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China CDC weekly 2023年第9期5卷 194-200,I0008页

作者： Xinyi Lyu jiajing jia Haishan Yang Yuzhi Deng Hanbin Wu Shuo Wang Chuanyu Zhao Jueming Lei Xiaoxuan Zou Ying Yang Graduate School of Peking Union Medical College Beijing MunicipalityChina National Research Institute for Family Planning Beijing MunicipalityChina National Human Genetic Resources Center Beijing MunicipalityChina Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing MunicipalityChina Haidian Maternal&Child Health Hospital Beijing MunicipalityChina

Summary What is already known about this topic?Hematological parameters may indicate the presence of chronic low-grade inflammation and increasing viscosity,which are involved in the pathological processes of gestational diabetes mellitus(GDM).However,the association between several hematological parameters in early pregnancy and GDM has yet to be *** is added by this report?Hematological parameters in the first trimester,particularly red blood cell(RBC)count and systematic immune index,have a significant impact on GDM *** neutrophils(NEU)count in the first trimester was particularly pronounced for *** upward trend of RBC,white blood cell(WBC),and NEU counts was consistent across all GDM *** are the implications for public health practice?Early pregnancy hematological parameters are associated with the risk of GDM.

关键词： pregnancy inflammation Diabetes

Maternal Preconception Serum Alanine Aminotransferase Levels and Risk of Preterm Birth among Reproductive-Aged Women—China,2013-2017

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China CDC weekly 2024年第10期6卷 181-188,I0001页

作者： Chuanyu Zhao jiajing jia Hanbin Wu Qin Xu Xinyi Lyu Meiya Liu Xuan Hu Jueming Lei Yuzhi Deng Yuan He Yuanyuan Wang Zuoqi Peng Ya Zhang Hongguang Zhang Qiaomei Wang Haiping Shen Yiping Zhang Donghai Yan Ying Yang Xu Ma National Research Institute for Family Planning BeijingChina National Human Genetic Resources Center BeijingChina Graduate School of Peking Union Medical College BeijingChina Department of Epidemiology Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Summary What is already known about this topic?The significance of maternal liver health concerning preterm birth(PTB)is well recognized;however,there is a gap in understanding the precise influence of preconception s... 详细信息

关键词： Serum precise concerning

育龄期高水平生殖激素对大鼠围绝经期及绝经后血压的影响

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山东大学学报（医学版） 2017年第11期55卷 7-14,21页

作者：贾佳静王志萍山东大学公共卫生学院流行病学系山东济南250012 山东大学公共卫生学院劳动卫生与职业病学系山东济南250012

目的探讨雌性大鼠育龄期体内高水平17-β雌二醇(17-βE2)或孕酮(P)对其围绝经期及绝经后血压的影响,并观察血管紧张素Ⅱ-1型受体(AT1R)的变化。方法间情期切除大鼠双侧卵巢,利用17-β E_2和P建立人工动情周期模型,共分为3组:高剂量雌激... 详细信息

目的探讨雌性大鼠育龄期体内高水平17-β雌二醇(17-βE2)或孕酮(P)对其围绝经期及绝经后血压的影响,并观察血管紧张素Ⅱ-1型受体(AT1R)的变化。方法间情期切除大鼠双侧卵巢,利用17-β E_2和P建立人工动情周期模型,共分为3组:高剂量雌激素加低剂量孕激素组(HELP)、高剂量孕激素加低剂量雌激素组(HPLE)和卵巢切除组(OVX)。经按周期给予17-β E_2和P(8周)、递减剂量(5周)和停止给予(6周)依次模拟自然状态下的育龄期、围绝经期与绝经期,监测血压、血清E2、P、腹主动脉AT1R蛋白及其mRNA的表达水平。结果与OVX组比较,HELP组与HPLE组增加各模拟期的收缩压(P<0.05),HELP组明显升高围绝经模拟期与绝经模拟期的舒张压(P<0.05),并增加育龄模拟期和围绝经模拟期AT1R蛋白及其mRNA的表达(P<0.05);AT1R蛋白表达水平与血清E_2、SBP呈正相关(P<0.01)。结论育龄期体内高水平的E2能升高大鼠围绝经期及绝经后血压,且SBP的升高伴随腹主动脉中AT1R蛋白的高表达。

关键词：雌激素孕激素血压育龄期绝经期血管紧张素Ⅱ-1型受体

Association of psychological stress with wives’hypertension across over 10 million Chinese married female population aged 20-49 years

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Chinese Medical Journal 2024年第13期137卷 1583-1591页

