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ILF3 safeguards telomeres from aberrant homologous recombination as a telomeric R-loop reader

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Protein & Cell 2024年第7期15卷 493-511页

作者： Chuanle Wang Yan huang Yue Yang Ruofei Li Yingying Li Hongxin Qiu jiali Wu Guang Shi Wenbin Ma Zhou Songyang MOE Key Laboratory of Gene Function and Regulation State Key Laboratory of Biocontrol and Guangzhou Key Laboratory of Healthy AgingSchool of LifesciencesSun Yat-sen UniversityGuangzhou 510275China Department of Oncology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510275China Department of Nephrology The First Affiliated HospitalSun Yat-sen UniversityGuangzhou 510080China

Telomeres are specialized structures at the ends of linear chromosomes that protect genome *** telomeric repeat-containing RNA(TERRA)that is transcribed from subtelomeric regions can invade into double-stranded DNA regions and form RNA:DNA hybrid-containing structure called *** tumor cells,R-loop formation is closely linked to gene expression and the alternative lengthening of telomeres(ALT)*** R-loops can cause stalled replication forks and telomere ***,how R-loops are recognized and regulated,particularly at telomeres,is not well *** discovered that ILF3 selectively associates with telomeric R-loops and safeguards telomeres from abnormal homologous *** out ILF3 results in excessive R-loops at telomeres and triggers telomeric DNA damage *** addition,ILF3 deficiency disrupts telomere homeostasis and causes abnormalities in the ALT *** the proximity-dependent biotin identification(BioID)technology,we mapped the ILF3 interactome and discovered that ILF3 could interact with several DNA/RNA helicases,including ***,ILF3 may aid in the resolution of telomeric R-loops through its interaction with *** findings suggest that ILF3 may function as a reader of telomeric R-loops,helping to prevent abnormal homologous recombination and maintain telomere homeostasis.

关键词： ILF3 RNA:DNA hybrids telomeric R-loops homologous recombination telomeric DNA damage responses

Causality Between Gut Microbiota and Inflammatory Bowel Disease:A Bidirectional Mendelian Randomization Study

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Infectious Microbes & Diseases 2024年第2期6卷 93-99页

作者： Qi Zheng Yuetong Li jiali Ni Yong huang Jiajun Wu Xiang Xu Guoping Sheng Lanjuan Li State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhouChina Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province Shulan(Hangzhou)Hospital Affiliated to Shulan International Medical CollegeZhejiang Shuren UniversityHangzhouChina Zhejiang Chinese Medical University HangzhouChina

The exact relationship between inflammatory bowel disease(IBD)and gut microbiota(GM)is still *** study aimed to explore the cause-and-effect relationship between IBD and GM by Mendelian randomization *** IBD data used in this study were obtained from Genome-Wide Association *** GM data were from the Dutch Microbiome Project and included 207 taxa and 205 microbiota-associated *** Mendelian randomization analysis was performed to investigate the relationship between GM and *** results demonstrated that susceptibility to developing IBD is negatively correlated with class Clostridia(OR=0.80,P=0.003),family Sutterellacea(OR=0.87,P=0.014),genus Coprobacter(OR=0.90,P=0.009),order Clostridiales(OR=0.80,P=0.003),phylum Firmicutes(OR=0.82,P=0.002)and Coprobacter fastidiosus(OR=0.90,P=0.009).Conversely,the risk of developing IBD was positively correlated with the phosphopantothenate biosynthesis I pathway(OR=1.17,P=0.006),Bacteroides caccae(OR=1.14,P=0.021)and Bacteroides uniformis(OR=1.26,P=0.003).Reverse causality was found between the phosphopantothenate biosynthesis I pathway and IBD(OR=1.03,P=0.04),but not for the remaining specific GM *** conclusion,our study demonstrated a causal relationship between specific GM features and IBD.

