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NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao Lin Changzhou Ying Xiaoli Si Naijia Xue Yi Liu Ran Zheng Ying Chen jiali Pu Baorong Zhang Department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2.3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2.expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2.3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease

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低危分化型甲状腺癌流行现状及诊疗规范的再思考

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中华医学杂志 2024年第30期104卷 2791-2796页

作者：秦嘉黎刘善廷洛阳市中心医院郑州大学附属洛阳中心医院甲乳外科洛阳河南省肿瘤医院郑州大学附属肿瘤医院头颈甲状腺外科郑州

甲状腺癌是一种起源于甲状腺上皮或滤泡旁上皮细胞的恶性肿瘤, 也是头颈部最常见的恶性肿瘤。目前甲状腺癌的发病率居所有常见恶性肿瘤的第九位, 已成为十大常见恶性肿瘤之一。近年来, 随着各类指南的发布, 全球甲状腺癌的诊疗逐渐规范... 详细信息

甲状腺癌是一种起源于甲状腺上皮或滤泡旁上皮细胞的恶性肿瘤, 也是头颈部最常见的恶性肿瘤。目前甲状腺癌的发病率居所有常见恶性肿瘤的第九位, 已成为十大常见恶性肿瘤之一。近年来, 随着各类指南的发布, 全球甲状腺癌的诊疗逐渐规范化, 我国也开始推行甲状腺肿瘤诊疗质量控制, 规范诊疗行为, 促进全国范围内甲状腺肿瘤诊疗规范化、标准化, 以期最终提升甲状腺癌患者的生存率和生活质量。本文以当前国内外甲状腺癌诊疗变化为背景, 对甲状腺癌的流行现状、诊疗现状、规范化诊治新理念、新进展等方面进行论述。

关键词：甲状腺肿瘤诊断治疗动态监测

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“双一流”高校图书馆纸质资源政府采购合同的现状、问题与优化--基于中国政府采购网合同公告信息的分析

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大学图书馆学报 2024年第1期42卷 56-64,106页

作者：向佳丽厦门大学图书馆福建厦门361005

从中国政府采购网“政府采购合同公告系统”收集整理“双一流”高校图书馆纸质资源政府采购合同公告479份、合同原始文本402.。通过统计和文本分析,展示“双一流”高校图书馆纸质资源政府采购合同的整体情况和核心条款,梳理“双一流”... 详细信息

从中国政府采购网“政府采购合同公告系统”收集整理“双一流”高校图书馆纸质资源政府采购合同公告479份、合同原始文本402.。通过统计和文本分析,展示“双一流”高校图书馆纸质资源政府采购合同的整体情况和核心条款,梳理“双一流”高校图书馆纸质资源政府采购合同存在的问题,并结合最新法律法规及业务实践,从规范合同信息的签订和公告流程、避免盲目套用合同示范文本、加强合同金额/价款条款的合规性审查、细化产品质量服务标准及违约责任条款、明确约定结算与支付条款、将履约验收要求纳入合同条款并加以细化等方面提出优化建议,以期为我国高校图书馆纸质资源政府采购合同的规范管理提供有益参考。

关键词：高校图书馆纸质资源政府采购合同现状分析问题优化

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低纹波空间可调高压电源设计

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北京大学学报（自然科学版） 2024年第2期60卷 195-202页

作者：陈佳黎邹鸿叶雨光北京大学空间物理与应用技术研究所北京100871

为了满足空间探测载荷(如质谱仪和能量粒子探测器等)对高压电源输出纹波的要求,设计一款小功率、低纹波、最大输出电压为10 kV的可调高压直流电源。设计中使用罗耶架构的逆变器和倍压整流电路,利用反馈回路,使纹波电压峰峰值小于2.V;使... 详细信息

为了满足空间探测载荷(如质谱仪和能量粒子探测器等)对高压电源输出纹波的要求,设计一款小功率、低纹波、最大输出电压为10 kV的可调高压直流电源。设计中使用罗耶架构的逆变器和倍压整流电路,利用反馈回路,使纹波电压峰峰值小于2.V;使用51系列单片机控制电源输出电压,监测电源的工作状态。除在原理设计方面降低输出电压纹波外,还提出其他降低输出电压纹波的措施。测试结果表明,所设计的高压电源具有输出电压稳定可调、纹波低的特点,可以满足空间探测载荷对高压电源的基本性能要求。

关键词：高压电源倍压整流低纹波可变输出单片机

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High formability Mg-Zn-Gd wire facilitates ACL reconstruction via its swift degradation to accelerate intra-tunnel endochondral ossification

