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Gut microbiota-derived short-chain fatty acids ameliorate methamphetamine-induced depression-and anxiety-like behaviors in a Sigmar-1 receptor-dependent manner

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Acta Pharmaceutica Sinica B 2023年第12期13卷 4801-4822页

作者： Kaikai Zhang Lijian Chen Jianzheng Yang Jiali Liu jiahao Li Yi Liu Xiuwen Li Long Chen Clare Hsu jiahao zeng Xiaoli Xie Qi Wang Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification School of Forensic MedicineSouthern Medical UniversityGuangzhou 510515China Department of Toxicology School of Public HealthSouthern Medical University(Guangdong Provincial Key Laboratory of Tropical Disease Research)Guangzhou 510515China

Methamphetamine(Meth)abuse can cause serious mental disorders,including anxiety and depression.The gut microbiota is a crucial contributor to maintaining host mental health.Here,we aim to investigate if microbiota participate in Meth-induced mental disorders,and the potential mechanisms involved.Here,15 mg/kg Meth resulted in anxiety-and depression-like behaviors of mice successfully and suppressed the Sigma-1 receptor(SIGMAR1)/BDNF/TRKB pathway in the hippocampus.Mean-while,Meth impaired gut homeostasis by arousing the Toll-like receptor 4(TLR4)-related colonic inflammation,disturbing the gut microbiome and reducing the microbiota-derived short-chain fatty acids(SCFAs).Moreover,fecal microbiota from Meth-administrated mice mediated the colonic inflam-mation and reproduced anxiety-and depression-like behaviors in recipients.Further,SCFAs supple-mentation optimized Meth-induced microbial dysbiosis,ameliorated colonic inflammation,and repressed anxiety-and depression-like behaviors.Finally,Sigmarl knockout(Sigmar1^(-/-))repressed the BDNF/TRKB pathway and produced similar behavioral phenotypes with Meth exposure,and elim-inated the anti-anxiety and-depression effects of SCFAs.The activation of SIGMAR1 with fluvoxamine attenuated Meth-induced anxiety-and depression-like behaviors.Our findings indicated that gut microbiota-derived SCFAs could optimize gut homeostasis,and ameliorate Meth-induced mental disorders in a SIGMAR1-dependent manner.This study confirms the crucial role of microbiota in Methrelated mental disorders and provides a potential preemptive therapy.

关键词： Methamphetamine Gut microbiota Short-chain fatty acids Sigma-1 receptor Mental disorders Colonic inflammation Intestinal barrier Gut-brain axis

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Physiological and transcriptome analyses of Chinese cabbage in response to drought stress

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Journal of Integrative Agriculture 2024年第7期23卷 2255-2269页

作者： Lin Chen Chao Li jiahao Zhang Zongrui Li Qi zeng Qingguo Sun Xiaowu Wang Limin Zhao Lugang Zhang Baohua Li State Key Laboratory for Crop Stress Resistance and High-Efficiency Production College of HorticultureNorthwest A&F UniversityYangling 712100China Institute of Vegetables and Flowers Chinese Academy of Agricultural SciencesBeijing 100081China

Chinese cabbage is an important leafy vegetable crop with high water demand and susceptibility to drought stress.To explore the molecular mechanisms underlying the response to drought,we performed a transcriptome analysis of drought-tolerant and-sensitive Chinese cabbage genotypes under drought stress,and uncovered core droughtresponsive genes and key signaling pathways.A co-expression network was constructed by a weighted gene coexpression network analysis(WGCNA)and candidate hub genes involved in drought tolerance were identified.Furthermore,abscisic acid(ABA)biosynthesis and signaling pathways and their drought responses in Chinese cabbage leaves were systemically explored.We also found that drought treatment increased the antioxidant enzyme activities and glucosinolate contents significantly.These results substantially enhance our understanding of the molecular mechanisms underlying drought responses in Chinese cabbage.

关键词： Chinese cabbage drought stress abscisic acid weighted gene co-expression network analysis glucosinolate

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基于声学特征分析的镨钕合金无损检测方法研究

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中国有色冶金 2024年第1期53卷 119-126页

作者：钟睿曾波华李嘉豪曹乐乐赣州职业技术学院江西赣州341000 江西理工大学江西赣州341000

当前镨钕等稀土合金铸锭成品的质量检测工序均采用人工钻检法和化学分析法,存在着质检周期长、成本高、严重依赖人工经验等缺陷,本文基于声学特征分析的技术,结合传感器、信号处理、经典工程控制等理论,提出了一种无损的物理检测方法。... 详细信息

