检索结果-南通市图书馆

Computer Modeling in Engineering & Sciences 2023年第2期134卷 1137-1158页

作者： Hongliang Wang jiahua hu Danhuang Dong Cenfeng Wang Feixia Tang Yizheng Wang Changsen Feng Economic Research Institute of State Grid Hangzhou310016China College of Information Engineering Zhejiang University of TechnologyHangzhou310023China

With the rapid and wide deployment of renewable energy,the operations of the power system are facing greater challenges when dispatching flexible resources to keep power balance.The output power of renewable energy is uncertain,and thus flexible regulation for the power balance is highly demanded.Considering the multi-timescale output characteristics of renewable energy,a flexibility evaluation method based on multi-scale morphological decomposition and a multi-timescale energy storage deployment model based on bi-level decision-making are proposed in this paper.Through the multi-timescale decomposition algorithm on the basis of mathematical morphology,the multi-timescale components are separated to determine the flexibility requirements on different timescales.Based on the obtained flexibility requirements,a multi-timescale energy resources deployment model based on bi-level optimization is established considering the economic performance and the flexibility of system operation.This optimization model can allocate corresponding flexibility resources according to the economy,flexibility and reliability requirements of the power system,and achieve the trade-off between them.Finally,case studies demonstrate the effectiveness of our model and method.

关键词： Multi-timescale morphological decomposition flexibility evaluation energy storage deployment

Sulforaphane Attenuates CD36-mediated Platelet Hyperreactivity through Modulating cAMP/PKA/NOX2 Signaling in Hyperlipidemic Conditions

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Science and human Wellness 2024年

作者： Weiqi Li Chunting Wu Xinyu Zhou Xinhui huang Chunmei Zhang Yongjie Ma Jinqiu hu Xiaoyan Bi Junyu Ma Mengyao Li Dong Lu Liang hu jiahua Fan Fuli Ya Department of Nutrition School of Public Health Dali University Department of Laboratory Teaching Center School of Public Health Dali University Department of Health Management Gem Flower Xi'an Changqing Staff Hospital Shanghai Frontiers Science Center of TCM Chemical Biology Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese Medicine School of Integrative Medicine Shanghai University of Traditional Chinese Medicine School of Public Health Sun Yat-sen University Institute of Translational Medicine for Metabolic Diseases Dali University

Hyperlipidemia is a risk factor for clinically significant thrombotic events in cardiovascular diseases. Platelet reactivity in hyperlipidemic conditions is enhanced when platelet scavenger receptor CD36 recognizes oxidized lipids in oxidized low-density lipoprotein (ox-LDL) particles， a process that induces atherothrombosis. Sulforaphane (SFN) is a dietary isothiocyanate enriched in cruciferous vegetables and exerts multiple biological activities. The current study sought to investigate the efficacy of SFN on platelet hyperreactivity under hyperlipidemic conditions in vitro and in vivo. Using a series of platelet functional assays in human platelets in vitro， we demonstrated that SFN attenuated ox-LDL-increased platelet aggregation and activation (surface CD62P expression). Mechanistically， studies using pharmacological inhibitors clarified that these inhibitory effects of SFN were mainly modulated by down-regulating CD36-mediated activation of Src kinases， leading to enhanced activation of cAMP/PKA signaling， and resultant inhibition of NAD phosphate oxidase 2 (NOX2)-dependent generation of reactive oxygen species (ROS). Moreover， 12-week supplementation of SFN-enriched broccoli sprout extract (BSE， 0.06% diet) in hyperlipidemic C57BL/6J mice also decreased platelet hyperreactivity. Studies using pharmacological inhibitors of CD36， PKA and NOX2 showed that the efficacy of BSE supplementation was mainly through modulating CD36-mediated the cAMP/PKA/NOX2 signaling. Thus， through modulating the cAMP/PKA/NOX2 pathway and attenuating CD36-mediated platelet hyperreactivity， SFN may play important protective roles in atherothrombosis under hyperlipidemic conditions.

关键词：

Economic research on application of electric heating system based on game theory

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Global Energy Interconnection 2021年第3期4卷 315-323页

作者： Tonxin Feng Hong Zhang Guoping Chen jiahua hu Chao Ning Tiejiang Yuan Changji Electricity Corporation of State Gird Changji 831100P.R.China School of Electrical Engineering Dalian University of TechnologyDalian 116024P.R.China

The use of clean electricity to replace fossil energy burning for heating is an important emission reduction way to achieve carbon neutrality.Without a good business model,it is very difficult to promote electric heating as a replacement for coal-fired systems in some areas with abundant coal resources.This study proposed a new business model for electric heating with stakeholders that included the government,the power grid company,and heat users.Based on this model,a specific tri-objective optimization model was proposed with the electric heating promotion power,heating electricity price,and government subsidy as variables to characterize the game relationship of the stakeholders,and the components of the stakeholder benefit function were analyzed in detail.A classical multi-objective genetic algorithm was used to solve the model.Finally,an"electrical heating"project for a typical area in China was analyzed,and four promotion cases were examined.The results showed that the power grid company and users had an antagonistic relationship in relation to the electricity price,but the best solution was found for all three stakeholders due to the high financial subsidies provided by the government.

