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The complex effects of miR-146a in the pathogenesis of Alzheimer's disease

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Neural Regeneration Research 2025年第5期20卷 1309-1323页

作者： Yunfan Long jiajia liu Yu Wang Haidong Guo Guohong Cui Department of Neurology Shanghai No.9 People’s HospitalShanghai Jiaotong University School of MedicineShanghaiChina Academy of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina School of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Neurology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina

Alzheimer's disease is a neurodegenerative disorder characterized by cognitive dysfunction and behavioral *** plaques formed through the extracellular deposition of amyloid-βproteins,as well as neurofibrillary tangles formed by the intracellular deposition of hyperphosphorylated tau proteins,comprise two typical pathological features of Alzheimer's *** symptomatic treatment,there are no effective therapies for delaying Alzheimer's disease ***(miR)are small,non-coding RNAs that negatively regulate gene expression at the transcriptional and translational levels and play important roles in multiple physiological and pathological ***,miR-146a,a NF-κB-regulated gene,has been extensively implicated in the development of Alzheimer's disease through several *** has demonstrated substantial dysregulation of miR-146a both during the initial phases and throughout the progression of this *** R-146a is believed to reduce amyloid-βdeposition and tau protein hyperphosphorylation through the TLR/IRAK1/TRAF6 pathway;however,there is also evidence supporting that it can promote these processes through many other pathways,thus exacerbating the pathological manifestations of Alzheimer's *** has been widely reported that miR-146a mediates synaptic dysfunction,mitochondrial dysfunction,and neuronal death by targeting m RNAs encoding synapticrelated proteins,mitochondrial-related proteins,and membrane proteins,as well as other *** the impact on glial cells,miR-146a also exhibits differential *** one hand,it causes widespread and sustained inflammation through certain pathways,while on the other hand,it can reverse the polarization of astrocytes and microglia,alleviate neuroinflammation,and promote oligodendrocyte progenitor cell differentiation,thus maintaining the normal function of the myelin sheath and exerting a protective effect on *** this review,we provide a

关键词： Alzheimer's disease amyloid-β glial cells microRNAs miR-146a neuroinflammatory

Virtual reality-based cognitive-behavioural therapy for the treatment of anxiety in patients with acute myocardial infarction:a randomised clinical trial

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General Psychiatry 2024年第2期37卷 189-196页

作者： Yuanyuan Li Juan Peng Pingyuan Yang Jiajun Weng Yan'e Lu jiajia liu Shikun Xu Lihua Guan Dong Huang Qibing Wang Juying Qian Zexin Zhao Yabin Wei Junbo Ge Xiao Huang Department of Psychological Medicine Zhongshan Hospital Fudan UniversityShanghaiChina Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesNational Clinical Research Center for Interventional MedicineShanghaiChina Department of Psychological Medicine Shanghai Geriatric Medical CenterShanghaiChina School of Nursing Peking UniversityBeijingChina Beijing Key Laboratory of Drug Dependence Research National Institute on Drug DependencePeking UniversityBeijingChina

Background The presence of mental health conditions is pervasive in patients who experienced acute myocardial infarction(AMI),significantly disrupting their *** timely and easily accessible psychological interventions using virtual reality-based cognitive-behavioural therapy(VR-CBT)could potentially improve both acute and long-term symptoms affecting their mental *** We aim to examine the effectiveness of VR-CBT on anxiety symptoms in patients with AMI who were admitted to the intensive care unit(ICU)during the acute stage of their *** In this single-blind randomised clinical trial,participants with anxiety symptoms who were admitted to the ICU due to AMI were continuously recruited from December 2022 to February *** who were Han Chinese aged 18-75 years were randomly assigned(1:1)via block randomisation to either the VR-CBT group to receive VR-CBT in addition to standard mental health support,or the control group to receive standard mental health support ***-CBT consisted of four modules and was delivered at the bedside over a 1-week *** were done at baseline,immediately after treatment and at 3-month *** intention-to-treat analysis began in June *** primary outcome measure was the changes in anxiety symptoms as assessed by the Hamilton Anxiety Rating Scale(HAM-A).Results Among 148 randomised participants,70 were assigned to the VR-CBT group and 78 to the control *** 1-week VR-CBT intervention plus standard mental health support significantly reduced the anxiety symptoms compared with standard mental health support alone in terms of HAM-A scores at both post intervention(Cohen’s d=−1.27(95%confidence interval(CI):−1.64 to−0.90,p<0.001)and 3-month follow-up(Cohen’s d=−0.37(95%CI:−0.72 to−0.01,p=0.024).Of the 70 participants who received VR-CBT,62(88.6%)completed the entire *** was the main reported adverse event(n=5).Conclusions Our results indicate that VR-CB

