检索结果-南通市图书馆

Journal of Polyphenols 2023年第2期5卷 51-59页

作者： Hanxin Zhang Junan Zhen jiajun yin Caihong Shi Xiangrong Zhang Faculty of Functional Food and Wine Shenyang Pharmaceutical UniversityShenyang 110016China

The aim of this study was to investigate the extraction process and antioxidant activity of polyphenols from Yunnan Mengzi pomegranate *** factor and orthogonal test were used as optimize the extract rate(ER)of polyphenols from pomegranate peel(PGP).The polyphenols antioxidant activity was evaluated by DPPH·,·OH and total reducing ability,and compared with that of *** optimum extraction conditions of polyphenols were as follows:ethanol concentration of 50%,liquid-solid ratio of 50:1,extraction temperature of 90°C,extraction for 4 *** these conditions,the ER of polyphenols from GPG was 8.15%.The results showed that the scavenging effects of polyphenols and Vc on DPPH·,·OH increased with increasing concentration,and the scavenging effect of polyphenols on DPPH·was higher than Vc in rang of 0.1-1.6µg/*** the concentration is greater than 0.6µg/mL,the scavenging effects of plyphenols on·OH is higher than *** total reducing ability of polyphenols from PGP improved with the increase of concentration,and when the concentration was 8µg/mL,the total reducing ability was 114 U/mL.

关键词： pomeranate peel total polyphenols extraction process orthogonal experiment antioxidant activity

Polyphenol content and antioxidant activity in mulberry powder treated at high temperature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Polyphenols 2023年第2期5卷 81-87页

作者： jiajun yin Junan Zheng Xin Li Jiaqing Cao Xinyao Guan Xiangrong Zhang Faculty of Functional Food and Wine Shenyang Pharmaceutical UniversityShenyang 110016China

The aim of this study was to investigate changes of polyphenols content and the antioxidant activity of mulberry fruit powder after heating at high *** mulberry fruit powder was heated by baking method at different temperature and *** DPPH scavenging ability,the OH^(•-) scavenging ability and the O_(2)^(•-) scavenging ability were used to evaluate the changes in the antioxidant activity of the mulberry fruit powder after the heat *** results showed that 74.87%of the polyphenols in the mulberry powder were lost after heating at 150℃for 5 min,and almost all the polyphenols were lost with the increase of the heating time and *** antioxidant experiment showed that the DPPH scavenging rate,OH^(•-) scavenging rate and O_(2)^(•-) scavenging rate of mulberry fruit powder were 68.90%,39.15%and 14.09%,respectively after treatment at 150℃ for 5 *** fruit powder still has some potential to be added to baked goods as a functional ingredient.

关键词： fruit powder polyphenol mulberry high temperature treatment antioxidant activity

胃旁路术对2型糖尿病大鼠脂肪组织胰岛素受体β及胰岛素受体底物-1表达的影响

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华胃肠外科杂志 2015年第1期18卷 65-68页

作者：徐键林杉尹家俊大连大学附属中山医院肝胆腹腔镜外科 116001

目的：观察胃旁路术对2型糖尿病大鼠（GK大鼠）脂肪组织胰岛素受体β（IR-β）及胰岛素受体底物-1（IRS-1）表达的影响，探讨其改善胰岛素抵抗的机制。方法30只8周龄雄性GK大鼠（糖尿病模型）采用数字表法分为手术组（行胃旁路手术）、... 详细信息

目的：观察胃旁路术对2型糖尿病大鼠（GK大鼠）脂肪组织胰岛素受体β（IR-β）及胰岛素受体底物-1（IRS-1）表达的影响，探讨其改善胰岛素抵抗的机制。方法30只8周龄雄性GK大鼠（糖尿病模型）采用数字表法分为手术组（行胃旁路手术）、假手术组（与手术组大鼠相同部位切断后原位端端吻合）和饮食配对组（与手术组大鼠同种和同等质量的饮食），每组10只，另10只8周龄雄性SD大鼠作为空白对照组（自由进食及饮水）。检测术前与术后4周各组大鼠空腹血糖（FPG）和空腹胰岛素（FINS）水平，计算术前及术后4周胰岛素抵抗指数（HOMA-IR），应用蛋白印迹（Western blot）技术检测各组术后4周脂肪组织IR-β和IRS-1的表达。结果手术组术后4周FPG及 HOMA-IR 较术前明显降低（分别为5.13±0.22比11.73±0.37，2.16±0.18比5.10±0.29；均P0.05）；而假手术组和饮食配对组较术前无显著变化（均P＞0.05）；术后4周手术组IR-β及IRS-1表达量均明显高于其他3组（均P〈0.05）。结论胃旁路术能上调2型糖尿病大鼠胰岛素信号转导通路中IR-β及IRS-1的表达，改善脂肪组织胰岛素抵抗，提高胰岛素的敏感性。