关键词： Carbon neutrality Electric hating Business model Multi-objective optimization Triple win

在线全文

学校读者我要写书评

暂无评论

基于二阶锥凸松弛的海上风电场内部无功优化

电力建设 2024年第1期45卷 92-101页

作者：张磊姜贞强倪佳华周胡陆艳艳项基中国电建集团华东勘测设计研究院有限公司杭州市311122 浙江大学电气工程学院杭州市310027

为了减少海上风电场有功网损,提出一种基于二阶锥凸松弛的海上风电场无功出力优化模型。该模型考虑最优潮流过程中所涉及的电网稳定要求与安全裕度,在各风机最大化有功出力的前提下,优化各风机无功出力,以减少网损,提高风场整体出力。... 详细信息

为了减少海上风电场有功网损,提出一种基于二阶锥凸松弛的海上风电场无功出力优化模型。该模型考虑最优潮流过程中所涉及的电网稳定要求与安全裕度,在各风机最大化有功出力的前提下,优化各风机无功出力,以减少网损,提高风场整体出力。通过二阶锥凸松弛的数学优化方法,解决多种约束下的潮流优化问题,给出了最大化风电场整体有功出力下的各风机无功出力最优值。最后,以舟山普陀海上风电场为例,对各机组无功出力进行了优化,并与基于启发式的粒子群优化算法和经典的内点法优化算法进行了对比,结果表明所提算法能明显减少系统有功损耗,提升风电场整体有功出力。

关键词：海上风电场无功优化最优潮流凸优化

在线全文

学校读者我要写书评

暂无评论

基于协同知识嵌入注意网络的推荐算法研究

计算机应用与软件 2024年第4期41卷 297-305页

作者：师博雅梁光成孙宇健张家华胡泉中国航天系统科学与工程研究院北京100048 航天宏康智能科技(北京)有限公司北京100048

推荐系统广泛用于实际应用场景中,现有利用图神经网络的基于知识图谱的解决方法忽略了对知识图谱中蕴含丰富关系知识的有效编码。提出一种协同知识嵌入注意网络模型,通过在知识高阶传播过程中融入翻译模型对以三元组形式表示的知识进行... 详细信息

推荐系统广泛用于实际应用场景中,现有利用图神经网络的基于知识图谱的解决方法忽略了对知识图谱中蕴含丰富关系知识的有效编码。提出一种协同知识嵌入注意网络模型,通过在知识高阶传播过程中融入翻译模型对以三元组形式表示的知识进行有效编码,实现协同信息与知识传播更高效的融合方式,并通过拓展端到端模型CKAN完成推荐算法的设计。在三个真实推荐场景中的实验结果表明,相对于现有的KGCN、KGNN-LS、KGAT等方法,所提算法在点击率预测中的AUC值在Last.FM数据集上达到了0.8473,在Book-Crossing数据集上达到了0.7538,在Dianping-Food数据集上达到了0.8783;在Top-K推荐中的召回率均优于基准算法。

关键词：推荐系统协同过滤异质信息网络知识图谱嵌入图卷积神经网络

肠道病毒C组96型VP1蛋白线性B细胞表位筛选与鉴定

在线全文

学校读者我要写书评

暂无评论

华夏医学 2024年第2期37卷 1-9页

作者：何韵怡刘阳阳胡嘉华刘洪波桂林医学院医学检验学院桂林541199 桂林医学院第二附属医院检验科桂林541199 桂林医学院第二附属医院科研科桂林541199 广东省疾病预防控制中心广州511430

目的鉴定肠道病毒C组96型(enterovirus C96,EV-C96)VP1蛋白的线性B细胞表位。方法采用IEDB网站提供的在线分析工具分析、预测EV-C96 VP1蛋白的线性B细胞表位,结合其二级结构、β-转角、抗原性、亲水性等多项参数,筛选出优势候选表位;应... 详细信息

