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The Influence of Meridional Variation in North Pacific Sea Surface Temperature Anomalies on the Arctic Stratospheric Polar Vortex

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Advances in Atmospheric Sciences 2023年第12期40卷 2262-2278页

作者： Tao WANG Qiang FU Wenshou tian Hongwen LIU Yifeng PENG Fei XIE Hongying tian jiali LUO College of Atmospheric Sciences Lanzhou UniversityLanzhou 730000China Key Laboratory of Western China's Environmental Systems of the Ministry of Education College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China Department of Atmospheric Sciences University of WashingtonSeattle 98101USA College of Global Change and Earth System Science Beijing Normal UniversityBeijing 100875China

This study examines the dependence of Arctic stratospheric polar vortex(SPV)variations on the meridional positions of the sea surface temperature(SST)anomalies associated with the first leading mode of North Pacific *** principal component 1(PC1)of the first leading mode is obtained by empirical orthogonal function *** data,numerical experiments,and CMIP5 model outputs all suggest that the PC1 events(positive-minus-negative PC1 events),located relatively northward(i.e.,North PC1 events),more easily weaken the Arctic SPV compared to the PC1 events located relatively southward(i.e.,South PC1 events).The analysis indicates that the North PC1-related Aleutian low anomaly is located over the northern North Pacific and thus enhances the climatological trough,which strengthens the planetary-scale wave 1 at mid-to-high latitudes and thereby weakens the *** weakened stratospheric circulation further extends into the troposphere and favors negative surface temperature anomalies over *** contrast,the South PC1-related Aleutian low anomaly is located relatively southward,and its constructive interference with the climatological trough is less efficient at high ***,the South PC1 events could not induce an evident enhancement of the planetary-scale waves at high latitudes and thereby a weakening of the SPV on *** Eurasian cooling associated with South PC1 events(positive-minus-negative PC1 events)is also not *** results of this study suggest that the meridional positions of the PC1 events may be useful for predicting the Arctic SPV and Eurasian surface temperature variations.

关键词： Arctic stratospheric polar vortex stratosphere-troposphere interactions North Pacific sea surface temperature Aleutian low

Comparisons of AGRI/FY-4A Cloud Fraction and Cloud Top Pressure with MODIS/Terra Measurements over East Asia

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Journal of Meteorological Research 2019年第4期33卷 705-719页

作者： Tao WANG jiali LUO Jinglin LIANG Baojian WANG Wenshou tian Xiaoyan CHEN Key Laboratory for Semi-Arid Climate Change of the Ministry of Education College of Atmospheric SciencesLanzhou UniversityLanzhou 730000 Gansu Meteorological Bureau Lanzhou 730030

Fengyun-4 A(FY-4 A),the second generation of China’s geostationary meteorological satellite,provides high spatiotemporal resolution cloud products over East *** this study,cloud fraction(CFR)and cloud top pressure(CTP)products in August 2017 derived from the Advanced Geosynchronous Radiation Imager(AGRI)aboard FY-4 A(AGRI/FY-4 A)are retrospectively compared with those from the Moderate Resolution Imaging Spectroradiometer(MODIS)aboard Terra(MODIS/Terra)over East *** avoid possible errors in the comparison caused by the lower temporal coverage of MODIS/Terra products compared to that of AGRI/FY-4 A over the same region and to account for time lags between observations of the two instruments,we construct datasets of AGRI/FY-4 A CFR and CTP to match those of MODIS/Terra in each scan over East Asia in August *** show that the CFR and CTP datasets of the two instruments generally agree well,with the linear correlation coefficients(R)between CFR(CTP)data of 0.83(0.80)regardless of time *** longer time lags contribute to the worse consistency between CFR(CTP)data derived from observations of the two instruments in most cases,large CFR/CTP discrepancies do not always match with long time *** CFR discrepancies appear in the vicinity of the Tibetan Plateau(TP;28°–45°N,75°–105°E).These differences in the cloud detection by the two instruments largely occur when MODIS/Terra detects clear-sky while AGRI/FY-4 A detects higher values of CFR,and this accounts for 61%of the CFR discrepancy greater than 50%near the *** the case of CTP,the largest discrepancies appear in the eastern Iranian Plateau(IP;25°–45°N,60°–80°E),where there are some samples with long time lags(20–35 min)and fewer daily data samples are available for computing monthly means compared to other regions since there are many clearsky data samples there during the study period.