作者： Zhenyan Zhao jiajing jia Xinyi Lyu Lihua Zhang Yuanyuan Wang Yuan He Zuoqi Peng Ya Zhang Hongguang Zhang Qiaomei Wang Haiping Shen Yiping Zhang Donghai Yan Xu Ma Ying Yang State Key Laboratory of Cardiovascular Disease Department of CardiologyFuwai HospitalNational Center for Cardiovascular DiseaseChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100037China National Research Institute for Family Planning Beijing 100081China National Human Genetic Resources Center Beijing 102206China Graduate School of Peking Union Medical College Beijing 100730China Department of Maternal and Child Health National Health and Family Planning Commission of the PRCBeijing 100044China

Background:Psychological stress has been reported to be a potential risk factor for hypertension among females,but it remains unclear whether spousal chronic stress levels alter the risk of hypertension among *** examined the associations between stress within the family and hypertension among married ***:Reproductive-aged women who were planning for pregnancy and their husbands were recruited from the National Free Pre-pregnancy Checkup Projects(NFPCP)across 31 provinces in China in 2016 and *** stress of wives or husbands was measured with a 5-point Likert-type scale,and assessed from three domains:work/life-related stress,economic stress,and overall ***-adjusted logistic regression models were used to assess the associations between stress status and the prevalence of ***:Of 10,027,644 couples,261,098(2.60%)women had *** results showed that higher stress levels among themselves or their husbands were associated with a higher prevalence of hypertension in women(P_(for trend)<0.001).Compared with non-stressed participants,female participants with the highest stress themselves were at a greater risk of hypertension,with adjusted odds ratio(OR)of 1.31(95%confidence interval[CI]:1.25-1.37);and compared with participants whose husbands had no stress,those whose husbands had the highest stress level were at a higher risk of hypertension with adjusted OR of 1.24(95%CI:1.20-1.29).Moreover,compared with non-stressed status for both couples,only-wife-stressed,only-husband-stressed,and both-stressed couples were found to be significantly associated with increased risks of wives’hypertension,with adjusted ORs of 1.28(95%CI:1.25-1.31),1.19(95%CI:1.17-1.21),and 1.28(95%CI:1.26-1.31),***:Moderate to severe stress in both spouses might be associated with female hypertension prevalence,which highlights the importance of paying attention to the psychological stresses of couples within the f

关键词： Psychological stress Hypertension Occupational stress Life stress Financial stress

The IAA-and ABA-responsive transcription factor CgMYB58 upregulates lignin biosynthesis and triggers juice sac granulation in pummelo

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Horticulture Research 2020年第1期7卷 846-859页

作者： Meiyan Shi Xiao Liu Haipeng Zhang Zhenyu He Hongbin Yang jiajing Chen jia Feng Wenhui Yang Youwu jiang jia-Long Yao Cecilia Hong Deng Juan Xu Key Laboratory of Horticultural Plant Biology Ministry of EducationWuhanHubei 430070China The New Zealand Institute for Plant and Food Research Limited Private Bag 92169Auckland 1142New Zealand

In citrus,lignin overaccumulation in the juice sac results in granulation and an unpleasant fruit texture and *** integrating metabolic phenotyping and transcriptomic analyses,we found 702 differentially expressed genes(DEGs),including 24 transcription factors(TFs),to be significantly correlated with lignin ***58 was further identified as a critical R2R3 MYB TF involved in lignin overaccumulation owing to its high transcript levels in Huanong Red-fleshed pummelo(HR,Citrus grandis)*** expression of CgMYB58 led to an increase in the lignin content in the pummelo fruit mesocarp,whereas its stable overexpression significantly promoted lignin accumulation and upregulated 19 lignin biosynthetic *** these genes,CgPAL1,CgPAL2,Cg4CL1,and CgC3H were directly modulated by CgMYB58 through interaction with their promoter ***,we showed that juice sac granulation in pummelo fruits could be affected by indole-3-acetic acid(IAA)and abscisic acid(ABA)*** HR pummelo,ABA significantly accelerated this granulation,whereas IAA effectively inhibited this *** together,these results provide novel insight into the lignin accumulation mechanism in citrus *** also revealed the theoretical basis via exogenous IAA application,which repressed the expression of CgMYB58 and its target genes,thus alleviating juice sac granulation in orchards.

