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Tackling application limitations of high-safetyγ-butyrolactone electrolytes:Exploring mechanisms and proposing solutions

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Journal of Energy Chemistry 2024年第6期93卷 193-201,I0005页

作者： Haojun Wu Zhangyating Xie Guanjie Li Lei Zheng Zhiwei Zhao Jiarong He Yanbin Shen jiahao hu Zhangquan Peng Guiming Zhong Lidan Xing Weishan Li School of Chemistry South China Normal UniversityGuangzhou 510006GuangdongChina National and Local Joint Engineering Research Center of MPTES in High Energy and Safety LIBs Engineering Research Center of MTEES(Ministry of Education)Research Center of BMET(Guangdong Province)and Key Lab.of ETESPG(GHEI)South China Normal UniversityGuangzhou 510006GuangdongChina Laboratory of Advanced Spectroelectrochemistry and Li-ion Batteries Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina i-Lab CAS Center for Excellence in NanoscienceSuzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of SciencesSuzhou 215123JiangsuChina School of Chemical Engineering Faculty of SciencesEngineering and TechnologyThe University of AdelaideSA 5005Australia

Developing wide-temperature and high-safety lithium-ion batteries(LIBs)presents significant challenges attributed to the absence of suitable solvents possessing broad liquid range and non-flammability properties.γ-Butyrolactone(GBL)has emerged as a promising solvent;however,its incompatibility with graphite anode has hindered its *** limitation necessitates a comprehensive investigation into the underlying mechanisms and potential *** this study,we achieve a molecular-level understanding of the perplexing interphase formation process by employing in-situ spectroelectrochemical techniques and density function *** findings reveal that,even at high salt concentrations,GBL consistently occupies the primary Li^(+)solvation sheath,leading to extensive GBL decomposition and the formation of a high-impedance and inorganic-poor solid-electrolyte interphase(SEI)*** to manipulating solvation structures,our research demonstrates that the utilization of filmforming additives with higher reduction potential facilitates the pre-establishment of a robust SEI film on the graphite *** approach effectively inhibits GBL decomposition and significantly enhances the battery's *** study provides the first reported intrinsic understanding of the unique GBLgraphite incompatibility and offers valuable insights for the development of wide-temperature and high-safety LIBs.

关键词： γ-Butyrolactone/Graphite incompatibility Unique solvation structure SEI film Lithium-ion batteries

A novel FGFR1 inhibitor CYY292 suppresses tumor progression,invasion,and metastasis of glioblastoma by inhibiting the Akt/GSK3β/snail signaling axis

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Genes & Diseases 2024年第1期11卷 479-494页

作者： Yanran Bi Ruiling Zheng jiahao hu Ruiqing Shi Junfeng Shi Yutao Wang Peng Wang Wenyi Jiang Gyudong Kim Zhiguo Liu Xiaokun Li Li Lin School of Pharmaceutical Science Wenzhou Medical UniversityWenzhouZhejiang 325035China College of Pharmacy and Research Institute of Drug Development Chonnam National UniversityGwangju 61186Republic of Korea Department of Dermatology Wenzhou Hospital of Integrated Traditional Chinese and Western MedicineWenzhouZhejiang 325000China Zhejiang Lab for Regenerative Medicine Oujiang LaboratoryWenzhouZhejiang 325035China

Glioblastoma(GBM)is a malignant brain tumor that grows quickly,spreads widely,and is resistant to *** growth factor receptor(FGFR)1 is a receptor tyrosine kinase that regulates cellular processes,including proliferation,survival,migration,and ***1 was predominantly expressed in GBM tissues,and FGFR1 expression was negatively correlated with overall *** rationally designed a novel small molecule CYY292,which exhibited a strong affinity for the FGFR1 protein in GBM cell lines in ***292 also exerted an effect on the conserved Ser777 residue of ***292 dose-depen-dently inhibited cell proliferation,epithelial-mesenchymal transition,stemness,invasion,and migration in vitro by specifically targeting the FGFR1/AKT/Snail pathways in GBM cells,and this effect was prevented by pharmacological inhibitors and critical gene *** vivo experiments revealed that CYY292 inhibited U87MG tumor growth more effectively than ***292 also efficiently reduced GBM cell proliferation and increased survival in orthotopic GBM *** study further elucidates the function of FGFR1 in the GBM and reveals the effect of CYY292,which targets FGFR1,on downstream signaling pathways directly reducing GBM cell growth,invasion,and metastasis and thus impairing the recruitment,activation,and function of immune cells.

