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碾焉煤矿8号煤层瓦斯抽采系统优化

山东煤炭科技 2024年第7期42卷 77-82页

作者：孙佳磊中煤科工集团沈阳研究院有限公司辽宁抚顺113122 煤矿灾害防控全国重点实验室辽宁抚顺113122 煤矿火灾及瓦斯防控国家矿山安全监察局重点实验室辽宁抚顺113122

为了降低矿井巷道掘进工作量,提高资源的回收率,碾焉煤矿8号煤层采用了沿空留巷的采煤技术方法,相较于传统采煤工艺其瓦斯运移规律有所不同。为了解决新的采煤方法所带来的瓦斯灾害问题,针对邻近层瓦斯涌出量较大的问题,通过对回采工作... 详细信息

为了降低矿井巷道掘进工作量,提高资源的回收率,碾焉煤矿8号煤层采用了沿空留巷的采煤技术方法,相较于传统采煤工艺其瓦斯运移规律有所不同。为了解决新的采煤方法所带来的瓦斯灾害问题,针对邻近层瓦斯涌出量较大的问题,通过对回采工作面采出后上覆岩层“三带”分布特征分析,提出利用高位钻孔抽采邻近层瓦斯,通过现场试验确定了抽采钻孔施工的相关参数,同时优化了新、老采空区瓦斯抽采方法及技术参数。通过现场试验8103工作面邻近层瓦斯采用高位钻孔抽采后抽采量为12.39 m^(3)/min,采用现采空区插管法抽采后现采空区抽采量为15.77 m^(3)/min,回采工作面瓦斯抽采率为57.15%。抽采优化研究提高了碾焉煤矿8号煤层瓦斯抽采效率,抽采效果及抽采浓度均达到预期效果。

关键词：瓦斯抽采邻近层高位钻孔采空区插管抽采

益生菌的表面成分影响其胃肠道黏附定殖的研究进展

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食品研究与开发 2024年第16期45卷 213-219页

作者：林夫欣王宇孙嘉蕾吕依蔓韩雪哈尔滨工业大学黑龙江哈尔滨150000

益生菌能够黏附定殖在人体肠道细胞上是充分发挥其益生作用的重要前提。益生菌的表面成分作为黏附因子与黏附位点间的相互作用是影响益生菌黏附定殖的关键环节。在黏附位点上与黏附因子相互作用的受体,除了黏液层中的某些物质,还有肠道... 详细信息

益生菌能够黏附定殖在人体肠道细胞上是充分发挥其益生作用的重要前提。益生菌的表面成分作为黏附因子与黏附位点间的相互作用是影响益生菌黏附定殖的关键环节。在黏附位点上与黏附因子相互作用的受体,除了黏液层中的某些物质,还有肠道细胞上分泌的胞外物质。益生菌表面蛋白类和非蛋白类的黏附因子具有黏附特异性,通过调控黏附因子的表达可以促进益生菌的肠道黏附定殖。该文对近年来关于肠道黏附位点的研究情况进行综述,对生物膜形成过程中部分黏附因子的表达与黏附关系进行分析,为黏附因子更好地在人体内发挥益生价值提供参考,为探究生物膜的形成对黏附的影响奠定理论基础。

关键词：益生菌肠道黏附位点黏附因子表面成分

Temporal variability of global potential water erosion based on an improved USLE model

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International Soil and Water Conservation Research 2024年第1期12卷 1-12页

作者： jialei Li Muqi Xiong Ranhao sun Liding Chen State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing100085China University of Chinese Academy of Sciences Beijing100049China Key Laboratory of Water Cycle and Related Land Surface Processes Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing100101China

Assessing spatiotemporal variation in global soil erosion is essential for identifying areas that require greater attention and management under the effects of anthropogenic activities and climate *** erosion can be modelled using the universal soil loss equation(USLE),which includes rainfall erosivity(R-factor),vegetation cover(C-factor),topography(LS-factor),soil erodibility(K-factor),and management practices(P-factor).However,global soil erosion modeling faces numerous challenges,including data acquisition,calculation processes,and parameter calibration under different climatic and topographic ***,we presented an improved USLE-based model using highly distributed *** R-,C-,and P-factors were modified by the climate zone,country,and *** distributed model was applied to estimate the intensity and variations in global soil erosion from 1992 to *** validated the accuracy of this model by comparing simulations with measurements from 11,439 plot years of erosion *** results showed that i)the average global erosion rate was 5.78 t ha^(-1)year^(-1),with an increase rate of 4.26×10^(-3)t ha^(-1)year^(-1);ii)areas with significantly increasing erosion accounted for 16%of the land with water erosion,whereas those with significantly decreasing erosion accounted for 7%;and iii)areas with severe erosion included the western Ghats,Abyssinian Plateau,Brazilian Plateau,south and east of the Himalayas,and western coast of South *** erosion occurred mainly on the Amazon Plain and the northern coast of the *** study provides an improved water erosion prediction model and accurate information for researchers and policymakers to identify the drivers underlying changes in water erosion in different regions.