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Journal of Magnesium and Alloys 2024年第1期12卷 295-315页

作者： Xuan He Ye Li Hongwei Miao Jiankun Xu Michael Tim-yun Ong Chenmin Wang Lizhen Zheng jiali Wang Le Huang Haiyue Zu Zhi Yao Jie Mi Bingyang Dai Xu Li Patrick Shu-hang Yung Guangyin Yuan Ling Qin Musculoskeletal Research Laboratory of Department of Orthopaedics&Traumatology and Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory of Li Ka Shing Institute of Health Sciences The Chinese University of Hong KongHong KongChina National Engineering Research Center of Light Alloy Net Forming School of Materials Science&EngineeringShanghai Jiao Tong UniversityShanghaiChina Department of Orthopaedics and Traumatology Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Orthopaedic Department Peking University Third HospitalBeijingChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong KongChina

After reconstructing the anterior cruciate ligament(ACL),unsatisfactory bone tendon interface healing may often induce tunnel enlargement at the early healing *** good biological features and high formability,Magnesium-Zinc-Gadolinium(ZG2.)wires are developed to bunch the tendon graft for matching the bone tunnel during ***,tensile strength,degradation,and cytotoxicity of ZG2. wire are *** rabbit model is used for assessing the biological effects of ZG2. wire by Micro-CT,histology,and mechanical *** SEM/EDS,immunochemistry,and in vitro assessments are performed to investigate the underlying *** tests demonstrate the high formability of ZG2. wire as surgical ***-CT shows ZG2. wire degradation accelerates tunnel bone formation,and histologically with earlier and more fibrocartilage regeneration at the healing *** mechanical test shows higher ultimate load in the ZG2. *** SEM/EDS presents ZG2. wire degradation triggered calcium phosphate(Ca-P)*** results demonstrate upregulation of Wnt3a,BMP2.and VEGF at the early phase and TGFβ3 and Type II collagen at the late phase of *** vitro tests also confirmed the Ca-P in the metal extract could elevate the expression of Wnt3a,βcatenin,ocn and opn to stimulate *** vivo tests of clinical samples indicated suturing with ZG2. wire did not weaken the ultimate loading of human tendon *** conclusion,the ZG2. wire is feasible for tendon graft *** degradation products accelerated intra-tunnel endochondral ossification at the early healing stage and therefore enhanced bone-tendon interface healing in ACL reconstruction.

关键词： Magnesium wire ACL reconstruction Magnesium alloy Biomaterials Endochondral ossification

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基于Bert-TextCNN的开源威胁情报文本的多标签分类方法

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信息安全研究 2024年第8期10卷 760-768页

作者：陆佳丽北京天融信网络安全技术有限公司北京100193

开源威胁情报对网络安全防护十分重要,但其存在着分布广、形式多、噪声大的特点.所以如何能对收集到的海量开源威胁情报进行高效的整理和分析就成为亟需解决的问题.因此,探索了一种以Bert-TextCNN模型为基础且同时考虑标题、正文和正则... 详细信息

开源威胁情报对网络安全防护十分重要,但其存在着分布广、形式多、噪声大的特点.所以如何能对收集到的海量开源威胁情报进行高效的整理和分析就成为亟需解决的问题.因此,探索了一种以Bert-TextCNN模型为基础且同时考虑标题、正文和正则判断的多标签分类方法.根据情报源发布文本的特点,设置正则判断规则,以弥补模型的欠缺;为更全面反映开源威胁情报文本所涉及的威胁主题,针对标题和正文分别设置了Bert-TextCNN多标签分类模型,并将2.分标签整理去重以得到文本的最终威胁类别.通过与只依据正文建立的Bert-TextCNN多标签分类模型进行对比,所设置的模型在性能上有所提升,且召回率提升明显,能为开源威胁情报分类工作提供有价值的参考.