关键词： AGRI/FY-4A MODIS/Terra cloud fraction cloud top pressure

Arabidopsis PRK6 interacts specifically with AtRopGEF8/12 and induces depolarized growth of pollen tubes when overexpressed

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Science China(Life Sciences) 2018年第1期61卷 100-112页

作者： Yuexuan Yu jiali Song Xiaohui tian Haiwen Zhang Legong Li Huifen Zhu College of Life Sciences Capital Normal University

The pollen receptor kinases (PRK) are critical regulators of pollen tube growth. The Arabidopsis genome encodes eight PRK genes, of which six are highly expressed in pollen tubes. The potential functions of AtPRK1 through AtPRK5, but not of AtPRK6,in pollen growth were analyzed in tobacco. Herein, AtPRK6 was cloned, and its function was identified. AtPRK6 was expressed specifically in pollen tubes. A yeast two-hybrid screen of AtPRK6 against 14 Arabidopsis Rop guanine nucleotide exchange factors (RopGEFs) showed that AtPRK6 interacted with AtRopGEF8 and AtRopGEF12. These interactions were confirmed in Arabidopsis mesophyll protoplasts. The interactions between AtPRK6 and AtRopGEF8/12 were mediated by the C-termini of AtRopGEF8/12 and by the juxtamembrane and kinase domain of AtPRK6, but were not dependent on the kinase activity. In addition, transient overexpression of AtPRK6::GFP in Arabidopsis protoplasts revealed that AtPRK6 was localized to the plasma membrane. Tobacco pollen tubes overexpressing AtPRK6 exhibited shorter tubes with enlarged tips. This depolarized tube growth required the kinase domain of AtPRK6 and was not dependent on kinase activity. Taken together, the results show that AtPRK6,through its juxtamembrane and kinase domains (KD), interacts with AtRopGEF8/12 and plays crucial roles in polarized growth of pollen tubes.

关键词： pollen receptor kinase pollen tube polarized growth RopGEF Arabidopsis

Ultrasound features of extranodal extension in the metastatic cervical lymph nodes of papillary thyroid cancer:a case-control study

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Cancer Biology & Medicine 2018年第2期15卷 171-177页

作者： jiali Mu Xiaofeng Liang Fangxuan Li Juntian Liu Sheng Zhang Jing tian Department of Ultrasound Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China Department of Cancer Prevention Center Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China Department of Ultrasound The Secondary Hospital of Tianjin Medical UniversityTianjin 300211China

Objective：Extranodal extension in cervical lymph nodes is an important risk factor for the progression and prognosis of papillary thyroid *** purpose of this study was to identify the common and characteristic preoperative ultrasonography features that are associated with the pathologic extranodal extension of metastatic papillary thyroid ***：We retrospectively assessed and compared clinicopathologic and ultrasound features between 60 papillary thyroid cancer patients with extranodal extension and 120 control patients with papillary thyroid cancer without extranodal ***：With respect to the pathological N stage and clinicopathologic features,N1b stage papillary thyroid carcinomas were more frequently found in patients who were extranodal extension-positive,in comparison with those who were extranodal extension-negative（78.3%vs.63.3%,P=0.043）.Extranodal extension was detected most frequently in level VI cervical lymph nodes（48.7%）.In our univariate analysis of patients with papillary thyroid carcinoma,cervical lymph nodes with extranodal extension showed higher incidences of node matting,microcalcification,cystic area,aspect ratio＆lt;2,and larger diameter than those without extranodal extension（all P〈0.05）.Our multivariate analysis demonstrated that node matting and cystic area were independent risk factors for the presence of extranodal extension[odds ratio（OR）：4.751,95%confidence interval（CI）：1.212~18.626,P=0.025;OR：2.707,95%CI：1.127~6.502,P=0.026].Conclusions：Common ultrasound features may indicate the presence of extranodal extension in patients with metastatic cervical lymph nodes of papillary thyroid carcinoma.

