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MSIsensor-pro: Fast, Accurate, and Matched-normal-sample-free Detection of Microsatellite Instability

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Genomics, Proteomics & Bioinformatics 2020年第1期18卷 65-71页

作者： Peng Jia Xiaofei Yang Li Guo Bowen Liu jiadong Lin Hao Liang Jianyong Sun Chengsheng Zhang Kai Ye School of Automation Science and Engineering Faculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China MOE Key Laboratory for Intelligent Networks&Networks Security Faculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China School of Computer Science and Technology Faculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China School of Life Science and Technology Xi’an Jiaotong UniversityXi’an 710049China Leiden Institute of Advanced Computer Science Leiden UniversityLeiden 2311 ZENetherlands School of Mathematics and Statistics Xi’an Jiaotong UniversityXi’an 710049China Precision Medicine Center the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China Jackson Laboratory for Genomic Medicine FarmingtonCT 06032USA Genome Institute the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China

Microsatellite instability(MSI)is a key biomarker for cancer therapy and *** experimental assays are laborious and time-consuming,and next-generation sequencingbased computational methods do not work on leukemia samples,paraffin-embedded samples,or patient-derived xenografts/organoids,due to the requirement of matched normal ***,we developed MSIsensor-pro,an open-source single sample MSI scoring method for research and clinical ***-pro introduces a multinomial distribution model to quantify polymerase slippages for each tumor sample and a discriminative site selection method to enable MSI detection without matched normal *** demonstrate that MSIsensor-pro is an ultrafast,accurate,and robust MSI calling *** samples with various sequencing depths and tumor purities,MSIsensor-pro significantly outperformed the current leading methods in both accuracy and computational ***-pro is available at https://***/xjtu-omics/msisensor-pro and free for non-commercial use,while a commercial license is provided upon request.

关键词： Microsatellite Polymerase slippage Multinomial distribution Microsatellite instability Tumor

A focus review on 3D printing of wearable energy storage devices

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Carbon Energy 2022年第6期4卷 1242-1261页

作者： Yuxuan Zhu jiadong Qin Ge Shi Chuang Sun Malaika Ingram Shangshu Qian Jiong Lu Shanqing Zhang Yu Lin Zhong Centre for Catalysis and Clean Energy School of Environment and ScienceGold Coast CampusGriffith UniversityQueenslandGold CoastAustralia Queensland Micro-and Nanotechnology Centre School of Environment and ScienceGriffith UniversityNathanQueenslandAustralia State Key Laboratory of Pulp and Paper Engineering South China University of TechnologyGuangzhouGuangdongChina School of Chemistry and Materials Chemistry Jiangsu Normal UniversityXuzhouJiangsuChina Department of Chemistry National University of SingaporeSingaporeSingapore

Three-dimensional(3D)printing has gained popularity in a variety of applications,particularly in the manufacture of wearable *** by the large degree of freedom in customizable fabrication,3D printing can cater towards the practical requirements of wearable devices in terms of light weight and *** particular,this focus review aims to cover the important aspect of wearable energy storage devices(WESDs),which is an essential component of most wearable ***,the topics discussed are the fundamentals of 3D printing inks used,the optimizing strategies in improving the mechanical and electrochemical properties of wearable devices and the recent developments and challenges of wearable electrochemical systems such as batteries and *** can be expected that,with the development of 3D printing technology,realization of the full potential of WESDs and seamless integration into smart devices also needs further in-depth investigations.

关键词： 3D printing batteries direct ink writing supercapacitors wearable energy storage devices

Modulating Pd e_(g) orbital occupancy in Pd-Au metallic aerogels for efficient carbon dioxide reduction

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Journal of Energy Chemistry 2023年第12期87卷 98-104,I0004页

作者： Yao Chen Juan Wang Tingjie Mao Cun Chen Hanjun Li Honggang Huang Hui Fu Feili Lai jiadong Chen Nan Zhang Tianxi Liu Key Laboratory of Synthetic and Biological Colloids Ministry of EducationSchool of Chemical and Material EngineeringInternational Joint Research Laboratory for Nano Energy CompositesJiangnan UniversityWuxi 214122JiangsuChina Key Laboratory of Leather of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035ZhejiangChina Department of Chemistry KU LeuvenCelestijnenlaan 200FLeuven 3001Belgium