关键词：开源威胁情报多标签分类文本分类 Bert模型 TextCNN模型

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Utilizing engineered extracellular vesicles as delivery vectors in the management of ischemic stroke:a special outlook on mitochondrial delivery

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Neural Regeneration Research 2025年第8期20卷 2181-2198页

作者： jiali Chen Yiyang Li Xingping Quan Jinfen Chen Yan Han Li Yang Manfei Zhou Greta Seng Peng Mok Ruibing Wang Yonghua Zhao Institute of Chinese Medical Sciences State Key Laboratory of Quality Research in Chinese MedicineUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmacy Hunan Provincial People’s Hospitalthe First Affiliated Hospital of Hunan Normal UniversityChangshaHunan ProvinceChina Department of Electrical and Computer Engineering University of MacaoTaipaMacao Special Administrative RegionChina Department of Pharmaceutical Sciences Faculty of Health SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina

Ischemic stroke is a secondary cause of mortality worldwide,imposing considerable medical and economic burdens on *** vesicles,serving as natural nanocarriers for drug delivery,exhibit excellent biocompatibility in vivo and have significant advantages in the management of ischemic ***,the uncertain distribution and rapid clearance of extracellular vesicles impede their delivery *** utilizing membrane decoration or by encapsulating therapeutic cargo within extracellular vesicles,their delivery efficacy may be greatly ***,previous studies have indicated that microvesicles,a subset of large-sized extracellular vesicles,can transport mitochondria to neighboring cells,thereby aiding in the restoration of mitochondrial function post-ischemic *** extracellular vesicles have also demonstrated the capability to transfer mitochondrial components,such as proteins or deoxyribonucleic acid,or their sub-components,for extracellular vesicle-based ischemic stroke *** this review,we undertake a comparative analysis of the isolation techniques employed for extracellular vesicles and present an overview of the current dominant extracellular vesicle modification *** the complex facets of treating ischemic stroke,we also delineate various extracellular vesicle modification approaches which are suited to different facets of the treatment ***,given the burgeoning interest in mitochondrial delivery,we delved into the feasibility and existing research findings on the transportation of mitochondrial fractions or intact mitochondria through small extracellular vesicles and microvesicles to offer a fresh perspective on ischemic stroke therapy.

关键词： delivery engineering extracellular vesicles identification ischemic stroke isolation mitochondria targeting strategy therapeutic effects

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Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang Nan Zheng Qingming Lin Yan You Zheng Gong Yangping Zhuang jiali Wu Yu Wang Hanlin Huang Jun Ke Feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

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Measurement Research Based on Bayesian Structural Equation Cognitive Model

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Journal of Applied Mathematics and Physics 2024年第4期12卷 1163-1177页

作者： Shuixian Fei Sanzhi Shi Jixin Li jiali Zheng Xinyi Yu Yifan Huang Xiang Li School of Mathematics and Statistics Changchun University of Science and Technology Changchun China

The Bayesian structural equation model integrates the principles of Bayesian statistics, providing a more flexible and comprehensive modeling framework. In exploring complex relationships between variables, handling uncertainty, and dealing with missing data, the Bayesian structural equation model demonstrates unique advantages. Therefore, Bayesian methods are used in this paper to establish a structural equation model of innovative talent cognition, with the measurement of college students’ cognition of innovative talent being studied. An in-depth analysis is conducted on the effects of innovative self-efficacy, social resources, innovative personality traits, and school education, aiming to explore the factors influencing college students’ innovative talent. The results indicate that innovative self-efficacy plays a key role in perception, social resources are significantly positively correlated with the perception of innovative talents, innovative personality tendencies and school education are positively correlated with the perception of innovative talents, but the impact is not significant.

关键词： Bayesian Structural Equation Model Innovative Talents Measure of Cognition Innovative Self-Efficacy Social Resources

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Muon energy reconstruction in the high-energy neutrino observations

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Astronomical Techniques and Instruments 2024年第3期1卷 197-202页

作者： Ying Qi jiali Liu Maoyuan Liu Mingjun Chen Zike Wang Tianqi Huang Peiyuan Chu College of Science Tibet UniversityLhasa 850000China Key Laboratory of Cosmic Rays Ministry of EducationTibet UniversityLhasa 850000China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Tianfu Cosmic Ray Research Center Chengdu 610000China University of Chinese Academy of Sciences Beijing 100049China

The reconstruction of muon energies is crucial for the data analysis of neutrino experiments using large water Cherenkov detectors,but the resolution for muon energy reconstruction using traditional methods is ***,we propose a revised approach to remove noisy optical modules along the track produced by the propagation of muons through *** number of photons on the optical modules is first corrected by the attenuation properties of light in *** the difference in time between the observed optical modules and the expected ones is determined based on the geometry of the triggered optical ***,the standard of correction is measured by the ratio of photon number before and after *** modules selection conditions were optimized according to these parameters,with most noisy optical modules successfully removed,improving the resolution of muon energy reconstruction.

关键词： dE/dx detectors Neutrino detectors Data processing

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