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Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin jiahui kang Xuan Cheng Hui Gao Shujia Huo Haiwei Xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

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Improving the Performance of DC Microgrids by Utilizing Adaptive Takagi-Sugeno Model Predictive Control

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CSEE Journal of Power and Energy Systems 2023年第4期9卷 1472-1481页

作者： Hui Hwang Goh jiahui kang Dongdong Zhang Hui Liu Wei Dai Tonni Agustiono Kurniawan Kai Chen Goh School of Electrical Engineering Guangxi UniversityNanningGuangxi 530004China the College of the Environment and Ecology Xiamen UniversityFujian 361102China Department of Technology Management Faculty of Construction Management and BusinessUniversity Tun Hussein Onn Malaysia86400 Parit RajaJohorMalaysia.

In naval direct current(DC)microgrids,pulsed power loads(PPLs)are becoming more prominent.A solar sys-tem,an energy storage system,and a pulse load coupled directly to the DC bus compose a DC microgrid in this *** DC mi-crogrids equipped with sonar,radar,and other sensors,pulse load research is *** to high pulse loads,there is a possibility of severe power pulsation and voltage *** original contribution of this paper is that we are able to address the nonlinear problem by applying the Takagi-Sugeno(TS)model formulation for naval DC ***,we provide a nonlinear power observer for estimating major disturbances affecting DC *** demonstrate the TS-potential,we examine three approaches for mitigating their negative effects:instantaneous power control(IPC)control,model predictive control(MPC)formulation,and TS-MPC approach with compensated *** results reveal that the TS-MPC approach with adjusted PPLs effectively shares power and regulates bus voltage under a variety of load conditions,while greatly decreasing detrimental impacts of the pulse ***,the comparison confirmed the efficiency of this *** Terms-DC microgrids(MG),model predictive control(MPC),pulsed power loads(PPLs),nonlinear power observer,Takagi-Sugeno(TS)fuzzy model.

关键词： DC microgrids(MG) model predictive control(MPC) pulsed power loads(PPLs) nonlinear power observer Takagi-Sugeno(TS)fuzzy model.

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CONCENTRATIONS AND FLUXES OF DISSOLVED NUTRIENTS IN THE YANGTZE RIVER: LONG-TERM TRENDS AND ECOLOGICAL IMPACTS

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Frontiers of Agricultural Science and Engineering 2021年第4期8卷 559-567页

作者： Yandan FU jiahui kang Ziyue LI Xuejun LIU Wen XU College of Resources and Environmental Sciences National Academy of Agriculture Green DevelopmentKey Laboratory of Plant-Soil Interactions of the Ministry of the EnvironmentChina Agricultural UniversityBeijing 100193China

Intensifying human activity in the Yangtze River Basin(YRB) has substantially increased nutrient concentrations in the Yangtze River Estuary,leading to degradation of the coastal *** of nutrient determinations published over the past 50 years reveals a gradual decreasing trend in the concentrations and fluxes of dissolved silicate(DSi).However,both dissolved inorganic nitrogen(DIN) and dissolved inorganic phosphate(DIP) concentrations have increased significantly since the 1970 *** frequency and area covered by red tide outbreaks have increased greatly during this period,mainly due to changes in nutrient supply ratios [i.e.,N/P(DIN/DIP),N/Si(DIN/DSi),P/Si(DIP/DSi)].A strong correlation was found between the riverine DIN fluxes and the estimated DIN inputs from the major N sources,particularly fertilizers and atmospheric *** data provide a comprehensive assessment of nutrients in the YRB and their ecological impacts and indicate a potentially significant influence of atmospheric deposition on DIN loadings and fluxes.