目的鉴定肠道病毒C组96型(enterovirus C96,EV-C96)VP1蛋白的线性B细胞表位。方法采用IEDB网站提供的在线分析工具分析、预测EV-C96 VP1蛋白的线性B细胞表位,结合其二级结构、β-转角、抗原性、亲水性等多项参数,筛选出优势候选表位;应用间接ELISA法检测候选表位与EV-C96免疫血清的反应性以及与21种其他常见手足口病病原血清的交叉反应性;应用微量中和试验测定表位抗体的中和效价;采用序列比对分析表位的序列保守性;应用结构对齐分析表位的结构特异性。结果通过生物信息学筛选出EVC96 VP1蛋白7个候选表位(P1~P7);ELISA法检测发现P7(氨基酸序列位置为282~304)与EV-C96多克隆抗体有强反应性,与其他常见EV多克隆抗体不发生明显反应;微量中和试验显示,P7抗体的中和效价低于1∶2;序列及结构分析结果显示,P7的氨基酸序列在EV-C96型内具有较高保守性,与其他EV相应位点氨基酸序列的结构有明显差异。结论P7表位为EV-C96特异的非中和性B细胞表位,可作为开发EV-C96检测试剂盒的候选抗原表位。

关键词：肠道病毒C组96型 VP1蛋白线性B细胞表位手足口病

在线全文

学校读者我要写书评

暂无评论

松滋市施肥现状与化肥减量增效调查分析

绿色科技 2024年第7期26卷 185-188页

作者：陈元畅胡斌李家华谢承平段炼松滋市新江口街道农业技术服务中心湖北松滋434200 湖北省农业科学院农业经济技术研究所湖北武汉430064

科学施肥是农业提质增效的重要手段和途径。为保护耕地地力,提高化肥利用率,促进农业提质增效,采取定田块、定农户入户调查的方式获取第一手数据,并对2006年、2021年、2022年3年的数据进行分析,结果表明:化肥用量大幅下降,2006-2022年,... 详细信息

科学施肥是农业提质增效的重要手段和途径。为保护耕地地力,提高化肥利用率,促进农业提质增效,采取定田块、定农户入户调查的方式获取第一手数据,并对2006年、2021年、2022年3年的数据进行分析,结果表明:化肥用量大幅下降,2006-2022年,亩平化肥用量(折纯)下降了6.8 kg,下降率为22.3%;同时施肥结构和施肥方式也有很大改进,单质肥用量下降,复合肥、有机肥、中微量元素肥料用量上升,施肥方式也从传统的撒施方式向机械集中深施方式转变。因此,提出了化肥减量增效途径主要体现在“精准施肥减量增效”“调优结构减量增效”“改进方式减量增效”“多元替代减量增效”4个方面。

关键词：肥料种类施肥方式施肥结构减量增效

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

乳房整形美容术后早期疼痛的临床特征研究

组织工程与重建外科 2024年第1期20卷 104-110页

作者：屠轶华杨琳陆吟文陆亭宇胡佳骅上海交通大学医学院附属第九人民医院整复外科上海市200011

目的调查三类乳房整形美容手术后早期患者疼痛的临床特征,为优化疼痛管理方案提供依据。方法收集2021年11月至2022年8月收治的72例行隆乳术、乳房缩小成形术、乳房悬吊术的患者资料,于术后1 d、2 d、3 d分别记录疼痛水平(数字疼痛评分... 详细信息

目的调查三类乳房整形美容手术后早期患者疼痛的临床特征,为优化疼痛管理方案提供依据。方法收集2021年11月至2022年8月收治的72例行隆乳术、乳房缩小成形术、乳房悬吊术的患者资料,于术后1 d、2 d、3 d分别记录疼痛水平(数字疼痛评分、修订版面部表情疼痛评估法)、疼痛部位、伴随症状、用药情况,分析疼痛的临床特征。结果术后1~3 d的疼痛水平总体呈现下降趋势。隆乳术后的患者疼痛水平最高,持续处于中等疼痛水平,疼痛部位以腋下(68.60%)、乳房上方(49%)居多;乳房缩小成形术、乳房悬吊术后患者的疼痛部位以乳房下缘(33.30%)、乳晕(33.30%)和乳房外侧(26.70%)为主,部分位置的双侧乳房疼痛发生率不一致。多数患者不伴有其他症状。58.33%的患者在术后1 d使用1种药物镇痛,37.5%的患者在术后2 d使用2种及以上药物镇痛,76.39%的患者在术后3 d无需使用药物。结论隆乳术后患者的早期疼痛值得重点关注,疼痛发生位置主要与切口、引流留置、假体植入、血肿发生有关。在评估疼痛时应关注双侧乳房疼痛的区域特征,识别疼痛原因,尽早发现并预防血肿。镇痛药物的选择应避免同机制药物的叠加使用,实施多模式镇痛,联合非药物干预措施,共同管理疼痛及药物不良反应。

关键词：乳房整形美容术隆乳术乳房缩小成形术乳房悬吊术疼痛

Detection and quantification of intracellular miR-222 to estimate drug resistance of breast cancer

在线全文

学校读者我要写书评

暂无评论

Detection and quantification of intracellular miR-222 to est...

