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Differential expression of Kindlin-1 and Kindlin-2 correlates with esophageal cancer progression and epidemiology

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Science China(Life Sciences) 2017年第11期60卷 1214-1222页

作者： peng wang jun zhan jiagui song yunling wang weigang fang zhihua liu hongquan zhang department of anatomy histology and embryologykey laboratory of carcinogenesis and translational researchministry of educationand state key laboratory of natural and biominelic drugspeking university health science centerBeijing 100191China department of pathology peking university health science centerBeijing 100191China institute of cardiovascular research peking university health science centerBeijing 100191China state key laboratory of motecular oncology national cancer center/cancer hospitalchinese academy of medical sciences and peking union medical collegeBeijing 100121China

Esophageal cancer （EC） is one of the most lethal malignancies in China, but the etiology and risk factors remain unclear. The integrin-interacting proteins Kindlin-1 and Kindlin-2 are focal adhesion molecules that activate transmembrane receptor integrins and regulate tumor cell growth, invasion, and metastasis. Here, we report that Kindlin-1 and Kindlin-2 are differentially expressed among Chinese EC patients. For this, Kindlin-1 and Kindlin-2 expression was evaluated in 220 EC patients by immunohistochemistry （IHC） and found to be correlated with the EC progression, along with a variety of epidemiologic parameters, including smoking, family EC history, and EC invasion status. Moreover, data downloaded from the Oncomine database revealed that both Kindlin- 1 and Kindlin-2 were upregulated in ECs compared with normal esophageal tissues; although Kindlin-1 was highly expressed in well-differentiated tumors, whereas Kindlin-2 was more prevalent in poorly differentiated tumors. Collectively, these data suggest that Kindlin-1 may inhibit, while Kindlin-2 may promote, EC progression. This study, for the first time, linked the expression of Kindlin-1 and Kindlin-2 with EC family genetic background and living habits, which may help further our understanding of the various causes of EC.

关键词： Kindlin-l Kindlin-2 esophageal cancer epidemiology

Integrin-interacting protein Kindlin-2 induces mammary tumors in transgenic mice

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Science China(Life Sciences) 2019年第2期62卷 225-234页

作者： Bing Li Xiaochun Chi jiagui song Yan Tang Juan Du Xiaokun He Xiaoran Sun Zhenwu Bi Yunling Wang Jun Zhan Hongquan Zhang Department of Anatomy Histology and Embryology Key Laboratory of Carcinogenesis and Translational Research Ministry of Educationand State Key Laboratory of Natural and Biomimetic Drugs Peking University Health Science Center Institute of Cardiovascular Research Peking University Health Science Center

Kindlin-2, an integrin-interacting protein, regulates breast cancer progression. However, currently, no animal model to study the role of Kindlin-2 in the carcinogenesis of mammary gland is available. We established a Kindlin-2 transgenic mouse model using a mammary gland-specific promoter, mammary tumor virus(MMTV) long terminal repeat(LTR). Kindlin-2 was overexpressed in the epithelial cells of the transgenic mice. The mammary gland ductal trees were found to grow faster in MMTV-Kindlin-2 transgenic mice than in control mice during puberty. Kindlin-2 promoted mammary gland growth as indicated by more numerous duct branches and larger lumens, and more alveoli were formed in the mammary glands during pregnancy under Kindlin-2 overexpression. Importantly, mammary gland-specific expression of Kindlin-2 induced tumor formation at the age of 55 weeks on average. Additionally, the levels of estrogen receptor and progesterone receptor were decreased, whereas human epidermal growth factor receptor 2 and β-catenin were upregulated in the Kindlin-2-induced mammary tumors. These findings demonstrated that Kindlin-2 induces mammary tumor formation via activation of the Wnt signaling pathway.

