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Decentralized Primary Frequency Regulation for Hybrid Multi-terminal Direct Current Power Systems Considering Multi-source Enhancement

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Journal of Modern Power Systems and Clean Energy 2024年第3期12卷 958-970页

作者： jialiang wu Zhen wang Ruixu Liu Yu Shan Chenxuan wang the College of Electrical Engineering Zhejiang UniversityHangzhou 310027China the Economic Research institute of State Grid Zhejiang Electric Power Co. Ltd.Hangzhou 310016China

Hybrid multi-terminal direct current(MTDC)transmission technology has been a research focus,and primary frequency regulation(FR)improvement in the receiving-end system is one of the problems to be *** paper presents a decentralized primary FR scheme for hybrid MTDC power systems considering multi-source enhancement to help suppress frequency disturbance in the receiving-end *** the converters only need local frequency or DC voltage signal input to respond to system disturbance without communication or a control center,i.e.,a decentralized control *** proposed scheme can activate appropriate power sources to assist in FR in various system disturbance severities with fine-designed thresholds,ensuring sufficient utilization of each power *** better balance FR performance and FR resource participation,an evaluation index is proposed and the parameter optimization problem is further ***,the validity of the proposed scheme is verified by simulations in MATLAB/Simulink.

关键词： Decentralized control scheme primary frequency regulation(FR) rate of change of frequency(ROCOF) system frequency disturbance

Mechanical properties and fracture surface roughness of thermally damaged granite under dynamic splitting

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Deep Underground Science and Engineering 2024年第1期3卷 103-116页

作者： Yijin Qian Peng Jia Songze Mao jialiang Lu School of Resources and Civil Engineering Northeastern UniversityShenyangChina

in order to understand the mechanical properties and the fracture surface roughness characteristics of thermally damaged granite under dynamic splitting,dynamic Brazilian splitting tests were conducted on granite samples after thermal treatment at 25,200,400,and 600℃.Results show that the dynamic peak splitting strength of thermally damaged granite samples increases with increasing strain rate,showing obvious strain‐rate *** increasing temperature,thermally induced cracks in granite transform from intergranular cracks to intragranular cracks,and to a transgranular crack *** induced damages reduce the dynamic peak splitting strength and the maximum absorbed energy w.ile increasing the peak radial *** fracture mode of the thermally damaged granite under dynamic loads is mode Ⅱ splitting *** using the axial roughness index Z2 a,the distribution ranges of the wedge‐shaped failure zones and the tensile failure zones in the fracture surfaces under dynamic Brazilian splitting can be effectively *** radial roughness index Z_(2)^(r)is sensitive to the strain rate and *** shows a linear correlation with the peak splitting strength and the maximum absorbed energy and a linear negative correlation with the peak radial strain.Z_(2)^(r)can be used to quantitatively estimate the dynamic parameters based on the models proposed.

关键词： dynamic splitting fracture surface roughness granite strain rate thermal treatment

Across two phylogeographic breaks: Quaternary evolutionary history of a mountain aspen (Populus rotundifolia) in the Hengduan Mountains

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Plant Diversity 2024年第3期46卷 321-332页

作者： Jieshi Tang Xiaoyan Fan Richard i.Milne Heng Yang wenjing Tao Xinran Zhang Mengyun Guo jialiang Li Kangshan Mao Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education College of Life SciencesState Key Laboratory of Hydraulics and Mountain River EngineeringSichuan UniversityChengdu 610065PR China institute of Molecular Plant Sciences University of EdinburghEdinburgh EH93JHUK School of Ecology and Environment Tibet UniversityLhasa 850000PR China

