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Multi-View & Transfer Learning for Epilepsy Recognition Based on EEG Signals

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Computers, Materials & Continua 2023年第6期75卷 4843-4866页

作者： jiali Wang Bing Li chengyu Qiu Xinyun Zhang Yuting cheng Peihua Wang Ta Zhou Hong Ge Yuanpeng Zhang Jing Cai Department of Medical Informatics Nantong UniversityNantong226001China The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer Hospital Zhengzhou450008China Department of Health Technology and Informatics Shenzhen Research InstituteThe Hong Kong Polytechnic UniversityShenzhen518057China

Epilepsy is a central nervous system disorder in which brain activity becomes ***(EEG)signals,as recordings of brain activity,have been widely used for epilepsy *** study epilep-tic EEG signals and develop artificial intelligence(AI)-assist recognition,a multi-view transfer learning(MVTL-LSR)algorithm based on least squares regression is proposed in this *** with most existing multi-view transfer learning algorithms,MVTL-LSR has two merits:(1)Since traditional transfer learning algorithms leverage knowledge from different sources,which poses a significant risk to data ***,we develop a knowledge transfer mechanism that can protect the security of source domain data while guaranteeing performance.(2)When utilizing multi-view data,we embed view weighting and manifold regularization into the transfer framework to measure the views’strengths and weaknesses and improve generalization *** the experimental studies,12 different simulated multi-view&transfer scenarios are constructed from epileptic EEG signals licensed and provided by the Uni-versity of Bonn,*** experimental results show that MVTL-LSR outperforms *** source code will be available on https://***/didid5/MVTL-LSR.

关键词： Multi-view learning transfer learning least squares regression epilepsy EEG signals

Tal6b/AvrXa27A,a hidden TALE targeting the susceptibility gene OsSWEET11a and the resistance gene Xa27 in rice

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Plant Communications 2024年第2期5卷 122-134页

作者： Zhengyin Xu Xiameng Xu Ying Li Linlin Liu Qi Wang Yijie Wang Yong Wang jiali Yan Guanyun cheng Lifang Zou Bo Zhu Gongyou Chen Shanghai Collaborative Innovation Center of Agri-Seeds School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Microbial Metabolism Shanghai Jiao Tong UniversityShanghai 200240China

Xanthomonas oryzae ***(Xoo)secretes transcription activator-like effectors(TALEs)to activate rice susceptibility(S)genes,causing bacterial blight(BB),as well as resistance(R)genes,leading to de-fense against *** activation follows a gene-for-gene paradigm that results in an arms race between the TALE of the pathogen and effector-binding elements(EBEs)in the promoters of host *** this study,we characterized a novel TALE,designated Tal6b/AvrXa27A,that activates the rice S gene OsSWEET11a and the rice R gene ***6b/AvrXa27A is a member of the AvrXa27/TalAO class and contains 16 repeat variable diresidues(RVDs);one RVD is altered and one is deleted in Tal6b/AvrXa27A compared with AvrXa27,a known avirulence(avr)effector of ***6b/AvrXa27A can transcriptionally activate the expression of Xa27 and OsSWEET11a via EBEs in their corresponding promoters,leading to effector-triggered immunity and susceptibility,*** 16 RVDs in Tal6b/AvrXa27A have no obvious similarity to the 24 RVDs in the effector PthXo1,but EBETal6b and EBEPthXo1 are overlapped in the OsSWEET11a ***6b/AvrXa27A is prevalent among Asian Xoo isolates,but PthXo1 has only been reported in the Philippine strain *** editing of EBETal6b in the OsSWEET11a pro-moter further confirmed the requirement for OsSWEET11a expression in Tal6b/AvrXa27A-dependent susceptibility to ***,Tal6b/AvrXa27A resulted in higher transcription of Xa27 than of OsSWEET11a,which led to a strong,rapid resistance response that blocked disease *** suggest that Tal6b/AvrXa27A has a dual function:triggering resistance by activating Xa27 gene expression as an avirulence factor and inducing transcription of the S gene OsSWEET11a,resulting in ***,Tal6b/AvrXa27A,but not AvrXa27,can bind to the promoter of *** underlying recognition mechanism for this binding remains unclear but appears to deviate from the currently accepted TALE code.