关键词： admitted behaviour treatment

A centromere map based on super pan-genome highlights the structure and function of rice centromeres

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Journal of Integrative Plant Biology 2024年第2期66卷 196-207页

作者： Yang Lv Congcong liu Xiaoxia Li Yueying Wang Huiying He Wenchuang He Wu Chen Longbo Yang Xiaofan Dai Xinglan Cao Xiaoman Yu jiajia liu Bin Zhang Hua Wei Hong Zhang Hongge Qian Chuanlin Shi Yue Leng Xiangpei liu Mingliang Guo Xianmeng Wang Zhipeng Zhang Tianyi Wang Bintao Zhang Qiang Xu Yan Cui Qianqian Zhang Qiaoling Yuan Noushin Jahan Jie Ma Xiaoming Zheng Yongfeng Zhou Qian Qian Longbiao Guo Lianguang Shang State Key Laboratory of Rice Biology China National Rice Research InstituteHangzhou 310006China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China Yazhouwan National Laboratory No.8 Huanjin RoadYazhou DistrictSanya City 572024China National Key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop ScienceChinese Academy of Agricultural SciencesBeijing 100081China

Rice(Oryza sativa)is a significant crop worldwide with a genome shaped by various evolutionary *** centromeres are crucial for chromosome segregation,and contain some unreported *** to the diverse and complex centromere region,a comprehensive understanding of rice centromere structure and function at the population level is *** constructed a high-quality centromere map based on the rice super pangenome consisting of a 251-accession panel comprising both cultivated and wild species of Asian and African *** showed that rice centromeres have diverse satellite repeat CentO,which vary across chromosomes and subpopulations,reflecting their distinct evolutionary *** also revealed that long terminal repeats(LTRs),especially young Gypsy-type LTRs,are abundant in the peripheral CentO-enriched regions and drive rice centromere expansion and ***,high-quality genome assembly and complete telomere-to-telomere(T2T)reference genome enable us to obtain more centromeric genome information despite mapping and cloning of centromere genes being *** investigated the association between structural variations and gene expression in the rice centromere.A centromere gene,OsMAB,which positively regulates rice tiller number,was further confirmed by expression quantitative trait loci,haplotype analysis and clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein9 *** revealing the new insights into the evolutionary patterns and biological roles of rice centromeres,our finding will facilitate future research on centromere biology and crop improvement.

关键词： centromere super pan-genome CentoO satellite repeat rice

日粮中添加鞣花酸对乳鸽生长发育和屠宰性能的影响

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中国饲料 2024年第7期 52-57页

作者：刘佳佳韩涛新疆畜牧科学院畜牧研究所新疆乌鲁木齐830001 新疆畜牧科学院兽医研究所新疆乌鲁木齐830099

为研究日粮添加鞣花酸对乳鸽生长性能及屠宰性能的影响,试验选取遗传背景相同的24月龄欧洲肉鸽亲鸽120羽和同一天出壳、体况良好的0日龄乳鸽180羽,将120羽亲鸽和180羽乳鸽随机分为对照组、试验Ⅰ、Ⅱ组和试验Ⅲ组,采用“2+3”的孵育模... 详细信息