The electronic structure of electrocatalysts plays a critical role in energy conversion,whereas for an efficient catalyst,it is challenging to modulate the ***,we present a new strategy to modulate the e_(g) orbital occupancy of Pd by constructing composition-controllable Pd-Au metallic aerogels(MAs),optimizing the d-band center of Pd to achieve excellent performance for electrochemical carbon dioxide reduction reaction(CO_(2)RR).Specifically,Pd_(1)Au_(2) MAs achieve almost 100% Faraday efficiency(FE) of CO in the range of-0.40 to-0.80 V *** hydrogen electrode(RHE),as well as the long-term stability,being one of the best Pd-based materials for CO_(2)*** X-ray photoelectron spectroscopy(XPS) results and density functional theory(DFT) calculations demonstrate that the introduction of Au modulates the Pd e_(g) orbital occupancy,which significantly weakens *CO adsorption on Pd,reduces the CO_(2)RR energy barrier and consequently improves the electrocatalytic activity and stability for long-term *** work highlights a new strategy for designing efficient electrocatalysts for CO_(2)RR and beyond.

关键词： Pd Carbon dioxide reduction Alloy Aerogels Orbital occupancy

Time for a New Framework

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Beijing Review 2020年第30期63卷 30-31页

作者： Zhang jiadong Center for South Asian Studies Fudan University in Shanghai

China and India should enhance strategic mutual trust,reduce sensitivity of boundary question in relationship In June,a serious clash between Chinese and Indian border troops at the Galwan Valley pushed the two countries to the brink of *** incident,which caused injuries and deaths,was a result of the escalation of tension in the border areas.

关键词： mutual injuries border

基于ScAlN薄膜的高频PMUT阵列的设计与制造

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压电与声光 2024年第4期46卷 496-504页

作者：塔桂峰刘建河李加东姚术涛刘浩杰苗斌商文玲陶金燕长春理工大学机电工程学院吉林长春130012 中国科学院苏州纳米技术与纳米仿生研究所江苏苏州215123 中国科学院多功能材料与轻巧系统重点实验室江苏苏州215123 中国科学技术大学纳米技术与纳米仿生学院安徽合肥230026 上海大学理学院上海200072

高频压电微机械超声换能器(PMUT)应用于各种场景,如指纹识别、无损检测、医疗成像。在当前非侵入式血管成像应用中,存在换能器使用锆钛酸铅压电陶瓷(PZT)及局限于1-D PMUT阵列的问题。设计并制作了一种基于ScAlN材料压电薄膜的2D-PMUT... 详细信息

高频压电微机械超声换能器(PMUT)应用于各种场景,如指纹识别、无损检测、医疗成像。在当前非侵入式血管成像应用中,存在换能器使用锆钛酸铅压电陶瓷(PZT)及局限于1-D PMUT阵列的问题。设计并制作了一种基于ScAlN材料压电薄膜的2D-PMUT阵列。为了进一步得到阵列最佳的输出性能,降低栅瓣影响,设计了间距为波长的1/2(300μm)的并联六边形阵列,增大了填充因子,降低了阻抗,提高了输出电流。采用SOI晶片作为PMUT的基本结构,设计了微机电系统(MEMS)工艺流程,并完成了晶片制作。通过扫描电子显微镜和聚焦离子束切割确定PMUT的形貌和结构尺寸,并且测得在水中的谐振频率为2.36 MHz。仿真与测试结果表明,测试误差为9.2%,位移灵敏度较好,有望满足非侵入式血管成像应用需求。

关键词：高频压电微机械超声换能器阵列(PMUT) ScAlN薄膜有限元仿真器件制备非侵入式血管成像

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星载产品开机后的内部压力变化仿真研究

真空科学与技术学报 2024年第8期44卷 668-672页

作者：崔寓淏孙立臣窦仁超史纪军齐嘉东毕海林王文丙北京卫星环境工程研究所北京100094 合肥工业大学机械工程学院合肥230009

气体压力作为星载大功率产品开机运行的一个重要参数,会影响到产品的安全和在轨寿命。由于星载大功率产品开机后温度升高,部件放气会发生压力反弹现象,对产品安全带来隐患。文章从材料释气和内部气体扩散浓度随温度变化关系研究入手,基... 详细信息