关键词： gut microbiota inflammatory bowel disease Mendelian randomization

KIF5B-mediated internalization of FMDV promotes virus infection

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Virologica Sinica 2024年第3期39卷 378-389页

作者： Wei Zhang Fan Yang Yang Yang Weijun Cao Wenhua Shao jiali Wang Mengyao huang Zhitong Chen Xiaoyi Zhao Weiwei Li Zixiang Zhu Haixue Zheng State Key Laboratory for Animal Disease Control and Prevention College of Veterinary MedicineLanzhou UniversityLanzhou Veterinary Research InstituteChinese Academy of Agricultural SciencesLanzhou 730000China Gansu Province Research Center for Basic Disciplines of Pathogen Biology Lanzhou 730046China

Foot-and-mouth disease(FMD)is a highly contagious and economically important disease,which is caused by the FMD virus(FMDV).Although the cell receptor for FMDV has been identified,the specific mechanism of FMDV internalization after infection remains *** this study,we found that kinesin family member 5B(KIF5B)plays a vital role during FMDV ***,we confirmed the interaction between KIF5B and FMDV structural protein VP1 by co-immunoprecipitation(Co-IP)and co-localization in FMDV-infected *** particular,the stalk[amino acids(aa)413–678]domain of KIF5B was indispensable for KIF5B-VP1 ***,overexpression of KIF5B dramatically enhanced FMDV replication;consistently,knockdown or knockout of KIF5B suppressed FMDV ***,we also demonstrated that KIF5B promotes the internalization of FMDV via regulating clathrin ***5B also promotes the transmission of viral particles to early and late endosomes during the early stages of *** conclusion,our results demonstrate that KIF5B promotes the internalization of FMDV via regulating clathrin uncoating and intracellular *** study may provide a new therapeutic target for developing FMDV antiviral drugs.

关键词： FMDV VP1 protein KIF5B Endosome Clathrin

“时间链接、资本孕育与情境转场”:美国高校教师实践性知识的TRS螺旋建构

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江苏高教 2022年第5期 110-117页

作者：肖立黄嘉莉湖北第二师范学院教育科学学院武汉430205 北京师范大学教师教育研究中心北京100088

文章以叙事故事所具有的“时间性(temporal)、关联性(relational)、情境性(situational)”(TRS)三维特征为理论分析框架,对五位任职于美国科罗拉多大学,且同期参加大学教师发展中心PBL教学策略工作坊的教师展开实践性知识的叙事研究。采... 详细信息

文章以叙事故事所具有的“时间性(temporal)、关联性(relational)、情境性(situational)”(TRS)三维特征为理论分析框架,对五位任职于美国科罗拉多大学,且同期参加大学教师发展中心PBL教学策略工作坊的教师展开实践性知识的叙事研究。采用Nvivo11对叙事故事、现场观察、半结构式访谈的多角数据进行编码分析,在呈现了教师螺旋建构实践性知识的全貌后发现,教师积累、运用、建设、分享实践性知识在“时间链接、资本孕育、情境转场”三向维度上显示出立体的“交互建构景观”。据此,最终生成了揭示教师实践性知识“历时沉淀、生产增值、传播联结”过程的TRS三维可持续发展模型。

关键词：教师实践性知识时间链接资本孕育情境转场 TRS

质性研究路径的方法一致性分析:以四类研究路径为例

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学位与研究生教育 2023年第9期 27-35页

作者：周钧黄嘉莉北京师范大学教师教育研究中心北京100875

质性研究范式下有多种研究路径,每一种研究路径在其研究目的、研究问题、样本选择、数据收集与数据分析等5个环节有具体的要求,各环节指向同一研究路径要求的一致性原则,是求其可靠描述和解释研究现象的本质和意义,追求高质量的必要原... 详细信息

质性研究范式下有多种研究路径,每一种研究路径在其研究目的、研究问题、样本选择、数据收集与数据分析等5个环节有具体的要求,各环节指向同一研究路径要求的一致性原则,是求其可靠描述和解释研究现象的本质和意义,追求高质量的必要原则。以民族志、扎根理论、个案研究以及解释现象学分析四类研究路径为例,选取8篇质性研究文章进行对比,系统分析不同研究路径的方法一致性和方法矛盾是如何体现的。研究发现,样本文章出现方法矛盾的原因是:混淆量化研究和质性研究的区别而采用质性研究方法去回答量化研究的问题,没有理解质性研究适宜回答什么样的研究问题,没有真正理解研究路径的方法要求,将三级编码误解为简单归纳的过程,以及回避描述步骤等问题。这些发现对研究生或新手研究者辨识研究目的与问题、选择适合研究途径进行高质量质性研究有重要的贡献。

