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Salmonella-mediated blood-brain barrier penetration,tumor homing and tumor microenvironment regulation for enhanced chemo/bacterial glioma therapy

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Acta Pharmaceutica Sinica B 2023年第2期13卷 819-833页

作者： Ze Mi Qing Yao Yan Qi Jinhai Zheng jiahao liu Zhenguo liu Hongpei Tan Xiaoqian Ma Wenhu Zhou Pengfei Rong Department of Radiology The Third Xiangya HospitalCentral South UniversityChangsha 410013China Xiangya School of Pharmaceutical Sciences Central South UniversityChangsha 410013China Department of Pathology Shihezi University School of Medicine and the First Affiliated Hospital to Shihezi University School of MedicineShihezi 832003China Key Laboratory of Biological Nanotechnology of National Health Commission Changsha 410082China School of Biomedical Sciences Hunan UniversityChangsha 410082China Department of Pathology Cangzhou Central Hospital&the Affiliated to Hebei Medical UniversityCangzhou 062650China

Chemotherapy is an important adjuvant treatment of glioma,while the efficacy is far from satisfactory,due not only to the biological barriers of blood-brain barrier(BBB)and blood-tumor barrier(BTB)but also to the intrinsic resistance of glioma cells via multiple survival mechanisms such as upregulation of P-glycoprotein(P-gp).To address these limitations,we report a bacteria-based drug delivery strategy for BBB/BTB transportation,glioma targeting,and *** selectively colonized into hypoxic tumor region and modulated tumor microenvironment,including macrophages repolarization and neutrophils ***,tumor migration of neutrophils was employed as hitchhiking delivery of doxorubicin(DOX)-loaded bacterial outer membrane vesicles(OMVs/DOX).By virtue of the surface pathogen-associated molecular patterns derived from native bacteria,OMVs/DOX could be selectively recognized by neutrophils,thus facilitating glioma targeted delivery of drug with significantly enhanced tumor accumulation by 18-fold as compared to the classical passive targeting ***,the P-gp expression on tumor cells was silenced by bacteria typeⅢsecretion effector to sensitize the efficacy of DOX,resulting in complete tumor eradication with 100%survival of all treated *** addition,the colonized bacteria were finally cleared by anti-bacterial activity of DOX to minimize the potential infection risk,and cardiotoxicity of DOX was also avoided,achieving excellent *** work provides an efficient trans-BBB/BTB drug delivery strategy via cell hitchhiking for enhanced glioma therapy.

关键词： Glioma Neutrophil hitchhiking Blood-brain barrier Chemo-sensitization Outer membrane vesicles Doxorubicin P-glycoprotein Salmonella

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烟草NtJAZ15基因对腺毛发生的影响

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中国烟草科学 2024年第2期45卷 80-89页

作者：裴文毅张新要朱文奇季盈彤娄哲刘家豪闫筱筱崔红河南农业大学烟草学院郑州450046 湖南中烟工业有限公司长沙410007

为验证NtJAZ15对烟草腺毛发生的影响,探究NtJAZ15调控腺毛发生的分子机制,本研究从K326中克隆了NtJAZ15基因,并对其进行了生物信息学和组织表达模式分析,通过创制NtJAZ15敲除和过表达突变体,分析其对腺毛发生的调控作用。结果表明,NtJAZ... 详细信息

为验证NtJAZ15对烟草腺毛发生的影响,探究NtJAZ15调控腺毛发生的分子机制,本研究从K326中克隆了NtJAZ15基因,并对其进行了生物信息学和组织表达模式分析,通过创制NtJAZ15敲除和过表达突变体,分析其对腺毛发生的调控作用。结果表明,NtJAZ15-1和NtJAZ15-2在不同烟草品种中高度保守,具有典型的TIFY和Jas结构域,属于JAZ家族。NtJAZ15在各组织中均表达,且各组织中NtJAZ15-2表达量均高于NtJAZ15-1。NtJAZ15基因敲除突变体烟叶长柄和短柄腺毛密度增加,过表达突变体则相反。qRT-PCR结果表明NtJAZ15可显著影响NtWo、NtCycB2、NtHD9、NtHD12的表达,但对NtMIXTA的表达影响不显著。因此,NtJAZ15负调控烟草长柄和短柄腺毛发生,NtWo、NtCycB2、NtHD9、NtHD12可能参与NtJAZ15调控烟草腺毛发生。

关键词：烟草 NtJAZ15 基因编辑过表达腺毛

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Hybrid Two-Phase Task Allocation for Mobile Crowd Sensing

