检索结果-南通市图书馆

Residual Thermal Stresses of Laser Cladding of Intermetallic-Ceramic Composite Coatings

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 1997年第2期11卷 31-33页

作者： zhou Xianglin HU Hanqi YU jiahong(Metallurgy Engineering School, USTB, Beijing 100083, China)(Department of Materials Engineering, Shandong University of Technology, 250014) USTB Beijing China

The stresses in laser cladding of Ni3Al-WC composite coating co and in heat affect zone (HAZ) σh have been induced based on considering the influences of laser processing parameters power P and beam traverse speed *** to the calculated results, certain limits of P and v are necessary in order to obtain crack free coatings. It agrees well with the experimental results.

关键词： intermetallics ceramics composite coatings residual thermal stress laser cladding

Upconversion Luminescence Properties of Mn^(2+)-Doped NaYF_4:Yb/Er Nanoparticles

在线全文

学校读者我要写书评

暂无评论

Wuhan University Journal of Natural Sciences 2013年第3期18卷 207-212页

作者： LI Haiyang WANG jiahong NAN Fan LIANG Shan ZHONG Yuting zhou Li WANG Ququan School of Physics and Technology/Key Laboratory of Artificial Micro-and Nano-Structures of Ministry of Education Wuhan University

NaYF 4：Yb/Er upconversion nanoparticles doped with Mn 2＋ were synthesized by hydrothermal *** upconversion photoluminescence measured by 975 nm continuous wave laser indicates that the as-synthesized samples generated green and red color emission with various intensity ratio ranging from 3.25 to 548.35,which is highly correlative to the dopant concentration of Mn 2＋.However,there is no red emission enhancement observed in Cu 2＋-doped NaYF 4：Yb/Er nanoparticles.

关键词： upconversion luminescence NaYF 4:Yb/Er nanoparticles Mn 2+ doped

Effects of seismic surge waves and implications for moraine-dammed lake outburst

在线全文

学校读者我要写书评

暂无评论

Frontiers of Earth Science 2016年第3期10卷 570-577页

作者： Cui DU Lingkan YAO Yidan HUANG jiahong YAN Subhashsagar SHAKYA MOE Key Laboratory of High-speed Railway Engineering Southwest Jiaotong University Chengdu 610031 China Road and Railway Engineering Research Institute Sichuan Key Laboratory of Aseismic Engineering and Technology Chengdu 610031 China School of Civil Engineering Henan University of Science and Technology Luoyang 471023 China

Moraine dams usually collapse due to over- topping by the surge wave in the dammed lake, and the surge wave is most likely caused by an earthquake. The seismic water wave （SWW） is a major factor causing the dam to break in the earthquake zone. This paper focused on the SWW by model experiments with a shaking water tank under conditions of various water depths, seismic waves, and peak ground accelerations. Two empirical equations were obtained for estimating maximal wave height for the low and high frequency, respectively. Finally, we present the application of the empirical equations on Midui Glacier Lake in Tibet plateau.

关键词： seismic water wave shaking water tankexperiment seismic wave moraine-dammed lake outburst

Plasma Extracellular Vesicle MicroRNA Analysis of Alzheimer’s Disease Reveals Dysfunction of a Neural Correlation Network

在线全文

学校读者我要写书评

暂无评论

Research 2023年第4期2023卷 689-699页

作者： Yuzhe Sun Zhen Hefu Benchao Li Wang Lifang Song Zhijie Li zhou Yan Deng Liu Zhili jiahong Ding Tao Li Wenwei Zhang Nie Chao Shuang Rong Department of Nutrition and Food Hygiene School of Public HealthMedical CollegeWuhan University of Science and TechnologyWuhanChina BGI-Shenzhen ShenzhenChina Shenzhen Key Laboratory of Neurogenomics BGI-ShenzhenShenzhen 518120China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China.

Small extracellular vesicle(sEV)is an emerging source of potential biomarkers of Alzheimer's disease(AD),but the role of microRNAs(miRNAs)in sEV is not well *** this study,we conducted a comprehensive analysis of sEV-derived miRNAs in AD using small RNA sequencing and coexpression network *** examined a total of 158 samples,including 48 from AD patients,48 from patients with mild cognitive impairment(MCI),and 62 from healthy *** identified an miRNA network module(M1)that was strongly linked to neural function and showed the strongest association with AD diagnosis and cognitive *** expression of miRNAs in the module was decreased in both AD and MCI patients compared to *** analysis revealed that M1 was highly preserved in the healthy control group but dysfunctional in the AD and MCI groups,suggesting that changes in the expression of miRNAs in this module may be an early response to cognitive decline prior to the appearance of AD *** further validated the expression levels of the hub miRNAs in M1 in an independent *** functional enrichment analysis showed that 4 hub miRNAs might interact with a GDF11-centered network and play a critical role in the neuropathology of *** summary,our study provides new insights into the role of sEV-derived miRNAs in AD and suggests that M1 miRNAs may serve as potential biomarkers for the early diagnosis and monitoring of AD.

