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长链非编码RNA与骨性关节炎

中国组织工程研究 2025年第11期29卷 2357-2367页

作者：郑善斌夏天卫孙家豪陈志远曹逊张超沈计荣南京中医药大学南京中医药大学附属医院南京中医药大学第一临床医学院江苏省南京市210000

背景:骨性关节炎作为中老年常见疾病,发病机制尚不清晰。长链非编码RNA通过多种途径参与骨性关节炎发病过程,如调控翻译、促进或者抑制mRNA表达、吸附miRNA等。目的:综述多种长链非编码RNA在骨性关节炎中的作用机制及研究进展。方法:检... 详细信息

背景:骨性关节炎作为中老年常见疾病,发病机制尚不清晰。长链非编码RNA通过多种途径参与骨性关节炎发病过程,如调控翻译、促进或者抑制mRNA表达、吸附miRNA等。目的:综述多种长链非编码RNA在骨性关节炎中的作用机制及研究进展。方法:检索中国知网、万方数据库、维普数据库、PubMed、Web of Science和Sciencedirect数据库,以“osteoarthritis,degenerative joint disease,degenerative arthritis,OA,LncRNA,long non-coding RNA,long noncoding RNA,long intergenic non-coding RNA”为英文检索词,以“骨性关节炎,骨关节炎,OA,长链非编码RNA,长链非编码核糖核酸,LncRNA”为中文检索词,检索1976年至2024年5月发表的所有相关文献,并对其进行筛选、归纳、分析、总结,最后纳入93篇文献进行综述。结果与结论:①收集了目前与骨性关节炎关系研究较多且较深入的25种长链非编码RNA;②长链非编码RNA可以充当miRNA的分子海绵,作为竞争性内源性RNA竞争性吸附miRNA,进而影响下游靶点;③长链非编码RNA可以调控软骨细胞的凋亡与增殖、软骨细胞外基质降解以及炎症反应等生理病理进程;④长链非编码RNA有望成为骨性关节炎临床诊断及治疗预后的生物标志物和潜在治疗靶点,未来可能会成为骨性关节炎临床治疗的新策略。

关键词：骨性关节炎软骨细胞长链非编码RNA 信号传导基因表达综述

Pushing the limits of microwave absorption capability of carbon fiber in fabric design based on genetic algorithm

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Journal of Advanced Ceramics 2023年第2期12卷 329-340页

作者： Yuhao LIU Xiaoxiao HUANG Xu YAN Long XIA Tao ZHANG jiahao sun Yanan LIU Yu ZHOU State Key Laboratory of Advanced Welding and Joining Harbin Institute of TechnologyHarbin 150001China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China Beijing Institute of Radio Measurement China Aerospace Science and Industry Corporation LimitedBeijing 100854China School of Materials Science and Engineering Harbin Institute of TechnologyWeihaiWeihai 264209China

The field of electromagnetic wave absorption(EWA)requires the adaptability,tenability,and multifunction of high-performance materials in the *** design and preparation of EWA materials aiming at performance requirements is the latest research ***,a performancedriven strategy for simultaneously coordinating different target performances was proposed to optimize the structure of the periodical long continuous carbon/glass fiber fabric(PCGF)materials through algorithm and *** optimized structure of the PCGF not only improves the impedance matching,but also introduces the induced orientation effect for a high cooperative loss of conductivity,resonance,and periodic *** flexible PCGF shows a broad effective absorption bandwidth(EAB)of 32.7 GHz covering a part of the C-band and the whole X-,Ku-,K-,and Ka-bands with a thickness(d)of only 0.92 mm and a density of 5.6×10^(−4) kg·cm^(−3).This highly designable fabric is promising for the EWA practical application owing to integrating the characteristics of good flexibility,acid and alkali resistance,bending resistance,excellent mechanical properties,and easy large-scale preparation.

关键词： broadband microwave absorption carbon fiber impedance matching periodical long continuous carbon/glass fiber fabric(PCGF) multiple loss mechanism

A Robust Approach of Multi-sensor Fusion for Fault Diagnosis Using Convolution Neural Network

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Journal of Dynamics, Monitoring and Diagnostics 2022年第2期1卷 103-110页

作者： jiahao sun Xiwen Gu Jun He Shixi Yang Yao Tu Chenfang Wu State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhouChina Hangzhou Steam Turbine&Power Group Co. LtdHangzhouChina

Multi-sensor measurement iswidely employed in rotatingmachinery to ensure the safety *** information provided by the single sensor is not ***-sensor signals can provide complementary information in characterizing the health condition of *** paper proposed a multi-sensor fusion convolution neural network(MF-CNN)*** proposed model adds a 2-D convolution layer before the classical 1-D CNN to automatically extract complementary features of multi-sensor signals and minimize the loss of information.A series of experiments are carried out on a rolling bearing test rig to verify the *** and sound signals are fused to achieve higher classification accuracy than typical machine learning *** addition,the model is further applied to gas turbine abnormal detection,and shows great robustness and generalization.