基于数据挖掘和网络药理学分析国医大师李佃贵治疗复发性阿弗他溃疡的用药规律及作用机制

2017年中国肿瘤标志物学术大会暨第十一届肿瘤标志物青...

作者： jiahua hu Zhian Liu Jianhua Zhao Center of Clinical Laboratory Science Jiangsu Cancer Hospital Affiliated to Nanjing Medical University

Objective: Breast cancer, one of the most common malignancies in women, has become a major deadly cancer that threatens women’s health. The main obstacle to the clinical treatment of breast cancer is the formation of acquired-drug resistance of breast cancer cells. Growing evidence shows that miRNAs take part in the development, metastasis, and drug resistance of breast cancer, and our previous study has demonstrated that miR-222 is a specific miRNA for breast cancer drug resistance. In the process of drug resistance formation of breast cancer cells, miR-222 is selectively enriched by cells to their exosomes and then transferred to the surrounding sensitive breast cancer cells by exosomes, which results in the spread of acquired-drug resistance. And changes in the number of miR-222 cells in breast cancer cells by exogenous importing can also lead to a corresponding change in cell resistance. As the functions of miRNAs are increasingly recognized, there are more and more techniques for analyzing miRNA expression, including Northern blotting, microarray and polymerase chain reaction（PCR）. All of these methods are able to analyze the level of expression of miRNAs, but the downside is that they require the lysis of a cell population. Thus, the above method can not assess the miRNA abundance of a single cell. Fluorescence in situ hybridization（FISH） is a hotspot technology developed in recent years to detect miRNAs, as it can detect miRNAs without cleavage of cells. Locked nucleic acid（LNA） oligonucleotides can be used as hybridization probes to provide the spatial localization of miRNAs at the tissue, cellular, and subcellular levels. However, combining FISH with LNA（LNA-FISH） only provides tissue and intracellular distribution of miRNAs, it still can not provide accurate quantitative expression of miRNAs. Enzyme-labeled fluorescence（ELF） is an excellent solution to overcome the above shortage. The ELF signal amplification system is a unique immunofluorescence amplification technique to achieve high specificity and s

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

中医药导报 2024年第6期30卷 105-112,124页

作者：翟文静揣强赵蒙蒙刘建平王佳华张艺凡胡博乾河北中医药大学研究生学院河北石家庄050000 河北省中医院河北石家庄050000 河北省中西医结合胃肠病研究重点实验室河北石家庄050000

目的:通过数据挖掘技术和网络药理学分析国医大师李佃贵教授治疗复发性阿弗他溃疡(RAU)的用药规律,筛选核心处方并对其潜在机制进行分析,以期为临床治疗RAU提供思路及理论依据。方法:收集2021年1月至2023年7月李佃贵教授治疗RAU患者的... 详细信息

目的:通过数据挖掘技术和网络药理学分析国医大师李佃贵教授治疗复发性阿弗他溃疡(RAU)的用药规律,筛选核心处方并对其潜在机制进行分析,以期为临床治疗RAU提供思路及理论依据。方法:收集2021年1月至2023年7月李佃贵教授治疗RAU患者的门诊处方,运用SPSS Statistics 26.0、SPSS Modeler 18.0分析软件对筛选出的中药处方用药规律进行研究,并运用Cytoscape 3.9.1进行复杂网络的可视化,确定核心处方并通过网络药理学分析其治疗RAU的成分、靶点、作用通路等。结果:共纳入医案156则,录入有效中药处方103份,共计164味中药,总频数为2121。药物频数较高的是黄连、生地黄、黄芩、柴胡、清半夏、川牛膝、淡竹叶、蒲公英等,药性以寒、温居多,药味以苦、甘、辛为主,归经主要为肺、肝、胃经。核心处方为黄连、生地黄、黄芩、柴胡、清半夏,其重要活性成分有槲皮素、豆甾醇、山柰酚和生物素酰基-4-氨基丁酸等,关键靶点包括肿瘤坏死因子(TNF)、白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)、γ干扰素(IFN-γ)等,关键通路有PI3K-Akt信号通路、ACE-RACE信号通路等。结论:李佃贵教授认为浊毒内蕴是RAU的核心病机,并以清热化湿、泄浊解毒法治疗RAU。核心处方可能通过PI3K-Akt信号通路、ACE-RACE信号通路起到治疗RAU的作用。

关键词：复发性阿弗他溃疡数据挖掘网络药理学核心处方用药规律李佃贵