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计算机工程 2022年第3期48卷 139-145页

作者： liu jiahao JIN Hanxin QIANG Lei GAO Guoju DU Yang HUANG He School of Computer Science and Technology Soochow UniversitySuzhouJiangsu 215006China

As a result of the popularity of mobile devices,Mobile Crowd Sensing (MCS) has attracted a lot of attention. Task allocation is a significant problem in MCS. Most previous studies mainly focused on stationary spatial tasks while neglecting the changes of tasks and workers. In this paper,the proposed hybrid two-phase task allocation algorithm considers heterogeneous tasks and diverse *** heterogeneous tasks,there are different start times and deadlines. In each round,the tasks are divided into urgent and non-urgent tasks. The diverse workers are classified into opportunistic and participatory *** former complete tasks on their way,so they only receive a fixed payment as employment compensation,while the latter commute a certain distance that a distance fee is paid to complete the tasks in each round as needed apart from basic employment compensation. The task allocation stage is divided into multiple rounds consisting of the opportunistic worker phase and the participatory worker phase. At the start of each round,the hiring of opportunistic workers is considered because they cost less to complete each task. The Poisson distribution is used to predict the location that the workers are going to visit,and greedily choose the ones with high utility. For participatory workers,the urgent tasks are clustered by employing hierarchical clustering after selecting the tasks from the uncompleted task *** completing the above steps,the tasks are assigned to participatory workers by extending the Kuhn-Munkres (KM) *** rest of the uncompleted tasks are non-urgent tasks which are added to the task set for the next *** are conducted based on a real dataset,Brightkite,and three typical baseline methods are selected for comparison. Experimental results show that the proposed algorithm has better performance in terms of total cost as well as efficiency under the constraint that all tasks are completed.

关键词： Mobile Crowd Sensing(MCS) two-phase task allocation Kuhn-Munkres(KM)algorithm opportunistic worker participatory worker

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Estimating shear strength of high-level pillars supported with cemented backfilling using the HoekeBrown strength criterion

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第2期16卷 454-469页

作者： Kaizong Xia Congxin Chen Xiumin liu Yue Wang Xuanting liu jiahao Yuan State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China

Deep metal mines are often mined using the high-level pillars with subsequent cementation backfilling(HLSCB)mining *** the design stage,it is therefore important to have a reasonable method for determining the shear strength of the high-level pillars(*** and internal friction angle)when they are supported by cemented *** this study,a formula was derived for the upper limit of the confining pressure σ3max on a high-level pillar supported by cemented backfilling in a deep metal mine.A new method of estimating the shear strength of such pillars was then proposed based on the Hoek eBrown failure *** analysis indicates that the horizontal stress σhh acting on the cemented backfill pillar can be simplified by expressing it as a constant value.A reasonable and effective value for σ3max can then be *** value of s3max predicted using the proposed method is generally less than 3 *** this range,the shear strength of the high-level pillar is accurately calculated using the equivalent MohreCoulomb *** proposed method can effectively avoid the calculation of inaccurate shear strength values for the high-level pillars when the original HoekeBrown criterion is used in the presence of large confining pressures,*** situation in which the cohesion value is too large and the friction angle is too small can effectively be *** proposed method is applied to a deep metal mine in China that is being excavated using the HLSCB *** shear strength parameters of the high-level pillars obtained using the proposed method were input in the numerical *** numerical results show that the recommended level heights and sizes of the high-level pillars and rooms in the mine are rational.

关键词： Deep metal mines High-level pillars HoekeBrown strength criterion Cemented backfilling Confining pressure Shear strength

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基于等效载噪比的WiFi与北斗三号RSMC出站信号的兼容性分析

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无线电工程 2024年第4期54卷 971-976页

作者：李刚郭磊支春阳刘佳浩郝泽华深圳市远东华强导航定位有限公司广东深圳518073

近年来,北斗导航系统建设逐渐完善,北斗三号区域短报文通信(Reginal Short Message Communication, RSMC)服务已进入行业应用越来越广的关键时期。WiFi信号与北斗三号RSMC出站信号频率接近,在实际使用过程中,2个系统可能存在兼容性问题... 详细信息

近年来,北斗导航系统建设逐渐完善,北斗三号区域短报文通信(Reginal Short Message Communication, RSMC)服务已进入行业应用越来越广的关键时期。WiFi信号与北斗三号RSMC出站信号频率接近,在实际使用过程中,2个系统可能存在兼容性问题。针对WiFi信号干扰对北斗三号RSMC出站信号性能的影响问题,介绍了北斗三号RSMC出站信号的空口特性,分析了WiFi信号对北斗三号RSMC出站信号的带外干扰和带内干扰,基于等效载噪比的分析方法,从载噪比损失方面对干扰的强度做了仿真分析,并给出了改进方法。研究结果为WiFi和北斗区域短报文服务兼容并存提供技术基础。