关键词：胃旁路术 2型糖尿病胰岛素受体胰岛素受体底物-1 大鼠

在线全文

学校读者我要写书评

暂无评论

无电解电容PMSM驱动系统过调制算法研究

电气传动 2019年第5期49卷 25-30页

作者：罗慧尹家俊尹泉华中科技大学自动化学院湖北武汉430074

无电解电容永磁同步电机(PMSM)驱动系统的直流母线电容储能少,逆变器输出功率能影响网侧输入功率,因此,控制逆变器输出功率可间接改善网侧电流波形。由于无电解电容PMSM驱动系统的母线上缺少大容值的平波电容,单相整流桥输出的直流母线... 详细信息

无电解电容永磁同步电机(PMSM)驱动系统的直流母线电容储能少,逆变器输出功率能影响网侧输入功率,因此,控制逆变器输出功率可间接改善网侧电流波形。由于无电解电容PMSM驱动系统的母线上缺少大容值的平波电容,单相整流桥输出的直流母线电压将周期性脉动,导致空间矢量调制(SVPWM)算法周期性地进入过调制区。传统的过调制算法改变了逆变器的输出功率,偏离了控制目标。针对该问题,提出了一种基于二分搜索的最小功率误差过调制算法,该算法使逆变器输出功率以最小误差跟随其给定功率。最后通过Simulink仿真验证了该算法的有效性。

关键词：无电解电容过调制空间矢量脉宽调制永磁同步电机

核仁复合孔相关蛋白4在活化T细胞中的功能探索

在线全文

学校读者我要写书评

暂无评论

生物工程学报 2024年第11期40卷 4057-4070页

作者：尹家军郭洁张建华中国科学院微生物研究所中国科学院病原微生物与免疫学重点实验室北京100101 山东第一医科大学基础医学院山东济南250000

核仁复合孔相关蛋白4(nucleolar complex associated 4 homolog,NOC4L)是一种重要的核糖体生物发生因子。为从翻译调控方面初步探究其在活化后T细胞中的作用,本研究首先利用构建好的Noc4l~(mCherry)转基因报告小鼠,通过流式细胞术检测NO... 详细信息

核仁复合孔相关蛋白4(nucleolar complex associated 4 homolog,NOC4L)是一种重要的核糖体生物发生因子。为从翻译调控方面初步探究其在活化后T细胞中的作用,本研究首先利用构建好的Noc4l~(mCherry)转基因报告小鼠,通过流式细胞术检测NOC4L在不同状态下的CD4^(+)T细胞中的表达水平;之后进一步检测在Th1和Th17细胞极化条件下,NOC4L随细胞增殖的表达情况;最后通过一系列体外实验检测在Th1和Th17细胞活化过程中与NOC4L相互作用的蛋白质,探究NOC4L发挥作用的可能机制。结果显示,NOC4L在活化的CD4^(+)T细胞中表达水平增加,并且NOC4L的表达与活化后T细胞的增殖水平及分裂特性密切相关;体外实验发现,在T细胞活化过程中,NOC4L与核糖体组装及增殖代谢相关蛋白之间存在相互作用。本研究为进一步探究辅助性T细胞的转录后调控奠定了基础,对深入理解T细胞的活化和调控机制具有重要意义。

关键词：核仁复合孔相关蛋白4 活化T细胞翻译调控细胞增殖

胃转流术对2型糖尿病大鼠肝细胞胰岛素受体-β及葡萄糖转运蛋白-2表达的影响

在线全文

学校读者我要写书评

暂无评论

中华实验外科杂志 2016年第1期33卷 51-53页

作者：吴惧徐键尹敏尹家俊程楠遵义医学院 563000 大连大学附属中山医院肝胆胰腹腔镜外科 116001

目的观察胃转流术（GBP）对自发性2型糖尿病大鼠（GK大鼠）肝细胞胰岛素受体-β（IR—β）及葡萄糖转运蛋白-2（GLUT-2）表达的影响，探讨其改善胰岛素抵抗的机制。方法30只8周龄雄性GK大鼠随机分为手术组（10只）、假手术组（10只）、... 详细信息

