检索结果-南通市图书馆

人文关怀结合中医特色护理对晚期肝癌患者癌痛、心理应激、睡眠质量的影响

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

中国现代医生 2021年第30期59卷 164-167,171页

作者：丁佳慧解敏君汤佳静郑双浙江省台州市第一人民医院普外科浙江台州318020 浙江省台州市第一人民医院血液肿瘤内科浙江台州318020

目的探讨人文关怀结合中医特色护理对晚期肝癌患者癌痛、心理应激、睡眠质量的影响。方法选取2018年2月至2020年3月本院96例晚期肝癌患者,随机分为A、B、C三组,每组各32例。A组给予人文关怀结合中医特色护理,B组给予中医特色护理,C组... 详细信息

目的探讨人文关怀结合中医特色护理对晚期肝癌患者癌痛、心理应激、睡眠质量的影响。方法选取2018年2月至2020年3月本院96例晚期肝癌患者,随机分为A、B、C三组,每组各32例。A组给予人文关怀结合中医特色护理,B组给予中医特色护理,C组给予常规护理干预,比较三组患者不适症状、癌痛、心理应激、应对方式、睡眠质量。结果 A组头晕乏力、睡眠困难、食欲减退症状发生率分别为15.63%、15.63%、9.38%,B组为15.63%、18.75%、12.50%,均低于C组的43.75%、46.88%、34.38%(P<0.05);A组与B组干预后癌痛情况改善优于C组(P<0.05);A组干预后SAS、SDS评分低于B组,B组低于C组(P<0.05);A组干预后面对维度评分高于B组,B组高于C组,回避、屈服维度评分低于B组,B组低于C组(P<0.05);A组患者干预后睡眠质量、入睡时间、睡眠障碍、睡眠时间、睡眠效率、催眠药物、日间功能评分低于B组,B组低于C组(P<0.05)。结论人文关怀结合中医特色护理可有效改善晚期肝癌患者不适症状,减轻患者癌痛和心理应激,加强积极应对疾病的心理,提高睡眠质量。

关键词：晚期肝癌癌痛心理应激睡眠质量中医特色护理人文关怀

同方期刊数据库

津力达颗粒辅助治疗糖尿病周围神经病变伴认知功能障碍的临床疗效

在线全文

学校读者我要写书评

暂无评论

联勤军事医学 2024年第2期38卷 133-137,156页

作者：柯璐林萱陈军梅房莹郭红艳卢新妍吴嘉慧丁家豪武汉科技大学附属华润武钢总医院内分泌科湖北武汉430080 武汉科技大学医学部医学院武汉科技大学附属华润武钢总医院中医科

目的探讨中成药津力达颗粒辅助治疗糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)患者伴认知障碍的临床疗效。方法选取2022-12-01/2023-03-31日于作者医院内分泌科就诊的DPN伴认知功能障碍的80例患者为研究对象。使用随机信... 详细信息

目的探讨中成药津力达颗粒辅助治疗糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)患者伴认知障碍的临床疗效。方法选取2022-12-01/2023-03-31日于作者医院内分泌科就诊的DPN伴认知功能障碍的80例患者为研究对象。使用随机信封法将受试者分为观察组和对照组,每组40人。两组患者均给予预混胰岛素进行降糖治疗,同时给予依帕司他片营养神经治疗,观察组在此基础上加用津力达颗粒,两组患者均治疗12周。于治疗前后,采用简易智能精神状态检查量表(Mini-Mental State Examination,MMSE)、中文版蒙特利尔认知评估量表(Montreal Cognitive Assessment,MoCA)评估患者的认知功能,采用密歇根神经病变筛查量表(Michigan Neuropathy Screening Instrument,MNSI)和下肢肌电图评估患者的周围神经病变严重程度,测量患者的血糖、血脂及糖化血红蛋白(haemoglobin A_(1)c,HbA_(1)c)水平。结果经过12周的治疗,观察组的MoCA视空间与执行能力、总分,DPN治疗总有效率显著高于对照组(P0.05);餐后2h血糖(postprandial 2-hour blood glucose,2hPG)、HbA_1c、总胆固醇(total cholesterol,TC)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)显著低于对照组,高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)显著高于对照组,组间比较差异具有统计学意义(P<0.05)。结论津力达颗粒辅助治疗DPN伴认知功能障碍疗效显著。

关键词：津力达颗粒 2型糖尿病糖尿病周围神经病变认知功能障碍

在线全文

学校读者我要写书评

暂无评论

考虑风光功率短期预测的电力系统调度

通信电源技术 2023年第1期40卷 66-68页

作者：彭颖丁家会张财宝高泽呈南京师范大学中北学院能源互联网研究所江苏丹阳212300

考虑到我国主动配电网具有多级管控的特点,为保证电网安全,短期功率的精准预测具有重要意义,但配电网上集成的可控资源具有随机性和波动性,因此精确预测短期功率的难度较大.通过比较各类全局寻优算法,最终发现应用遗传算法(Genetic Algo... 详细信息

考虑到我国主动配电网具有多级管控的特点,为保证电网安全,短期功率的精准预测具有重要意义,但配电网上集成的可控资源具有随机性和波动性,因此精确预测短期功率的难度较大.通过比较各类全局寻优算法,最终发现应用遗传算法(Genetic Algorithms,GA)优化BP神经网络能够明显提高短期功率的预测精度,降低成本.

