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基于全气象参数的南水北调中线冬季水气热交换模型

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水利学报 2024年第2期55卷 179-189,201页

作者：潘佳佳郭新蕾王涛付辉陈玉壮李明新流域水循环模拟与调控国家重点实验室中国水利水电科学研究院北京100038 中国南水北调集团中线有限公司北京100038

针对南水北调中线干渠水体表面热交换精细模拟技术欠缺和多气象因素相互作用机理不明等关键问题,考虑太阳高度角、日照时间、云层遮挡和反照率等因素对太阳辐射的影响,并综合分析水体吸收、反射和发射的净长波辐射、涵盖水体蒸散发失热... 详细信息

针对南水北调中线干渠水体表面热交换精细模拟技术欠缺和多气象因素相互作用机理不明等关键问题,考虑太阳高度角、日照时间、云层遮挡和反照率等因素对太阳辐射的影响,并综合分析水体吸收、反射和发射的净长波辐射、涵盖水体蒸散发失热、水面温差引起的热传导和降雪引起的失热,建立了基于全气象参数的大型明渠水气热交换数学模型。结合南水北调中线全线通水后5年的冬季水温、气温、相对湿度、气压、风速、太阳辐射等原型观测资料,重点分析和模拟了典型年北拒马河、漕河渡槽和滹沱河倒虹吸等渠池的净热通量量值及其组分占比。结果表明,模型能够精细模拟不同渠池水体逐小时吸收的太阳辐射、释放的长波辐射、蒸发失热和水气热传导。模拟结果和观测资料均显示中线干渠冬季以失热为主,其中太阳辐射对净热通量的贡献最大,其次分别为长波辐射、蒸散发失热、温差引起的热传导,占比分别为43.1%、30.9%、17.2%和8.8%。本文量化了中线干渠冬季热通量组成,为进一步研究中线水温冰情精细模拟和输水能力提升提供了基础。

关键词：热交换全气象要素南水北调中线冬季输水数学模型

Rethinking the Encoder-decoder Structure in Medical Image Segmentation from Releasing Decoder Structure

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Journal of Bionic Engineering 2024年第3期21卷 1511-1521页

作者： jiajia Ni Wei Mu An pan Zhengming Chen School of Artificial Intelligence Anhui Polytechnic UniversityWuhu241000China School of Information Science and Engineering HoHai UniversityChangzhou213000China

Medical image segmentation has witnessed rapid advancements with the emergence of encoder-decoder based *** the encoder-decoder structure,the primary goal of the decoding phase is not only to restore feature map resolution,but also to mitigate the loss of feature information incurred during the encoding ***,this approach gives rise to a challenge:multiple up-sampling operations in the decoder segment result in the loss of feature *** address this challenge,we propose a novel network that removes the decoding structure to reduce feature information loss(CBL-Net).In particular,we introduce a Parallel Pooling Module(PPM)to counteract the feature information loss stemming from conventional and pooling operations during the encoding ***,we incorporate a Multiplexed Dilation Convolution(MDC)module to expand the network's receptive ***,although we have removed the decoding stage,we still need to recover the feature map ***,we introduced the Global Feature Recovery(GFR)*** uses attention mechanism for the image feature map resolution recovery,which can effectively reduce the loss of feature *** conduct extensive experimental evaluations on three publicly available medical image segmentation datasets:DRIVE,CHASEDB and MoNuSeg *** results show that our proposed network outperforms state-of-the-art methods in medical image *** addition,it achieves higher efficiency than the current network of coding and decoding structures by eliminating the decoding component.

关键词： Medical image segmentation Encoder-decoder architecture Attention mechanisms Releasing decoder architecture Neural network

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石头埠水文站设计潮位计算分析

陕西水利 2024年第4期 25-28页

作者：潘嘉嘉刘惠雯覃新松肖大远广西沿海水文中心广西钦州535000

采用极值Ⅰ型分布计算石头埠水文站长系列潮水位资料,通过皮尔逊Ⅲ型分布参数估计法进行对比分析,提出最高潮水位和最低潮水位的设计值。计算分析结果可为铁山港附近海域的海堤工程、航道工程和海港工程等设计提供应用参考。

关键词：石头埠水文站铁山港湾设计潮位极值Ⅰ型分布

Coronaviruses RNA interacts with host miR-500a-5p and miR-501-5p to regulate multiple pathways

