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Evaluation of freeze-thaw erosion in Tibet based on the cloud model

Frontiers of Earth Science 2021年第3期15卷 495-506页

作者： Junfu FAN Taoying HU Xiao YU jiahao chen Liusheng HAN Yuke ZHOU School of Architectural Engineering Shandong University of TechnologyZibo 255000China Bureau of Natural Resources Shiquan 725200China Ecology Observing Network and Modeling Laboratory Institute of Geographical Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China

Freeze-thaw erosion can lead to accelerated soil loss,which is an important factor related to soil erosion in cold *** is a typical region that is seriously affected by freeze-thaw ***,the analytic hierarchy process(AHP)method is used to calculate the weight of the factors in evaluations of freeze-thaw erosion,but this method cannot accurately depict the fuzziness and randomness of the *** overcome this disadvantage,this study proposed an improved AHP method based on the cloud model for the evaluation of the factors impacting freeze-thaw *** establish an improved evaluation method for freeze-thaw erosion in Tibet,the following six factors were selected:mean annual air temperature,mean annual ground surface temperature,average annual precipitation,aspect,vegetation coverage,and topographic *** traditional AHP and the cloud model were combined to assign the weights of the impacting factors,and a consistency check was *** comprehensive evaluation index model was used to evaluate the intensity of freeze-thaw erosion in *** results show that freeze-thaw erosion is extensive,stretching over approximately 66.1%of ***,mild erosion and moderate erosion are the most widely distributed erosion intensity levels,accounting for 36.4%and 34.4%of the total freeze-thaw erosion,*** intensity of freeze-thaw erosion gradually increased from slight erosion in the northwest to severe erosion in the southeast of the study *** evaluation results for the intensity and distribution of freeze-thaw erosion in Tibet were confirmed to be consistent with the actual *** brief,this study supplies a new approach for quantitatively evaluating the intensity of freeze-thaw erosion in Tibet.

关键词： freeze-thaw erosion cloud model AHP Tibet

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Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases

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Acta Pharmaceutica Sinica B 2023年第2期13卷 678-693页

作者： Haowen Xu jiahao chen Pan chen Weifeng Li Jingjing Shao Shanshan Hong Yi Wang Lingfeng chen Wu Luo Guang Liang Chemical Biology Research Center School of Pharmaceutical SciencesWenzhou Medical UniversityWenzhou 325035China School of Pharmaceutical Sciences Hangzhou Medical CollegeHangzhou 311399China Medical Research Center the First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China

The NLRP3 inflammasome’s core and most specific protein,NLRP3,has a variety of functions in inflammation-driven ***(COS)is the major active ingredient of the traditional Chinese medicinal herb Saussurea lappa and has anti-inflammatory activity,but the principal mechanism and molecular target of COS remain ***,we show that COS covalently binds to cysteine 598 in NACHT domain of NLRP3,altering the ATPase activity and assembly of NLRP3 *** declare COS’s great anti-inflammasome efficacy in macrophages and disease models of gouty arthritis and ulcerative colitis via inhibiting NLRP3 inflammasome *** also reveal that theα-methylene-γ-butyrolactone motif in sesquiterpene lactone is the certain active group in inhibiting NLRP3 *** together,NLRP3 is identified as a direct target of COS for its anti-inflammasome ***,especially theα-methylene-γ-butyrolactone motif in COS structure,might be used to design and produce novel NLRP3 inhibitors as a lead compound.

