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TRIB3-GSK-3β interaction promotes lung fibrosis and serves as a potential therapeutic target

Acta Pharmaceutica Sinica B 2021年第10期11卷 3105-3119页

作者： Shanshan Liu Xiaoxi Lv Xupeng Wei Chang Liu Qiao Li jiali min Fang Hua Xiaowei Zhang Ke Li Pingping Li Yang Xiao Zhuowei Hu Bing Cui State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaCAMS Key Laboratory of Molecular Mechanism and Target Discovery of Metabolic Disorder and TumorigenesisChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Department of Pharmacy Pharmacy CollegeHebei UniversityBaoding 071000China National Clinical Research Center for Metabolic Diseases Department of Metabolism and Endocrinologythe Second Xiangya HospitalCentral South UniversityChangsha 410011China Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China

Pulmonary fibrosis(PF)is a chronic,progressive,fatal interstitial lung disease with limited available therapeutic strategies.We recently reported that the protein kinase glycogen synthase kinase-3β(GSK-3β)interacts with and inactivates the ubiquitin-editing enzyme A20 to suppress the degradation of the transcription factor CCAAT/enhancer-binding protein beta(C/EBPβ)in alveolar macrophages(AMs),resulting in a profibrotic phenotype of AMs and promoting the development of PF.Here,we showed that chronic lung injury upregulated the stress response protein tribbles homolog 3(TRIB3),which interacted with GSK-3βand stabilized GSK-3βfrom ubiquitination and degradation.Elevated GSK-3βexpression phosphorylated A20 to inhibit its ubiquitin-editing activity,causing the accumulation of C/EBPβand the production of several profibrotic factors in AMs and promoting PF development.Activated C/EBPβ,in turn,increased the transcription of TRIB3 and GSK-3β,thereby establishing a positive feedback loop in AMs.The knockdown of TRIB3 expression or the pharmacologic disruption of the TRIB3-GSK-3βinteraction was an effective PF treatment.Our study reveals an intact profibrotic axis of TRIB3-GSK-3β-A20-C/EBPβin AMs,which represents a target that may provide a promising treatment strategy for PF.

关键词： E3 ligase Lung injury Protein phosphorylation Protein-protein interaction Ubiquitination TRIB3 GSK-3β

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Construction of biomimetic proton transport channels in metal-organic framework

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Chinese Chemical Letters 2024年第3期35卷 513-517页

作者： Xiao-min Li Junchao Jia Danting Yang jiali Jin Junkuo Gao School of Materials Science and Engineering Institute of Functional Porous MaterialsZhejiang Sci-Tech UniversityHangzhou 310018China Zhejiang Key Laboratory of Pathophysiology School of Public HealthSchool of MedicineNingbo UniversityNingbo 315211China

Construction of proton transport channels in metal-organic frameworks(MOFs)with simple synthesis processes,high proton conductivities and good performance stabilities has been of great interest for proton exchange membrane fuel cell(PEMFC).Herein,we mimic the proton transport behavior of amino acid residues in bacteriorhodopsin,select UiO-66-COOH as the host,glycine and aspartic acid as the functional guest molecules,and then functionalize the MOF framework with amino acids to obtain biomimetic proton transport channels.This strategy endows UiO-66-COOH-Asp a high proton conductivity of 1.19×10^(-2)S/cm at 70℃and 98%RH,excellent cycle stability of performances and performance durability,which can be comparable to the reported MOFs-based proton conductors.Moreover,the proton conduction mechanism in UiO-66-COOH-Asp is elaborated in detail due to its visual structure,which is also one of the advantages of adopting MOFs as research platform,making it possible to optimize the structure-activity relationship of advanced materials.Notably,this strategy has clear objectives and simple synthesis,which has made certain contributions to both theoretical research and future industrial production of proton conductors.