关键词： integrating treatment citrus

孕前血清丙氨酸氨基转移酶水平与妊娠期糖尿病发病风险相关性

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中国计划生育学杂志 2021年第1期29卷 65-70页

作者：贾佳静邹晓璇邓雨芝王硕郭同磊彭左旗胡美娜张亚赵银珠陈一昕马旭杨英北京协和医学院研究生院 100730 国家卫生健康委科学技术研究所北京市海淀区妇幼保健院华盛顿大学计算机科学与工程系

目的:探讨孕前血清丙氨酸氨基转移酶(ALT)水平与妊娠期糖尿病(GDM)发病风险关系。方法:采用回顾性队列研究方法,纳入2013年1月-2017年10月在北京市海淀区妇幼保健院建档、产检并分娩且参加过国家免费孕前优生健康检查项目的1398名女性... 详细信息

目的:探讨孕前血清丙氨酸氨基转移酶(ALT)水平与妊娠期糖尿病(GDM)发病风险关系。方法:采用回顾性队列研究方法,纳入2013年1月-2017年10月在北京市海淀区妇幼保健院建档、产检并分娩且参加过国家免费孕前优生健康检查项目的1398名女性为研究对象,建立以孕前优生健康检查项目为起点,贯穿整个孕期至妊娠期糖尿病(GDM)为终点事件的回顾性备孕妊娠队列,调取研究对象在孕前优生健康检查项目及整个孕期至GDM诊断期间的相关问卷调查和诊疗等信息。采用logistic回归模型评估孕前ALT水平对GDM发病风险的影响,并分析孕前体质指数(BMI)作为效应修饰因子与ALT水平的交互作用。结果:经多因素调整后,与ALT正常组(0-40U/L)相比,孕前血清ALT升高(>40U/L)发生GDM的OR值为2.52(95%CI 1.39-4.58);与ALT<10U/L相比,孕前血清ALT在正常范围内每升高10U/L,GDM风险平均增加31.7%(趋势性检验P<0.001)。分层分析显示,与孕前ALT水平正常且BMI<24kg/m^ 2者相比,ALT水平升高且超重或肥胖者发生GDM的风险增加了6.72倍(OR=7.72,95%CI 3.20~18.60)。交互作用分析显示,孕前超重或肥胖对血清ALT与GDM发病风险间的关联具有正向相加交互作用,相对超额风险度为4.38。结论:孕前血清ALT升高能明显增加其患GDM的风险且血清ALT水平升高与GDM风险增加呈正相关。超重或肥胖对孕前ALT升高所致的GDM风险增加具有协同效应。

关键词：妊娠期糖尿病丙氨酸氨基转移酶体质指数超重或肥胖队列研究

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非均质各向异性土体中桩加固边坡稳定性研究

铁道科学与工程学报 2023年第1期20卷 169-177页

作者：张平韦家敬李嘉杨小礼深圳市天健坪山建筑工程有限公司广东深圳518118 中南大学土木工程学院湖南长沙410075

岩土工程中自然土质边坡稳定性问题是常见的基础性问题之一。自然界中的边坡常常处于一个维持自身稳定的状态,即内部的抵抗力不小于外部扰动力,而内部抵抗力和外部扰动力则随着边坡形状、施加在边坡的外力的改变而发生动态变化。如果在... 详细信息

岩土工程中自然土质边坡稳定性问题是常见的基础性问题之一。自然界中的边坡常常处于一个维持自身稳定的状态,即内部的抵抗力不小于外部扰动力,而内部抵抗力和外部扰动力则随着边坡形状、施加在边坡的外力的改变而发生动态变化。如果在外力扰动较为强烈的情况下,边坡容易出现失稳,进而导致破坏。基于极限分析上限定理,通过建立对数螺线破坏机制,将边坡的局部土体视为滑动体,由对数螺旋坐标体系推导出内部抵抗力,即内部耗散率和外部扰动力,即外部工作率,从而对边坡进行三维分析。在抗滑桩加固作用下,基于非均质各向异性土体,推导出安全系数的功率计算表达式,基于强度折减理论获得最优的安全系数。研究结果表明:抗滑桩通过增强边坡的内部抵抗力,提高边坡安全系数。土体非均质各向异性表明边坡土体重要参数出现一定的增加或减少,这2个性质对边坡安全系数的影响不一致。边坡安全系数随非均质系数的增加而增加,随各向异性系数的增加而减少。通过与前人的研究成果对比,验证了本文计算方法与计算结果的正确性。将研究结果应用于实际边坡工程,研究了三维效应和桩加固作用对边坡安全系数的影响,获得了桩加固作用下边坡安全系数的分布规律,为类似的工程设计与施工提供参考。