关键词： Blood-brain barrier EMT FGFR1 FGFR1 inhibitor Glioblastoma

SiO_(2) Induces Iron Overload and Ferroptosis in Cardiomyocytes in a Silicosis Mouse Model

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Biomedical and Environmental Sciences 2024年第6期37卷 617-627页

作者： Yongheng Wang Ning Li Yi Guan Tong LI Yuxiu Zhang Hong Cao Zhihua Yu Zhiheng Li Shuoyan Li jiahao hu Wenxin Zhou Sisi Qin Shuang Li Sanqiao Yao School of Public Health North China University of Science and TechnologyTangshan 063210HebeiChina Hebei Key Laboratory of Occupational Health and Safety for Coal Industry North China University of Science and TechnologyTangshan 063210HebeiChina Occupational Disease Prevention and Control Institute of Jinneng Holding Coal Industry Group Co. LtdDatong 037001ShanxiChina China Pingmei Shenma Group Occupational Disease Prevention and Control Hospital Pingdingshan 467000HenanChina School of Public Health Xinxiang Medical UniversityXinxiang 453003HenanChina

Objective The aim of this study was to explore the role and mechanism of ferroptosis in SiO_(2)-induced cardiac injury using a mouse *** Male C57BL/6 mice were intratracheally instilled with SiO_(2) to create a silicosis ***-1(Fer-1)and deferoxamine(DFO)were used to suppress *** biomarkers,oxidative stress markers,histopathology,iron content,and the expression of ferroptosis-related proteins were *** SiO_(2) altered serum cardiac injury biomarkers,oxidative stress,iron accumulation,and ferroptosis markers in myocardial ***-1 and DFO reduced lipid peroxidation and iron overload,and alleviated SiO_(2)-induced mitochondrial damage and myocardial ***_(2) inhibited Nuclear factor erythroid 2-related factor 2(Nrf2)and its downstream antioxidant genes,while Fer-1 more potently reactivated Nrf2 compared to *** Iron overload-induced ferroptosis contributes to SiO_(2)-induced cardiac *** ferroptosis by reducing iron accumulation or inhibiting lipid peroxidation protects against SiO_(2) cardiotoxicity,potentially via modulation of the Nrf2 pathway.

关键词： SiO_(2) exposure Iron overload Ferroptosis Cardiac injury Nrf2

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肝脏微创外科近10年的发展与展望

中华外科杂志 2024年第1期62卷 6-9页

作者：蔡秀军胡家豪浙江大学医学院附属邵逸夫医院普外科杭州310016

随着微创外科手术与器械的推广与普及,微创技术已广泛应用于肝脏疾病的诊断与治疗。近十年来,微创相关器械设备的研发、技术水平的提升,以及理论体系的完善,使个体化微创精准理念在肝脏微创外科中越来越受到关注,肝脏微创外科也朝着创... 详细信息

随着微创外科手术与器械的推广与普及,微创技术已广泛应用于肝脏疾病的诊断与治疗。近十年来,微创相关器械设备的研发、技术水平的提升,以及理论体系的完善,使个体化微创精准理念在肝脏微创外科中越来越受到关注,肝脏微创外科也朝着创新驱动高质量发展的目标不断前进。

关键词：外科手术,微创性肝切除术进展发展趋势

Corrigendum to"A novel FGFR1 inhibitor CYY292 suppresses tumor progression,invasion,and metastasis of glioblastoma by inhibiting the Akt/GSK3β/snail signaling axis"[Genes&Diseases 11(2024)479-494]

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Genes & Diseases 2024年第3期11卷 485-490页

作者： Yanran Bi Ruiling Zheng jiahao hu Ruiqing Shi Junfeng Shi Yutao Wang Peng Wang Wenyi Jiang Gyudong Kim Zhiguo Liu Xiaokun Li Li Lin School of Pharmaceutical Science Wenzhou Medical UniversityWenzhou 325035China College of Pharmacy and Research Institute of Drug Development Chonnam National UniversityGwangju 61186Republic of Korea Department of Dermatology Wenzhou Hospital of Integrated Traditional Chinese and Western MedicineWenzhou 325000China Zhejiang Lab for Regenerative Medicine Oujiang LaboratoryWenzhou 325035China

The authors regret that in Figure 3C,the Western Blot(WB)image representing GAPDH levels was mistakenly chosen as the same image for ERK(indicated by the red dotted-line rectangle).We have attached the original WB strip for GAPDH to demonstrate that this was an unintentional error in image ***,we noticed that the Transwell images in the two upper panels of the right column in Figure 4J are misleading due to errors in image *** have attached the original data to show that this was also an unintentional *** assure you that these two corrections do not alter the scientificconclusionof thearticle.

关键词： GSK3β invasion metastasis

领导成员交换对酒店员工的服务创新行为的影响——以组织信任为中介变量

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科技和产业 2024年第1期24卷 131-137页

作者：胡家豪海南师范大学经济与管理学院海口571158

创新是引领发展的第一动力,员工的创新行为是企业持续发展和提升竞争力的关键所在。以社会交换理论为基础,基于286份酒店员工问卷构建结构方程模型,实证探究领导成员交换对酒店员工服务创新行为的影响及其作用机制。结果表明:领导成员... 详细信息

创新是引领发展的第一动力,员工的创新行为是企业持续发展和提升竞争力的关键所在。以社会交换理论为基础,基于286份酒店员工问卷构建结构方程模型,实证探究领导成员交换对酒店员工服务创新行为的影响及其作用机制。结果表明:领导成员交换和组织信任对酒店员工的服务创新行为存在显著正向影响;组织信任在领导成员交换和员工服务创新行为之间起到中介作用。该研究能够丰富上下级关系和员工服务创新行为的相关研究成果,对于改进酒店行业的管理实践也具有一定的现实意义。