关键词：短期功率预测遗传算法(GA)优化BP神经网络辐照强度和温度电力系统

PMN-MDSCs modulated by CCL20 from cancer cells promoted breast cancer cell stemness through CXCL2-CXCR2 pathway

维普期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2023年第4期8卷 1828-1841页

作者： Rui Zhang Mengxue Dong Juchuanli Tu Fengkai Li Qiaodan Deng jiahui Xu Xueyan He Jiajun ding Jie Xia Dandan Sheng Zhaoxia Chang Wei Ma Haonan Dong Yi Zhang Lixing Zhang Lu Zhang Suling Liu Fudan University Shanghai Cancer Center&Institutes of Biomedical Sciences State Key Laboratory of Genetic EngineeringCancer InstitutesKey Laboratory of Breast Cancer in ShanghaiThe Shanghai Key Laboratory of Medical EpigeneticsShanghai Key Laboratory of Radiation OncologyThe International Co-laboratory of Medical Epigenetics and MetabolismMinistry of Science and TechnologyShanghai Medical CollegeFudan UniversityShanghai 200032China Breast Surgery Obstetrics and Gynecology Hospital of Fudan UniversityShanghaiChina Department of Breast and Thyroid Surgery Southwest Hospitalthe First Affiliated Hospital of the Army Military Medical UniversityChongqing 400038China Jiangsu Key Lab of Cancer Biomarkers Prevention and TreatmentCollaborative Innovation Center for Cancer MedicineNanjing Medical UniversityNanjing 211166China

Our previous studies have showed that C-C motif chemokine ligand 20(CCL20)advanced tumor progression and enhanced the chemoresistance of cancer cells by positively regulating breast cancer stem cell(BCSC)***,it is unclear whether CCL20 affects breast cancer progression by remodeling the tumor microenvironment(TME).Here,we observed that polymorphonuclear myeloid-derived suppressor cells(PMN-MDSCs)were remarkably enriched in TME of CCL20-overexpressing cancer cell orthotopic allograft ***,CCL20 activated the differentiation of granulocyte-monocyte progenitors(GMPs)via its receptor C-C motif chemokine receptor 6(CCR6)leading to the PMN-MDSC ***-MDSCs from CCL20-overexpressing cell orthotopic allograft tumors(CCL20-modulated PMN-MDSCs)secreted amounts of C-X-C motif chemokine ligand 2(CXCL2)and increased ALDH+BCSCs via activating CXCR2/NOTCH1/HEY1 signaling ***,C-X-C motif chemokine receptor 2(CXCR2)antagonist SB225002 enhanced the docetaxel(DTX)effects on tumor growth by decreasing BCSCs in CCL20high-expressing *** findings elucidated how CCL20 modulated the TME to promote cancer development,indicating a new therapeutic strategy by interfering with the interaction between PMN-MDSCs and BCSCs in breast cancer,especially in CCL20high-expressing breast cancer.

关键词： CCL20 CXCR2 breast

A Kaposi’s sarcoma-associated herpes virus-encoded microRNA contributes to dilated cardiomyopathy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2023年第7期8卷 3443-3454页

作者： Yanru Zhao Huaping Li Hengzhi Du Zhongwei Yin Mengying He jiahui Fan Xiang Nie Yang Sun Huiying Hou Beibei Dai Xudong Zhang Yuanyuan Cai Kunying Jin Nan ding Zheng Wen Jiang Chang Chen Chen Dao Wen Wang Division of Cardiology Department of Internal MedicineTongji HospitalTongji Medical CollegeHuazhong University of Science and Technology430030 WuhanChina Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders 430030 WuhanChina Division of Cardiology Department of Internal MedicineHubei Provincial Renmin Hospital430030 WuhanChina Division of Cardiology Department of Internal MedicineThe First People’s Hospital of Anqing246004 AnqingChina Department of Epidemiology and Biostatistics Key Laboratory for Environment and HealthSchool of Public HealthTongji Medical CollegeHuazhong University of Science and Technology430030 WuhanChina

Dilated cardiomyopathy(DCM)is the leading cause of heart *** microRNA(miRNA)array,a Kaposi’s sarcoma-associated herpes virus(KSHV)-encoded miRNA,kshv-miR-K12-1-5p,was detected in patients with *** KSHV DNA load and k... 详细信息

关键词： Kaposi cardiomyopathy sarcoma

Life Cycle Assessment and Prediction of Proton Exchange Membrane Fuel Cell Vehicles for 2020

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Life Cycle Assessment and Prediction of Proton Exchange Memb...