关键词：质性研究研究路径方法一致性方法矛盾

从演化的角度评价北京市经济系统可持续发展趋势

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生态学报 2010年第24期30卷 7038-7044页

作者：黄茄莉徐中民中国科学院内陆河流域生态水文重点试验室甘肃兰州730000

评价系统可持续性是可持续相关学科讨论的热点问题。从演化的角度评价系统可持续发展趋势是可持续评价的新视角。以热力学、信息论和网络分析等为基础解析系统结构,发现系统演化的能力由两个因素组成:上升性和恢复力。上升性或恢复力过... 详细信息

评价系统可持续性是可持续相关学科讨论的热点问题。从演化的角度评价系统可持续发展趋势是可持续评价的新视角。以热力学、信息论和网络分析等为基础解析系统结构,发现系统演化的能力由两个因素组成:上升性和恢复力。上升性或恢复力过高的系统都不可持续,只有当上升性和恢复力达到一定的平衡状态,系统才能实现可持续发展。利用该演化模型,评价了北京市经济系统1985—2005年可持续发展趋势。结果表明:1985—1987,1993—2002年间系统向最优可持续点靠近;1988—1992,2003—2005年间系统远离最优可持续点。通过分析北京市2005年一阶路径对上升性的边际贡献,得出使系统更可持续的途径是强化对上升性边际贡献大的路径。

关键词：可持续发展系统演化上升性恢复力

Modulating p-type doping of two-dimensional material palladium diselenide

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Nano Research 2024年第4期17卷 3232-3244页

作者： jiali Yang Yu Liu En-Yang Wang Jinbo Pang Shirong huang Thomas Gemming Jinshun Bi Alicja Bachmatiuk Hao Jia Shu-Xian Hu Chongyun Jiang Hong Liu Gianaurelio Cuniberti Weijia Zhou Mark H Rümmeli Institute for Advanced Interdisciplinary Research(iAIR) University of JinanJinan 250022China Institute for Materials Chemistry Leibniz Institute for Solid State and Materials Research Dresden(IFW Dresden)20 Helmholtz StrasseDresden 01069Germany State Key Lab of Transducer Technology Shanghai Institute of Microsystem and Information TechnologyChinese Academy of SciencesShanghai 200050China College of Energy Soochow Institute for Energy and Materials Innovations Soochow UniversitySuzhou 215006China Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu Province Soochow UniversitySuzhou 215006China School of Integrated Circuits University of Chinese Academy of SciencesBeijing 101408China Institute of Microelectronics of Tianjin Binhai New Area Tianjin 300451China Institute of Microelectronics Chinese Academy of SciencesBeijing 100029China Lukasiewicz Research Network PORT Polish Center for Technology DevelopmentStablowicka 147Wroclaw 54-066Poland School of Mathematics and Physics University of Science and Technology BeijingBeijing 100083China College of electronic information and optical engineering Nankai UniversityTianjin 300350China Centre of Polymer and Carbon Materials Polish Academy of SciencesM.Curie Sklodowskiej 34Zabrze 41-819Poland Center for Energy and Environmental Technologies VŠB-Technical University of Ostrava17.Listopadu 15Ostrava 70833Czech Republic State Key Laboratory of Crystal Materials Center of Bio&Micro/Nano Functional MaterialsShandong UniversityJinan 250100China Dresden Center for Computational Materials Science Technische Universität DresdenDresden 01062Germany Dresden Center for Intelligent Materials(GCL DCIM) Technische Universität DresdenDresden 01062Germany Institute for Materials Science and Max Bergmann Center of Biomaterials Technische Universität DresdenDresden 01069Germany Center for Advancing Electronics Dresden Technische Universität DresdenDresden 01069Germany