Biogeographical barriers to gene flow are central to plant *** East Asia,plant distribution is greatly influenced by two phylogeographic breaks,the Mekong-Salween Divide and Tanaka-Kaiyong Line,however,few studies have investigated how these barriers affect the genetic diversity of species that are distributed across *** we used 14 microsatellite loci and four chloroplast DNA fragments to examine genetic diversity and distribution patterns of 49 populations of Populus rotundifolia,a species that spans both the Mekong-Salween Divide and the Tanaka-Kaiyong Line in southwestern *** and migration hypotheses were tested using coalescent-based *** historical gene flow was observed between the western and eastern groups of ***,but substantial flow occurred across both the Mekong-Salween Divide and Tanaka-Kaiyong Line,manifesting in clear admixture and high genetic diversity in the central ***-borne pollen and seeds may have facilitated the dispersal of *** following prevalent northwest winds in the *** also found that the Hengduan Mountains,where multiple genetic barriers were detected,acted on the whole as a barrier between the western and eastern groups of *** niche modeling suggested that *** has undergone range expansion since the last glacial maximum,and demographic reconstruction indicated an earlier population expansion around 600 *** phylogeographic pattern of *** reflects the interplay of biological traits,wind patterns,barriers,niche differentiation,and Quaternary climate *** study emphasizes the need for multiple lines of evidence in understanding the Quaternary evolution of plants in topographically complex areas.

关键词： Chloroplast DNA Microsatellite Phylogeographic break Populus rotundifolia Quaternary history wind direction

Conservation genomic investigation of an endangered conifer,Thuja sutchuenensis,reveals low genetic diversity but also low genetic load

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Plant Diversity 2024年第1期46卷 78-90页

作者： Tongzhou Tao Richard iMilne jialiang Li Heng Yang Shiyang wang Sihan Chen Kangshan Mao Key Laboratory for Bio-Resource and Eco-Environment of Ministry of Education&Sichuan Zoige Alpine wetland Ecosystem National Observation and Research Station College of Life ScienceSichuan UniversityChengduChina institute of Molecular Plant Science School of Biological ScienceUniversity of EdinburghEdinburgh EH93BFUK College of Science Tibet UniversityLhasa 850000Xizang Autonomous RegionPR China

Endangered species generally have small populations with low genetic diversity and a high genetic *** sutchuenensis is an endangered conifer endemic to southwestern *** was once considered extinct in the wild,but in 1999 was ***,little is known about its genetic *** collected 67 individuals from five wild,isolated *** populations,and used 636,151 SNPs to analyze the level of genetic diversity and genetic load in *** to delineate the conservation units of ***,based on whole transcriptome sequencing data,as well as target capture sequencing *** found that populations of *** could be divided into three *** groups had low levels genetic diversity and were moderately genetically *** findings also indicate that *** suffered two severe bottlenecks around the Last Glaciation Period and Last Glacial *** Thuja species,*** presented the lowest genetic load and hence might have purged deleterious mutations efficiently through purifying ***,distribution of fitness effects analysis indicated a high extinction risk for *** lines of evidence identified three management units for *** *** possesses a low genetic load,low genetic diversity,suboptimal fitness,and anthropogenic pressures all present an extinction risk for this rare *** might also hold true for many endangered plant species in the mountains all over the world.

关键词： Sichuan Arborvitae Genetic load Deleterious mutations Demographic history Conservation genomics

web Layout Design of Large Cavity Structures Based on Topology Optimization

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 2665-2689页

作者： Xiaoqiao Yang jialiang Sun Dongping Jin State Key Laboratory ofMechanics and Control for Aerospace Structures College of Aerospace EngineeringNanjing University of Aeronautics and AstronauticsNanjing210016China

Large cavity structures are widely employed in aerospace engineering, such as thin-walled cylinders, blades andwings. Enhancing performance of aerial vehicles w.ile reducing manufacturing costs and fuel consumptionhas become a focal point for contemporary researchers. Therefore, this paper aims to investigate the topologyoptimization of large cavity structures as a means to enhance their performance, safety, and efficiency. By usingthe variable density method, lightw.ight design is achieved without compromising structural strength. Theoptimization model considers both concentrated and distributed loads, and utilizes techniques like sensitivityfiltering and projection to obtain a robust optimized configuration. The mechanical properties are checked bycomparing the stress distribution and displacement of the unoptimized and optimized structures under the sameload. The results confirm that the optimized structures exhibit improved mechanical properties, thus offering keyinsights for engineering lightw.ight, high-strength large cavity structures.