当前镨钕等稀土合金铸锭成品的质量检测工序均采用人工钻检法和化学分析法,存在着质检周期长、成本高、严重依赖人工经验等缺陷,本文基于声学特征分析的技术,结合传感器、信号处理、经典工程控制等理论,提出了一种无损的物理检测方法。首先对熔盐电解得到镨钕合金进行成分分析,确定其碳含量指标可作为金属质量的分类特征,并且依靠声学信号能判断金属碳含量;其次采集镨钕合金受到外界脉冲激励时的声学信号,通过分析声学信号的时域波形,建立镨钕合金碳含量与其声学信号特征的内在关联模型;最后正交实验结果表明,声学信号的时域特征能较好区别镨钕合金的高低碳差异。

关键词：熔盐电解质量检测声学特征碳含量镨钕合金无损检测

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巡航高度对飞机燃油箱水污染物生成特性的影响

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航空动力学报 2024年第7期39卷 189-195页

作者：杨文举邵垒曾宪君周宝成贺佳伟杨家豪重庆交通大学航空学院重庆400074 重庆交通大学绿色航空技术研究院重庆401120

为研究巡航高度对燃油箱内水污染物生成的系统性影响,基于传热传质方程建立水污染物生成模型,对不同巡航高度下燃油箱内的溶解水、析出水、冷凝水、游离水等水污染物生成特性进行计算.结果表明:飞行过程中产生的析出水主要在爬升阶段,... 详细信息

为研究巡航高度对燃油箱内水污染物生成的系统性影响,基于传热传质方程建立水污染物生成模型,对不同巡航高度下燃油箱内的溶解水、析出水、冷凝水、游离水等水污染物生成特性进行计算.结果表明:飞行过程中产生的析出水主要在爬升阶段,且巡航高度越高产生的析出水越多,11 km巡航高度产生的析出水较7km时多出5.5%;冷凝水主要产生在巡航阶段,冷凝水总量随着巡航高度的增加而减少,11 km巡航高度产生的冷凝水较7km时减少了 34.4%;飞行过程中产生的游离水总量随着巡航高度的增加而增加,但增加幅度逐渐减缓,9km巡航高度产生的游离水较7km增加了 1.88%,11 km巡航高度产生的游离水较9 km增加了 0.92%.

关键词：水污染物巡航高度飞机燃油箱传热传质燃油温度

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基于相似日的光伏组件积灰损失预测

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热力发电 2024年第6期53卷 21-29页

作者：曾侨飞李斌李新福陈佳豪杨雨昂华北电力大学能源动力与机械工程学院河北保定071003

为研究灰尘对光伏发电性能的影响,通过搭建的实验台采集清洁与污染光伏组串每天的发电数据,同时监测气象数据,分析积灰及天气对光伏组件发电性能的影响。结果表明,冬季PM2.5质量浓度的上升和春季沙尘暴天气的频发使得光伏组件表面灰尘... 详细信息

为研究灰尘对光伏发电性能的影响,通过搭建的实验台采集清洁与污染光伏组串每天的发电数据,同时监测气象数据,分析积灰及天气对光伏组件发电性能的影响。结果表明,冬季PM2.5质量浓度的上升和春季沙尘暴天气的频发使得光伏组件表面灰尘积累较多,累计发电量损失增长较快,而夏季由于降水增加,灰尘难以积聚在光伏组件上,累计发电量损失增长缓慢。此外,利用DTW(dynamic time warping)算法来寻找相似日。首先通过熵值法计算出各气象参数的权重,然后按日期逆序逐个计算出每个历史日各个气象参数对应的DTW值,再乘以其权重并相加得到历史日的综合DTW值。通过比较各历史日的综合DTW值,选出与当前日最接近的气象相似日。在避开极端天气的情况下,选择数据集中的一部分作为验证集,并对寻找相似日的判据进行优化,选取每天09:00—15:00的数据分为3个时间段进行分析,并设定平均太阳辐照度不小于600 W/m2的条件。优化后,预测模型的评价指标决定系数为0.83,均方根误差为0.22,预测效果显著提升。最后利用该算法为光伏电站制定清洗策略,经过累计发电量损失与清洗成本的对比,确定在长期不降雨情况下,电站应每28天进行一次清洗。

关键词：光伏组件积尘气象因素相似日 DTW算法

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人工智能赋能高等教育:逻辑理路、典型场景与实践进路

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西安交通大学学报（社会科学版） 2024年第3期44卷 11-20页

作者：刘嘉豪曾海军金婉莹李至晟祁彬斌北京师范大学教育学部北京100875 北京师范大学智慧学习研究院北京100875 北京师范大学互联网教育智能技术及应用国家工程研究中心北京102206

人工智能正在重构教育空间与活动流程,改变高等教育领域中师生的学习、生活与思维模式。通过对人工智能赋能高等教育的整体性和贯通式分析,探索迈向智能时代的高等教育可持续发展与推进路径。首先,基于赋能理论,沿着“目标—手段—主体... 详细信息