目的观察胃转流术（GBP）对自发性2型糖尿病大鼠（GK大鼠）肝细胞胰岛素受体-β（IR—β）及葡萄糖转运蛋白-2（GLUT-2）表达的影响，探讨其改善胰岛素抵抗的机制。方法30只8周龄雄性GK大鼠随机分为手术组（10只）、假手术组（10只）、饮食配对组（10只），另8周龄雄性SD作为空白对照组（10只）。检测和比较术前及术后4周各组大鼠空腹血糖（FPG）、空腹胰岛素（FINS）水平，计算术前及术后4周胰岛素抵抗指数（HOMA-IR），应用Western blot技术检测各组术后4周肝细胞IR-β、GLUT-2的表达。结果GK手术组术后4周FPG水平[（5．13±0．22）mmol／L]明显低于术前（P〈0．05）；术后4周HOMA-IR[（2．16±0．18）mmol／L]明显降低（P〈0．01）；术后4周IR—β、GLUT-2表达明显增加（P〈0．01）。结论GBP能上调2型糖尿病大鼠肝细胞胰岛素信号转导通路中IR-B及GLUT-2的表达，改善肝细胞胰岛素抵抗，提高胰岛素的敏感性。

关键词：胃转流术胰岛素受体-β 葡萄糖转运蛋白_2

基于多元线性回归模型对遵义东贸直营店配件出库量预测和解释

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

时代汽车 2021年第10期 173-174页

作者：尹佳君湖北汽车工业学院湖北省十堰市442000

配件销售等于服务商内部维修出库加经销商外销出库,考虑数据封闭性、可得性、准确性,本论文聚焦服务商的内部维修出库。通过应用统计学学习,了解到应用统计学可以通过Eviews软件多元回归模型,通过可决系数、F检验,T检验,确定模型的拟合... 详细信息

配件销售等于服务商内部维修出库加经销商外销出库,考虑数据封闭性、可得性、准确性,本论文聚焦服务商的内部维修出库。通过应用统计学学习,了解到应用统计学可以通过Eviews软件多元回归模型,通过可决系数、F检验,T检验,确定模型的拟合度,因子的显著性,从而可以达到预测配件出库量。

关键词：商用车配件 Eviews软件多元线性回归预测

强化教学活动创新提升体育教学成效——对初中体育教学改革的几点探究

在线全文

学校读者我要写书评

暂无评论

科教导刊 2011年第17期 115-115,161页

作者：尹家军泰兴市广陵中学江苏泰兴225463

在初中体育教学中,改革与创新是永恒的主题,笔者在教学实践之中注重改革创新,从学生身心特点、教材内容特点以及教学实际状况等方面入手,全面优化教学活动,取得了初步成效,本文将作简要论述。

关键词：初中体育改革研究

Irinotecan hydrochloride liposome HR070803 in combination with 5-fluorouracil and leucovorin in locally advanced or metastatic pancreatic ductal adenocarcinoma following prior gemcitabine-based therapy (PAN-HEROIC-1): a phase 3 trial

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第10期9卷 4628-4636页

作者： Jiujie Cui Shukui Qin Yuhong Zhou Shuang Zhang Xiaofeng Sun Mingjun Zhang Jiuwei Cui Weijia Fang Kangsheng Gu Zhihua Li Jufeng Wang Xiaobing Chen Jun Yao Jun Zhou Gang Wang Yuxian Bai Juxiang Xiao Wensheng Qiu Bangmao Wang Tao Xia Chunyue Wang Li Kong jiajun yin Tao Zhang Xionghu Shen Deliang Fu Chuntao Gao Huan Wang Quanren Wang Liwei Wang Oncology Department and State Key Laboratory of Systems Medicine for Cancer of Shanghai Cancer Institute Renji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghaiChina GI Cancer Center Nanjing Tianyinshan HospitalChina Pharmaceutical UniversityNanjingChina Medical Oncology Zhongshan Hospital Affiliated with Fudan UniversityShanghaiChina Department of Biotherapy West China School of Medicine/West China Hospital of Sichuan UniversityChengduChina Internal Medicine Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjingChina Medical Oncology The Second Affiliated Hospital of Anhui Medical UniversityHefeiChina Department of Oncology The First Hospital of Jilin UniversityChangchunChina Medical Oncology III The First Affiliated HospitalZhejiang University School of MedicineHangzhouChina Medical Oncology The First Affiliated Hospital of Anhui Medical UniversityHefeiChina Department of Oncology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Department of Oncology The Affiliated Cancer HospitalZhengzhou UniversityZhengzhouChina Department of Oncology The First Affiliated Hospital of Henan University of Science and TechnologyLuoyangChina Department of Gastrointestinal Oncology Peking University Cancer Hospital&InstituteBeijingChina Department of Oncology The First Affiliated Hospital of USTC Anhui Provincial HospitalHefeiChina Department of Oncology Harbin Medical University Cancer HospitalHarbinChina Medical Oncology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anChina Department of Oncology The Affiliated Hospital of Qingdao UniversityQingdaoChina Department of Gastroenterology Tianjin Medical University General HospitalTianjinChina Division of Gastrointestinal and Pancreatic Surgery Zhejiang Provincial People’s HospitalHangzhouChina Medical Oncology The First Affiliated Hospital of Xiamen UniversityXiamenChina Department of Oncology Shandong Cancer Hospital a