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Genes & Diseases 2023年第2期10卷 385-388页

作者： Qi Guo Linghui Tan jiajia pan Songfang Wu Jiansong Huang Fang Yu Jinghan Wang Department of Nephrology The First Affiliated HospitalSchool of Medicine Zhejiang UniversityHangzhouZhejiang 310003China Zhejiang University School of Medicine HangzhouZhejiang 310003China Shanghai Xuhui Central Hospital/Zhongshan-Xuhui Hospital Fudan UniversityShanghai 200000China Department of Pathology The First Affiliated HospitalSchool of Medicine Zhejiang UniversityHangzhouZhejiang 310003China Department of Hematology The First Affiliated HospitalSchool of Medicine Zhejiang UniversityHangzhouZhejiang 310003China

The Coronavirus disease is the contagious disease. Clinical manifests vary from no symptoms, upper and lower respiratory tract infections, and even severe acute respiratory distress syndrome and multiple organs failure. Recently, three of new beta-coronaviruses have emerged to cause serious and widespread illness and death, such as the Severe Acute Respiratory Syndrome Coronaviruses (SARS-CoV), Middle East Respiratory Syndrome Coronaviruses (MERS-CoV), and 2019-nCoV (the causative pathogen of Coronavirus Disease 2019 (COVID-19). The COVID-19 is continuing to spread globally. However, the detailed molecular mechanisms have not yet been fully clarified. Since the similarity of the pathological features among 2019-nCoV, SARS-CoV and MERS-CoV, we could speculate the biological features of current COVID-19 by researching those of MERS-CoV and SARS-CoV. Therefore, we analyzed expression levels of miRNA and mRNA profiles of MERS-CoV, SARS-CoV and 2019-nCoV from five public GEO datasets (Table S1). As a result, we found 16 miRNAs potentially target a group of hub genes clustering together to tune the immune response. Notably, viral RNAs have the ability to sponge miR-500a-5p and miR-501-5p, indicating viral RNAs sequestering these two miRNAs to trigger genes expression and contribute to pathogenesis. We hope this study will pave the way to better understand 2019-nCoV pathogenesis and develop the innovative therapeutics.

关键词： miR organs sponge

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75份青稞种质的品质性状综合评价

麦类作物学报 2024年第7期44卷 855-864页

作者：刘雅洁李茂李超李文博田敏潘佳佳赵辉余国武冯宗云四川农业大学农学院四川温江611130

为有效利用青稞种质资源、促进专用型品种的选育,利用主成分分析和因子分析法对75份青稞品种(系)在3个生态点的籽粒中蛋白质、γ-氨基丁酸、总淀粉、β-葡聚糖和花青素含量共5个籽粒品质性状进行分析与评价。结果显示,基因型、生态点及... 详细信息

为有效利用青稞种质资源、促进专用型品种的选育,利用主成分分析和因子分析法对75份青稞品种(系)在3个生态点的籽粒中蛋白质、γ-氨基丁酸、总淀粉、β-葡聚糖和花青素含量共5个籽粒品质性状进行分析与评价。结果显示,基因型、生态点及生态点与基因型互作对5个被测性状均有显著影响,5个性状的变异系数为3.88%~118.92%,广义遗传率为15.29%~90.13%,其中蛋白质、β-葡聚糖和花青素含量的广义遗传率大于60%,表明遗传是其含量差异的主要原因。利用主成分分析可将5个性状简化为3个公因子,其携带总信息量的73.73%。经过Promax旋转后的载荷结果显示,3个公因子分别反映青稞籽粒的氨基酸累积量、次生代谢物累积量和多糖累积量。加权评分后的综合排名和分层聚类结果显示,勾芒青稞、龙中紫、2009-119、XQ0168、次玛、4TH HBSNS-57、813、长芒黑青稞、白勾芒、耐那、对芒黑青稞、褐青稞、北青4号、白青稞和昆仑14号共15个材料的综合品质较好;单性状优势的统计分析结果表明,高蛋白育种适宜选用龙中紫,低β-葡聚糖育种适宜选择白勾芒、对芒黑青稞和褐青稞,高蛋白质且低β-葡聚糖含量育种适宜选择2009-119和XQ0168,高γ-氨基丁酸和高花青素育种适宜选择次玛,高γ-氨基丁酸和低葡聚糖育种适宜选择4TH HBSNS-57。

