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A high-speed 2D optoelectronic in-memory computing device with 6-bit storage and pattern recognition capabilities

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Nano Research 2022年第3期15卷 2472-2478页

作者： jialin meng Tianyu Wang Zhenyu He Qingxuan Li Hao Zhu Li Ji Lin Chen Qingqing Sun David Wei Zhang State Key Laboratory of ASIC and System School of MicroelectronicsFudan UniversityShanghai 200433China National Integrated Circuit Innovation Center No.825 Zhangheng RoadShanghai 201203China

The explosively developed era of big-data compels the increasing demand of nonvolatile memory with high efficiency and excellent storage ***,we fabricated a high-speed photoelectric multilevel memory device for neuromorphic *** novel two-dimensional(2D)MoSSe with a unique Janus structure was employed as the channel,and the stack of Al_(2)O_(3)/black phosphorus quantum dots(BPQDs)/Al_(2)O_(3)was adopted as the *** storage performance of the resulting memory could be verified by the endurance and retention tests,in which the device could remain stable states of programming and erasing even after 1,000 cycles and 1,000 *** multibit storage could be realized through both different voltage amplitudes and pulse numbers,which could achieve 6 bits(64 distinguishable levels)under pulse width of 50 ***,our memory device also could realize the simulations of synapses in human brain with optical and electric modulations synergistically,such as excitatory post-synaptic current(EPSC),long-term potentiation/depression(LTP/LTD),and spike-timing-dependent plasticity(STDP).Neuromorphic computing was successfully achieved through a high recognition of handwritten digits up to 92.5%after 103 *** research is a promising avenue for the future development of efficient memory and artificial neural network systems.

关键词： memory multibit two-dimensional(2D) MoSSe Co-modulation

InGaZnO-based photoelectric synaptic devices for neuromorphic computing

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Journal of Semiconductors 2024年第9期45卷 42-47页

作者： Jieru Song jialin meng Tianyu Wang Changjin Wan Hao Zhu Qingqing Sun David Wei Zhang Lin Chen School of Microelectronics State Key Laboratory of Integrated Chips and SystemsFudan UniversityShanghai 200433China School of Integrated Circuits Shandong UniversityJinan 250100China National Integrated Circuit Innovation Center Shanghai 201203China School of Electronic Science and Engineering Nanjing UniversityNanjing 210023China Jiashan Fudan Institute Jiashan 314102China

Photoelectric synaptic devices could emulate synaptic behaviors utilizing photoelectric effects and offer promising prospects with their high-speed operation and low crosstalk. In this study, we introduced a novel InGaZnO-based photoelectric memristor. Under both electrical and optical stimulation, the device successfully emulated synaptic characteristics including excitatory postsynaptic current (EPSC), paired-pulse facilitation (PPF), long-term potentiation (LTP), and long-term depression (LTD). Furthermore, we demonstrated the practical application of our synaptic devices through the recognition of handwritten digits. The devices have successfully shown their ability to modulate synaptic weights effectively through light pulse stimulation, resulting in a recognition accuracy of up to 93.4%. The results illustrated the potential of IGZO-based memristors in neuromorphic computing, particularly their ability to simulate synaptic functionalities and contribute to image recognition tasks.

关键词： InGaZnO artificial synapse neuromorphic computing photoelectric memristor

从中国特色社会主义民主政治的视角看思想政治教育的新使命

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教学与研究 2018年第3期 90-96页

作者：谢晓娟孟佳琳辽宁大学马克思主义学院

改革开放以来,中国特色社会主义民主政治取得了新发展,这就要求思想政治教育要教育广大人民群众形成对中国共产党的领导、对社会主义制度以及对习近平新时代中国特色社会主义思想的高度认同。推进全面深化改革要求思想政治教育帮助人们... 详细信息

改革开放以来,中国特色社会主义民主政治取得了新发展,这就要求思想政治教育要教育广大人民群众形成对中国共产党的领导、对社会主义制度以及对习近平新时代中国特色社会主义思想的高度认同。推进全面深化改革要求思想政治教育帮助人们树立改革开放的信心,并保证改革开放的社会主义方向;依法治国的推进要求思想政治教育加大法律知识传播的力度和广度,同时要帮助人们形成法治思维,形成法治文化;全面从严治党要求思想政治教育要把党员干部的理想信念的培养放在首位,要强化对共产党领导的政治认同的塑造,强化对执政党建设规律的研究。