关键词：区域短报文通信北斗三号邻频干扰 WiFi 卫星通信

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一种基于热阻矩阵的2.5D封装芯片结温预测模型

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电子产品可靠性与环境试验 2024年第1期42卷 63-67页

作者：刘加豪古莉娜陈方舟郭小童赵昊工业和信息化部电子第五研究所广东广州511370 重庆赛宝工业技术研究院有限公司重庆401332

随着2.5D封装芯片的封装尺寸不断减小和功率密度持续增加,芯片内部温度急剧上升。为了满足芯片散热和可靠性需求,准确预测服役过程中芯片的结温具有重要的意义。在充分考虑热耦合效应后,从2.5D封装芯片的热阻网络拓扑结构出发,提出了一... 详细信息

随着2.5D封装芯片的封装尺寸不断减小和功率密度持续增加,芯片内部温度急剧上升。为了满足芯片散热和可靠性需求,准确预测服役过程中芯片的结温具有重要的意义。在充分考虑热耦合效应后,从2.5D封装芯片的热阻网络拓扑结构出发,提出了一种基于热阻矩阵的2.5D封装芯片结温预测模型。同时,采用FloTHERM热仿真软件对该预测模型进行了验证。结果表明,在对2.5D封装芯片施加不同功率后,该模型的计算结果和FloTHERM仿真结果相对误差小于5%。由此说明,该模型能够高效准确地预测2.5D封装芯片的结温。

关键词： 2.5D封装热阻矩阵热耦合效应结温预测有限元分析

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Mesoporous MnO_(2)nanosheets for efficient electrocatalytic nitrogen reduction via high spin polarization induced by oxygen vacancy

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Nano Research 2023年第4期16卷 4664-4670页

作者： Yangyang Wen jiahao liu Feiran Zhang Zhenxing Li Ping Wang Zhao Fang Miao He Jingshuai Chen Weiyu Song Rui Si Lianzhou Wang State Key Laboratory of Heavy Oil Processing College of New Energy and MaterialsChina University of Petroleum(Beijing)Beijing 102249China College of Science China University of Petroleum(Beijing)Beijing 102249China School of Chemistry and Chemical Engineering Anhui UniversityHefei 230601China Shanghai Synchrotron Radiation Facility Shanghai Institute of Applied PhysicsChinese Academy of SciencesShanghai 201204China Nanomaterials Centre School of Chemical Engineering and Australian Institute for Bioengineering and NanotechnologyThe University of QueenslandBrisbaneQLD 4072Australia

The electrochemical N_(2)reduction reaction(NRR)represents a green and sustainable route for NH_(3)synthesis under ambient ***,the mechanism of N_(2)activation in the electrocatalytic NRR remains ***,we found that the high spin state Mn^(3+)-Mn^(3+)pairs induced by oxygen vacancy in MnO_(2)nanosheets greatly enhance the catalytic *** strong electron transfer between d orbital of Mn and orbital of N2 forces the N_(2)to be of radical nature,which activates the hydrogenation process and weakens the N≡N *** on the density functional theory(DFT)calculation results,we precisely designed mesoporous MnO_(2)nanosheets with rich oxygen vacancies via using methyltriphenylphosphonium bromide(MPB)to induce more Mn^(3+)-Mn^(3+)pairs(Mn^(3-3)-MnO_(2)),which can achieve a fairly high ammonia yield of up to 147.2μg·h^(−1)·mgcat−***−0.75 V *** hydrogen electrode(RHE)and a high Faradaic efficiency(FE)of 11%.Furthermore,these mesoporous MnO_(2)nanosheets exhibit the superior durability with negligible changes in both NH3 yield and FE after a consecutive 6-recycle test and the current density electrolyzed over a 24-hour *** findings offer an approach to designing highly active transition metal catalysts for electrocatalytic nitrogen reduction.