关键词：青稞综合评价主成分分析因子分析分层聚类

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Metabolic plasticity of T cell fate decision

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Chinese Medical Journal 2024年第7期137卷 762-775页

作者： Xiaoli pan jiajia Wang Lianjun Zhang Guideng Li Bo Huang National Key Laboratory of Immunity and Inflammation Suzhou Institute of Systems MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeSuzhouJiangsu 215123China Key Laboratory of Synthetic Biology Regulatory Element Suzhou Institute of Systems MedicineChinese Academy of Medical Sciences&Peking Union Medical CollegeSuzhouJiangsu 215123China Department of Immunology&National Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences(CAMS)&Peking Union Medical CollegeBeijing 100005China Department of Biochemistry&Molecular Biology Tongji Medical CollegeHuazhong University of Science&TechnologyWuhanHubei 430030China

The efficacy of adaptive immune responses in cancer treatment relies heavily on the state of the T *** antigen exposure,T cells undergo metabolic reprogramming,leading to the development of functional effectors or memory ***,within the tumor microenvironment(TME),metabolic stress impairs CD8+T cell anti-tumor immunity,resulting in exhausted *** studies suggested that targeting T cell metabolism could offer promising therapeutic opportunities to enhance T cell *** this review,we provide a comprehensive summary of the intrinsic and extrinsic factors necessary for metabolic reprogramming during the development of effector and memory T cells in response to acute and chronic inflammatory ***,we delved into the different metabolic switches that occur during T cell exhaustion,exploring how prolonged metabolic stress within the TME triggers alterations in cellular metabolism and the epigenetic landscape that contribute to T cell exhaustion,ultimately leading to a persistently exhausted *** the intricate relationship between T cell metabolism and cancer immunotherapy can lead to the development of novel approaches to improve the efficacy of T cell-based treatments against cancer.

关键词： T cell immunotherapy T cell differentiation T cell exhaustion Metabolic reprogramming Tumor microenvironment

Recycling of waste aluminum scraps to fabricate sulfidated zero-valent iron-aluminum particles for enhanced chromate removal

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Journal of Environmental Sciences 2024年第4期138卷 650-659页

作者： Yahui Zhang Liguo Zhang jiajia Zeng Shuqun Xu Jianyu pan Wenzhuo Huang Jianliang Sun Feng Jiang Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety&MOE Key Laboratory of Theoretical Chemistry of Environment School of EnvironmentSouth China Normal UniversityGuangzhou 510006China Guangdong Provincial Key Lab of Environmental Pollution Control and Remediation Technology School of Environmental Science&EngineeringSun Yat-Sen UniversityGuangzhou 510275China

Massive waste aluminum scraps produced from the spent aluminum products have high electron capacity and can be recycled as an attractive alternative to materials based on zerovalent iron(Fe^(0))for the removal of oxidative contaminants from *** study thus proposed an approach to fabricate micron-sized sulfidated zero-valent iron-aluminum particles(S-Al^(0)@Fe^(0))with high reactivity,electron selectivity and capacity using recycled waste aluminum scraps.S-Al^(0)@Fe^(0)with a three-layer structure contained zero-valent aluminum(Al^(0))core,Fe^(0) middle layer and iron sulfide(FeS)*** rates of chromate(Cr(Ⅵ))removal by S-Al^(0)@Fe^(0)at pH 5.0-9.0 were 1.6-5.9 times greater than that by sulfidated zero-valent iron(S-Fe^(0)).The Cr(Ⅵ)removal capacity of S-Al^(0)@Fe^(0)was 8.2-,11.3-and 46.9-fold greater than those of S-Fe0,zero-valent iron-aluminum(Al^(0)-Fe^(0))and Fe^(0),*** chemical cost of S-Al^(0)@Fe^(0) for the equivalent Cr(Ⅵ)removal was 78.5%lower than that of S-Fe^(0).Negligible release of soluble aluminum during the Cr(Ⅵ)removal was *** significant enhancement in the reactivity and capacity of S-Al^(0)@Fe^(0)was partially ascribed to the higher reactivity and electron density of the Al0core than Fe^(0).More importantly,S-Al^(0)@Fe^(0) served as an electric cell to harness the persistent and selective electron transfer from the Al^(0)-Fe^(0) core to Cr(Ⅵ)at the surface via coupling Fe^(0)-Fe^(2+)-Fe^(3+)redox cycles,resulting in a higher electron utilization ***,S-Al^(0)@Fe^(0) fabricated using recycled waste aluminum scraps can be a cost-effective and environmentally-friendly alternative to S-Fe^(0) for the enhanced removal of oxidative contaminants in industrial wastewater.