关键词： Soil erosion Distributed USLE model Rainfall erosivity Soil conservation Global change

Global Quantitative Mapping of Enhancers in Rice by STARR-seq

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Genomics, Proteomics & Bioinformatics 2019年第2期17卷 140-153页

作者： jialei sun Na He Longjian Niu Yingzhang Huang Wei Shen Yuedong Zhang Li Li Chunhui Hou Department of Biology Southern University of Science and Technology Shenzhen 518055 China Department of Bioinformatics Huazhong Agricultural University Wuhan 430070 China Hubei Key Laboratory of Agricultural Bioinformatics Huazhong Agricultural University Wuhan 430070 China Department of Biology Nankai University Tianjin 300071 China

Enhancers activate transcription in a distance-,orientation-,and position-independent manner,which makes them difficult to be identified. Self-transcribing active regulatory region sequencing (STARR-seq) measures the enhancer activity of millions of DNA fragments in parallel. Here we used STARR-seq to generate a quantitative global map of rice enhancers. Most enhancers were mapped within genes,especially at the 5' untranslated regions (5'UTR) and in coding sequences. Enhancers were also frequently mapped proximal to silent and lowly-expressed genes in transposable element (TE)-rich regions. Analysis of the epigenetic features of enhancers at their endogenous loci revealed that most enhancers do not co-localize with DNase I hypersensitive sites (DHSs) and lack the enhancer mark of histone modification H3K4me1. Clustering analysis of enhancers according to their epigenetic marks revealed that about 40%of identified enhancers car-ried one or more epigenetic marks. Repressive H3K27me3 was frequently enriched with positive marks,H3K4me3 and/or H3K27ac,which together label enhancers. Intergenic enhancers were also predicted based on the location of DHS regions relative to genes,which overlap poorly with STARR-seq enhancers. In summary,we quantitatively identified enhancers by functional analysis in the genome of rice,an important model plant. This work provides a valuable resource for further mechanistic studies in different biological contexts.

关键词： Plant Enhancer Functional analysis Epigenetic modification Gene expression

响应面法优化复合益生菌固态发酵玉米-豆粕型日粮工艺

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饲料工业 2024年第13期45卷 105-111页

作者：李月钱周泽袁宇婷庾浩洋孙佳磊陈国信刘洁郭云霞河北农业大学生命科学学院河北保定071000 青县农业农村局河北沧州061000 石家庄市农林科学研究院河北石家庄050048

研究旨在对复合益生菌发酵玉米-豆粕型日粮产生酸溶蛋白的工艺进行优化,为复合益生菌发酵饲料的应用提供参考。在单因素试验的基础上以酸溶蛋白含量为响应值,以接种量、料水比、发酵时间、发酵温度为自变量,通过Box-Behnken设计试验,优... 详细信息

研究旨在对复合益生菌发酵玉米-豆粕型日粮产生酸溶蛋白的工艺进行优化,为复合益生菌发酵饲料的应用提供参考。在单因素试验的基础上以酸溶蛋白含量为响应值,以接种量、料水比、发酵时间、发酵温度为自变量,通过Box-Behnken设计试验,优化复合益生菌发酵玉米-豆粕型日粮的发酵工艺。结果表明:乳酸杆菌RSG-1∶枯草芽孢杆菌B-1∶地衣芽孢杆菌Y5-39为1∶1∶4时,酸溶蛋白含量最高为5.30%;响应面优化后复合益生菌最佳发酵工艺为:含水量48%,接种量10%,发酵温度48℃,发酵时间10 d,酸溶蛋白含量为13.31%,在考虑生产实际的情况下,将发酵温度调整为37℃。综上,研究确定了多菌种组合固态发酵玉米-豆粕型日粮的最佳工艺条件:含水量为48%、接种量(乳酸杆菌∶枯草芽孢杆菌∶地衣芽孢杆菌=1∶1∶4)10%、发酵温度37℃、发酵时间10 d,酸溶蛋白含量达到13.06%。