关键词： Mn^(3+)-Mn^(3+)pair MnO_(2)nanosheets mesopores ammonia synthesis electrocatalytic nitrogen reduction

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Mesoporous silica stabilized MOF nanoreactor for highly selective semi-hydrogenation of phenylacetylene via synergistic effect of Pd and Ru single site

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Nano Research 2022年第3期15卷 1983-1992页

作者： Zhenxing Li Mingliang Hu jiahao liu Weiwei Wang Yanjie Li Wenbin Fan Yixuan Gong Jiasai Yao Ping Wang Miao He Yongle Li State Key Laboratory of Heavy Oil Processing College of New Energy and MaterialsBeijing Key Laboratory of Biogas Upgrading UtilizationChina University of Petroleum(Beijing)Beijing 102249China Department of Physics International Center of Quantum and Molecular Structuresand Shanghai Key Laboratory of High Temperature SuperconductorsShanghai UniversityShanghai 200444China Division of Chemistry and Chemical Engineering California Institute of Technology1200 California Blvd.PasadenaCalifornia 91125USA

Selective semi-hydrogenation of phenylacetylene to styrene is a crucial step in the polystyrene *** Pd-based catalysts are widely used in this reaction due to their excellent hydrogenation activity,the selectivity for styrene remains a great ***,we designed a mesoporous silica stabilized Pd-Ru@ZIF-8(MS Pd-Ru@ZIF-8)nanoreactor with novel Pd and Ru single site synergistic catalytical system for semi-hydrogenation of *** nanoreactor exhibited a superior performance,achieving 98%conversion of phenylacetylene and 96%selectivity to *** frequency(TOF)of nanoreactor was up to as high as 2,188 h^(−1),which was 25 times and 5 times more than the single metal species catalysts,mesoporous silica stabilized Pd@ZIF-8 nanoreactor(MS Pd@ZIF-8),and mesoporous silica stabilized Ru@ZIF-8 nanoreactor(MS Ru@ZIF-8).This catalytic activity was attributed to the synergistic effect of Pd and Ru single site anchored strongly into the framework of ZIF-8,which reduced the desorption energy of styrene and increased the hydrogenation energy barrier of ***,since the ordered mesoporous silica was introduced into the nanoreactor shell to stabilize ZIF-8,MS Pd-Ru@ZIF-8 showed excellent reusability and *** the five cycles,the catalytical activity and selectivity still *** work provides insights for a synergistic catalytic system based on single-site active sites for selective hydrogenation reactions.

关键词： mesoporous silica metal–organic frameworks(MOF) semi-hydrogenation of phenylacetylene synergistic effect single site

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基于改进多因素老化法的极寒地区复合绝缘子伞裙性能退化研究

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绝缘材料 2024年第2期57卷 100-105页

作者：张欣伟周丽英王博戴雨薇端木天翔郭鑫喆刘佳浩邢云琪国网内蒙古东部电力有限公司电力科学研究院内蒙古呼和浩特010000 河北工业大学省部共建电工装备可靠性与智能化国家重点实验室天津300130

为探明极寒地区复合绝缘子老化机理,本文采用改进多因素老化方法,研究老化时间对复合绝缘子伞裙理化性能、力学性能以及电气性能的影响规律。结果表明:随着老化时间的增加,硅橡胶材料表面出现裂纹、孔洞和颗粒物堆积等现象,憎水性明显降... 详细信息

为探明极寒地区复合绝缘子老化机理,本文采用改进多因素老化方法,研究老化时间对复合绝缘子伞裙理化性能、力学性能以及电气性能的影响规律。结果表明:随着老化时间的增加,硅橡胶材料表面出现裂纹、孔洞和颗粒物堆积等现象,憎水性明显降低,材料整体硬度增加,断裂伸长率迅速降低,力学性能明显下降。同时,硅橡胶材料的介电常数明显增大,介质损耗不断增加,深陷阱能级密度变低,浅陷阱能级密度升高,表面电导率大幅增加,闪络电压急剧下降。

关键词：多因素老化极寒地区复合绝缘子硅橡胶伞裙老化性能

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Correcting of the unexpected localization measurement for indoor automatic mobile robot transportation based on a neural network

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Transportation Safety and Environment 2024年第2期6卷 24-35页

作者： jiahao Huang Steffen Jung inger Hui liu Kerstin Thurow Center for Life Science Automation(CELISCA) University of RostockRostock 18119Germany Institute of Automation University of RostockRostock 18119Germany Institute of Artificial Intelligence&Robotics(IAIR) School of Traffic&Transportation EngineeringCentral South UniversityChangsha 410075HunanChina

The increasing use of mobile robots in laboratory settings has led to a higher degree of laboratory ***,when mobile robots move in laboratory environments,mechanical errors,environmental disturbances and signal interruptions are *** can compromise the accuracy of the robot’s localization,which is crucial for the safety of staff,robots and the laboratory.A novel time-series predicting model based on the data processing method is proposed to handle the unexpected localization measurement of mobile robots in laboratory *** proposed model serves as an auxiliary localization system that can accurately correct unexpected localization errors by relying solely on the historical data of mobile *** experimental results demonstrate the effectiveness of this proposed method.

关键词： mobile robots laboratory automation indoor localization neural network

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