关键词： Kindlin-2 breast cancer mouse mammary gland growth mammary tumorigenesis transgenic mouse

C1orf106, an innate immunity activator, is amplified in breast cancer and is required for basal-like/luminal progenitor fate decision

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Science China(Life Sciences) 2019年第9期62卷 1229-1242页

作者： Ji Ma Cheng Liu Decao Yang jiagui song Jing Zhang Tianzhuo Wang Mengyuan Wang Weizhi Xu Xueying Li Shigang Ding Jun Zhan Hongquan Zhang Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of AnatomyHistology and Embryologyand State Key Laboratory of Natural and Biomimetic DrugsPeking University Health Science CenterBeijing 100191China Department of Gastroenterology Peking University Third HospitalBeijing 100191China

Basal-like breast cancer with a luminal progenitor gene expression profile is an aggressive subtype of breast cancer with a poorer prognosis compared with other ***,genes that specifically promote basal-like breast cancer development remain largely ***,we report that a novel gene C1orf106 plays an important role in maintaining the feature of basal-like/luminal progenitors.C1orf106 is frequently amplified and overexpressed in basal-like breast cancer and is associated with a poor outcome in *** human TCGA database,C1orf106 expression was correlated with upregulation of ELF5 and downregulation of GATA3,two transcription factors that regulate mammary gland stem cell *** expression of C1orf106 promotes tumor progression and expression of basal-like/luminal progenitor marker ELF5;depletion of C1orf106 suppresses tumorigenesis and expression of basal-like/luminal progenitor marker *** findings suggest that C1orf106 maintains the basal-like/luminal progenitor character through balancing the expression of ELF5 and *** together,we demonstrated that C1orf106 is an important regulator for basal-like/luminal progenitors and targeting C1orf106 is of therapeutic value for breast cancer.

关键词： C1orf106 basal-like luminal progenitor breast cancer ELF5 GATA3

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金川矿区土壤重金属污染评价

有色金属（矿山部分） 2018年第2期70卷 88-93页

作者：徐琪龚甲桂宋德东李强苏大勇中国冶金地质总局山东正元地质勘查院济南210025

矿山的开发活动可能对矿区及周围地区造成很严重的土壤重金属污染。以金川矿区为主要调查区,测定了矿山及周边土壤的重金属含量,采用单因子污染指数、内梅罗指数、改进内梅罗指数和潜在生态风险指数4种评价方法对调查区进行土壤重金属... 详细信息

矿山的开发活动可能对矿区及周围地区造成很严重的土壤重金属污染。以金川矿区为主要调查区,测定了矿山及周边土壤的重金属含量,采用单因子污染指数、内梅罗指数、改进内梅罗指数和潜在生态风险指数4种评价方法对调查区进行土壤重金属污染评价。结果显示:采矿区内二矿区及周边的铁路和工业厂区受到轻微污染,其它地区并未受到污染,矿山的开采和矿石的运输是造成调查区土壤重金属污染污染的主要原因。

关键词：土壤重金属污染相关性分析评价方法

Dating formation of natural gas pools using fluid inclusion data from reservoirs

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Chinese Science Bulletin 2002年第18期47卷 1567-1572页

作者： Xianming Xiao Zufa Liu Jiaku Mi Dehan Liu jiagui Shen Zhiguang song Chinese Acad Sci Guangzhou Inst Geochem State Key Lab Organ Geochem Guangzhou 510640 Peoples R China

A method has been suggested which is based on the homogenization temperatures and other data of fluid inclusions from a reservoir rock, with the combination of burial and geothermal history of the hosted rock, to date the gas reservoir formation. On the basis of this, a case study of the Carboniferous-Permian gas pools in the Ordos Basin has been conducted. The results have shown that the reservoir sandstones of the gas pool were filled by gases during 125-150 Ma, earlier in the southern area and later in the northern area, which is consistent with the basin’s geological and geochemical background under which the gas pools formed.

关键词： fluid inclusion Ordos Basin geochronology of gas res-ervoir deep basin gas trap.

An Analysis of the Characteristics of Regional Industrialization in China

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Social Sciences in China 2007年第3期28卷 168-170页

作者： Chen jiagui Huang Qunhui Zhong Hongwu song Jun(译) the Chinese Academy of Social Sciences 不详

If we take the year 2004 as a temporal cross-section, we find great differences in different Chinese regions＇ degree of industrialization. While the overall shape was that of the classic pyramid structure, there was ... 详细信息

关键词：中国工业化地方区域经济

UPFC与IPFC提升系统输电能力比较研究

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电力系统保护与控制 2020年第9期48卷 128-134页

作者：吴熙王亮陈曦刘玙陶加贵滕松陈轩东南大学电气工程学院江苏南京210096 国网江苏省电力有限公司科信部江苏南京210024 国网江苏省电力有限公司检修分公司江苏南京211102