关键词： Costunolide NLRP3 inflammasome Inflammation Molecular target NACHT domain α-Methylene-γ-butyrolactone Gouty arthritis Ulcerative colitis

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ncFO:A Comprehensive Resource of Curated and Predicted ncRNAs Associated with Ferroptosis

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Genomics, Proteomics & Bioinformatics 2023年第2期21卷 278-282页

作者： Shunheng Zhou Yu’e Huang Jiani Xing Xu Zhou Sina chen jiahao chen Lihong Wang Wei Jiang Department of Biomedical Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China Department of Pathophysiology School of MedicineSoutheast UniversityNanjing 210009China

Ferroptosis is a form of regulated cell death driven by the accumulation of lipid *** of ferroptosis might be beneficial to cancer ***-coding RNAs(ncRNAs)are a class of RNA transcripts that generally cannot encode proteins and have been demonstrated to play critical roles in regulating ***,we developed ncFO,the ncRNA-ferroptosis association database,to document the manually curated and predicted ncRNAs that are associated with ***,ncFO contains 90 experimentally verified entries,including 46 microRNAs(miRNAs),21 long non-coding RNAs(lncRNAs),and 17 circular RNAs(circRNAs).In addition,ncFO also incorporates two online prediction tools based on the regulation and co-expression of ncRNA and ferroptosis *** default parameters,we obtained 3260 predicted entries,including 598 miRNAs and 178 lncRNAs,by regulation,as well as 2,592,661 predicted entries,including 967 miRNAs and 9632 lncRNAs,by ncRNA-ferroptosis gene co-expression in more than 8000 samples across 20 cancer *** detailed information of each entry includes ncRNA name,disease,species,tissue,target,regulation,publication time,and PubMed *** also provides survival analysis and differential expression analysis for *** summary,ncFO offers a user-friendly platform to search and predict ferroptosisassociated ncRNAs,which might facilitate research on ferroptosis and discover potential targets for cancer treatment.

关键词： Ferroptosis microRNA Long non-coding RNA Circular RNA Cancer

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Integrated network analyses identify MYB4R1 neofunctionalization in the UV-B adaptation of Tartary buckwheat

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Plant Communications 2022年第6期3卷 267-281页

作者： Moyang Liu Wenjun Sun Zhaotang Ma Chaocheng Guo jiahao chen Qi Wu Xiyin Wang Hui chen College of Life Science Sichuan Agricultural UniversityYa’an 625014China Joint Center for Single Cell Biology School of Agriculture and BiologyShanghai Jiao Tong UniversityShanghai 200240China Shanghai Collaborative Innovation Center of Agri-Seeds/School of Agriculture and Biology Shanghai Jiao Tong UniversityShanghai 200240China School of Life Science North China University of Science and TechnologyTangshan 063210China State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Key Laboratory of Major Crop Diseases and Rice Research InstituteSichuan Agricultural UniversityChengdu 611130China

A hallmark of adaptive evolution is innovation in gene function,which is associated with the development of distinct roles for genes during plant evolution;however,assessing functional innovation over long periods of time is not *** buckwheat(Fagopyrum tataricum)originated in the Himalayan region and has been exposed to intense UV-B radiation for a long time,making it an ideal species for studying novel UV-B response mechanisms in ***,we developed a workflow to obtain a co-functional network of UV-B responses using data from more than 10,000 samples in more than 80 projects with multi-species and multiomics *** the entire network revealed that flavonoid biosynthesis was most significantly related to the UV-B ***,we found that the regulatory factor MYB4R1,which resides at the core of the network,has undergone *** vitro and in vivo experiments demonstrated that MYB4R1 regulates flavonoid and anthocyanin accumulation in response to UV-B in buckwheat by binding to L-box motifs in the FtCHS,FtFLS,and FtUFGT *** used deep learning to develop a visual discrimination model of buckwheat flavonoid content based on natural populations exposed to global UV-B *** study highlights the critical role of gene neofunctionalization in UV-B adaptation.

关键词： neofunctionalization deep learning MYB UV-B radiation Tartary buckwheat

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Insight into the characteristics of an important evolutionary model bird(Geospiza magnirostris)mitochondrial genome through comparison

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BIOCELL 2022年第7期46卷 1733-1746页

作者： ZHENGGANG XU LIANG WU jiahao chen YUNLIN ZHAO CHONGXUAN HAN TIAN HUANG GUIYAN YANG Key Laboratory of National Forestry and Grassland Administration on Management of Western Forest Bio-Disaster College of ForestryNorthwest A&F UniversityYangling712100China Engineering Research Center for Internet of Animals Changsha410000China Key Laboratory of Forestry Remote Sensing Based Big Data&Ecological Security for Hunan Province Central South University of Forestry and TechnologyChangsha410004China