关键词： Xanthomonas oryzae pv.oryzae TALE AvrXa27 tal6b Xa27 OsSWEET11a

Layer-by-layer epitaxy growth of thickness-controllable two-dimensional tungsten disulfide

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Science China(Information Sciences) 2024年第5期67卷 302-310页

作者： Jieyuan LIANG Zixing ZOU Junwu LIANG Di WANG Biao WANG Anshi CHU jiali YI cheng ZHANG Lizhen FANG Tian ZHANG Huawei LIU Xiaoli ZHU Dong LI Anlian PAN Key Laboratory for Micro-Nano Physics and Technology of Hunan Province State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan Institute of Optoelectronic IntegrationCollege of Materials Science and Engineering School of Physics and ElectronicsHunan University School of Electronic Information and Electrical Engineering Changsha University School of Physics and Telecommunication Engineering Yulin Normal University Units Semiconductor Technology Co. Ltd. School of Physics and Electronics Hunan Normal University

Bilayer transition metal dichalcogenides（TMDs） balance the high mobility of single layers with the high state density of multilayers and therefore have promising application prospects in high-performance electronics. However, the layer-controlled growth of 2D materials is still confronted with challenges such as poor repeatability between different labs and a limited understanding of the growth mechanism at the atomic scale. Herein, we report a new carbon-assisted chemical vapor deposition process that can realize the growth of WS2sheets with high yield, precise thickness controllability, and repeatability. We show that carbon can act as a reducing agent and catalyst that preferentially reacts with the WO3precursor to form intermediate WO3-xproducts with low-valence state W. The resulting oxycarbide gas has a low surface adsorption energy when deposited on the surface of as-grown WS2, which provides nucleation sites for the subsequent layer of WS2growth and leads to the vertical growth of WS2sheets. The growth mechanism is thoroughly investigated. Electrical transport measurements show that the produced bilayer WS2possesses a high carrier mobility(up to 58 cm2·V-1·s-1) and small subthreshold swing（estimated to be 148 mV/decade）,which are among the best reported results for TMDs produced using CVD.

关键词： WS$_2$ thickness-controlled growth chemical vapor deposition additive carbon

A Personalized Cloud Services Recommendation Based on Cooperative Relationship between Services

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Journal of Software Engineering and Applications 2013年第12期6卷 623-629页

作者： chengwen Zhang jiali Bian Bo cheng Lingfei Li Beijing Key Laboratory of Intelligent Telecommunications Software and Multimedia Beijing University of Posts & Telecommuni- cations Beijing China Beijing University of Posts & Telecommunications Beijing China State Key Laboratory of Networking and Switching Technology Beijing University of Posts & Telecommunications Beijing China

A personalized recommendation for cloud services, which is based on usage history and the cooperative relationship of cloud services, is presented. According to service groups, a service group could be defined as several services that were used together by one user at a time, and cooperative relationship between each two services can be calculated. In the process of recommendation, the services which are highly related to the service that the user has selected would be obtained firstly, the result should then take the QoS (Quality of Service) similarity between service’s QoS and user’s preference into account, so the final result combining the cooperative relationship and similarity will meet the functional needs of users and also meet the user’s personalized non-functional requirements. The simulation proves that the algorithm works effectively.

关键词： Personalized Recommendation Cloud Service Quality of Service Similarity Cooperative Relationship

Targeting tumor endothelial hyperglycolysis enhances immunotherapy through remodeling tumor microenvironment

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Acta Pharmaceutica Sinica B 2022年第4期12卷 1825-1839页

作者： Yunlong Shan Qi Ni Qixiang Zhang Mengying Zhang Bin Wei Lingge cheng Chongjin Zhong Xinyu Wang Qingqing Wang jiali Liu Jingwei Zhang Jingjing Wu Guangji Wang Fang Zhou Key Laboratory of Drug Metabolism and Pharmacokinetics State Key Laboratory of Natural MedicinesChina Pharmaceutical UniversityNanjing 210009China Department of Hematology and Oncology the Affiliated Huaian No.1 People’s Hospital of Nanjing Medical UniversityHuai’an 223300China

Vascular abnormality is a hallmark of most solid tumors and facilitates immune *** the abnormal metabolism of tumor endothelial cells(TECs)may provide an opportunity to improve the outcome of ***,in comparison to vascular endothelial cells from adjacent peritumoral tissues in patients with colorectal cancer(CRC),TECs presented enhanced glycolysis with higher glyceraldehyde-3-phosphate dehydrogenase(GAPDH)*** an unbiased screening identified that osimertinib could modify the GAPDH and thus inhibit its activity in ***-dose osimertinib treatment caused tumor regression with vascular normalization and increased infiltration of immune effector cells in tumor,which was due to the reduced secretion of lactate from TECs by osimertinib through the inhibition of ***,osimertinib and anti-PD-1 blockade synergistically retarded tumor *** study provides a potential strategy to enhance immunotherapy by targeting the abnormal metabolism of TECs.