关键词： Extranodal extension papillary thyroid cancer ultrasound lymph node metastasis

interRAI家庭照护评估工具在社区居家老年人综合评估与照护需求分析中的初步应用

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中国护理管理 2016年第11期16卷 1448-1452页

作者：刘宇张素陈鹏冯冬梅田家利王秀英北京大学护理学院 100191 北京大学人民医院呼吸科江苏省人民医院护理部四川大学华西医院老年医学中心北京大学第一医院心内科

目的：使用inter RAI家庭照护评估工具分析社区居家老年人的健康状况与照护需求,同时验证该工具在我国老年人社区居家照护方面的可行性。方法：采用便利抽样方法抽取北京市西城区120例接受居家照护服务的老年人,使用inter RAI家庭照护... 详细信息

目的：使用inter RAI家庭照护评估工具分析社区居家老年人的健康状况与照护需求,同时验证该工具在我国老年人社区居家照护方面的可行性。方法：采用便利抽样方法抽取北京市西城区120例接受居家照护服务的老年人,使用inter RAI家庭照护评估工具进行调查,并使用inter RAI家庭照护评估工具所对应的临床评估协议分析老年人面临的主要健康问题及照护需求,与目前接受的照护服务进行对比分析。结果：老年人存在的健康问题涉及生理、心理、社会等多维度。每位老人存在的问题数目从1~5个不等,平均存在2个问题,且随着年龄的增长（rs=0.45,P=0.03）、患有慢性病种类的增加（rs=0.34,P=0.04）,老年人所伴有的健康问题也随之增多。老年人在心血管呼吸系统问题、疼痛、ADL受限、非正式社会支持不足、压疮风险等问题所接受的服务率相对较高,均达到70%以上;以健康促进不足、家庭环境优化、IADL受限、尿失禁、营养不良、身体活动不足等问题所接受的服务率相对较低,均未达到40%。结论：inter RAI家庭照护评估工具可以从老年综合评估的角度发现老年人存在的需要重点关注和干预的问题,为社区居家照护服务提供了具体的干预方向。未来可以进一步尝试使用该工具,并对社区居家照护的效果进行动态监测。

关键词：老年人居家照护老年综合评估照护需求

西归含药血清对脂多糖诱导的小鼠巨噬细胞RAW264.7炎症因子的影响研究

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药学研究 2018年第9期37卷 497-499,502页

作者：田佳丽郭美仙刘光明沈磊刘晓波大理大学药学与化学学院云南大理671000 云南省昆虫生物医药研发重点实验室云南大理671000

目的研究西归含药血清对脂多糖诱导的巨噬细胞炎症因子的影响。方法 SD大鼠灌胃给予西归乙醇提取物以制备西归含药血清,采用噻唑蓝(MTT)法观察给予不同浓度的西归含药血清对RAW 264.7增殖的影响;采用1μg·m L^(-1)的脂多糖(LPS)建立RAW... 详细信息

目的研究西归含药血清对脂多糖诱导的巨噬细胞炎症因子的影响。方法 SD大鼠灌胃给予西归乙醇提取物以制备西归含药血清,采用噻唑蓝(MTT)法观察给予不同浓度的西归含药血清对RAW 264.7增殖的影响;采用1μg·m L^(-1)的脂多糖(LPS)建立RAW 264.7细胞体外炎症模型,酶联免疫吸附测定(ELISA)法检测细胞上清液中肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、白细胞介素2(IL-2)的含量。结果脂多糖刺激细胞后,给药组均引起肿瘤坏死因子α、白细胞介素6、白细胞介素2的高表达;而西归含药血清干预后,能显著抑制肿瘤坏死因子α和白细胞介素6的高表达(P<0.05或P<0.01);但对白细胞介素2没有显著影响。结论西归具有抗炎的作用,其抗炎作用可能是通过抑制脂多糖诱导的巨噬细胞炎症反应来发挥的。

关键词：西归醇提物含药血清巨噬细胞肿瘤坏死因子α 白细胞介素6

Global trends of tropopause folds in recent decades

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Atmospheric and Oceanic Science Letters 2024年第3期17卷 14-19页

作者： Yufeng Lin Wenshou tian Haiyang Xue jiali Luo Jiankai Zhang Hongying tian Wenjun Liang College of Atmospheric Sciences Lanzhou UniversityLanzhouChina School of Atmospheric Sciences Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Sun Yat-sen UniversityZhuhaiChina

对流层顶折卷是平流层-对流层物质交换的主要机制.本研究采用三维标记方法,利用1979-2020年间的ERA5再分析数据,分析了对流层顶折卷的时空变化特征及机理.研究结果表明,全球对流层顶折卷的多年变化趋势存在明显的季节性和区域性差异.总... 详细信息

对流层顶折卷是平流层-对流层物质交换的主要机制.本研究采用三维标记方法,利用1979-2020年间的ERA5再分析数据,分析了对流层顶折卷的时空变化特征及机理.研究结果表明,全球对流层顶折卷的多年变化趋势存在明显的季节性和区域性差异.总体上,对流层顶折卷呈增加趋势,其中北半球的春季,夏季和冬季,对流层顶折卷主要沿副热带急流区呈现明显增加的趋势.进一步分析表明,对流层顶折卷发生频率的增加与大气斜压性增大导致的锋生增强有关,而经向位温梯度的增大使得次级环流增强,也可能促进了对流层顶折卷活动的增多.