关键词：非均质性各向异性桩边坡稳定性

风光电源故障暂态解析及实用化短路电流峰值计算

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电网技术 2024年第2期48卷 830-838页

作者：贾科李英孔嘉靖毕天姝胡薇刘嘉超新能源电力系统国家重点实验室(华北电力大学) 北京市昌平区102206 国网青岛供电公司山东省青岛市266000

研究风光电源的故障暂态过程及短路电流峰值能为设备选型及保护整定提供重要依据。然而,现有的风光电源暂态短路电流计算模型过于依赖参数,计算模型难以满足工程应用需求。因此,该文首先分别对光伏电源、永磁同步风机及双馈感应风机进... 详细信息

研究风光电源的故障暂态过程及短路电流峰值能为设备选型及保护整定提供重要依据。然而,现有的风光电源暂态短路电流计算模型过于依赖参数,计算模型难以满足工程应用需求。因此,该文首先分别对光伏电源、永磁同步风机及双馈感应风机进行故障暂态解析,继而构建形式简洁实用的短路电流峰值表达式。对于光伏电源及永磁同步风机,在恒功率控制阶段建立了基于故障期间电源出力变化的暂态短路电流计算模型;在限幅控制阶段通过分析阻尼比系数,得到短路电流峰值的实用化表达式。对于双馈感应风机,通过分析其故障后定转子磁链的耦合关系,得到Crowbar电阻投入阶段短路电流的简化条件,进而求解出短路电流峰值表达式。最后通过录波数据与仿真数据验证了理论的可行性和正确性。

关键词：风光电源故障暂态解析短路电流计算短路电流峰值

The bright star survey telescope for the planetary transit survey in Antarctica

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Science Bulletin 2016年第5期61卷 383-390页

作者： Qiguo Tian Peng jiang Fujia Du jian Wang Zhengyang Li Xiaoyan Li Zhiyong Zhang Haiping Lu Xiangyan Yuan Huigen Liu Hui Zhang Luming Sun Liang Chang jianguo Wang Shaohua Zhang Tuo Ji Xiheng Shi Jie Chen Guangyu Zhang Minghao jia jiajing Liu Junyan Zhou Xiang Pan Shucheng Dong Fengxin jiang Hongfei Zhang Jilin Zhou Lifan Wang Hongyan Zhou Polar Research Institute of China Shanghai 200136 China School of Astronomy and Space Science Nanjing UniversityNanjing 210093 China National Astronomical Observatories/Nanjing Institute of Astronomical Optics and Technology Chinese Academy of Sciences Nanjing 210042 China State Key Laboratory of Technologies of Particle Detection and Electronics Department of Modern Physics University of Science and Technology of China Hefei 230026 China Key Laboratory of Modern Astronomy and Astrophysics(Nanjing University) Ministry of Education Nanjing 210093China Key Laboratory for Research in Galaxies and Cosmology Department of Astronomy University of Science and Technology of China Chinese Academy of Sciences Hefei 230026 China National Astronomical Observatories/Yunnan Observatory Chinese Academy of Sciences Kunming 650011 China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of Sciences Kunming 650011 China Purple Mountain Observatory Chinese Academy of ScienceNanjing 210008 China

Transiting extrasolar planets(exoplanets),especially those orbiting bright stars, are desired for study of the diversity of planetary compositions, internal structures and atmospheres beyond our solar system. Dome A at Antarctica is a promising site for planetary transit surveys,where the continuous darkness and the large clear-sky fraction in the winter months greatly enhance the detection efficiency. The Chinese Small Telescope ARray and the Antarctic Survey Telescopes are the first facilities that have been operated at Dome A for use in exoplanet surveys. To increase the sky coverage, a low-temperature-resistant wide-field robotic telescope, named the bright star survey telescope(BSST), has been developed to join the ongoing planetary transit survey in Antarctica. The BSST has an aperture size of 300 mm and is equipped with a largeframe 4K×4K CCD camera to receive starlight from a 3.°4×3.°4 field of view. The BSST was operated at Lijiang observatory in April and May 2015 for a test *** precision of 3.5 mmag was achieved for stars with V～11 mag using 75 s exposures. The transiting events of two Jupiter-size exoplanets, HAT-P-3b and HATP-12 b, were observed on May 10 and May 20, 2015,respectively.

关键词： Instrumentation Exoplanet Photometry Antarctic Site

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挠性陀螺寻北仪解算方法研究

航天控制 2017年第1期35卷 82-85页

作者：贾智学张小凯任佳婧中国航天科技集团公司第九研究院七一Ο七厂宝鸡721006

研究了挠性寻北仪解算算法,首先介绍了寻北仪的组成和算法原理,在此基础上建立了陀螺和加速度计的误差模型。根据二位置寻北方法,分别推导了寻北系统在基座水平和倾斜情况下的寻北算法,试验表明该算法能满足中低寻北精度要求。

关键词：挠性陀螺仪寻北仪寻北技术方案误差模型实验