关键词： Endothelial glycolysis GAPDH Osimertinib Normalized glycolysis Immunometabolism Colorectal cancer Tumor microenvironment Immunotherapy

Identification of bioactive anti-angiogenic components targeting tumor endothelial cells in Shenmai injection using multidimensional pharmacokinetics

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Acta Pharmaceutica Sinica B 2020年第9期10卷 1694-1708页

作者： Chongjin Zhong Chao Jiang Suiying Ni Qizhi Wang Lingge cheng Huan Wang Qixiang Zhang Wenyue Liu Jingwei Zhang jiali Liu Mulan Wang Min Jin Peiqiang Shen Xuequan Yao Guangji Wang Fang Zhou Key Laboratory of Drug Metabolism and Pharmacokinetics State Key Laboratory of Natural MedicinesChina Pharmaceutical UniversityNanjing 210009China Department of Digestive Tumor Surgery Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029China Chiatai Qingchunbao Pharmaceutical Co. Ltd.Hangzhou 310023China

Shenmai injection(SMI)is a well-defined herbal preparation that is widely and clinically used as an adjuvant therapy for ***,we found that SMI synergistically enhanced the activity of chemotherapy on colorectal cancer by promoting the distribution of drugs in xenograft ***,the underlying mechanisms and bioactive constituents remained *** the present work,the regulatory effects of SMI on tumor vasculature were determined,and the potential anti-angiogenic components targeting tumor endothelial cells(TECs)were *** pharmacokinetic profiles of ginsenosides in plasma,subcutaneous tumors,and TECs were *** results showed that the concentrations of protopanaxadiol-type(PPD)ginsenosides(Rb1,Rb2/Rb3,Rc,and Rd)in both plasma and tumors,were higher than those of protopanaxatriol-type(Rg1 and Re)and oleanane-type(Ro)*** PPD-type ginsenosides,Rd exhibited the greatest concentrations in tumors and TECs after repeated *** vivo bioactivity results showed that Rd suppressed neovascularization in tumors,normalized the structure of tumor vessels,and improved the anti-tumor effect of 5-fluorouracil(5 FU)in xenograft ***,Rd inhibited the migration and tube formation capacity of endothelial cells in *** conclusion,Rd may be an important active form to exert the anti-angiogenic effect on tumor after SMI treatment.

关键词： Shenmai injection Ginsenoside Rd Multidimensional pharmacokinetics Anti-angiogenic Tumor endothelial cell

基于部分极化转换表面与部分反射表面的宽带高增益圆极化天线设计

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电子与信息学报 2022年第12期44卷 4085-4094页

作者：程友峰王迎熹钟佳丽廖成西南交通大学电磁场与微波技术研究所成都610031

该文介绍了一种具有部分极化转换与部分反射功能的超表面结构,并将其应用到具有宽带高增益性能的圆极化法布里-珀罗(Fabry-Perot,F-P)谐振腔天线设计中。所设计的超表面在反射地板存在时能够表现出反射型部分极化转换功能从而用于F-P天... 详细信息

该文介绍了一种具有部分极化转换与部分反射功能的超表面结构,并将其应用到具有宽带高增益性能的圆极化法布里-珀罗(Fabry-Perot,F-P)谐振腔天线设计中。所设计的超表面在反射地板存在时能够表现出反射型部分极化转换功能从而用于F-P天线的圆极化源设计,而当反射地板被移除时其具有部分反射功能因而能够作为F-P天线的部分反射表面。通过在部分极化转换表面上方放置矩形贴片并加载寄生贴片与部分反射表面,辐射源贴片的线极化辐射能够被转变为高增益圆极化辐射,并且天线的阻抗带宽与轴比带宽均得到加强。所设计的天线经过仿真、加工与测试,测试结果表明其阻抗与轴比带宽分别为6.8~8.4 GHz(21.3%)和6.8~8.3 GHz(19.9%),峰值增益达10.5 dBi。

关键词：电磁超表面宽带圆极化天线法布里-珀罗谐振腔天线极化转换表面部分反射表面

Oscillation-specific nodal alterations in early to middle stages Parkinson’s disease

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Translational Neurodegeneration 2019年第1期8卷 450-465页

作者： Xiaojun Guan Tao Guo Qiaoling Zeng Jiaqiu Wang cheng Zhou Chunlei Liu Hongjiang Wei Yuyao Zhang Min Xuan Quanquan Gu Xiaojun Xu Peiyu Huang jiali Pu Baorong Zhang Min-Ming Zhang Department of Radiology The Second Affiliated HospitalZhejiang University School of MedicineNo.88 Jiefang RoadShangcheng DistrictHangzhou 310009China Department of Neurology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhouChina Helen Wills Neuroscience Institute University of CaliforniaBerkeleyCAUSA Department of Electrical Engineering and Computer Sciences University of CaliforniaBerkeleyCAUSA