人工智能正在重构教育空间与活动流程,改变高等教育领域中师生的学习、生活与思维模式。通过对人工智能赋能高等教育的整体性和贯通式分析,探索迈向智能时代的高等教育可持续发展与推进路径。首先,基于赋能理论,沿着“目标—手段—主体—场景”的思路,厘清人工智能赋能高等教育的逻辑理路,探讨可信人工智能作为高等教育赋能的关键引擎,与教育场景持续互动演进,助力高等教育强国建设。其次,基于“学生—教师—学校”多主体视角剖析人工智能赋能高等教育的典型场景,赋能学生体现在学习支持、生活支持与就业支持,赋能教师着眼于学术研究、课堂教学与专业发展,赋能学校主要聚焦学科建设、教育管理与环境升级等方面。最后,基于价值取向、数字能力、场景驱动、社会实验等视角,探讨人工智能赋能高等教育的实践进路,以期促进人工智能规范而有序地融入高等教育生态。

关键词：人工智能高等教育教育数字化赋能理论教育场景

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An improved bidirectional generative adversarial network model for multivariate estimation of correlated and imbalanced tunnel construction parameters

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第7期15卷 1797-1809页

作者： Yao Xiao Jia Yu Guoxin Xu Dawei Tong jiahao Yu Tuocheng zeng State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin300072China Hanjiang to Weihe River Valley Water Diversion Project Construction Co. Ltd.Xi’an710024China

Estimation of construction parameters is crucial for optimizing tunnel construction schedule.Due to the influence of routine activities and occasional risk events,these parameters are usually correlated and imbalanced.To solve this issue,an improved bidirectional generative adversarial network(BiGAN)model with a joint discriminator structure and zero-centered gradient penalty(0-GP)is proposed.In this model,in order to improve the capability of original BiGAN in learning imbalanced parameters,the joint discriminator separately discriminates the routine activities and risk event durations to balance their influence weights.Then,the self-attention mechanism is embedded so that the discriminator can pay more attention to the imbalanced parameters.Finally,the 0-GP is adapted for the loss of the discrimi-nator to improve its convergence and stability.A case study of a tunnel in China shows that the improved BiGAN can obtain parameter estimates consistent with the classical Gauss mixture model,without the need of tedious and complex correlation analysis.The proposed joint discriminator can increase the ability of BiGAN in estimating imbalanced construction parameters,and the 0-GP can ensure the stability and convergence of the model.

关键词： Multivariate parameters estimation Correlated and imbalanced parameters Bidirectional generative adversarial network(BiGAN) Joint discriminator Zero-centered gradient penalty(0-GP)

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A button switch inspired duplex hydrogel sensor based on both triboelectric and piezoresistive effects for detecting dynamic and static pressure

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Nanotechnology and Precision Engineering 2022年第2期5卷 12-20页

作者： Zhensheng Chen jiahao Yu Xiaoxi Zhang Haozhe zeng Yunjia Li Jin Wu Kai Tao Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace Northwestern Polytechnical UniversityXi’an 710072China AVIC Xi’an Aircraft Industry Group Company Ltd. Xi’an 710089China School of Electrical Engineering Xi’an Jiaotong UniversityXi’an 710049China State Key Laboratory of Optoelectronic Materials and Technologies and the Guangdong Province Key Laboratory of Display Material and Technology School of Electronics and Information TechnologySun Yat-sen UniversityGuangzhou 510275China

The capability to sense complex pressure variations comprehensively is vital for wearable electronics and flexible human–machine interfaces.In this paper,inspired by button switches,a duplex tactile sensor based on the combination of triboelectric and piezoresistive effects is designed and fabricated.Because of its excellent mechanical strength and electrical stability,a double-networked ionic hydrogel is used as both the conductive electrode and elastic current regulator.In addition,micro-pyramidal patterned polydimethylsiloxane(PDMS)acts as both the friction layer and the encapsulation elastomer,thereby boosting the triboelectric output performance significantly.The duplex hydrogel sensor demonstrates comprehensive sensing ability in detecting the whole stimulation process including the dynamic and static pressures.The dynamic stress intensity(10–300 Pa),the action time,and the static variations(increase and decrease)of the pressure can be identified precisely from the dual-channel signals.Combined with a signal processing module,an intelligent visible door lamp is achieved for monitoring the entire“contact–hold–release–separation”state of the external stimulation,which shows great application potential for future smart robot e-skin and flexible electronics.