关键词： atmospheric deposition ecological impacts nitrogen sources nutrients Yangtze River Delta

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Endoscopy-assisted lightweight diagnosis system based on transformers for colon polyp detection

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Optoelectronics Letters 2025年第1期21卷 57-64页

作者： FAN Weiming YU jiahui JU Zhaojie School of Automation and Electrical Engineering Shenyang Ligong University Department of Biomedical Engineering Zhejiang University School of Computing University of Portsmouth

The integration of endoscopy has significantly propelled the diagnosis and treatment of gastrointestinal diseases, with colonoscopy establishing itself as the primary method for early diagnosis and preventive care in colorectal cancer(CRC). Although deep learning holds promise in mitigating missed polyp rates, modern endoscopy examinations pose additional challenges, such as image blurring and atomizing. This study explores lightweight yet powerful attention mechanisms, introducing the spatial-channel transformer(SCT), an innovative approach that leverages spatial channel relationships for attention weight calculation. The method utilizes rotation operations for inter-dimensional dependencies, followed by residual transformation, encoding inter-channel and spatial information with minimal computational overhead. Extensive experiments on the CVC-Clinic DB polyp detection dataset, addressing endoscopy pitfalls, underscore the superiority of our SCT over other state-of-the-art methods. The proposed model maintains high performance, even in challenging scenarios.

关键词： Endoscopy

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Experimental Study on Diesel Spray and Flame Asymmetry Characteristics of Dual-Orifice Nozzles for a Medium-Speed Engine

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Journal of Thermal Science 2025年第1期34卷 303-322页

作者： JU Dehao LIU Rui ZHENG Liang DENG jiahui ZHANG Wenzheng HUO Jinlu HUANG Li Shanghai Marine Diesel Engine Research Institute National Key Laboratory of Marine Engine Science and Technology Key Laboratory for Power Machinery and Engineering Ministry of EducationShanghai Jiao Tong University

The asymmetry of the multi-orifice spray will cause uneven heat load of the marine diesel engine,thereby affecting its working performance and service ***,an in-depth understanding of the spray and flame characteristics of multi-orifice nozzles will guide the optimization of the nozzle structure,needle design and diesel atomization and combustion *** this reason,four groups of dual-orifice nozzles with different hole diameters(0.1-0.55 mm) and mass flow rates covering the typical marine medium-speed diesel injections are designed and customized,and the constant volume chamber(CVC) with high temperature and pressure is used to simulate the actual in-cylinder working conditions of the diesel engine for the spray visualization *** study the asymmetry of the fuel sprays discharged from a diesel injector,the multi-orifice nozzle is simplified as a dual-orifice nozzle in this *** with X-ray Computed Tomography(CT) imaging technology,the influences of the nozzle internal structure on the spray and flame asymmetry are studied in the constructed supercritical *** is found that the asymmetry of the inlet angle and the equivalent length-diameter ratio is positively correlated with the inconsistency of the dual *** an increase in the injection pressure and nozzle diameter,the asymmetry of the dual spray becomes more pronounced,resulting in greater disparities in the ignition delay times and ignition positions of the two ***,the increase in nozzle diameter also leads to combustion instability,resulting in a flame with a serrated *** the increase of ambient temperature,the proportion of liquid phase in the jet decreases and the relative density of spray front decreases.

关键词： atomization dual-orifice nozzle nozzle structure spray flame asymmetry

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Robust facial expression recognition via lightweight reinforcement learning for rehabilitation robotics

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Optoelectronics Letters 2025年第2期21卷 97-104页

作者： CHEN Yifan FAN Weiming GAO Hongwei YU jiahui JU Zhaojie School of Computing University of Portsmouth School of Automation and Electrical Engineering Shenyang Ligong University Department of Biomedical Engineering Zhejiang University

This paper proposes a lightweight reinforcement network (LRN) and auxiliary label distribution learning (ALDL)based robust facial expression recognition (FER) *** designed representation reinforcement (RR) network mainly comprises two modules,i.e.,the RR module and the auxiliary label space construction (ALSC) *** RR module highlights key feature messaging nodes in feature maps,and ALSC allows multiple labels with different intensities to be linked to one ***,LRN has a more robust feature extraction capability when model parameters are greatly reduced,and ALDL is proposed to contribute to the training effect of LRN in the condition of ambiguous training *** tested our method on FER-Plus and RAF-DB datasets,and the experiment demonstrates the feasibility of our method in practice during rehabilitation robots.