关键词： network analysis. diagnosis

SIRT6 as a key event linking P53 and NRF2 counteracts APAP-induced hepatotoxicity through inhibiting oxidative stress and promoting hepatocyte proliferation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2021年第1期11卷 89-99页

作者： Yanying zhou Xiaomei Fan Tingying Jiao Wenzhou Li Panpan Chen Yiming Jiang jiahong Sun Yixin Chen Pan Chen Lihuan Guan Yajie Wen Min Huang Huichang Bi School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China Shenzhen Baoan Women’s and Children’s Hospital Jinan UniversityShenzhen 518102China Department of Pharmacy the First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China

Acetaminophen(APAP)overdose is the leading cause of drug-induced liver injury,and its prognosis depends on the balance between hepatocyte death and *** 6(SIRT6)has been reported to protect against oxidative stress-associated DNA *** whether SIRT6 regulates APAPinduced hepatotoxicity remains *** this study,the protein expression of nuclear and total SIRT6 was up-regulated in mice liver at 6 and 48 h following APAP treatment,***6 knockdown in AML12 cells aggravated APAP-induced hepatocyte death and oxidative stress,inhibited cell viability and proliferation,and downregulated CCNA1,CCND1 and CKD4 protein ***6 knockdown signifi-cantly prevented APAP-induced NRF2 activation,reduced the transcriptional activities of GSTm andNQO1 and the m RNA levels of Nrf2,Ho-1,Gsta and ***,SIRT6 showed potential protein interaction with NRF2 as evidenced by co-immunoprecipitation(Co-IP)***,the protective effect of P53 against APAP-induced hepatocytes injury was *** Sirt6 m RNA was significantly down-regulated in P53à/àmice.P53 activated the transcriptional activity of SIRT6 and exerted interaction with *** results demonstrate that SIRT6 protects against APAP hepatotoxicity through alleviating oxidative stress and promoting hepatocyte proliferation,and provide new insights in the function of SIRT6 as a crucial docking molecule linking P53 and NRF2.

关键词： Acetaminophen Hepatotoxicity SIRT6 NRF2 P53

碳量子点@金纳米团簇比率荧光传感器的制备及应用

在线全文

学校读者我要写书评

暂无评论

硅酸盐学报 2024年第2期52卷 661-670页

作者：郑佳红周艳长安大学材料科学与工程学院西安710061

比率荧光传感器与单波长荧光传感器相比抗干扰能力强、更加灵敏、可视化检测结果可靠。采用水热法合成氮、硫掺杂的碳量子点(N,S-CQDs)及稳定性良好的金纳米团簇(BSA-Au NCs),构建了N,S-CQDs@BSA-AuNCs比率荧光传感器,用于连续测定Ce^(... 详细信息

比率荧光传感器与单波长荧光传感器相比抗干扰能力强、更加灵敏、可视化检测结果可靠。采用水热法合成氮、硫掺杂的碳量子点(N,S-CQDs)及稳定性良好的金纳米团簇(BSA-Au NCs),构建了N,S-CQDs@BSA-AuNCs比率荧光传感器,用于连续测定Ce^(4+)和AA(维生素C)。结果表明,该比率荧光传感器基于“关-开-关”检测机理在最优条件下,I_(F_(429))/I_(F_(692))与Ce^(4+)浓度之间有良好的线性关系,检测限为0.12μmmol/L;N,S-CQDs@BSA-AuNCs/Ce^(4+)加入AA后,I_(F_(429))/I_(F_(692))与不同浓度的AA在1~10μmol/L范围内也呈现良好的线性关系,检测限为0.19μmol/L。探究了一些可能共存物质的干扰,实现该比率荧光传感器对Ce^(4+)、AA的选择性识别和快速检测。

关键词：抗坏血酸铈离子比率荧光传感器碳量子点

Eu^(3+)参比碳点比率荧光传感器构建及用于环丙沙星检测

在线全文

学校读者我要写书评

暂无评论

硅酸盐学报 2022年第9期50卷 2477-2482页

作者：郑佳红周艳长安大学材料科学与工程学院西安710061

以碳量子点(CQDs)和铕离子(Eu^(3+))为荧光基团,构建比率荧光探针(CQDs/Eu^(3+)),用于环丙沙星(CIP)的检测。在395 nm波长激发下,CQDs/Eu^(3+)在459 nm处存在较强的蓝色荧光峰,在616 nm处存在较弱的红色荧光峰,当CIP存在时,基于天线效... 详细信息