关键词：领导成员交换组织信任员工服务创新行为

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剪力墙结构生成式设计与智能优化

建筑结构学报 2024年第7期45卷 22-30页

作者：王禄锋刘界鹏程国忠胡佳豪黄学思喻鹏重庆大学山地城镇建设与新技术教育部重点实验室重庆400045 重庆大学土木工程学院重庆400045 长厦安基工程设计有限公司重庆400041

目前,剪力墙结构的设计主要依赖设计师的设计经验以及不断试错。为了实现快速设计和最优设计,提出了生成式设计和智能优化相融合的剪力墙结构设计方法。基于Stable Diffusion(SD)模型对剪力墙结构进行生成式设计,并基于生成式设计的结... 详细信息

目前,剪力墙结构的设计主要依赖设计师的设计经验以及不断试错。为了实现快速设计和最优设计,提出了生成式设计和智能优化相融合的剪力墙结构设计方法。基于Stable Diffusion(SD)模型对剪力墙结构进行生成式设计,并基于生成式设计的结果使用禁忌搜索进行智能优化。基于SD模型的生成式设计主要包括使用小样本数据通过低秩适应方法对SD模型进行微调,矢量像素化和像素矢量化;基于禁忌搜索的智能优化包括参数空间的定义,邻域动作的定义,优化目标以及优化流程的设计。通过两个工程实例对所提出的方法进行了对比验证,结果表明,所提出的剪力墙结构生成式设计方法可在约30 s内生成满足基本设计需求的设计结果,智能优化后的设计结果与设计师的方案相似度可达85%,整个智能设计流程达到了辅助设计的目的。

关键词：剪力墙结构辅助设计智能设计生成式设计智能优化

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高层剪力墙结构多目标智能设计方法

土木工程学报 2024年第6期57卷 92-100页

作者：周绪红胡佳豪王禄锋刘界鹏程国忠齐宏拓黄学思颜峰重庆大学土木工程学院重庆400045 重庆大学山地城镇建设与新技术教育部重点实验室重庆400045 重庆重大建设工程质量检测有限公司重庆400045

高层剪力墙结构智能设计包括智能建模和智能优化两个环节。目前智能建模环节缺乏梁自动化布置和荷载自动化布置;智能优化环节只考虑材料成本而未考虑施工的便捷性。此外,现有的智能设计方法均局限于单标准层的高层剪力墙结构。为此,该... 详细信息

高层剪力墙结构智能设计包括智能建模和智能优化两个环节。目前智能建模环节缺乏梁自动化布置和荷载自动化布置;智能优化环节只考虑材料成本而未考虑施工的便捷性。此外,现有的智能设计方法均局限于单标准层的高层剪力墙结构。为此,该文提出了高层剪力墙结构多目标智能设计方法,包括多标准层高层剪力墙结构的智能建模和多目标优化。多标准层高层剪力墙结构智能建模包含剪力墙智能布置、梁自动化布置、板自动化布置和荷载自动化布置;以材料成本和施工便捷性为目标,采用分步优化策略和基于小生境技术的遗传算法对高层剪力墙结构进行多目标优化。通过实际工程算例对所提出的方法进行了验证,结果表明,所提出的高层剪力墙结构多目标智能设计方法稳定、可靠,可以较好地兼顾材料成本和施工的便捷性,并能显著缩短设计周期。

关键词：高层剪力墙结构智能设计智能建模多目标优化

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Y型管式油水分离结构分离特性仿真分析

工业水处理 2024年第5期44卷 192-197页

作者：华剑胡家浩马忠杰李伟王林虎长江大学机械结构强度与振动研究所湖北荆州434000

管式油水分离技术具有占地面积小、分离效率高、成本低等优点,基于管式油水分离原理,设计一种Y型管式油水分离结构,利用Fluent数值模拟软件,采用标准k-ε湍流模型和Mixture多相流模型,对Y型管内部流场特性以及外部参数对分离效率的影响... 详细信息

管式油水分离技术具有占地面积小、分离效率高、成本低等优点,基于管式油水分离原理,设计一种Y型管式油水分离结构,利用Fluent数值模拟软件,采用标准k-ε湍流模型和Mixture多相流模型,对Y型管内部流场特性以及外部参数对分离效率的影响进行了研究。结果表明,Y型管对流体扰动小,内部流场特性稳定不易产生涡流,能够实现油水分离,支管与主管交汇处存在油水分离现象;油水分离效率随着油滴粒径的增大而逐渐提高,油滴粒径越大越利于油相上浮聚集在Y型管上层,能有效提高油水分离效率;入口速度对油水分离效果的影响很大,速度越大,油相上浮时间越短,Y型管的分离效率越低;分离效率随支管分流比的增大而增大,当入口速度为0.5 m/s时,分流比超过0.4后,分离效率不再增加。研究结果为油水分离提供了新思路,可为Y型管的设计提供理论参考。

关键词： Y型管油水分离分离效率数值模拟