关键词： Duplex hydrogel sensor Triboelectric nanogenerator Piezoresistive sensor Dynamic and static sensing

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用于紫外线成像和无线报警的水凝胶基可伸缩、高稳定性和高性能的光电传感器

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Science China Materials 2024年第6期67卷 1926-1937页

作者：洪杰钊姚帝杰王浩丁琼玲罗艺冰于家豪张鹤曾令兴杨柏儒王冰陶凯吴进 State Key Laboratory of Optoelectronic Materials and Technologies and Guangdong Province Key Laboratory of Display Material and Technology School of Electronics and Information TechnologySun Yat-sen UniversityGuangzhou 510275China Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace Northwestern Polytechnical UniversityXi’an 710072China Research&Development Institute of Northwestern Polytechnical University in Shenzhen Northwestern Polytechnical UniversityShenzhen 518063China State Key Laboratory of Transducer Technology Shanghai 200050China Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing National Engineering Research Center of Novel Equipment for Polymer ProcessingKey Laboratory of Polymer Processing Engineering(SCUT)Ministry of EducationSouth China University of TechnologyGuangzhou 510641China Engineering Research Center of Polymer Green Recycling of Ministry of Education College of Environment and ResourcesFujian Normal UniversityFuzhou 350007China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065China

柔性可穿戴的紫外线探测器在个体紫外线暴露监测、智能仿生眼和军事领域受到广泛关注.然而,传统不可拉伸的材料和器件结构设计限制了设备在可动态变形的人体皮肤和非平面表面上的精确监测应用和稳定附着.在本研究中,我们提出了基于氧化... 详细信息

柔性可穿戴的紫外线探测器在个体紫外线暴露监测、智能仿生眼和军事领域受到广泛关注.然而,传统不可拉伸的材料和器件结构设计限制了设备在可动态变形的人体皮肤和非平面表面上的精确监测应用和稳定附着.在本研究中,我们提出了基于氧化铜/碳-水凝胶-氧化锌/碳的新型应变隔离异质结构的本征可拉伸(拉伸应变或弯曲高达150%)紫外线探测器,该探测器具有高灵敏度(开/关比为2100%)、高稳定性(大于4000次循环),以及快速响应和恢复时间(分别为1.5和4 s).值得注意的是,该探测器通过水凝胶桥在氧化铜/碳和氧化锌/碳电极之间引入的p-n结能带结构,以及离子导电水凝胶中I^(-)/I_(3)^(-)的电化学反应机制,显著提高了其载流子效率和紫外线响应强度.本文通过集成传感器与所设计的电路板,进一步开发了一种无线紫外线报警系统,用于紫外线强度超标警报.此外,本文还设计了一种光电传感器阵列,并将其用作视网膜假体,以实现对环境紫外线强度的实时监测和成像.本文基于水凝胶基异质结构为开发可穿戴、可拉伸的光电紫外线传感器单元和成像阵列提供了一种新的可行方法.

关键词： flexible hydrogel sensors stretchable UV sensors UV imaging array optoelectronic sensors wireless alarm

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The mitophagy pathway and its implications in human diseases

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Signal Transduction and Targeted Therapy 2023年第9期8卷 4015-4042页

作者： Shouliang Wang Haijiao Long Lianjie Hou Baorong Feng Zihong Ma Ying Wu Yu zeng jiahao Cai Da-wei Zhang Guojun Zhao The Sixth Affiliated Hospital of Guangzhou Medical University Qingyuan City People’s HospitalQingyuanGuangdongChina Xiangya Hospital Central South UniversityChangshaHunanChina Group on the Molecular and Cell Biology of Lipids and Department of Pediatrics Faculty of Medicine and DentistryUniversity of AlbertaEdmontonAlbertaCanada

Mitochondria are dynamic organelles with multiple functions.They participate in necrotic cell death and programmed apoptotic,and are crucial for cell metabolism and survival.Mitophagy serves as a cytoprotective mechanism to remove superfluous or dysfunctional mitochondria and maintain mitochondrial fine-tuning numbers to balance intracellular homeostasis.Growing evidences show that mitophagy,as an acute tissue stress response,plays an important role in maintaining the health of the mitochondrial network.Since the timely removal of abnormal mitochondria is essential for cell survival,cells have evolved a variety of mitophagy pathways to ensure that mitophagy can be activated in time under various environments.A better understanding of the mechanism of mitophagy in various diseases is crucial for the treatment of diseases and therapeutic target design.In this review,we summarize the molecular mechanisms of mitophagy-mediated mitochondrial elimination,how mitophagy maintains mitochondrial homeostasis at the system levels and organ,and what alterations in mitophagy are related to the development of diseases,including neurological,cardiovascular,pulmonary,hepatic,renal disease,etc.,in recent advances.Finally,we summarize the potential clinical applications and outline the conditions for mitophagy regulators to enter clinical trials.Research advances in signaling transduction of mitophagy will have an important role in developing new therapeutic strategies for precision medicine.

关键词： diseases homeostasis metabolism

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