关键词： deep learning engineering application fault diagnosis multi-sensor fusion

Assessment of spermatogenesis in camels via seminiferous tubule staging and testosterone profiling

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Asian pacific Journal of Reproduction 2024年第3期13卷 133-142页

作者： Saif Ullah Abdul Quddus Quanwei Wei Wael Ennab Sheeraz Mustafa jiahao sun Rahmani Mohammad Malyar Abdul Baseer Dagan Mao Fangxiong Shi College of Animal Science and Technology Nanjing Agricultural UniversityNanjing 210095China Faculty of Veterinary and Animal Sciences Lasbela University of Agriculture Water and Marine SciencesBalochistanPakistan Faculty of Veterinary and Animal Sciences Ziaddin University Karachi Pakistan

Objective:To investigate the successive morphological stages of spermatogenesis,hormonal regulation,and testosterone profile in dromedary camel ***:Testicular tissue samples were obtained from 12 dromedary bull camels aged 7 to 8 at a local *** histological assessment involved tissue processing,hematoxylin and eosin(H&E)staining,and examination under a *** analysis,germ cell identification,and assessment of seminiferous tubules and maturation were *** assay was performed by radioimmunoassay using blood samples collected at regular ***:The study revealed 12 phases of the dromedary camel's seminiferous epithelium cycle,highlighting distinct morphological characteristics and cellular *** migration,maturation,cap formation,and the Golgi-mediated synthesis of proacrosomal vesicles were also explained in dimension,as were the steps of acrosome *** and mature sperm cells were present when spermatogenesis phases were *** analysis of the dimensions of seminiferous tubules revealed specific measures for diameter,area,and epithelial height about luminal ***,there were noticeable variations in the serum testosterone concentrations during the study period,indicating temporal ***:This study outlines the spermatogenesis process in dromedary camels across 12 stages,emphasizing cellular dynamics and acrosomal *** also provides seminiferous tubule measurements and observes seasonal testosterone fluctuations,offering insights into reproductive regulation and potential strategies for camel breeding conservation.

关键词： Spermatogenesis Camel Testosterone profile Morphological staging

Epigenomic features associated with body temperature stabilize tissues during cold exposure in cold-resistant pigs

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Journal of Genetics and Genomics 2024年第11期51卷 1252-1264页

作者： Yaping Guo Mingyang Hu Hao Peng Yan Zhang Renzhuo Kuang Zheyu Han Daoyuan Wang Yinlong Liao Ruixian Ma Zhixiang Xu jiahao sun Yu Shen Changzhi Zhao Hong Ma Di Liu Shuhong Zhao Yunxia Zhao Key Laboratory of Agricultural Animal Genetics Breedingand Reproduction of the Ministry of Education and Key Laboratory of Swine Genetics and Breeding of Ministry of AgricultureHuazhong Agricultural UniversityWuhanHubei 430070China Yazhouwan National Laboratory SanyaHainan 572000China Institute of Animal Husbandry Heilongjiang Academy of Agricultural SciencesHarbinHeilongjiang 150086China The Cooperative Innovation Center for Sustainable Pig Production WuhanHubei 430070China

Cold stress in low-temperature environments can trigger changes in gene expression,but epigenomics regulation of temperature stability in vital tissues,including the fat and diencephalon,is still ***,we explore the cold-induced changes in epigenomic features in the diencephalon and fat tissues of two cold-resistant Chinese pig breeds,Min and Enshi black(ES)pigs,utilizing H3K27ac CUT&Tag,RNA-seq,and selective signature *** results show significant alterations in H3K27ac modifications in the diencephalon of Min pigs and the fat of ES pigs after cold *** changes in H3K27ac modifications in the diencephalon of Min pig are primarily associated with genes involved in energy metabolism and hormone regulation,whereas those in the fat of ES pig are primarily associated with immunity-related ***,transcription factors PRDM1 and HSF1,which show evidence of selection,are enriched in genomic regions presenting cold-responsive alterations in H3K27ac modification in the Min pig diencephalon and ES pig fat,*** results indicate the diversity of epigenomic response mechanisms to cold exposure between Min and ES pigs,providing unique epigenetic resources for studies of low-temperature adaptation in large mammals.

关键词： Cold exposure Diencephalon tissue Fat tissue H3K27ac modification Breed difference Multi-omics

相邻区域环境规制促进或抑制当地技术创新投入?——基于技术溢出与污染溢出角度

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江西师范大学学报（自然科学版） 2019年第3期43卷 260-267页

作者：徐晔孙家豪江西财经大学统计学院江西南昌330013

该文从环境规制的技术溢出效应与污染溢出效应2个角度,分析相邻区域环境规制对当地技术创新投入的影响,研究在这2种效应强弱对比发生变化的情况下,相邻区域环境规制溢出影响的异质性.在此基础上采用2003—2015年长三角地区26个主要城市... 详细信息

该文从环境规制的技术溢出效应与污染溢出效应2个角度,分析相邻区域环境规制对当地技术创新投入的影响,研究在这2种效应强弱对比发生变化的情况下,相邻区域环境规制溢出影响的异质性.在此基础上采用2003—2015年长三角地区26个主要城市数据,使用EBM模型测度绿色创新效率,利用中介效应检验程序与空间面板杜宾模型对理论分析结论进行实证检验.结果表明:相邻区域环境规制强度提升会促进当地绿色创新效率的增加;在施行环境规制政策的前期,相邻区域环境规制强度提升会造成当地技术创新投入减少;在施行环境规制政策一段时间后,相邻区域环境规制强度提升会造成当地技术创新投入增加.