关键词： MOF Amino acids Biomimetic proton transport channels Synergistic effect Proton conduction mechanism

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Trends in Respiratory Infectious Pathogens in Children Under the Age of 14—Xiamen City,Fujian Province,China,2017-2023

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China CDC weekly 2024年第8期6卷 143-147页

作者： jiali Cao Jie Pan Xiaoqing Yang Jumei Liu min Zhu Zeyu Zhao Ling Chen Tianmu Chen Huiming Ye Department of Laboratory Medicine Fujian Key Clinical Specialty of Laboratory MedicineWomen and Children’s HospitalSchool of MedicineXiamen UniversityXiamen CityFujian ProvinceChina State Key Laboratory of Vaccines for Infectious Diseases Xiang An Biomedicine LaboratorySchool of Public HealthXiamen UniversityXiamen CityFujian ProvinceChina Department of Pediatrics Women and Children's HospitalSchool of MedicineXiamen UniversityXiamen CityFujian ProvinceChina

Summary What is already known about this topic?Respiratory infections pose a significant burden on public health.Despite recent outbreaks occurring in various locations,there is limited information available on the pr... 详细信息

关键词： Xiamen spite Fujian

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A cascade of in situ conversion of bicarbonate to CO_(2) and CO_(2) electroreduction in a flow cell with a Ni-N-S catalyst

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Journal of Energy Chemistry 2024年第1期88卷 183-193,I0005页

作者： Linghui Kong min Wang Yongxiao Tuo Shanshan Zhou Jinxiu Wang Guangbo Liu Xuejing Cui jiali Wang Luhua Jiang Nanomaterials and Electrocatalysis Laboratory College of Materials Science and EngineeringQingdao University of Science and TechnologyQingdao 266042ShandongChina State Key Laboratory of Heavy Oil Processing College of New EnergyChina University of Petroleum(East China)Qingdao 266580ShandongChina

Combination of CO_(2) capture using inorganic alkali with subsequently electrochemical conversion of the resultant HCO_(3)^(-)to high-value chemicals is a promising route of low cost and high efficiency.The electrochemical reduction of HCO_(3)^(-)is challenging due to the inaccessible of negatively charged molecular groups to the electrode surface.Herein,we adopt a comprehensive strategy to tackle this challenge,i.e.,cascade of in situ chemical conversion of HCO_(3)^(-)to CO_(2) and CO_(2) electrochemical reduction in a flow cell.With a tailored Ni-N-S single atom catalyst(SACs),where sulfur(S)atoms located in the second shell of Ni center,the CO_(2)electroreduction(CO_(2)ER)to CO is boosted.The experimental results and density functional theory(DFT)calculations reveal that the introduction of S increases the p electron density of N atoms near Ni atom,thereby stabilizing^(*)H over N and boosting the first proton coupled electron transfer process of CO_(2)ER,i.e.,^(*)+e^(-)+^(*)H+^(*)CO_(2)→^(*)COOH.As a result,the obtained catalyst exhibits a high faradaic efficiency(FE_(CO)~98%)and a low overpotential of 425 mV for CO production as well as a superior turnover frequency(TOF)of 47397 h^(-1),outcompeting most of the reported Ni SACs.More importantly,an extremely high FECOof 90%is achieved at 50 mA cm^(-2)in the designed membrane electrode assembly(MEA)cascade electrolyzer fed with liquid bicarbonate.This work not only highlights the significant role of the second coordination on the first coordination shell of the central metal for CO_(2)ER,but also provides an alternative and feasible strategy to realize the electrochemical conversion of HCO_(3)^(-)to high-value chemicals.

关键词： S doped Ni-N-C single atom catalysts CO_(2)electrochemical reduction DFT calculations Membrane electrode assembly Reduction of bicarbonate

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OsWRKY78 regulates panicle exsertion via gibberellin signaling pathway in rice

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Journal of Integrative Plant Biology 2024年第4期66卷 771-786页

作者： Enyang Mei mingliang He min Xu Jiaqi Tang jiali Liu Yingxiang Liu Zhipeng Hong Xiufeng Li Zhenyu Wang Qingjie Guan Xiaojie Tian Qingyun Bu State Key Laboratory of Black Soils Conservation and Utilization Key Laboratory of Soybean Molecular Design BreedingNortheast Institute of Geography and AgroecologyChinese Academy of SciencesHarbin 150081China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Saline-alkali Vegetation Ecology Restoration Northeast Forestry UniversityMinistry of EducationHarbin 150040China College of Life Science Northeast Forestry UniversityHarbin 150040China

