG YongPing HE YaoHua ZHU ZhaoJin JIANG Yao ZHANG Jian niu jialin MAO Lin YUAN GuangYin Department of Orthopaedics Sixth People's Hospital of Shanghai Jiao Tong UniversityShanghai 200233China National Engineering Research Center of Light Alloys Net Forming School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China

In this study,in vitro degradation and biocompatibility of Mg-Nd-Zn-Zr(NZK) alloy were investigated to determine its suitability as a degradable medical *** corrosion properties were evaluated by static immersion test,electrochemical corrosion test,scanning electron microscopy(SEM),and energy dispersive spectroscopic(EDS) analysis,and in vitro biocompatibilities were assessed by hemolysis and cytotoxicity *** magnesium was used as *** results of static immersion test and electrochemical corrosion test in simulated body fluid(SBF) demonstrated that the addition of alloying elements could improve the corrosion *** hemolysis test found that the hemolysis rate of calcium phosphate coated NZK alloy was 4.8%,which was lower than the safe value of 5%.The cytotoxicity test indicated that NZK alloy extracts did not significantly reduce MC3T3-E1 cell *** test and cytotoxicity test display excellent hemocompatibility and cytocompatibility of NZK alloy in *** data indicate that NZK alloy has excellent biocompatibility and thus can be considered as a potential degradable medical biomaterial for orthopedic applications.

关键词：生物相容性体外降解锆合金纯镁电化学腐蚀试验医用生物材料扫描电子显微镜溶血试验

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于单片机的铜热电阻传感器基本参数测试

引用

实验技术与管理 2018年第3期35卷 29-31,34页

作者：陈虹丽牛佳林彭辉哈尔滨工程大学自动化学院黑龙江哈尔滨150001 中国飞行试验研究院陕西西安710089

设计制作了符合实验教学要求的铜热电阻传感器,进行了基本参数测试以及在直流电桥、差动放大电路下铜热电阻温度测量及误差分析。利用铜热电阻以及阻值固定的电阻搭建桥式电路,将铜热电阻阻值变化量转化为相应电压值;然后通过仪用放大... 详细信息

设计制作了符合实验教学要求的铜热电阻传感器,进行了基本参数测试以及在直流电桥、差动放大电路下铜热电阻温度测量及误差分析。利用铜热电阻以及阻值固定的电阻搭建桥式电路,将铜热电阻阻值变化量转化为相应电压值;然后通过仪用放大器将采集到的电压信号进行放大,再通过51单片机、A/D转换与显示电路搭建的电压采集系统对电压信号进行采集和显示。此外,设计一个模拟加热炉系统以提供不同温度给铜热电阻,从而进行基本参数测试。

关键词：铜热电阻传感器 51单片机 A/D转换模拟加热炉

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

中性粒细胞与淋巴细胞比值评估老年急性ST段抬高型心肌梗死患者冠状动脉病变程度及预后

引用

中华老年心脑血管病杂志 2022年第4期24卷 385-388页

作者：颜波滕圣敏牛家林马正金徐强滕州市中心人民医院急诊科 277500 滕州市中心人民医院病理科

目的探讨外周血中性粒细胞/淋巴细胞比值(NLR)对老年急性ST段抬高型心肌梗死(STEMI)患者冠状动脉病变严重程度及PCI术后预后评估价值。方法纳入老年STEMI急诊PCI患者241例,根据Gensini积分三分位数值分为低分位组80例、中分位组81例... 详细信息