Background:Different oscillations of brain networks could carry different dimensions of brain *** aimed to investigate oscillation-specific nodal alterations in patients with Parkinson’s disease(PD)across early stage to middle stage by using graph theory-based ***:Eighty-eight PD patients including 39 PD patients in the early stage(EPD)and 49 patients in the middle stage(MPD)and 36 controls were recruited in the present *** theory-based network analyses from three oscillation frequencies(slow-5:0.01–0.027 Hz;slow-4:0.027–0.073 Hz;slow-3:0.073–0.198 Hz)were *** metrics(*** degree centrality,betweenness centrality and nodal efficiency)were ***:Our results showed that(1)a divergent effect of oscillation frequencies on nodal metrics,especially on nodal degree centrality and nodal efficiency,that the anteroventral neocortex and subcortex had high nodal metrics within low oscillation frequencies while the posterolateral neocortex had high values within the relative high oscillation frequency was observed,which visually showed that network was perturbed in PD;(2)PD patients in early stage relatively preserved nodal properties while MPD patients showed widespread abnormalities,which was consistently detected within all three oscillation frequencies;(3)the involvement of basal ganglia could be specifically observed within slow-5 oscillation frequency in MPD patients;(4)logistic regression and receiver operating characteristic curve analyses demonstrated that some of those oscillation-specific nodal alterations had the ability to well discriminate PD patients from controls or MPD from EPD patients at the individual level;(5)occipital disruption within high frequency(slow-3)made a significant influence on motor impairment which was dominated by akinesia and ***:Coupling various oscillations could provide potentially useful information for large-scale network and progressive oscillation-specific no

关键词： Parkinson’s disease Network Functional magnetic resonance imaging Oscillation frequency Graph theory analysis Akinesia and rigidity

我国4个典型城市近30年绿色空间时空演变规律

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林业科学 2020年第3期56卷 61-72页

作者：金佳莉王成贾宝全中国林业科学研究院林业研究所国家林业和草原局林木培育重点实验室国家林业和草原局城市森林研究中心北京100091

【目的】以长沙、大连、南昌和深圳为例,探究城市绿色空间格局近30年来的时空演变规律及主要影响因素,为完善城市景观生态学的相关理论和模型提供数据支持,为城市绿色空间管理提升和政策调整提供参考依据。【方法】以30 m分辨率的Landsa... 详细信息

【目的】以长沙、大连、南昌和深圳为例,探究城市绿色空间格局近30年来的时空演变规律及主要影响因素,为完善城市景观生态学的相关理论和模型提供数据支持,为城市绿色空间管理提升和政策调整提供参考依据。【方法】以30 m分辨率的Landsat TM/ETM+合成影像为数据源,运用NDVI阈值将绿色空间分为4种类型,利用景观指数量化绿色空间格局特征,并引入距离归一化指数(NDI)进行城乡梯度分析,使用Mann-Kendall趋势检测分别计算绿色空间格局在时间和城乡梯度上的单调变化趋势,运用时间动态弯曲法(DTW)探究不同城市绿色空间格局时空变化轨迹的差异性,采用最大信息非参数勘探法(MINE)对影响绿色空间格局变化的主要因素进行相关性分析。【结果】1985—2011年,长沙、大连和深圳高密度植被面积比例平均增加0.26%,斑块面积平均增加0.11 hm^2,而中密度植被面积比例平均下降0.40%;中密度植被平均斑块面积在南昌和深圳均呈上升趋势,分别增加0.15和0.04 hm^2,而在长沙和大连则分别减少0.01和0.08 hm^2;低密度植被面积比例和平均斑块面积在长沙和南昌均呈增加趋势,其面积比例分别增加0.12%和0.23%,平均斑块面积分别增加0.04和0.01 hm^2,而在大连和深圳则均呈减少趋势,低密度植被面积比例分别减少0.22%和0.63%,平均斑块面积分别减少0.04和0.06 hm^2;高密度植被面积比例在长沙和南昌呈“∩”型轨迹;低密度植被面积比例在长沙和深圳呈单调下降轨迹,而在大连和南昌呈“∪”型轨迹;绿色空间格局的时空变化与城市居民人均年收入、人均国民生产总值、城市人口比例和城市市区面积比例之间有极强的非线性相关。【结论】1985—2011年,长沙、大连和深圳高密度植被比例增加,其斑块空间分布更集中,而中密度植被则相反;所选城市中,内陆城市的低密度植被比例增加,破碎度减少,而沿海城市则相反;绿色空间的城乡梯度轨迹主要呈3种规律,一是抛物线“∩/∪”型,二是平稳“—”型,三是递增或递减型;绿色空间在城市中心或城郊区域有显著的大幅变化趋势。

关键词：城市绿色空间景观格局城乡梯度时空变化