Panicle exsertion is one of the crucial agronomic traits in rice(Oryza sativa).Shortening of panicle exsertion often leads to panicle enclosure and severely reduces seed production.Gibberellin(GA)plays important roles in regulating panicle exsertion.However,the underlying mechanism and the relative regulatory network remain elusive.Here,we characterized the oswrky78 mutant showing severe panicle enclosure,and found that the defect of oswrky78 is caused by decreased bioactive GA contents.Biochemical analysis demonstrates that OsWRKY78 can directly activate GA biosynthesis and indirectly suppress GA metabolism.Moreover,we found OsWRKY78 can interact with and be phosphorylated by mitogen-activated protein kinase(MAPK)kinase OsMAPK6,and this phosphorylation can enhance OsWRKY78 stability and is necessary for its biological function.Taken together,these results not only reveal the critical function of OsWRKY78,but also reveal its mechanism via mediating crosstalk between MAPK and the GA signaling pathway in regulating panicle exsertion.

关键词： gibberellin MAPK cascades OsWRKY78 panicle exsertion rice

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Solid-state synthesis and ion transport characteristics of the β-KSbF_(4) for all-solid-state fluoride-ion batteries

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Journal of Energy Chemistry 2024年第7期94卷 758-767页

作者： jiali Liu Huahui Zhao Jingcheng Xia Lingguang Yi Xiaoyi Chen Dongdu Li Shuhan Ni Xinyi Su Yixuan Chen min Liu Xianyou Wang National Base for International Science&Technology Cooperation National Local Joint Engineering Laboratory for Key Materials of New Energy Storage BatteryHunan Province Key Laboratory of Electrochemical Energy Storage&ConversionSchool of ChemistryXiangtan UniversityXiangtan 411105HunanChina College of New Energy Ningbo University of TechnologyNingbo 315336ZhejiangChina

All-solid-state fluoride ion batteries(FIBs)have been recently considered as a post-lithium-ion battery system due to their high safety and high energy density.Just like all solid-state lithium batteries,the key to the development of FIBs lies in room-temperature electrolytes with high ionic conductivity.β-KSbF_(4) is a kind of promising solid-state electrolyte for FIBs owing to its rational ionic conductivity and relatively wide electrochemical stability window at room temperature.However,the previous synthesis routes ofβ-KSbF_(4) required the use of highly toxic hydrofluoric acid and the ionic conductivity of as-prepared product needs to be further improved.Herein,the β-KSbF_(4) sample with an ionic conductivity of 1.04×10^(-4)s cm^(-1)(30°C)is synthesized through the simple solid-state route.In order to account for the high ionic conductivity of the as-synthesizedβ-KSbF_(4),X-ray diffraction(XRD),scanning electron microscopy(SEM),and energy dispersive X-ray spectroscopy(EDS)are used to characterize the physic-ochemical properties.The results show that the as-synthesizedβ-KSbF_(4) exhibits higher carrier concentra-tion of 1.0×10^(-6)S cm-Hz^(-1)K and hopping frequency of 1.31×10^(6)Hz at 30°C due to the formation of the fluorine vacancies.Meanwhile,the hopping frequency shows the same trend as the changes of ionic conductivity with the changes of temperature,while the carrier concentration is found to be almost con-stant.The two different trends indicate the hopping frequency is mainly responsible for the ionic conduc-tion behavior withinβ-KSbF_(4).Furthermore,the all-solid-state FIBs,in which Ag and Pb+PbF_(2) are adopted as cathode and anode,andβ-KSbF_(4) as fluoride ion conductor,are capable of reversible charge and discharge.The assembled FIBs show a discharge capacity of 108.4 mA h g^(-1) at 1st cycle and 74.2 mA h g^(-1) at 50th cycle.Based on an examination of the capacity decay mechanism,it has been found that deterioration of the electrolyte/electrode interface is an important reason for hindering the