关键词： Topology optimization lightw.ight design web layout design cavity structure

High-power,electrically-driven continuous-wave 1.55-μm Si-based multi-quantum well lasers with a wide operating temperature range grown on wafer-scale inP-on-Si(100)heterogeneous substrate

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Light(Science & Applications) 2024年第8期13卷 1512-1523页

作者： jialiang Sun Jiajie Lin Min Zhou Jianjun Zhang Huiyun Liu Tiangui You Xin Ou National Key Laboratory of Materials for integrated Circuits Shanghai Institute of Microsystem and Information TechnologyCASShanghai 200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences100049 BeijingChina College of information Science and Engineering Jiaxing UniversityJiaxing 314001China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of Sciences100190 BeijingChina Department of Electronic and Electrical Engineering University College LondonLondon WC1E 7JEUK

A reliable,efficient and electrically-pumped Si-based laser is considered as the main challenge to achieve the integration of all key building blocks with silicon *** the impressive advances that have been made in developing 1.3-μm Si-based quantum dot(QD)lasers,extending the wavelength window to the widely used 1.55-μm telecommunication region remains *** this study,we develop a novel photonic integration method of epitaxial growth of iii-V on a wafer-scale inP-on-Si(100)(inPOS)heterogeneous substrate fabricated by the ion-cutting technique to realize integrated lasers on Si *** ion-cutting plus epitaxial growth approach decouples the correlated root causes of many detrimental dislocations during heteroepitaxial growth,namely lattice and domain *** this approach,we achieved state-of-the-art performance of the electrically-pumped,continuouswave(Cw)1.55-μm Si-based laser with a room-temperature threshold current density of 0.65 kA/cm-2,and output power exceeding 155mw per facet without facet coating in Cw *** lasing at 120℃ and pulsed lasing at over 130℃ were *** generic approach is also applied to other material systems to provide better performance and more functionalities for photonics and microelectronics.

关键词： pumped power quantum

Late-stage modification of bioactive compounds:improving druggability through efficient molecular editing

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1030-1076页

作者： Tongyu Huo Xinyi Zhao Zengrui Cheng jialiang w.i Minghui Zhu Xiaodong Dou Ning Jiao State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Changping Laboratory Beijing 102206China Shanghai Key Laboratory of Green Chemistry and Chemical Processes East China Normal UniversityShanghai 200062China

Synthetic chemistry plays an indispensable role in drug discovery,contributing to hit compounds identification,lead compounds optimization,candidate drugs preparation,and so *** Nobel Prize laureate James Black emphasized,“the most fruitful basis for the discovery of a new drug is to start with an old drug”***-stage modification or functionalization of drugs,natural products and bioactive compounds have garnered significant interest due to its ability to introduce diverse elements into bioactive compounds *** modifications alter the chemical space and physiochemical properties of these compounds,ultimately influencing their potency and *** enrich a toolbox of chemical modification methods for drug discovery,this review focuses on the incorporation of halogen,oxygen,and nitrogen—the ubiquitous elements in pharmacophore components of the marketed drugs—through late-stage modification in recent two decades,and discusses the state and challenges faced in these *** also emphasize that increasing cooperation between chemists and pharmacists may be conducive to the rapid discovery of new activities of the functionalized ***,we hope this review would serve as a valuable resource,facilitating the application of late-stage modification in the construction of novel molecules and inspiring innovative concepts for designing and building new drugs.