气体压力作为星载大功率产品开机运行的一个重要参数,会影响到产品的安全和在轨寿命。由于星载大功率产品开机后温度升高,部件放气会发生压力反弹现象,对产品安全带来隐患。文章从材料释气和内部气体扩散浓度随温度变化关系研究入手,基于某星载产品开机供电后温升引起的材料脱附气体增多,以烘烤温度,烘烤时长和静置的情景作为边界条件,计算了分子流状态下产品开机前后内部压力变化情况,并进行数值模拟。文章为星载产品空间环境下开机运行压力变化预估以及开机后是否存在安全隐患提供理论依据。

关键词：真空度航天器真空放电压力预测

Ionospheric electromagnetic perturbations observed on DEMETER satellite before Chile M7.9 earthquake

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Earthquake Science 2009年第3期22卷 251-255页

作者： Xuemin Zhang jiadong Qian Xinyan Ouyang Xuhui Shen Jin'an Cai Shufan Zhao Institute of Earthquake Science China Earthquake Administration Beijing 100036 China

Based on the ionospheric electromagnetic data observed on DEMETER satellite of France, the ionospheric electromagnetic signals were analyzed within 10 days before Chile M7.9 earthquake on November 14, 2007. It is found that, low frequency electromagnetic disturbances began to increase in a large scale of latitude, and reached to a maximum one week prior to the earthquake, and at about three days before the quake, the peak values shifted to lower latitude. Taking three days as a group, spatial images of a few parameters were analyzed, from which it can be seen during the five days prior to this earthquake, the amplitude and scale of anomalies are enlarged, while the epicenter is located at the boundary of anomalous region. The anomalous tempo-spatial variation in electron density prior to the earthquake were also obtained in terms of tracing the data from revisited orbits in half a year prior to the quake.

关键词： DEMETER satellite ionosphere electromagnetic disturbance electron density

祖师麻注射液穴位注射联合浮针治疗腰椎间盘突出症验案两则

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中国中医药现代远程教育 2024年第8期22卷 89-91页

作者：雷港柴进华(指导) 郭焱龙杨贤海江佳栋湖北中医药大学针灸骨伤学院湖北武汉430000 湖北中医药大学附属荆门市中医医院针灸·风湿病科湖北荆门448000

文章列举两则医案,系统地论述了祖师麻注射液穴位注射联合浮针疗法在腰椎间盘突出症中的具体运用,并以中医经络辨证为指导,分别列举了足太阳经和足少阳经两种不同类型的腰椎间盘突出症的治疗。借此阐述了二者的中西医理论依据及相关现... 详细信息

文章列举两则医案,系统地论述了祖师麻注射液穴位注射联合浮针疗法在腰椎间盘突出症中的具体运用,并以中医经络辨证为指导,分别列举了足太阳经和足少阳经两种不同类型的腰椎间盘突出症的治疗。借此阐述了二者的中西医理论依据及相关现代研究,创造性地将中医经络腧穴理论与浮针的患肌理论相结合。两种方法联合运用,操作简便、效果显著,突出了两种疗法不同于常规治疗的鲜明特色,值得临床推广运用。

关键词：腰痹腰椎间盘突出症祖师麻注射液穴位注射疗法浮针疗法医案

Terrorist Activities in Yemen and the US Countermeasures

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Asian Journal of Middle Eastern and Islamic Studies 2010年第1期4卷 101-115,I0006页

作者： ZHANG jiadong Center for American Studies Fudan University

Since late 2009,the threat imposed on the international community,especially on the US,by the al Qaeda in Yemen has aroused strong concern across the *** major concern of the international anti-terrorism camp is the Houthi rebellion in North Yemen and the possibility of al Qaeda's comeback in *** its backward economy,unstable and multipolar society and traditional culture of violence,it's really difficult for Yemen to get rid of terrorism within a short period of *** that terrorism in Yemen has become a severe threat to the US it's likely that the US may create a third battlefield of anti-terrorism in Yemen as it started the Iraq and Afghan wars.

关键词： US Yemen Terrorism Al Qaeda