关键词： Solid-state electrolyte Carrier concentration Hopping frequency β-KSbF_(4) All-solid-state fluoride ion batteries

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Rapid Degrading Carbamazepine in a Novel Advanced Oxidation Process of Bisulfite Activated by Lithium Cobaltate Recovered from Spent Lithium-ion Battery

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Chemical Research in Chinese Universities 2024年第1期40卷 127-135页

作者： Yan jiali Yang Kaiying Wang Xi Zhai Jinli Zhu Wenjie Yang Daoli Luo Yongming Gao Xiaoya Faculty of Environmental Science and Engineering Kunming University of Science and TechnologyKunming650500P.R.China Innovation Team for Volatile Organic Compounds Pollutants Control and Resource Utilization of Yunnan Province Kunming650500P.R.China Higher Educational Key Laboratory for Odorous Volatile Organic Compounds Pollutants Control of Yunnan Province Kunming650500P.R.China

Maximizing the sustainable recycling of spent lithium-ion batteries(LIBs)shows economic and environmental significance.This study recovered lithium cobaltate(LiCoO_(2),LCO)from spent LIBs cathode powder.The recovered LCO was then combined with NaHSO_(3)to remove refractory organic pollutants of carbamazepine(CBZ)in water.The degradation of CBZ reached 80.0%within 60 min,by 1O_(2),SO_(4),OH and O_(2)^(-)generated in the LCO/NaHSO_(3)reaction.The electron transfer between Co(III)and Co(II)was beneficial to the generation of free radicals.The LCO/NaHSO_(3)degraded CBZ effectively in both secondary outlet water and tap water.However,high concentrations of inorganic ions(Cl^(−),HCO_(3)^(-),HPO_(4)^(2-),SO_(2)−4,NO_(3)^(-))and natural organic matter(humic acid,HA)could inhibit the degradation of CBZ.After three cycles,the stability of the LCO/NaHSO_(3)system was demonstrated by the maintained high efficiency in the degradation of CBZ.The obtained data indicate that the LCO/NaHSO_(3)system holds great application potential in the field of advanced oxidation degradation of pollutants.

关键词： Spent lithium-ion battery Lithium cobaltate Carbamazepine NaHSO_(3) Advanced oxidation

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尿液中大麻及合成大麻素MDMB-4en-PINACA、ADB-BUTINACA酶水解条件研究

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中国法医学杂志 2024年第1期39卷 44-49页

作者：张佳丽王鑫向平山西医科大学法医学院、法医学山西省重点实验室山西晋中030600 司法鉴定科学研究院、上海市法医学重点实验室、上海市司法鉴定专业技术服务平台、司法部司法鉴定重点实验室上海200063

目的合成大麻素类(synthetic cannabinoids,SCs)新精神活性物质进入人体后被广泛代谢,在尿液中通常很难检出合成大麻素原体,大多数以代谢物及代谢物葡糖醛酸结合形式存在,需在尿液前处理方法中断裂葡糖醛苷酸链,将葡萄糖醛酸结合物还原... 详细信息

目的合成大麻素类(synthetic cannabinoids,SCs)新精神活性物质进入人体后被广泛代谢,在尿液中通常很难检出合成大麻素原体,大多数以代谢物及代谢物葡糖醛酸结合形式存在,需在尿液前处理方法中断裂葡糖醛苷酸链,将葡萄糖醛酸结合物还原。本研究针对尿液中SCs的酶水解条件进行优化。方法采用液相色谱串联质谱(LC-MS/MS)分析方法,对阳性尿液中11-去甲基-9-羧基-THC(Δ^(9)-THC-COOH)的酶水解条件进行优化,并与碱消解方法进行比较;同时对MDMB-4en-PINACA、ADB-BUTINACA阳性尿液的酶水解条件进行了优化研究。结果在55℃条件下,添加3μL的β-d-葡萄糖醛苷酸酶溶液(>100000 units/mL)酶解30min可充分水解Δ^(9)-THC-COOH葡萄糖醛酸结合物,在75℃条件下,添加3μL的β-d-葡萄糖醛苷酸酶溶液(>100000units/mL)孵育30min可充分水解MDMB-4en-PINACAM和ADB-BUTINACAM葡萄糖醛酸结合物。结论该研究可为检测尿液中合成大麻素类新精神活性物质建立快速、准确、可靠的酶水解方法提供参考。