关键词： Late-stage modification Drug space Halogenation Oxygenation Nitrogenation Synthetic chemistry

Moderate expression of CD39 in GPC3-CAR-T cells shows high efficacy against hepatocellular carcinoma

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FRONTiERS OF MEDiCiNE 2024年第4期18卷 708-720页

作者： Zou, Fan w.i, jialiang Zhuang, Jialang Liu, Yafang Tan, Jizhou Huang, Xianzhang Liu, Ting Guangdong Acad Med Sci Guangdong Prov Peoples Hosp Guangdong Cardiovasc Inst Guangzhou 510080 Peoples R China Southern Med Univ Guangdong Prov Peoples Hosp Med Res Inst Guangdong Acad Med Sci Guangzhou 510080 Peoples R China Guangzhou Univ Chinese Med Guangdong Prov Hosp Chinese Med State Key Lab Tradit Chinese Med Syndrome Dept Lab MedClin Med Coll 2 Guangzhou 510120 Peoples R China Guangxi Med Univ Affiliated Hosp 1 Dept Med Oncol Nanning 530021 Peoples R China Sun Yat Sen Univ Affiliated Hosp 1 Dept Stomatol Guangzhou 510080 Peoples R China Shenzhen Polytech Univ Sch Food & Drug Shenzhen 518055 Peoples R China Shenzhen Univ Affiliated Hosp 1 Shenzhen Peoples Hosp 2 Shenzhen 518055 Peoples R China

CD39 serves as a crucial biomarker for neoantigen-specific CD8+ T cells and is associated with antitumor activity and exhaustion. However, the relationship between CD39 expression levels and the function of chimeric antigen receptor T (CAR-T) cells remains controversial. This study aimed to investigate the role of CD39 in the functional performance of CAR-T cells against hepatocellular carcinoma (HCC) and explore the therapeutic potential of CD39 modulators, such as mitochondrial division inhibitor-1 (mdivi-1), or knockdown CD39 through short hairpin RNA. Our findings demonstrated that glypican-3-CAR-T cells with moderate CD39 expression exhibited a strong antitumor activity, w.ile high and low levels of CD39 led to an impaired cellular function. Methods modulating the proportion of CD39 intermediate (CD39int)-phenotype CAR-T cells such as mdivi-1 and CD39 knockdown enhanced and impaired T cell function, respectively. The combination of mdivi-1 and CD39 knockdown in CAR-T cells yielded the highest proportion of infiltrated CD39int CAR-T cells and demonstrated a robust antitumor activity in vivo. in conclusion, this study revealed the crucial role of CD39 in CAR-T cell function, demonstrated the potential therapeutic efficacy of combining mdivi-1 with CD39 knockdown in HCC, and provided a novel treatment strategy for HCC patients in the field of cellular immunotherapy.

关键词： CD39 CAR-T cells mdivi-1 hepatocellular carcinoma antitumor activity CD73

Two-dimensional flow vector measurement based on all-fiber laser feedback frequency-shifted multiplexing technology

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Photonics Research 2024年第7期12卷 1371-1378页

作者： LEi ZHANG jialiang LV YUNKUN ZHAO JiE Li KEYAN LiU Qi YU HONGTAO Li BENLi YU LiANG LU information Materials and intelligent Sensing Laboratory of Anhui Province Anhui UniversityHefei 230601China Key Laboratory of Opto-Electronic information Acquisition and Manipulation of Ministry of Education Anhui UniversityHefei 230601China School of Physics and Optoelectronic Engineering Anhui UniversityHefei 230601China School of Optics and Photonics Beijing Institute of TechnologyBeijing 100081China

The decomposition and identification of signals are crucial for flow vector acquisition in a multi-dimensional measurement. Here, we proposed a two-dimensional(2D) flow vector measurement system based on all-fiber laser feedback frequency-shifted multiplexing technology. The reliable performance of the system is characterized by experimental verification and numerical simulation. An orthogonal dual-beam structure is employed to eliminate the impact of an unknown incident angle in the practical application. Meanw.ile, the vector velocity signals in 2D can be decomposed into one-dimensional(1D) scalar signals by adopting the frequency-shifted multiplexing,w.ich makes it easy to obtain the vector information and velocity distribution of fluid motion through the self-mixing interference frequency spectrum.

关键词： fiber shifted flow