目的探讨外周血中性粒细胞/淋巴细胞比值(NLR)对老年急性ST段抬高型心肌梗死(STEMI)患者冠状动脉病变严重程度及PCI术后预后评估价值。方法纳入老年STEMI急诊PCI患者241例,根据Gensini积分三分位数值分为低分位组80例、中分位组81例、高分位组80例。根据PCI术后是否发生主要不良心脑血管事件(MACCE),分为无MACCE组214例和MACCE组27例。采用Spearman相关性分析、Cox分析和ROC曲线分析。结果高分位组高敏C反应蛋白、白细胞计数和NLR水平较低分位组和中分位组明显升高(P<0.01);单核细胞和中性粒细胞计数较低分位组明显升高(P<0.01)。外周血NLR与Gensini积分呈正相关(r=0.192,P=0.003)。NLR(HR=1.168,95%CI:1.050~1.299),Gensini积分(HR=1.014,95%CI:1.004~1.025)是患者术后1年内发生MACCE的独立危险因素。ROC曲线分析,NLR预测MACCE的曲线下面积为0.649(95%CI:0.532~0.766),最佳临界值为4.645,敏感性77.8%,特异性为57.9%。结论外周血NLR水平与老年STEMI患者Gensini积分呈正相关,辅助预测患者PCI术后发生MACCE的价值较高。

关键词：中性白细胞淋巴细胞 ST段抬高型心肌梗死冠状动脉疾病经皮冠状动脉介入治疗

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

糖尿病酮症酸中毒的急诊急救方法应用效果

引用

糖尿病新世界 2024年第11期27卷 11-14页

作者：牛家林魏巍马正金滕州市中心人民医院急诊内科山东滕州277500

目的评估糖尿病酮症酸中毒中采用急诊急救治疗的价值。方法选取2022年10月—2023年10月滕州市中心人民医院急诊内科收治的76例糖尿病酮症酸中毒患者为研究对象,按照不同的治疗方法分为对照组(38例,常规治疗)与观察组(38例,急诊急救治疗)... 详细信息

目的评估糖尿病酮症酸中毒中采用急诊急救治疗的价值。方法选取2022年10月—2023年10月滕州市中心人民医院急诊内科收治的76例糖尿病酮症酸中毒患者为研究对象,按照不同的治疗方法分为对照组(38例,常规治疗)与观察组(38例,急诊急救治疗),比较两组血糖指标(空腹血糖、餐后2 h血糖、糖化血红蛋白)、并发症发生率(低血钾、低血糖、脑水肿以及急性肾损伤)、酸中毒纠正时间和尿酮体转阴时间。结果治疗后,观察组血糖水平均低于对照组,差异有统计学意义(P均<0.05)。观察组并发症发生率低于对照组,差异有统计学意义(P<0.05)。观察组酸中毒纠正时间和尿酮体转阴时间均短于对照组,差异有统计学意义(P均<0.05)。结论糖尿病酮症酸中毒中采用急诊急救治疗可以有效控制血糖,降低并发症发生率。

关键词：急诊急救方法糖尿病酮症酸中毒并发症发生率

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

评价药物联合血液灌流治疗重度急性有机磷中毒的效果

引用

系统医学 2024年第22期9卷 105-107,119页

作者：牛家林何洪洋魏巍滕州市中心人民医院急诊内科山东滕州277500

目的探讨重度急性有机磷中毒患者采用药物+血液灌流治疗的临床效果。方法非随机选取2022年1月—2023年5月滕州市中心人民医院收治的68例重度急性有机磷中毒患者为研究对象,按治疗方式不同分为两组,每组34例,参照组采用盐酸戊乙奎醚+血... 详细信息

目的探讨重度急性有机磷中毒患者采用药物+血液灌流治疗的临床效果。方法非随机选取2022年1月—2023年5月滕州市中心人民医院收治的68例重度急性有机磷中毒患者为研究对象,按治疗方式不同分为两组,每组34例,参照组采用盐酸戊乙奎醚+血必净治疗,研究组在参照组基础上联用血液灌流治疗。比较两组的治疗效果、不良反应发生率、治疗恢复进程及心肾功能水平。结果研究组的总有效率为97.06%(33/34),高于参照组的76.47%(26/34),差异有统计学意义(χ^(2)=4.610,P0.05)。研究组的治疗恢复进程以及心肾功能均优于参照组,差异有统计学意义(P均<0.05)。结论重度急性有机磷中毒患者联合使用药物以及血液灌流治疗,可确保安全性,同时提升疗效,有效缩短治疗恢复进程并改善心肾功能水平。

关键词：重度急性有机磷中毒药物血液灌流疗效不良反应治疗恢复进程心肾功能水平

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：