关键词： Recycled waste aluminum scraps Oxidative contaminants Cr(Ⅵ)reduction Sulfidated Al^(0)@Fe^(0)particle Electron transfer

Numerical modeling of scour and deposition around permeable cylindrical structures

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International Journal of Sediment Research 2020年第3期35卷 278-286页

作者： jiajia pan Zhiguo He Wurong Shih Niansheng Cheng Ocean College Zhejiang University Civil and Environmental Engineering.Lehigh University

Flow past wall-mounted cylindrical structures is commonly encountered in natural rivers where piers of bridge crossings or vegetation stalks are common within *** the current study,the influence of cylindrical structures on flow/bathymetric alterations for three different permeabilities is explored via two-dimensional numerical *** model construction processes,the structure permeability is varied with the surface void ratio along the perimeter of the cylinder,*** density of emergent and submerged solid elements is used to delineate the cylinder *** validation of this model is guaranteed through careful comparison with experimental data obtained for similar hydrodynamic conditions and cylinder *** validated model then is applied to investigate flow properties and scour and deposition patterns with structure permeabilities of 0.0,0.38,and *** results show that a permeable structure has less impeding effects on flow than a solid *** wake velocity reduction decreases 38% with a 63% increase in the structure permeability due to increasing intensity of the bleeding flow through surface voids,causing less flow contraction and diversion,lower turbulent kinetic energy,and lower lee-side scour around the permeable structure and less deposition downstream under live-bed conditions.

关键词： Structure permeability Scour and deposition Numerical modeling Flow characteristics

ACSL5,a prognostic factor in acute myeloid leukemia,modulates the activity of Wnt/β-catenin signaling by palmitoylation modification

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Frontiers of Medicine 2023年第4期17卷 685-698页

作者： Wenle Ye Jinghan Wang Jiansong Huang Xiao He Zhixin Ma Xia Li Xin Huang Fenglin Li Shujuan Huang jiajia pan Jingrui Jin Qing Ling Yungui Wang Yongping Yu Jie Sun Jie Jin Department of Hematology The First Affiliated HospitalZhejiang University College of MedicineHangzhou 310003China Key Laboratory of Hematopoietic Malignancies Diagnosis and TreatmentHangzhou 310009China Research Centre Centre hospitalier de l’Universitéde Montréal(CRCHUM)MontrealQuebec H2L 4M1Canada Women’s Hospital School of MedicineZhejiang UniversityHangzhou 310006China Zhejiang Province Key Laboratory of Anti-Cancer Drug Research College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Cancer Center Zhejiang UniversityHangzhou 310058China

Acyl-CoA synthetase long chain family member 5(ACSL5),is a member of the acyl-CoA synthetases(ACSs)family that activates long chain fatty acids by catalyzing the synthesis of fatty *** dysregulation of ACSL5 has been reported in some cancers,such as glioma and colon ***,little is known about the role of ACSL5 in acute myeloid leukemia(AML).We found that the expression of ACSL5 was higher in bone marrow cells from AML patients compared with that from healthy ***5 level could serve as an independent prognostic predictor of the overall survival of AML *** AML cells,the ACSL5 knockdown inhibited cell growth both in vitro and in ***,the knockdown of ACSL5 suppressed the activation of the Wnt/β-catenin pathway by suppressing the palmitoylation modification of ***,triacsin c,a pan-ACS family inhibitor,inhibited cell growth and robustly induced cell apoptosis when combined with ABT-199,the FDA approved BCL-2 inhibitor for AML *** results indicate that ACSL5 is a potential prognosis marker for AML and a promising pharmacological target for the treatment of molecularly stratified AML.

关键词： acute myeloid leukemia acyl-CoA synthetase long chain family member 5 Wnt3a palmitoylation ABT-199