关键词：响应面法复合益生菌玉米-豆粕型日粮发酵工艺酸溶蛋白

A Novel mRNA Signature Related to Immunity to Predict Survival and Immunotherapy Response in Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2022年第5期10卷 925-938页

作者： Chenhao Zhou jialei Weng Yuan Gao Chunxiao Liu Xiaoqiang Zhu Qiang Zhou Chia-Wei Li jialei sun Manar Atyah Yong Yi Qinghai Ye Yi Shi Qiongzhu Dong Yingbin Liu Mien-Chie Hung Ning Ren Department of Liver Surgery Liver Cancer InstituteZhongshan Hospitaland Key Laboratory of Carcinogenesis and Cancer Invasion(Ministry of Education)Fudan UniversityShanghaiChina Department of Molecular and Cellular Oncology The University of Texas MD Anderson Cancer CenterHoustonTXUSA Department of Biliary-Pancreatic Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongPok Fu LamHong Kong SARChina Biomedical Research Center Zhongshan HospitalFudan UniversityShanghaiChina Institute of Fudan Minhang Academic Health System and Key Laboratory of Whole-period Monitoring and Precise Intervention of Digestive Cancer(SMHC)Minhang Hospital&AHSFudan UniversityShanghaiChina Institutes of Biomedical Sciences Fudan UniversityShanghaiChina Graduate Institute of Biomedical Sciences and Center for Molecular Medicine China Medical UniversityTaichung

Background and Aims:Hepatocellular carcinoma(HCC)is the most common primary liver cancer and the incidence and mortality rates are *** the limited treatments of HCC and promising application of immunotherapy for cancer,we aimed to identify an immune-related prognostic signature that can predict overall survival(OS)rates and immunotherapy response in ***:The initial signature development was conducted using a training dataset from the Cancer Genome Atlas followed by independent internal and external validations from that resource and the Gene Expression Omnibus.A signature based nomogram was generated using multivariate Cox regression *** associations of signature score with tumor immune phenotype and response to immunotherapy were analyzed using single-sample gene set enrichment analysis and tumor immune dysfunction and exclusion algorithm.A cohort from Zhongshan Hospital was employed to verify the pre dictive robustness of the signature regarding prognostic risk and immunotherapy ***:The prognostic signature,IGS_(HCC),consisting of 22 immune-related genes,had independent prognostic ability,with training and validation ***,IGS_(HCC)stratified HCC patients with different outcomes in *** prognostic accuracy of IGS_(HCC)was better than three reported prognostic *** IGS_(HCC)-based nomogram had high accuracy and significant clinical benefits in predicting 3-and 5-year ***_(HCC)reflected distinct immunosuppressive phenotypes in low-and high-score *** with low IGS_(HCC)scores were more likely than those with high scores to benefit from ***:IGS_(HCC)predicted HCC prognosis and response to immunotherapy,and contributed to individualized clinical management.

关键词： Hepatocellular carcinoma Gene signature Immune microenvironment Prognosis Immunotherapy

Wild soybean(Glycine soja)transcription factor GsWRKY40 plays positive roles in plant salt tolerance

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The Crop Journal 2024年第3期12卷 766-775页

作者： Minglong Li Man Xue Huiying Ma Peng Feng Tong Chen Xiaohuan sun Qiang Li Xiaodong Ding Shuzhen Zhang jialei Xiao Key Laboratory of Agricultural Biological Functional Genes Northeast Agricultural UniversityHarbin 150030HeilongjiangChina Key Laboratory of Soybean Biology of Chinese Education Ministry Northeast Agricultural UniversityHarbin 150030HeilongjiangChina Department of Plant Science School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China College of Life Science Leshan Normal UniversityLeshan 614000SichuanChina Mudanjiang Branch of Heilongjiang Academy of Agricultural Sciences Mudanjiang 157401HeilongjiangChina