关键词：思想政治教育民主政治深化改革依法治国从严治党

大数据环境下多媒体网络舆情传播要素及运行机理研究

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图书情报工作 2015年第21期59卷 38-44,62页

作者：黄微李瑞孟佳林吉林大学管理学院长春130022 中国环境管理干部学院秦皇岛066000

[目的/意义]研究大数据环境下多媒体网络舆情信息传播要素和运行机理,为相关部门加强网络舆情信息监管提供参考。[方法/过程]以大数据技术、舆情理论、信息传播理论为基础,对大数据环境下多媒体网络舆情的特征进行分析,深入探讨大数据... 详细信息

[目的/意义]研究大数据环境下多媒体网络舆情信息传播要素和运行机理,为相关部门加强网络舆情信息监管提供参考。[方法/过程]以大数据技术、舆情理论、信息传播理论为基础,对大数据环境下多媒体网络舆情的特征进行分析,深入探讨大数据环境下多媒体网络舆情传播的主体、客体、媒体、本体、空间5个要素,在此基础上重点归纳总结大数据多媒体网络舆情传播机理,并构建传播机理的总体关系架构。[结果/结论]揭示多媒体技术环境下网络舆情信息传播的内在运行规律,为大数据环境下多媒体网络舆情信息传播的研究提供新视角。

关键词：网络舆情信息传播大数据多媒体运行机理

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航空用6061铝合金恒载荷应力腐蚀行为

腐蚀与防护 2023年第2期44卷 64-69页

作者：何祯拜斌张小明孟嘉琳航空工业第一飞机设计研究院西安710000 海军装备部驻西安地区军事代表局西安710000

采用恒载荷全浸腐蚀拉伸、断口扫描和室温拉伸等方法研究了拉应力对两种热处理状态6061铝合金(6061-T4和6061-T6)应力腐蚀行为的影响。结果表明,在O2和Cl-共存环境中,6061-T4铝合金的应力腐蚀敏感性很低,力学性能降低主要受腐蚀介质的... 详细信息

采用恒载荷全浸腐蚀拉伸、断口扫描和室温拉伸等方法研究了拉应力对两种热处理状态6061铝合金(6061-T4和6061-T6)应力腐蚀行为的影响。结果表明,在O2和Cl-共存环境中,6061-T4铝合金的应力腐蚀敏感性很低,力学性能降低主要受腐蚀介质的电化学腐蚀影响;6061-T6铝合金的应力腐蚀开裂敏感性高于6061-T4铝合金,其应力腐蚀开裂倾向受腐蚀影响为主,力学因素影响为辅;应力腐蚀后,6061-T4和6061-T6铝合金表层腐蚀区域为沿晶脆断,次表层为准解离断裂,中心为穿晶断裂;在腐蚀介质与应力同时作用下,6061-T4铝合金由点蚀发展为晶间腐蚀,并随应力增大变为剥落腐蚀;6061-T6铝合金点蚀不明显,但晶间腐蚀深度随应力增大而加深。

关键词： 6061铝合金应力腐蚀恒载荷热处理状态

Peripheral blood RNA biomarkers can predict lesion severity in degenerative cervical myelopathy

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Neural Regeneration Research 2025年第6期20卷 1764-1775页

作者： Zhenzhong Zheng jialin Chen Jinghong Xu Bin Jiang Lei Li Yawei Li Yuliang Dai Bing Wang Department of Spine Surgery The Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

Degenerative cervical myelopathy is a common cause of spinal cord injury,with longer symptom duration and higher myelopathy severity indicating a worse *** numerous studies have investigated serological biomarkers for acute spinal cord injury,few studies have explored such biomarkers for diagnosing degenerative cervical *** study involved 30 patients with degenerative cervical myelopathy(51.3±7.3 years old,12 women and 18 men),seven healthy controls(25.7±1.7 years old,one woman and six men),and nine patients with cervical spondylotic radiculopathy(51.9±8.6 years old,three women and six men).Analysis of blood samples from the three groups showed clear differences in transcriptomic *** analysis identified 128 differentially expressed genes that were enriched in patients with neurological *** least absolute shrinkage and selection operator analysis,we constructed a five-gene model(TBCD,TPM2,PNKD,EIF4G2,and AP5Z1)to diagnose degenerative cervical myelopathy with an accuracy of 93.5%.One-gene models(TCAP and SDHA)identified mild and severe degenerative cervical myelopathy with accuracies of 83.3%and 76.7%,*** of two immune cell types(memory B cells and memory-activated CD4^(+)T cells)predicted levels of lesions in degenerative cervical myelopathy with 80%*** results suggest that peripheral blood RNA biomarkers could be used to predict lesion severity in degenerative cervical myelopathy.