为研究日粮添加鞣花酸对乳鸽生长性能及屠宰性能的影响,试验选取遗传背景相同的24月龄欧洲肉鸽亲鸽120羽和同一天出壳、体况良好的0日龄乳鸽180羽,将120羽亲鸽和180羽乳鸽随机分为对照组、试验Ⅰ、Ⅱ组和试验Ⅲ组,采用“2+3”的孵育模式每组3个重复,每个重复15羽乳鸽。对照组饲喂未添加鞣花酸的基础日粮,3个试验组分别在基础日粮中添加1%、3%、6%的鞣花酸,试验期28 d。试验期间分别于乳鸽0、7、14、21、28日龄时称量体重。试验结束当天每组选择5笼鸽子进行屠宰试验,取内脏器官并计算脏器指数。结果表明:(1)乳鸽7日龄体重,试验Ⅰ、Ⅱ组和Ⅲ组均高于对照组,分别提高了8.17%、10.45%和7.68%(P>0.05)。乳鸽21日龄体重,试验Ⅱ组和试验Ⅲ组均高于对照组,分别提高了1.52%和2.24%(P>0.05)。乳鸽28日龄体重、总增重及平均日增重,试验Ⅲ组均高于对照组,分别提高了2.48%、2.6%和2.5%(P>0.05);(2)屠宰率,对照组及各试验组差异均不显著(P>0.05)。半净膛率,试验Ⅱ组显著高于试验Ⅰ组,提高了11.90%(P0.05)。肝脏指数,试验Ⅰ组和试验Ⅲ组高于对照组,分别提高了36.13%(P0.05)。脾脏指数,试验Ⅰ组显著高于对照组,提高了85.71%(P<0.05)。综上所述,在本试验条件下,日粮中添加鞣花酸能够促进乳鸽的生长发育,改善乳鸽脏器发育,提高乳鸽屠宰性能。

关键词：鞣花酸乳鸽生长发育屠宰性能

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考虑接头参数化的空间桁架轻量化设计

航空学报 2024年第5期45卷 352-364页

作者：张瑞桐汪雷刘佳佳朱继宏西北工业大学航宇材料结构一体化设计与增材制造装备技术国际联合研究中心西安710072 中国运载火箭技术研究院北京100076 北京宇航系统工程研究所北京100076

提出了一种考虑接头参数化建模的连杆布局优化方法,该建模过程是基于轴线夹角及尺寸完成的。管状接头结构的几何特性由被连接杆件之间的相互位置和尺寸决定,通过将其相对位置转化为接头轴线夹角,将其尺寸转化为接头主管及支管尺寸实现... 详细信息

提出了一种考虑接头参数化建模的连杆布局优化方法,该建模过程是基于轴线夹角及尺寸完成的。管状接头结构的几何特性由被连接杆件之间的相互位置和尺寸决定,通过将其相对位置转化为接头轴线夹角,将其尺寸转化为接头主管及支管尺寸实现了接头有限元模型的参数化建模。接头结构的空间位置可由被连接件的空间位置转化的轴线交点决定,综上可以实现接头有限元模型的嵌入及整体桁架结构的有限元模型建立。利用基于高斯过程的贝叶斯方法对于桁架连杆布局进行优化设计,同时将制造难度纳入考虑并给出具体的设计方案。数值算例表明,优化方法可有效提高优化目标即结构固有频率。

关键词：布局优化接头设计桁架新型航天器贝叶斯方法

富血小板血浆在卵巢低反应患者中的应用及研究进展

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中华生殖与避孕杂志 2024年第6期44卷 652-655页

作者：刘佳佳李虹维高明霞兰州大学第一临床医学院兰州730000 兰州大学第一医院生殖医学中心兰州730000

卵巢低反应(poor ovarian response,POR)是辅助生殖领域所面临的一大难题。富血小板血浆(platelet-rich plasma,PRP)作为一种新型治疗方法,已被证明在促进血管生成、细胞分化和增殖、卵泡生成等方面发挥着积极的作用,对于POR患者的治疗... 详细信息

卵巢低反应(poor ovarian response,POR)是辅助生殖领域所面临的一大难题。富血小板血浆(platelet-rich plasma,PRP)作为一种新型治疗方法,已被证明在促进血管生成、细胞分化和增殖、卵泡生成等方面发挥着积极的作用,对于POR患者的治疗具有巨大的优势。本文就PRP的来源及制备、对POR患者卵巢功能和妊娠结局的影响以及PRP可能的作用机制进行综述。此外,文章还探讨了在POR患者治疗过程中PRP所面临的挑战以及未来可关注的研究方向,旨在为临床和科研工作者提供参考。

关键词：富血小板血浆生殖技术,辅助卵巢低反应

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无线无源力/热传感器与测试技术研究现状

振动．测试与诊断 2024年第3期44卷 419-430,614页

作者：谭秋林刘佳佳王宁樊磊张磊冯瑞微纳器件与系统教育部重点实验室太原030051 省部共建动态测试技术国家重点实验室太原030051

针对力热传感器多数采用有线有源的技术方案,难以适用于高温、高压、强振以及机械动力旋转部件等环境下的力热参数原位测试问题,阐述了进行无线无源传感器件研究的重要意义,并对声表面波(surface acoustic wave,简称SAW)传感器、LC谐振... 详细信息