关键词： Reinforcement learning

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五运六气禀赋与葡萄膜炎病因病机的相关性研究

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中华中医药杂志 2023年第7期38卷 3363-3367页

作者：康佳荟周婉瑜韦东中国中医科学院西苑医院北京100091

目的:通过分析葡萄膜炎患者先天运气禀赋探究其体质性内因,并结合易患葡萄膜炎的流年运气学外因,明确葡萄膜炎的病因病机以预防其复发治未病。方法:采集2019年12月至2022年2月就诊于中国中医科学院西苑医院眼科并确诊为葡萄膜炎的患者... 详细信息

目的:通过分析葡萄膜炎患者先天运气禀赋探究其体质性内因,并结合易患葡萄膜炎的流年运气学外因,明确葡萄膜炎的病因病机以预防其复发治未病。方法:采集2019年12月至2022年2月就诊于中国中医科学院西苑医院眼科并确诊为葡萄膜炎的患者的出生日期,共979例。采集患者在2021年的发病情况,共收集发病日期161例。以采集到的出生日期和发病日期推演五运六气,统计各运气因素出现的频数并进行统计学分析。结果:①胎孕期岁运分布为太木最多。②胎孕期司天在泉分布为少阴君火司天,阳明燥金在泉最多。③胎孕期全运气禀赋分布为岁运太火,少阴君火司天,阳明燥金在泉最多。④葡萄膜炎患者于节气为寒露时出生者最多,季节为秋季出生者最多。⑤2021年二之运和二之气时段发病最多,其时主运为太火,客运为太木,主气为少阴君火,客气为少阴君火。以上结果分布差异均具有统计学意义(P<0.05)。结论:综合葡萄膜炎患者的易患体质和易于发病的流年运气学特点,葡萄膜炎的核心病因病机为金胜伐木,其次为水火交争,脾湿为患。

关键词：葡萄膜炎五运六气体质胎孕期病因

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Cu_2O@CuO-Pd核壳结构微纳米材料的制备与葡萄糖传感器应用研究

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中国陶瓷 2017年第5期53卷 14-20页

作者：钟哲康佳慧刘桂华南昌大学材料科学与工程学院南昌330000

通过液相法首先制备得到Cu_2O八面体前驱体,再通过添加Pd离子在液相条件下反应进行表面改性。研究了在不同Pd离子添加浓度情况下对表面形貌的影响,通过SEM及XRD检测分析,制备出棘刺状Cu_2O@CuO-Pd核壳结构微纳米材料,并对其应用在葡萄... 详细信息

通过液相法首先制备得到Cu_2O八面体前驱体,再通过添加Pd离子在液相条件下反应进行表面改性。研究了在不同Pd离子添加浓度情况下对表面形貌的影响,通过SEM及XRD检测分析,制备出棘刺状Cu_2O@CuO-Pd核壳结构微纳米材料,并对其应用在葡萄糖传感器的电化学性能进行测试。结果表明,添加Pd粒子后样品均得到了较好的表面改性,在Pd离子添加量为2.5 wt%的条件下,得到单分散性好,比表面积发达的Cu_2O@CuO-Pd核壳结构微纳米材料,检测表明在葡萄糖传感器应用中,灵敏度达545.83μA·cm^(-2)·m M^(-1),线性范围为0.01~6.50 mM,检出限为3μM,并具备很好的抗干扰性。

关键词：核壳结构 Pd离子 CuO 葡萄糖传感器

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不同微灌方式下水分调控对猕猴桃光合特性及产量的影响

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灌溉排水学报 2020年第4期39卷 17-25页

作者：甘雨康施浩然崔宁博康佳辉西华大学能源与动力工程学院成都610039 四川大学水力学与山区河流开发保护国家重点实验室成都610065 南方丘陵山区节水农业研究四川省重点实验室成都610066