Darwin’s finches are the most classic case of *** studies on the evolution of this species were mainly based on *** now,the mitochondrial genome of Geospiza magnirostris has been sequenced and the study explored the characteristics of the complete genome of *** and verified the evolutionary position of *** 13 PCGs initiated by ATN *** stop codons of three PCGs(ND2,COX3 and ND4)were incomplete,with only T-or TA-replacing complete form TAA or *** the tRNA genes expressed a typical cloverleaf secondary structure,except for tRNA^(Ser1)(AGY),whose dihydrouridine(DHU)arm was lack and instead with a simple *** the sequence of the control region of ***,we found six simple repeat tandem sequences with a total length of 42 *** characteristic conserved overlapping junction(ATGCTAA)and(CAAGAAAG)were observed as reported for eight selected Passeriformes birds.A special conserved overlapping junction(ATCTTACC)involved in mitochondrial transcription termination was found between tRNA^(Tyr) and COX1 in ***’s control *** most frequently used amino acids in ***’s PCGs were Leu1(CUN),Ile,Thr,*** codon usage of *** was relatively average,and there was no particular *** ratio Ka/Ks results showed that *** receives less natural selection *** phylogenetic relationships and cluster analysis of relative codon usage showed that *** and Thraupis episcopus clustered in one *** phylogenetic position of *** was consistent with the traditional taxonomic of *** results supported the conclusion that *** belongs to the morphological classification of the family Thraupidae.

关键词： Geospiza magnirostris Mitochondrial genome Comparative analysis Evolution analysis Phylogenetic relationships

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Mantle contributions to granitoids associated with Sn mineralization:Geochemical and isotopic evidence from the giant Dachang deposit,South China

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Geoscience Frontiers 2024年第1期15卷 187-208页

作者： Tingyi Wang Qihai Shu Xiaoping Xia Chao Li Yanning Wang jiahao chen Xiang Sun M.Santosh Qingfei Wang State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesBeijing 100083China Frontiers Science Center for Deep-time Digital Earth China University of Geosciences(Beijing)Beijing 100083China State Key Laboratory of Isotope Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China National Research Center for Geoanalysis Chinese Academy of Geological SciencesBeijing 100037China Department of Earth Science University of AdelaideAdelaideSouth Australia 5005Australia State Key Laboratory of Nuclear Resources and Environment East China University of TechnologyNanchang 330013China

Major Sn deposits are commonly linked to crust-derived and highly evolved granites,with magma generation aided by mantle ***,whether and how the mantle components contribute to Sn polymetallic mineralization remains *** this study,in combination with a compilation of equivalent data in the region,we provide new constraints on this issue based on detailed investigations on the petrogenesis and metallogenic significance of granitoids including the causative batholith and later granodiorite porphyry dike in the giant Dachang Sn deposit from South *** former has zircon U-Pb ages of 93-91 Ma and belongs to highly evolved S-type biotite granite,which experienced fractionation of massive *** latter shows zircon U-Pb ages of 90 Ma and displays I-type granite *** batholith was mainly derived from the dehydration melting of biotite in the metasedimentary sources,as revealed by the relatively low whole-rock Pb contents(850℃),whole-rock Mg#(52 to 58),apatiteεNd(t)(-9.2 to-6.5)and zirconεHf(t)(-7.6 to 2.5)values but lower zirconδ18O values(6.33 to 8.30‰)of the later granodiorite porphyry dike than those of the batholith also suggest that mantle material was involved in the generation of the dikes,which is evident by the variational features of zircon and apatite trace *** addition,at the zircon Hf0.05,the higher zirconΔFMQ values(mostly from-1.8 to 2.0)and H2O contents(100-1100 ppm)of the Dachang

关键词： Highly evolved S-type biotite granite I-type granodiorite porphyry dike Crust-mantle mixing Mantle contributions Dachang Sn mineralization