针对力热传感器多数采用有线有源的技术方案,难以适用于高温、高压、强振以及机械动力旋转部件等环境下的力热参数原位测试问题,阐述了进行无线无源传感器件研究的重要意义,并对声表面波(surface acoustic wave,简称SAW)传感器、LC谐振互感耦合传感器以及超材料传感器等3类无线无源力热传感器进行了总结及现状分析。首先,描述了无线无源力热传感器的需求情况;其次,介绍了3类传感器的工作原理、传感性能及其在独特场景下的具体应用;最后,讨论了无线无源传感器发展过程中的瓶颈问题,指出了未来可能改善和提升的发展方向。

关键词：无线无源传感器高温环境高旋环境振动测量

山西老陈醋通过JAK2/STAT3通路减轻高脂饮食诱导的大鼠肝损伤

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现代食品科技 2024年第1期40卷 10-18页

作者：刘佳佳申彤陈嘉庞全海山西农业大学动物医学学院山西晋中030801 山西农业大学食品科学与工程学院农产品贮藏保鲜研究所山西太原030031

旨在探究山西老陈醋通过JAK2/STAT3通路减轻高脂饮食诱导大鼠肝损伤的作用机制。使用高脂乳剂灌胃大鼠5周,构建高脂血症模型;同时低、中、高剂量(按体质量计1.35、2.7、5.4 g/kg)山西老陈醋灌胃大鼠10周。血清学检测血清中总胆固醇(TC)... 详细信息

旨在探究山西老陈醋通过JAK2/STAT3通路减轻高脂饮食诱导大鼠肝损伤的作用机制。使用高脂乳剂灌胃大鼠5周,构建高脂血症模型;同时低、中、高剂量(按体质量计1.35、2.7、5.4 g/kg)山西老陈醋灌胃大鼠10周。血清学检测血清中总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、超氧化物歧化酶(SOD)、谷胱甘肽还原酶(GRx)、总抗氧化能力(T-AOC)、谷草转氨酶(AST)、谷丙转氨酶(ALT)、碱性磷酸酶(ALK-P)水平;HE染色检测肝脏病理学变化;q-PCR和WB检测肝脏中JAK2、STAT3 mRNA和蛋白水平表达;免疫组化技术定位分析。结果显示,不同剂量山西老陈醋均能够极显著降低脂质含量和肝损伤程度,提高抗氧化酶活性,极显著抑制JAK2、STAT3 mRNA和蛋白含量(P<0.01);其中高剂量组TC、TG降低20.50%、48.65%,高、中剂量组对AST(32.79%、29.07%)、ALT(21.65%、20.67%)、ALK-P(19.42%、19.71%)效果最好;与低剂量组相比,高中剂量组JAK2(57.07%、34.02%)、STAT3(55.19%、41.45%)mRNA和JAK2(27.89%、24.09%)、STAT3(33.06%、26.64%)蛋白含量(极)显著降低(P<0.05,P<0.01)。综上,山西老陈醋减轻高脂饮食诱导大鼠的肝损伤的作用,可能是通过抑制JAK2/STAT3通路的活化来实现。

关键词：山西老陈醋 JAK2/STAT3通路高脂饮食大鼠肝损伤

直播带货对泾阳茯砖茶及其文化产品消费意愿的影响分析

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全国流通经济 2024年第14期 4-7页

作者：刘佳佳西安欧亚学院陕西西安710065

本文基于直播带货对泾阳茯砖茶及其文化产品消费影响进行研究,采取方便抽样方式,按照性别和年龄进行等额配比,通过线下线上相结合的方式共回收有效样本1253份。研究发现,茶农、商家愿意通过直播带货模式进行销售,消费者则认为直播带货... 详细信息

本文基于直播带货对泾阳茯砖茶及其文化产品消费影响进行研究,采取方便抽样方式,按照性别和年龄进行等额配比,通过线下线上相结合的方式共回收有效样本1253份。研究发现,茶农、商家愿意通过直播带货模式进行销售,消费者则认为直播带货中诱导消费问题最为严重,其次为产品质量问题,很大程度上影响了消费者通过直播带货消费的意愿。结果显示,直播带货模式对泾阳茯砖茶及其文化产品的消费意愿具有一定的促进作用,其中,在认知和情感两大因子中,情感因子影响最为显著。

关键词：直播带货泾阳茯砖茶消费意愿