【目的】为了研究不同微灌方式下水分调控对猕猴桃叶片光合特性及产量的影响,以"翠玉"猕猴桃为研究试材。【方法】采用小管出流(X)、微喷灌(P)和滴灌(D)3种灌溉方式在猕猴桃全生育期实施85%灌水量的轻度亏水(LD)、70%灌水量的中度亏水(M... 详细信息

【目的】为了研究不同微灌方式下水分调控对猕猴桃叶片光合特性及产量的影响,以"翠玉"猕猴桃为研究试材。【方法】采用小管出流(X)、微喷灌(P)和滴灌(D)3种灌溉方式在猕猴桃全生育期实施85%灌水量的轻度亏水(LD)、70%灌水量的中度亏水(MD1)、55%灌水量的偏重度亏水(MD2)和40%灌水量的重度亏水(SD)处理,并设置100%灌水量的对照组(CK),研究了猕猴桃叶片胞间CO2摩尔分数(Ci)、净光合速率(Pn)、气孔导度(Gs)、蒸腾速率(Tr)、羧化速率(CE)、瞬时水分利用效率(WUEi)、产量及产量水分利用效率(WUEET)在不同水分亏缺下的变化。【结果】与CK相比,D-MD1处理的日均WUEi及CE分别提高了8.5%和2.7%。P-MD1处理的日均Pn与CE较CK分别提高了10.7%和10.4%,X-MD1处理的日均Ci、Pn、CE较CK分别提高了10.9%、12.2%和11.4%。D、P和X三个处理的WUEET均较CK有不同程度的提高,但D、P和X的产量随着水分的亏缺程度的加大而下降,而滴灌各处理间无显著性差异。与CK相比D-MD1、P-MD1、X-MD1处理的产量分别提高了1.4%、1.6%、2.3%,重度亏水处理的产量显著低于其余水分处理,且其他各处理间无显著性差异。MD1处理在不降低产量的情况下,可以节约灌水同时提高WUEET,重度亏水与偏中度亏水间在WUEET无显著性差异,同时X-MD1的产量均高于其他处理。【结论】X-MD1处理是"翠玉"猕猴桃较为合适的灌溉水分亏缺模式。

关键词：灌溉方式亏水处理猕猴桃光合特性生理指标

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星载激光雷达探测云与气溶胶的仿真模拟

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激光与光电子学进展 2022年第10期59卷 388-401页

作者：廖淑君郜海阳寇蕾蕾康佳慧卜令兵王震南京信息工程大学中国气象局气溶胶-云-降水重点开放实验室江苏南京210044 南京信息工程大学大气物理学院江苏南京210044

在星载激光雷达的设计、研制和数据反演过程中,正演模型起到至关重要的作用。建立了一套星载激光雷达探测云与气溶胶的正演模型,整个模型具有模拟冰云场景、气溶胶场景等复杂多场景的能力,由8个子模块构成。针对532 nm通道的模拟结果表... 详细信息

在星载激光雷达的设计、研制和数据反演过程中,正演模型起到至关重要的作用。建立了一套星载激光雷达探测云与气溶胶的正演模型,整个模型具有模拟冰云场景、气溶胶场景等复杂多场景的能力,由8个子模块构成。针对532 nm通道的模拟结果表明:在深对流场景中的云层深厚,信号衰减严重,仅能获取云顶分布信息;而在冰云和气溶胶的场景中,需要考虑云层的微物理特性对气溶胶有效探测的影响。望远镜直径、卫星轨道高度和激光器单脉冲能量对信噪比的影响结果可以为星载激光雷达的参数设计提供支持。与CALIOP/CALIPSO实际探测结果的对比表明,正演模型计算的衰减后向散射系数与实际观测结果在结构分布上基本一致,但由于CALIPSO反演算法的不确定性及与正演模型参数设置上的差异性,在多廓线平均值的对比中,在不同高度上存在一定的差异。

关键词：星载激光雷达正演模型主动遥感云与气溶胶

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