Wild soybean(Glycine soja),a relative of cultivated soybean,shows high adaptability to adverse environmental *** identified and characterized a wild soybean transcription factor gene,GsWRKY40,that promotes plant salt ***40 was highly expressed in wild soybean roots and was up-regulated by salt ***40 was localized in nucleus and demonstrated DNA-binding activities but without transcriptional *** and overexpression of GsWRKY40 altered salt tolerance of Arabidopsis *** understand the molecular mechanism of GsWRKY40 in regulating plant salt resistance,we screened a cDNA library and identified a GsWRKY40 interacting protein GsbHLH92 by using yeast two-hybrid *** physical interaction of GsWRKY40 and GsbHLH92 was confirmed by co-immunoprecipitation(co-IP),GST pull-down,and bimolecular fluorescence complementation(BiFC)***,co-overexpression of GsWRKY40 and GsbHLH92 resulted in higher salt tolerance and lower ROS levels than overexpression of GsWRKY40 or GsbHLH92 in composite soybean plants,suggesting that GsWRKY40 and GsbHLH92 may synergistically regulate plant salt resistance through inhibiting ROS ***-PCR data indicated that the expression level of GmSPOD1 gene encoding peroxidase was cooperatively regulated by GsWRKY40 and GsbHLH92,which was confirmed by using a dual luciferase report system and yeast one-hybrid *** study reveals a pathway that GsWRKY40 and GsbHLH92 collaboratively up-regulate plant salt resistance through impeding GmSPOD1 expression and reducing ROS levels,providing a novel perspective on the regulatory mechanisms underlying plant tolerance to abiotic stresses.

关键词： Wild soybean Transcription factor Salt stress ROS

Facile Surface Engineering of NiCo_(2)O_(4) to Boost Propane Oxidation Activity

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China Petroleum Processing & Petrochemical Technology 2024年第1期26卷 19-26页

作者： Yang jialei Wang Fengyi Lei Yang Zhang Mingchao sun Shiqiang Xu Wenfan Ke Jiaxiang Wu Haojie Li Xingyun Qi Jian Institute of Materials for Energy and Environment College of Materials Science and EngineeringQingdao UniversityQingdao 266071China School of Chemistry and Chemical Engineering Hubei Key Laboratory of Coal Conversion and New Carbon MaterialsWuhan University of Science and TechnologyWuhan 430081China Department of Burn and Plastic Surgery Qingdao Municipal Hospital Affiliated to Rehabilitation UniversityQingdao 266000China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China

Spinel oxide(NiCo_(2)O_(4))has demonstrated great potential to replace noble metal catalysts for the oxidation reaction of air *** further boost the oxidation ability of such catalysts,in this study,a facile surface-engineering strategy wherein NiCo_(2)O_(4) was treated with different alkali solvents was *** obtained catalyst(NiCo_(2)O_(4)-OH)showed a higher surface alkalinity and more surface defects compared to the pristine spinel oxide,including enhanced structural distortion as well as promoted oxygen *** propane oxidation ability of NiCo_(2)O_(4)-OH was greatly enhanced,with a propane conversion rate that was approximately 6.4 times higher than that of pristine NiCo_(2)O_(4) at a reaction temperature 193℃.This work sets a valuable paradigm for the surface modulation of spinel oxide via alkali treatment to ensure a high-performance oxidation catalyst.

关键词： NiCo_(2)O_(4) surface defects alkali treatment propane oxidation

Germylene-Fe complexes caused by heterometallic coupling and investigation into the 3d-4p bonding

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Chinese Chemical Letters 2024年第3期35卷 304-307页

作者： Yingying Qin Yongmei Kang Lei Zhang Jianping sun Zhijing Zhang jialei Xu Fanlong Zeng Anyang Li Wenyuan Wang Weiqun Shi Key Laboratory of Synthetic and Natural Functional Molecule of Ministry of Education College of Chemistry and Materials ScienceNorthwest UniversityXi'an 710127China Laboratory of Nuclear Energy Chemistry Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Shaanxi Coal and Chemical Industry Xi'an 710054China

The interpretation of heterometallic bonding nature is a basic work of inorganic *** means of intermetallic substitution of germylene anions with iron halide complexes CpFe(CO)_(2)I andβ-diketiminato Fe^Ⅱchloride,the ferrogermylene complexes 3a,3b and 4a were synthesized and structurally *** structural and IR characterizations show the presence of the Ge←Feπbackbonding in molecules 3a,3b and *** computational works on frontier molecular orbitals and their comparison of energy states confirmed thatσdonation andπbackbonding are both weak in these molecules,despite three complexes have longer Ge-Fe bonds,whose strength decreases slightly with the degressive electron density around Fe environment in a sequence from 3a,3b to 4a.

关键词： Metallic bonding Germylene Iron Crystal structure σbond πbackbond