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Differential accumulation mechanisms of purine alkaloids and catechins in Camellia ptilophylla,a natural theobromine-rich tea

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Beverage Plant Research 2023年第1期3卷 128-136页

作者： chentao Ying Jiawen chen jiahao chen Peng Zheng Caibi Zhou Binmei Sun Shaoqun Liu College of Horticulture South China Agricultural UniversityGuangzhou 510642China College of Biological Science and Agriculture Qiannan Normal University for NationalitiesDuyun 558000China

Tea is consumed worldwide due to its charming flavor and the refreshing effects conferred by *** however has undesirable side effects,such as sleep *** ptilophylla is known for its low caffeine content,and the biosynthesis of purine alkaloids in this species has become a hot *** this study,the accumulation of purine alkaloids in a natural *** population(32 plants)was analyzed,and the results showed that 81.25%of this population were caffeine-free,containing only theobromine(TB),while six plants contained both theobromine and caffeine(CAF).RNA-seq analysis of two *** plants with contrasting purine alkaloid contents(TB and CAF)revealed that xanthosine synthesis genes of the SAM cycle and AMP pathway were significantly related to the differential accumulation of purine alkaloids between TB and *** high theobromine content in TB was attributed to the significantly higher expression of TCS-2,TCS-3 and MXMTs and downregulation of the xanthosine degradation pathway in comparison to ***,CsMYB184 was significantly upregulated in TB,opposing the expression pattern of TCS1,but consistent with that of other TCSs and ***,the upregulated expression of catechin biosynthesis genes,F3'H,F3'5'H and SCPLs in TB corresponded to a higher gallocatechin gallate(GCG)***,these findings provide new insights into the accumulation of theobromine and GCG,which may facilitate the development of tea plant cultivars with low-caffeine or high GCG to meet the diverse demands of consumers.

关键词： alkaloids purine attributed

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Kinetic study of key species and reactions of atmospheric pressure pulsed corona discharge in humid air

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Plasma Science and Technology 2022年第5期24卷 154-168页

作者： Yongkang PENG Xiaoyue chen Yeqiang DENG Lei LAN Haoyu ZHAN Xuekai PEI jiahao chen Yukuan YUAN Xishan WEN The School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072People’s Republic of China

In this study, we examined the key particles and chemical reactions that substantially influence plasma characteristics. In summarizing the chemical reaction model for the discharge process of N_(2)–O_(2)–H_(2)O(g)mixed gases, 65 particle types and 673 chemical reactions were investigated. On this basis, a global model of atmospheric pressure humid air discharge plasma was developed, with a focus on the variation of charged particles densities and chemical reaction rates with time under the excitation of a 0–200 Td pulsed electric field. Particles with a density greater than 1% of the electron density were classified as key particles. For such particles, the top ranking generation or consumption reactions(i.e. where the sum of their rates was greater than 95% of the total rate of the generation or consumption reactions) were classified as key chemical reactions. On the basis of the key particles and reactions identified, a simplified global model was derived. A comparison of the global model with the simplified global model in terms of the model parameters, particle densities, reaction rates(with time), and calculation efficiencies demonstrated that both models can adequately identify the key particles and chemical reactions reflecting the chemical process of atmospheric pressure discharge plasma in humid air. Thus, by analyzing the key particles and chemical reaction pathways, the charge and substance transfer mechanism of atmospheric pressure pulse discharge plasma in humid air was revealed, and the mechanism underlying water vapor molecules’ influence on atmospheric pressure air discharge was elucidated.