The van der Waals heterostructures have evolved as novel materials for complementing the Si-based semiconductor ***-10 noble metal dichalcogenides(e.g.,PtS_(2),PtSe_(2),PdS_(2),and PdSe_(2))have been listed into two-dimensional(2D)materials toolkit to assemble van der Waals *** them,PdSe_(2) demonstrates advantages of high stability in air,high mobility,and wide tunable ***,the regulation of p-type doping of PdSe_(2) remains unsolved problem prior to fabricating p–n junction as a fundamental platform of semiconductor ***,a quantitative method for the controllable doping of PdSe_(2) is yet to be *** this study,the doping level of PdSe_(2) was correlated with the concentration of Lewis acids,for example,SnCl_(4),used for *** the transfer characteristics,the threshold voltage(the gate voltage corresponding to the minimum drain current)increased after SnCl_(4) soaking ***_(2) transistors were soaked in SnCl_(4) solutions with five different *** threshold voltages from the as-obtained transfer curves were extracted for linear fitting to the threshold voltage versus doping concentration correlation *** study provides in-depth insights into the controllable p-type doping of PdSe_(2).It may also push forward the research of the regulation of conductivity behaviors of 2D materials.

关键词： two-dimensional(2D)materials Lewis acid treatment p-type doping field-effect transistors transfer characteristic

赋能教育对乳腺癌患者负性情绪和生活质量影响的meta分析

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中国医药科学 2024年第6期14卷 96-100页

作者：陈雨刘群慧黄珊邓雨欣刘玉婷黄家丽安徽中医药大学护理学院安徽合肥230012 中国科学技术大学附属第一医院(安徽省立医院)西区护理部安徽合肥230031 安徽三联学院护理学院安徽合肥230601

目的应用meta分析系统评价赋能教育对乳腺癌患者负性情绪和生活质量的干预效果。方法运用计算机检索Web of Science、Embase、CINAHL和PubMed、CBM、中国知网、维普和万方数据库从建库至2023年4月30日有关赋能教育对乳腺癌患者的所有可... 详细信息

目的应用meta分析系统评价赋能教育对乳腺癌患者负性情绪和生活质量的干预效果。方法运用计算机检索Web of Science、Embase、CINAHL和PubMed、CBM、中国知网、维普和万方数据库从建库至2023年4月30日有关赋能教育对乳腺癌患者的所有可获得的随机对照试验(RCT),并采用RevMan 5.4软件进行meta分析。结果共纳入10个RCT,合计1437例患者。研究组乳腺癌术后患者生活质量评分[SMD=1.17,95CI(1.02,1.33),P<0.00001],负性情绪评分[MD=-11.36,95CI(-13.73,-8.98),P<0.00001]均高于对照组。结论赋能教育能够改善乳腺癌患者生活质量,减轻负性情绪,但仍需更高质量研究进行验证。

关键词：赋能教育乳腺癌生活质量焦虑抑郁 meta分析

新管理主义思想下英格兰教师教育质量保障体系研究

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外国教育研究 2022年第7期49卷 87-100页

作者：刘梦婷黄嘉莉西安交通大学钱学森学(书)院陕西西安710049 北京师范大学教师教育研究所北京100875

自20世纪80年代起,新管理主义市场多元竞争与质量保障的理念极大程度上影响着全球教师教育改革,其中英格兰的教师教育政策较具代表性。英格兰教师教育政策改革引入设立目标、引入准市场、远程控制、绩效问责、质量评估等新管理主义理念... 详细信息

自20世纪80年代起,新管理主义市场多元竞争与质量保障的理念极大程度上影响着全球教师教育改革,其中英格兰的教师教育政策较具代表性。英格兰教师教育政策改革引入设立目标、引入准市场、远程控制、绩效问责、质量评估等新管理主义理念,构建了教师教育质量保障体系。在新管理主义思想的指导下,英格兰政府推动教师教育市场多元化,颁布教师培养标准和教师标准,设置远程督导机构,对认证后的教师教育机构进行督查,对师范生进行合格教师资格的把关,形成系统的管控体系。总地来说,将新管理主义用于保障教师教育质量,虽有其良意,但要警惕远程控制和集权管理的矛盾对市场造成的问题,应避免教师培养一致化和平熏化;也要警惕市场引入造成的教师培养以及教师专业性价值的问题,维护教师培养的专业性。

关键词：英格兰职前教师教育教师教育质量保障体系新管理主义