以碳量子点(CQDs)和铕离子(Eu^(3+))为荧光基团,构建比率荧光探针(CQDs/Eu^(3+)),用于环丙沙星(CIP)的检测。在395 nm波长激发下,CQDs/Eu^(3+)在459 nm处存在较强的蓝色荧光峰,在616 nm处存在较弱的红色荧光峰,当CIP存在时,基于天线效应使得459 nm处的CQDS荧光强度增强。研究优化了CQDs和Eu^(3+)比例、响应时间、稳定性等实验条件,结果表明:该比率荧光探针对CIP具有特异性识别能力,荧光强度比(F_(459)/F_(616))与不同浓度CIP(0~7×10^(-6)mol/L)之间存在良好的线性关系,对CIP的最低检测限为0.3×10^(-6)mol/L,随着CIP的加入,成功用于牛奶中CIP检测。

关键词：碳量子点铕离子比率荧光探针环丙沙星

在线全文

学校读者我要写书评

暂无评论

《石室秘录》从肾论治方药规律分析

亚太传统医药 2022年第6期18卷 171-176页

作者：周嘉虹许银坤林育纯朱悦鄢晓婷张定华王一凡张华豪许伟帅吴翠敏广州市正骨医院广东广州510030 广州中医药大学广东广州510006 肇庆学院广东肇庆526061 江西中医药大学江西南昌330004 广东省中医院广东广州510120

目的:研究医家陈士铎《石室秘录》中从肾论治组方的用药规律,为从肾论治疾病的临床运用与药物研发提供参考。方法:利用软件IBM SPSS Statistics(ISS)23、R Language(RL)等对《石室秘录》中的涉及从肾论治相关的方剂药物信息进行描述性... 详细信息

目的:研究医家陈士铎《石室秘录》中从肾论治组方的用药规律,为从肾论治疾病的临床运用与药物研发提供参考。方法:利用软件IBM SPSS Statistics(ISS)23、R Language(RL)等对《石室秘录》中的涉及从肾论治相关的方剂药物信息进行描述性分析、因子分析与聚类分析。结果:《石室秘录》从肾论治方中使用频数频率较高的药物共有31味,其中使用频率居前的有熟地黄、麦冬、人参、山茱萸、白术、五味子、茯苓与肉桂等;用药主要涉及11个药类,以补虚药、收涩药、利水渗湿药、温里药、清热药与化痰止咳平喘药等排名居前,累计频率可达72.97%;药味以甘、苦、辛味使用最频繁,药性中以温、寒、平三者为多;药物归经中,以肾经居首位,肺经与脾经居第二与第三位;药物来源基本都是植物,以根及根茎类为排名第一,频率为48.83%,果实及种子类居其次,频率为18.99%;因子分析共得出10个公因子,聚类分析出5个从肾论治新方。结论:《石室秘录》从肾论治组方注重以五行论治,金水互用,水火既济。金水互用使肺肾通调以利水渗湿;水火既济以交通心肾,安神益精。且重视从阴阳论理组方,专治肾阴,补敛固精,甘温补阳,兼治脾肾。

关键词：《石室秘录》陈士铎从肾论治方药规律数据挖掘

基于UiO–66–NH2@Eu–MOFs比率荧光探针的构建及其对PO_(4)^(3–)检测

在线全文

学校读者我要写书评

暂无评论

硅酸盐学报 2023年第3期51卷 796-802页

作者：郑佳红周艳长安大学材料科学与工程学院西安710061

以发射蓝色荧光的Ui O–66–NH2和发射红色荧光的Eu–MOFs为荧光基团,构建了比率荧光探针(Ui O–66–NH2@Eu–MOFs),成功应用于环境水样中的微量PO_(4)^(3–)的检测。将发射蓝色荧光UiO–66–NH2与发射红色荧光Eu–MOF结合,构建了测定... 详细信息

以发射蓝色荧光的Ui O–66–NH2和发射红色荧光的Eu–MOFs为荧光基团,构建了比率荧光探针(Ui O–66–NH2@Eu–MOFs),成功应用于环境水样中的微量PO_(4)^(3–)的检测。将发射蓝色荧光UiO–66–NH2与发射红色荧光Eu–MOF结合,构建了测定环境水样中的微量PO_(4)^(3–)的比率荧光探针。结果表明:当PO_(4)^(3–)存在时,由于配体–金属电荷转移(LMCT)效应的减弱,导致UiO–66–NH2的荧光增强;另一方面,PO_(4)^(3–)和Eu3+的强配位作用将阻止配体–金属的能量转移(LMET),破坏了“天线”效应并导致Eu–MOF的荧光猝灭,在最优条件下,F445/F633与PO_(4)^(3–)在1~12μmol/L浓度范围内呈现良好的线性关系,表明该传感器对检测PO_(4)^(3–)有较好的选择性和灵敏性,为PO_(4)^(3–)的快速检测提供了一种新思路。

关键词：荧光磷酸根离子配体–金属电荷转移配体–金属能量转移天线效应