关键词： atmospheric humid air key charged particles key chemical reactions reaction pathways

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The synergistic role of Pu.1 and Fms in zebrafish osteoclast-reducing osteopetrosis and possible therapeutic strategies

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Journal of Genetics and Genomics 2020年第9期47卷 535-546页

作者： Wei Liu Qianqian Di Kailun Li Jing Li Ning Ma Zhibin Huang jiahao chen Sheng Zhang Wenqing Zhang Yiyue Zhang Division of Cell Developmental and Integrative BiologySchool of MedicineSouth China University of TechnologyGuangzhou510006China Key Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases of Guangdong Higher Education Institutes Department of Developmental BiologySchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou510515China Department of Orthopedics and Traumatology Nanfang HospitalSouthern Medical UniversityGuangzhou510515China

Osteoclasts are bone resorption cells of myeloid origin. Osteoclast defects can lead to osteopetrosis, a genetic disorder characterized by bone sclerosis for which there is no effective drug treatment. It is known that Pu.1 and Fms are key regulators in myelopoiesis, and their defects in mice can lead to reduced osteoclast numbers and consequent osteopetrosis. Yet how Pu.1 and Fms genetically interact in the development of osteoclasts and the pathogenesis of osteopetrosis is still unclear. Here, we characterized pu.1^(G242) D;fms^(j4e1) double-deficient zebrafish, which exhibited a greater deficiency of functional osteoclasts and displayed more severe osteopetrotic symptoms than the pu.1^(G242) Dor fms^(j4e1) single mutants, suggesting a synergistic function of Pu.1 and Fms in the regulation of osteoclast development. We further demonstrated that Pu.1 plays a dominant role in osteoclastogenesis, whereas Fms plays a dominant role in osteoclast maturation. Importantly, treatment with the drug retinoic acid significantly relieved the different degrees of osteopetrosis symptoms in these models by increasing the number of functional osteoclasts. Thus, we report the development of valuable animal models of osteopetrosis, and our results shed light on drug development for antiosteopetrosis therapy.

关键词： Zebrafish Bone development Osteoclasts Osteopetrosis Therapeutics

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Glutaredoxin-1 alleviates acetaminophen-induced liver injury by decreasing its toxic metabolites

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Journal of Pharmaceutical Analysis 2023年第12期13卷 1548-1561页

作者： Ying Xu Yan Xia Qinhui Liu Xiandan Jing Qin Tang Jinhang Zhang Qingyi Jia Zijing Zhang Jiahui Li jiahao chen Yimin Xiong Yanping Li Jinhan He Department of Pharmacy Institute of Metabolic Diseases and PharmacotherapyWest China HospitalSichuan UniversityChengdu610041China

Excessive N-acetyl-p-benzoquinone imine(NAPQI)formation is a starting event that triggers oxidative stress and subsequent hepatocyte necrosis in acetaminophen(APAP)overdose caused acute liver failure(ALF).S-glutathionylation is a reversible redox post-translational modification and a prospective mechanism of APAP ***-1(Glrx1),a glutathione-specific thioltransferase,is a primary enzyme to catalyze *** objective of this study was to explored whether and how Glrx1 is associated with the development of ALF induced by *** Glrx1 knockout mice(Glrx1^(-/-))and liver-specific overexpression of Glrx1(AAV8-Glrx1)mice were produced and underwent APAPinduced ***(PFD),a potential inducer of Glrx1,was administrated preceding APAP to assess its protective *** results revealed that the hepatic total protein S-glutathionylation(PSSG)increased and the Glrx1 level reduced in mice after APAP ***1^(-/-)mice were more sensitive to APAP overdose,with higher oxidative stress and more toxic metabolites of *** was attributed to Glrx1 deficiency increasing the total hepatic PSSG and the S-glutathionylation of cytochrome p4503a11(Cyp3a11),which likely increased the activity of ***,AAV8-Glrx1 mice were defended against liver damage caused by APAP overdose by inhibiting the S-glutathionylation and activity of Cyp3a11,which reduced the toxic metabolites of APAP and oxidative *** precede administration upregulated Glrx1 expression and alleviated APAP-induced ALF by decreasing oxidative *** have identified the function of Glrx1 mediated PSSG in liver injury caused by APAP *** Glrx1 expression may be investigated for the medical treatment of APAP-caused hepatic injury.

关键词： Glutaredoxin-1 S-glutathionylation Acetaminophen Toxic metabolites Cyp3a11

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