Construction of Tripod BODIPYs via Low Temperature Substitution of Dipyrromethenes

2018中国汽车工程学会年会

作者： CHEN Yisong ding Zhensen LIU jiahui MA Jinqiu School of Automobile Chang’an University

Currently,fuel cell vehicles have attracted the attention of China and even the world,which perhaps will become the commanding point of technical competition in the automotive *** modeling with GaBi software,the prediction and quantitative analysis are made on life cycle energy saving and emission reduction for fuel cell vehicles in China in 2020 based on the 2020 target of China and the *** of Energy 2020 ***,sensitivity analysis was conducted for selected key *** result shows that the total resource depletion,energy consumption and environmental impact for fuel cell vehicles of China in its complete life cycle were 0.354 kg Sb-Eq.,7.38 × 105 MJ and 4.48 × 104 kg CO *** 2020,the impact of the power generation on the environment will decrease as the proportion of thermal power generation in the power structure declines,and it will provide a possibility for largescale electrolysis of water to produce hydrogen.

关键词： fuel cell vehicles life cycle assessment DOE 2020 target energy depletion and environmental impact

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Construction of Tripod BODIPYs via Low Temperature Substitut...

中国化学会全国第十一届有机合成化学学术研讨会

作者： jiahui Lu Liping ding Weiran Tang Xin Qi Department of Applied Chemistry College of Material Science and TechnologyNanjing University of Aeronautics and Astronautics

Borondipyrromethenes(BODIPY) as useful fluorophores have attracted much attention over the past two decades because of their advantages,such as high excitation coefficients,high fluorescence quantum yields and high stability against light and chemical reactions. Among the various synthetic strategies,the tripod BODIPY fluorescent structure based on 1,3,5-triazine,presents an interesting synthetic approach considering the convenient introduction of various functional groups without the post-modification on the BODIPY *** our way to exploit the scope and application of this tripod fluorescent structure,we reported here你 a new synthetic pathway via substitution reactions of the third chlorine atom in the tripod dipyrromethene intermediates1 at low temperature(Scheme.1).Different from the conventional higher temperature(65-95℃),the displacement of the 3 chlorine of the triazine with amines could be conducted at much lower ambient condition.A hypothetical mechanism was presented to elucidate the unanticipated reactivity of these tripod dipyrromethene *** the substitution,the subsequent comlexation reaction of 2 with BF·EtO in the same pot afforded the final products *** construction of tripod BODIPYs based on this kind of proposed mechanism is under investigation in our laboratory.

关键词： BODIPY Tripod dipyrromethene Substitution Low temperature

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

基于改进遗传算法的机器人路径规划

河南科技 2021年第27期40卷 6-8页

作者：丁家会冒宇露顾立博戴彦楚吴雪倩南京师范大学中北学院江苏丹阳212300

针对传统路径规划算法存在路径不可达、寻优计算规模大等缺陷导致算法的计算量大、收敛精度低等问题,本文提出采用改进遗传算法优化中间节点,结合Dijkstra算法求最短路径算法补齐节点间的路径形成一条完整路径的方式,保证遗传操作中的... 详细信息

针对传统路径规划算法存在路径不可达、寻优计算规模大等缺陷导致算法的计算量大、收敛精度低等问题,本文提出采用改进遗传算法优化中间节点,结合Dijkstra算法求最短路径算法补齐节点间的路径形成一条完整路径的方式,保证遗传操作中的路径全部为可行路径。与传统遗传算法作对比,试验结果表明改进后的算法在收敛精度和寻优能力上都取得了明显的效果。

关键词：遗传算法路径规划中间节点

在线全文

学校读者我要写书评

暂无评论

赤点石斑鱼群体遗传结构的微卫星分析

中山大学学报（自然科学版） 2012年第3期51卷 83-89页

作者：陈省平丁少雄陈嘉慧中山大学海洋功能分子广东高校重点实验室广东广州510080 中山大学中山医学院广东广州510080 厦门大学海洋科学与环境学院福建厦门361005

赤点石斑鱼Epinephelus akaara作为我国南方海域的经济水产鱼类,已面临着种质资源匮乏,过度开发的局面。为了开展其保护生物学研究和促进养殖业的健康发展,开展了赤点石斑鱼群体的微卫星分析,对中国东南沿海7个赤点石斑鱼群体的遗传变... 详细信息

赤点石斑鱼Epinephelus akaara作为我国南方海域的经济水产鱼类,已面临着种质资源匮乏,过度开发的局面。为了开展其保护生物学研究和促进养殖业的健康发展,开展了赤点石斑鱼群体的微卫星分析,对中国东南沿海7个赤点石斑鱼群体的遗传变异进行了研究,发现在不同渔场之间的种群存在着丰富的遗传多样性,并且具有明显的地理区域分布特征,这为赤点石斑鱼的种质资源研究和遗传育种提供了遗传学基础。

关键词：赤点石斑鱼简单序列重复标记种群遗传遗传多样性