关键词：法医学毒物分析酶水解合成大麻素 MDMB-4en-PINACA ADB-BUTINACA Δ^(9)-THC-COOH

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直井多段大规模压裂工艺技术研究与应用

采油工程

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采油工程 2024年第1期 8-11,77-78页

作者：陈佳丽大庆油田有限责任公司采油工艺研究院

低渗透难采储层物性差,常规改造工艺难以实现效益开发,采用多分支缝压裂工艺虽见到良好的效果,但是大规模压裂时,压裂工具磨损严重,管柱卡、工具断等问题频繁出现并影响安全施工,且还存在压裂施工防喷功能不配套问题。通过数值模拟、工... 详细信息

低渗透难采储层物性差,常规改造工艺难以实现效益开发,采用多分支缝压裂工艺虽见到良好的效果,但是大规模压裂时,压裂工具磨损严重,管柱卡、工具断等问题频繁出现并影响安全施工,且还存在压裂施工防喷功能不配套问题。通过数值模拟、工具结构优化设计、材料优选等,研制了Y344封隔器/混动坐封解封YK封隔器、耐磨蚀导压喷砂器、压控防喷器等关键压裂工具。经室内实验与现场试验,直井多段大规模压裂工艺满足耐温150℃、承压80MPa、施工排量8m^(3)/min、加砂规模516m^(3)、单趟管柱8段压裂技术指标,并在现场应用155口井,为海拉尔、塔木察格油田等难采储层低效开发治理提供了技术支持。

关键词：直井多段大规模分段压裂压控防喷器

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氧化黄铁矿活化过二硫酸盐降解卡马西平

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环境科学学报 2024年第6期44卷 101-112页

作者：翟锦丽晏佳丽罗永明高晓亚昆明理工大学环境科学与工程学院昆明650500 昆明理工大学挥发性有机污染防治与资源化省创新团队昆明650500 云南省恶臭挥发性有机物控制重点实验室昆明650500

黄铁矿(FeS_(2))作为一种低成本、含量丰富的天然半导体材料,被广泛用于环境污染物的催化降解.然而,黄铁矿在自然环境中极易发生氧化(氧化黄铁矿),目前关于氧化黄铁矿催化降解有机污染物活性尚不清楚.因此,以氧化黄铁矿为催化剂,卡马西... 详细信息

黄铁矿(FeS_(2))作为一种低成本、含量丰富的天然半导体材料,被广泛用于环境污染物的催化降解.然而,黄铁矿在自然环境中极易发生氧化(氧化黄铁矿),目前关于氧化黄铁矿催化降解有机污染物活性尚不清楚.因此,以氧化黄铁矿为催化剂,卡马西平(CBZ)为目标污染物,过二硫酸盐(PDS)为氧化剂,进行氧化黄铁矿激活PDS降解CBZ的研究.实验结果表明,在氧化黄铁矿/PDS体系中,30 min内CBZ完全降解.此外,系统地探究了催化剂剂量、PDS浓度、不同pH和共存离子对CBZ降解效率的影响.通过测量溶液中浸出的铁离子和加入螯合剂证明氧化黄铁矿中溶解的Fe^(2+)和表面结合Fe^(2+)(≡Fe^(2+))均可激活PDS促进CBZ降解.淬灭实验表明氧化黄铁矿/PDS体系中产生的活性物种为SO_(4)·^(-)、HO·、O_(2)·^(-)和1O_(2),且SO_(4)·^(-)和1O_(2)在降解CBZ中起主导作用.通过循环实验与氧化黄铁矿表征相结合,证实氧化黄铁矿良好的可重复使用性.最后,阐明了黄铁矿/PDS体系中均相反应和非均相反应协同高效降解CBZ的机理.研究结果为利用天然黄铁矿去除水体新兴有机污染物提供了新的见解.

关键词：氧化黄铁矿卡马西平过二硫酸盐活性物种

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