关键词： biomarkers candidate genes degenerative cervical myelopathy gene expression analysis immune cell types neurological disabilities peripheral blood RNA profiles spinal cord injury

Th17/Treg细胞在前列腺疾病中的作用研究进展

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中国免疫学杂志 2024年第9期40卷 1981-1985页

作者：李佳蔚孟佳林梁朝朝安徽医科大学第一附属医院泌尿外科合肥230022

初始CD4^(+)T细胞在免疫效应的启动和维持中起着关键作用,在细胞因子和共刺激分子的作用下可分化为Th1、Th2、Treg和Th17等细胞。近年来越来越多证据显示,Th17和Treg细胞在免疫稳定、自身免疫性疾病和肿瘤中发挥着重要作用。慢性前列腺... 详细信息

初始CD4^(+)T细胞在免疫效应的启动和维持中起着关键作用,在细胞因子和共刺激分子的作用下可分化为Th1、Th2、Treg和Th17等细胞。近年来越来越多证据显示,Th17和Treg细胞在免疫稳定、自身免疫性疾病和肿瘤中发挥着重要作用。慢性前列腺炎/慢性盆腔疼痛综合征(CP/CPPS)是发病率最高的前列腺炎类型,占90%~95%,并与良性前列腺增生和前列腺癌的疾病进展有着密不可分的关系。前列腺良性疾病和前列腺癌在免疫微环境上有诸多相似之处,故本综述以Th17和Treg细胞为视角,总结近年来关于Th17/Treg细胞及相关细胞因子在前列腺疾病中的作用研究进展。

关键词： Th17细胞 Treg细胞前列腺炎前列腺癌

核壳结构TiO_2微球的可控合成及其光催化性能

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钢铁钒钛 2014年第3期35卷 19-22页

作者：代海孟嘉琳任卫安文晓刚四川大学材料科学与工程学院四川成都610065

通过水热法制备出了核壳结构的锐钛矿TiO2微球,采用SEM、XRD等测试手段对TiO2的形貌、结构、晶型等进行表征,以甲基橙为目标污染物,测试产物TiO2的光催化性能。试验表明,核壳结构的TiO2具有良好的光催化活性,在紫外光条件下,1 h照射时... 详细信息

通过水热法制备出了核壳结构的锐钛矿TiO2微球,采用SEM、XRD等测试手段对TiO2的形貌、结构、晶型等进行表征,以甲基橙为目标污染物,测试产物TiO2的光催化性能。试验表明,核壳结构的TiO2具有良好的光催化活性,在紫外光条件下,1 h照射时间甲基橙的降解率达到了90%,其降解速率比其他两种结构快了20%。

关键词：二氧化钛核壳结构微球光催化水热法

The autophagy-lysosome pathway:a potential target in the chemical and gene therapeutic strategies for Parkinson’s disease

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Neural Regeneration Research 2025年第1期20卷 139-158页

作者： Fengjuan Jiao Lingyan meng Kang Du Xuezhi Li School of Mental Health Jining Medical UniversityJiningShandong ProvinceChina Shandong Collaborative Innovation Center for Diagnosis Treatment and Behavioral Interventions of Mental DisordersInstitute of Mental HealthJining Medical UniversityJiningShandong ProvinceChina

Parkinson’s disease is a common neurodegenerative disease with movement disorders associated with the intracytoplasmic deposition of aggregate proteins such asα-synuclein in *** one of the major intracellular degradation pathways,the autophagy-lysosome pathway plays an important role in eliminating these *** evidence has shown that upregulation of the autophagy-lysosome pathway may contribute to the clearance ofα-synuclein aggregates and protect against degeneration of dopaminergic neurons in Parkinson’s ***,multiple genes associated with the pathogenesis of Parkinson’s disease are intimately linked to alterations in the autophagy-lysosome ***,this pathway appears to be a promising therapeutic target for treatment of Parkinson’s *** this review,we briefly introduce the machinery of ***,we provide a description of the effects of Parkinson’s disease–related genes on the autophagy-lysosome ***,we highlight the potential chemical and genetic therapeutic strategies targeting the autophagy–lysosome pathway and their applications in Parkinson’s disease.

关键词： autophagy chemical therapy gene therapy Parkinson’s disease α-synuclein