Liposomal irinotecan has shown promising antitumor activity in patients with advanced or metastatic pancreatic ductal adenocarcinoma (PDAC) who have undergone prior gemcitabine-based therapies. This randomized, double-blind, parallel-controlled, multicenter phase 3 study (NCT05074589) assessed the efficacy and safety of liposomal irinotecan HR070803 combined with 5-fluorouracil (5-FU) and leucovorin (LV) in this patient population. Patients with unresectable, locally advanced, or metastatic PDAC who had previously received gemcitabine-based therapies were randomized 1:1 to receive either HR070803 (60 mg/m^(2) anhydrous irinotecan hydrochloride, equal to 56.5 mg/m^(2) free base) or placebo, both in combination with 5-FU (2000 mg/m^(2)) and LV (200 mg/m^(2)), all given intravenously every two weeks. The primary endpoint of the study was overall survival (OS). A total of 298 patients were enrolled and received HR070803 plus 5-FU/LV (HR070803 group, n = 149) or placebo plus 5-FU/LV (placebo group, n = 149). Median OS was significantly improved in the HR070803 group compared to the placebo group (7.4 months [95% CI 6.1–8.4] versus 5.0 months [95% CI 4.3–6.0];HR 0.63 [95% CI 0.48–0.84];two-sided p = 0.0019). The most common grade ≥ 3 adverse events in the HR070803 group were increased gamma-glutamyltransferase (19.0% versus 11.6% in placebo group) and decreased neutrophil count (12.9% versus 0 in placebo group). No treatment-related deaths occurred in the HR070803 group, while the placebo group reported one treatment-related death (abdominal infection). HR070803 in combination with 5-FU/LV has shown promising efficacy and manageable safety in advanced or metastatic PDAC in the second-line setting, representing a potential option in this patient population.

关键词： metastatic adenocarcinoma sided

袖状胃切除术对肥胖大鼠脂肪组织过氧化物酶体增殖体激活受体γ及解偶联蛋白-1表达的影响

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华内分泌外科杂志 2019年第3期13卷 198-201页

作者：徐键黄骄保吴惧尹敏程楠尹家俊大连大学附属中山医院肝胆腹腔镜外科

目的观察袖状胃切除术(SG)对肥胖大鼠(Zucker大鼠)脂肪组织过氧化物酶体增殖体激活受体γ(PPARγ)及解偶联蛋白-1(UCP-1)表达的影响,探讨其减重的机制。方法 30只10周龄雄性Zucker大鼠按随机数字表法随机分为手术组、假手术组、饮食配对... 详细信息

目的观察袖状胃切除术(SG)对肥胖大鼠(Zucker大鼠)脂肪组织过氧化物酶体增殖体激活受体γ(PPARγ)及解偶联蛋白-1(UCP-1)表达的影响,探讨其减重的机制。方法 30只10周龄雄性Zucker大鼠按随机数字表法随机分为手术组、假手术组、饮食配对组,每组10只。术后6周处死大鼠,取腹膜后脂肪组织,应用RT-PCR及Western blot技术检测各组PPARγ和UCP-1基因mRNA及蛋白表达水平。结果手术组术后6周体重较假手术组和饮食配对组明显降低,分别为[(250±5.8)、(370±10.0)、(310±9.6)]g(F=1385.62,P<0.05);手术组术后6周PPARγ和UCP-1基因mRNA及蛋白表达较假手术组和饮食配对组均明显升高(P<0.05)。结论 SG能增强肥胖大鼠脂肪组织产热相关基因PPARγ和UCP-1的表达,促进白色脂肪棕色化转变,增加能量消耗,是其减重的重要机制之一。

关键词：袖状胃切除术过氧化物酶体增殖体激活受体γ(PPARγ) 解偶联蛋白-1(UCP-1)