随着电力系统负荷及网架的日益发展,由系统潮流分布不均而引起的输电阻塞问题越来越严重,极大地制约了电力系统的输电能力与效率。利用FACTS设备提升电力系统输电能力相较于传统方案具有占地面积小、可控性高等多方面的优势。UPFC与IPF... 详细信息

随着电力系统负荷及网架的日益发展,由系统潮流分布不均而引起的输电阻塞问题越来越严重,极大地制约了电力系统的输电能力与效率。利用FACTS设备提升电力系统输电能力相较于传统方案具有占地面积小、可控性高等多方面的优势。UPFC与IPFC作为先进的第三代FACTS装置,在潮流调控方面均有着突出的应用优势。因此有必要对两者在提升系统输电能力方面进行技术经济比较研究,用以指导实际工程的解决方案选择。首先基于附加功率注入法分别对UPFC及IPFC进行稳态建模,推导了其数学表达式。之后以江苏南通西北片电网为例,将所建模型应用于实际电力系统,计算结果显示两者均能大幅提升系统输电能力以及安全可靠性。最后在多种工况下对这两种解决方案进行了技术经济比较分析,结果表明IPFC相较于UPFC而言在潮流调控方面的作用更为全面与突出。

关键词：统一潮流控制器线间潮流控制器功率注入模型系统输电能力

瓮安县王家院磷矿地质特征、成矿机制及找矿预测研究

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中国资源综合利用 2023年第8期41卷 96-100,108页

作者：宋普洪游家贵贵州省地质矿产勘查开发局104地质大队贵州都匀558000

为了详细查明瓮安县白岩磷矿周边磷矿资源,为瓮福磷矿区总体规划和开发提供地质依据,贵州省土地矿产资源储备局在瓮安县白岩磷矿东南空白区设立了王家院矿区磷矿勘探项目。通过地质测量、物探剖面测量、钻探工程、样品分析测试等方法,... 详细信息

为了详细查明瓮安县白岩磷矿周边磷矿资源,为瓮福磷矿区总体规划和开发提供地质依据,贵州省土地矿产资源储备局在瓮安县白岩磷矿东南空白区设立了王家院矿区磷矿勘探项目。通过地质测量、物探剖面测量、钻探工程、样品分析测试等方法,勘查人员查明矿区内存在3个工业磷矿体,其中主矿体走向长为1821 m,倾斜延伸为750 m,平均厚为12.64 m,P_(2)O_(5)平均品位为21.46%。经估算,矿区保有资源量为4520万t,伴生的有用矿产资源为氟和碘。王家院矿区磷矿勘探项目为2021年贵州省重点矿产资源大精查的代表性项目,是大型矿床周边空白区深部找矿的成功范例。本文从成矿地质背景、矿床地质特征、成矿机制等方面对该矿床进行整体阐述,分析了找矿潜力区,旨在介绍贵州省新一轮战略找矿的新成果,为我国震旦纪陡山沱时期磷矿深部勘查提供参考。

关键词：王家院磷矿地质特征成矿机制找矿预测瓮安县

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对立共存:广西“向食东盐”与“向食夷盐”研究

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盐业史研究 2021年第2期 72-80页

作者：徐家贵广西社会科学院

广东盐运销广西是两广之间区域性经济流动的一种重要形式。广西从西汉开始食用东部南海盐,北宋时出现“东盐入西”现象,到元朝广西盐产量达顶峰,使“东盐入西”受到一定影响,嗣后明朝过渡到“向食东盐”,并延至民国,期间广东一直负责广... 详细信息

广东盐运销广西是两广之间区域性经济流动的一种重要形式。广西从西汉开始食用东部南海盐,北宋时出现“东盐入西”现象,到元朝广西盐产量达顶峰,使“东盐入西”受到一定影响,嗣后明朝过渡到“向食东盐”,并延至民国,期间广东一直负责广西的食盐供应。然而,广西边远地区远离广东,广东盐难以运销至此,即便到此鬻卖,其价也甚昂。负担重、官引滞是两广盐商经营遭遇的常态,官盐缺、价格高则是广西边远地区始终面临的问题。遂使具备地缘、成本等优势的越南私盐在广西边远地区盛买,出现了“向食夷盐”现象。“向食东盐”与“向食夷盐”对立共存,共同满足广西的食盐需求,“向食夷盐”因之也成为“向食东盐”的一大障碍,损害了政府盐利。

关键词：广东盐 “向食东盐” 越南私盐 “向食夷盐”