关键词：对流层顶折卷趋势锋生大气斜压性

ILC3-derived OX40L is essential for homeostasis of intestinal Tregs in immunodeficient mice

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Cellular & Molecular Immunology 2020年第2期17卷 163-177页

作者： tian Deng Caixia Suo jiali Chang Rui Yang Jingyu Li Ting Cai Ju Qiu CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Jiao Tong University School of Medicine(SJTUSM)&Shanghai Institutes for Biological Sciences(SIBS)Chinese Academy of Sciences(CAS)Shanghai 200031China CAS Key Laboratory of Tissue Microenvironment and Tumor Shanghai Institutes for Biological SciencesUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China

OX40L is one of the co-stimulatory molecules that can be expressed by splenic lymphoid tissue inducer(Lti)cells,a subset of group 3 innate lymphoid cells(ILC3s).OX40L expression in subsets of intestinal ILC3s and the molecular regulation of OX40L expression in ILC3s are ***,we showed intestinal ILC3s marked as an OX40L high population among all the intestinal leukocytes and were the dominant source of OX40L in Rag1–/–*** ILC3 subsets expressed OX40L,and NCR–ILC3s were the most abundant source of *** expression of OX40L in ILC3s could be upregulated during *** addition to tumor necrosis factor(TNF)-like cytokine 1A(TL1A),which has been known as a trigger for OX40L,we found that Poly(I:C)representing viral stimulus promoted OX40L expression in ILC3s via a cell-autonomous ***,we demonstrated that IL-7-STAT5 signaling sustained OX40L expression by *** regulatory T cells(Tregs),most of which expressed OX40,had defective expansion in chimeric mice,in which ILC3s were specifically deficient for OX40L ***,co-localization of Tregs and ILC3s was found in the cryptopatches of the intestine,which suggests the close interaction between ILC3s and *** study has unveiled the crosstalk between Tregs and ILC3s in mucosal tissues through OX40–OX40L signaling,which is crucial for the homeostasis of intestinal Tregs.

关键词： Group 3 innate lymphoid cells OX40L Regulatory T cells Intestinal immunity

应用尿微量蛋白系列对比等渗造影剂与次高渗造影剂对肾损伤的临床研究

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中国循证心血管医学杂志 2021年第10期13卷 1191-1193,1197页

作者：田佳丽张勤肖模超王立峰汤松涛崔旭东哈尔滨医科大学附属第四医院心内科哈尔滨150001 哈尔滨医科大学附属第一医院心内科哈尔滨150001

目的应用尿微量蛋白系列对比等渗造影剂与次高渗造影剂对肾脏的损伤。方法采用前瞻性研究方法收集100例拟在我院行冠状动脉(冠脉)PCI手术的患者,并将其随机分为等渗造影剂组(碘克沙醇组,n=50)和次高渗造影剂组(碘普罗胺组,n=50),术前及... 详细信息

目的应用尿微量蛋白系列对比等渗造影剂与次高渗造影剂对肾脏的损伤。方法采用前瞻性研究方法收集100例拟在我院行冠状动脉(冠脉)PCI手术的患者,并将其随机分为等渗造影剂组(碘克沙醇组,n=50)和次高渗造影剂组(碘普罗胺组,n=50),术前及术后检测患者血肌酐、尿微量蛋白系列水平,比较碘克沙醇组与碘普罗胺组造影剂肾病的发生率及尿微量蛋白系列的变化。结果①碘克沙醇组与碘普罗胺组比较,造影剂肾病发病率无统计学意义(P>0.05)。②尿微量蛋白系列两组间比较显示:肾小球性蛋白尿(包括选择性蛋白尿、非选择性蛋白尿)发生率无统计学意义(P>0.05);而碘克沙醇组肾小管性蛋白尿及混合性蛋白尿(肾小球性蛋白尿+肾小管性蛋白尿)发生率显著低于碘普罗胺组(P<0.05)。结论与次高渗造影剂相比较,等渗造影剂具有减少肾小管性蛋白尿及混合性蛋白尿的益处。

关键词：等渗造影剂次高渗造影剂尿微量蛋白