关键词：环境规制技术创新投入空间溢出

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双转子风力机气动建模与控制仿真研究

动力工程学报 2023年第9期43卷 1198-1206页

作者：张文广骆伟健孙嘉壕华北电力大学控制与计算机工程学院北京102206

为研究双转子风力机的气动特性和风能利用率,基于NREL 5 MW和WindPACT 1.5 MW风力机转子,搭建了双转子风力机模型,并进行了功率优化控制仿真。首先,建立了双转子风力机的气动、塔影效应、传动链与发电机模型,在Matlab/Simulink中搭建了... 详细信息

为研究双转子风力机的气动特性和风能利用率,基于NREL 5 MW和WindPACT 1.5 MW风力机转子,搭建了双转子风力机模型,并进行了功率优化控制仿真。首先,建立了双转子风力机的气动、塔影效应、传动链与发电机模型,在Matlab/Simulink中搭建了双转子风力机模型。其次,基于自由涡尾迹法(Free Vortex Wake, FVW)对双转子风力机流场进行了不同风况下的仿真计算。最后,基于模糊控制设计了双转子风力机功率控制策略,并与PID控制策略进行了比较。结果表明:与CFD相比,FVW计算的流场风速相对误差绝对值小于10%,能够快速动态计算双转子风力机的流场分布;对比不同风况,双转子风力机的风能利用率可提高约24%;模糊控制策略在双转子风力机功率动态响应和抑制功率波动方面改善明显。

关键词：双转子风力机自由涡尾迹模糊控制风能利用率

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制孔偏差对铝合金单钉双剪连接性能的影响

现代制造工程 2022年第11期 97-102页

作者：孙家豪齐振超陈文亮南京航空航天大学机电学院南京210000

航空产品在手工制孔或移动式机器人制孔过程中易出现孔径超差、孔倾斜等问题,为结构件的使用留下安全隐患。以2A12-T4航空用铝合金为研究对象,通过开展静拉伸试验、疲劳试验,研究了孔径偏差、垂直度偏差对铝合金单钉双剪连接性能的影响... 详细信息

航空产品在手工制孔或移动式机器人制孔过程中易出现孔径超差、孔倾斜等问题,为结构件的使用留下安全隐患。以2A12-T4航空用铝合金为研究对象,通过开展静拉伸试验、疲劳试验,研究了孔径偏差、垂直度偏差对铝合金单钉双剪连接性能的影响。研究发现:铝合金单钉双剪连接结构的静拉伸失效以劈裂破坏为主,疲劳失效均为横截面断裂失效;垂直度偏差、孔径偏差对连接件静拉伸强度的影响较小,对静拉伸强度的折损均在10%以内;垂直度偏差、孔径偏差对连接件疲劳性能造成显著影响,其中垂直度偏差为4°、疲劳载荷为70%最大静拉伸力时的影响最大,会使疲劳寿命降低73.60%;制孔偏差对疲劳失效过程的影响主要表现在影响疲劳裂纹的萌生区域、扩展方向与扩展速度等。

关键词： 2A12-T4铝合金单钉双剪连接静拉伸强度疲劳性能

基于神经网络的316L不锈钢激光焊焊缝形貌预测

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焊接学报 2021年第12期42卷 40-47,I0003页

作者：孙家豪张超勇吴剑钊张帅坤祝磊华中科技大学数字制造装备与技术国家工程研究中心武汉430074 武汉恒立工程钻具股份有限公司武汉430000

在316L不锈钢的激光焊接过程中,其焊接工艺参数直接影响焊缝的形貌,建立焊接工艺参数与焊缝几何形状之间的关系对于优化焊接工艺参数,降低焊接成本非常重要.根据316L不锈钢焊缝二维不光滑轮廓形貌特点,采用分段函数思想,分别使用Hermit... 详细信息

在316L不锈钢的激光焊接过程中,其焊接工艺参数直接影响焊缝的形貌,建立焊接工艺参数与焊缝几何形状之间的关系对于优化焊接工艺参数,降低焊接成本非常重要.根据316L不锈钢焊缝二维不光滑轮廓形貌特点,采用分段函数思想,分别使用Hermite插值和最小二乘拟合的方法描述焊缝轮廓,构建广义回归神经网络焊缝二维形貌预测模型.结果表明,采用Hermite插值的方法能够获得更准确的焊缝形貌,其平均相对误差为-3.49%.该模型为316L不锈钢激光焊焊缝预测提供一种有效方法.

关键词： 316L不锈钢激光焊接焊缝预测 Hermite插值最小二乘法