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Nano Research 2018年第7期11卷 3886-3898页

作者： Fen Wang jiadong Pang Leilei Huang Ran Wang Qing Jiang Liming Zhang Kang Sun Department of Pathology The First Affiliated Hospital of Sun Yat-sen University Guangzhou 510080 China PCFM Lab and GDHPPC Lab School of Materials Science and Engineering Sun Yot-sen University Guongzhou 510275 Chino School of Engineering Sun Yat-sen University Guangzhou 510006 China School Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instruments Sun Yat-sen University Guangzhou S 10006 China

Osteosarcoma is the most common primary malignant neoplasm of the bone in children and adolescents and has a high risk of relapse and metastasis. Of the various methods to treat osteosarcoma, the use of genetic approaches to inhibit the rapid growth of osteosarcoma while limiting tumor metastasis has presented a challenge in its implementation. Here, we successfully synthesized a polysaccharide derivative （Amy-g-PLLD） for delivery of astrocyte elevated gene-1 （AEG-1） small-interfering RNA （siRNA）（siAEG-1）, and used it for the first time to suppress osteosarcoma tumors in vitro and in vivo. Amy-g-PLLD/ siAEG-1 complexes were delivered into 143B human osteosarcoma cells with low resultant cytotoxicity. Osteosarcoma tumor proliferation and invasion were inhibited in vitro. Intratumoral injection of Amy-g-PLLD/siAEG-1 complexes markedly inhibited tumor growth and lung metastasis in 143B tumor-bearing mice. This biocompatible and effective approach employing a natural material- siRNA complex should pave the way for more genetic research in treating osteosarcoma.

关键词： osteosarcoma amylose gene delivery astrocyte elevated gene-1(AEG-1) small-interfering RNA (siRNA)

基于CMADS和流域相似理论的无资料地区水文模拟——以元江-红河流域为例

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南水北调与水利科技（中英文） 2024年第3期22卷 534-544页

作者：王洁陈裕迪梁峰铭葛慧刘淼陈家栋王丽荣南京信息工程大学水文与水资源工程学院南京210044 广德市农业农村局安徽广德242200 江苏省水文水资源勘测局南京210029 江苏省水文水资源勘测局南京分局南京210007 河北省气象灾害防御和环境气象中心石家庄050021

无水文资料地区,水文模型的参数难以确定。基于此,提出一套无资料地区水文模拟的方法体系,首先利用开源再分析数据驱动水文模型,然后基于流域相似性理论进行模型参数移植,完成无资料地区水文模拟。以元江-红河多国跨界流域为例,将流域... 详细信息

无水文资料地区,水文模型的参数难以确定。基于此,提出一套无资料地区水文模拟的方法体系,首先利用开源再分析数据驱动水文模型,然后基于流域相似性理论进行模型参数移植,完成无资料地区水文模拟。以元江-红河多国跨界流域为例,将流域划分成123个子流域,基于根据高程、坡度、形状系数、森林覆盖率、降水与蒸散发等指标,利用主成分分析和流域相似度计算对123个子流域进行相似性分析;再基于水文资料和相似性结果,将7个有流量资料的子流域划分出4组相似流域;对有资料流域进行参数率定和验证,模拟结果良好,经过参数移植后,无资料流域的模拟结果均得到了提高。基于流域相似性的参数区域化和开源再分析数据的无资料地区水文模拟方法,可以为无资料地区的水文模拟与水资源管理带来更多可能。

关键词：无资料 CMADS SWAT模型流域相似性参数移植

Short-pulsed Raman fiber laser and its dynamics

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Science China(Physics,Mechanics & Astronomy) 2021年第1期64卷 12-32页

作者： Jun Liu jiadong Wu Hualong Chen Yu Chen Zhenhong Wang Chunyang Ma Han Zhang International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of Education Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen518060China China Key Laboratory for Micro/Nano Optoelectronic Devices of Ministry of Education and Hunan Provincial Key Laboratory of Low-Dimensional Structural Physics and Devices School of Physics and ElectronicsHunan UniversityChangsha410082China

We provide a perspective review over the recent development of short-pulsed Raman fiber lasers(RFLs),which can provide laser emissions with flexible wavelengths for a variety of applications as well as an excellent platform to investigate various nonlinear pulse dynamics behaviors that cannot be captured in conventional rare-earth(RE)doped *** pulse generation techniques have been explored in ***,the output pulse performance in terms of the pulse energy,duration and stability from short-pulsed RFLs is still inferior to their RE-doped counterparts despite significant advances made over the past few ***,more efforts are required to improve these *** this review,we present a detailed overview of the short-pulsed RFLs based on different mechanisms from the principle to the experiment,including the Q-switching,gainswitching,mode-locking,synchronous pumping and other innovative *** addition,Raman-induced pulse dynamics in ultrafast RFLs and RE-doped mode-locked fiber lasers(MLFLs)are briefly ***,a perspective outlook for the future ultrafast RFLs is provided based on their potential applications in industrial and scientific research areas.

关键词： Raman fiber laser mode-locking Q-switching Raman pulse dynamics

Comparison of Parallelization Strategies for Min-Sum Decoding of Irregular LDPC Codes

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Tsinghua Science and Technology 2013年第6期18卷 577-587页

作者： Hua Xu Wei Wan Wei Wang Jun Wang jiadong Yang Yun Wen State Key Laboratory on Intelligent Technology and Systems Tsinghua National Laboratory for Information Science and TechnologyDepartment of Computer Science and TechnologyTsinghua University Department of Electronics Engineering Tsinghua University

Low-Density Parity-Check （LDPC） codes are powerful error correcting codes. LDPC decoders have been implemented as efficient error correction codes on dedicated VLSI hardware architectures in recent years. This paper describes two strategies to parallelize min-sum decoding of irregular LDPC codes. The first implements min-sum LDPC decoders on multicore platforms using OpenMP, while the other uses the Compute Unified Device Architecture （CUDA） to parallelize LDPC decoding on Graphics Processing Units （GPUs）. Empirical studies on data with various scales show that the performance of these decoding processes is improved by these parallel strategies and the GPUs provide more efficient, fast implementation decoder.

关键词： Low-Density Parity-Check (LDPC) codes multicore OpenMP Graphic Processor Unit (GPU) ComputeUnified Device Architecture (CUDA)

不同频率rTMS联合生物反馈对难治性抽动障碍患儿血清 BDNF和S-100β水平的影响

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中国实用神经疾病杂志 2024年第7期27卷 853-857页

作者：孙家栋李雪梅刘君玲潍坊医学院附属医院山东潍坊261031

目的探讨不同频率重复经颅磁刺激(rTMS)联合生物反馈治疗难治性儿童抽动障碍对血清脑源性神经营养因子(BDNF)、中枢神经特异性蛋白(S-100β)水平的影响。方法选取2018-01—2022-06在潍坊医学院附属医院门诊就诊的120例抽动障碍患儿,依... 详细信息

目的探讨不同频率重复经颅磁刺激(rTMS)联合生物反馈治疗难治性儿童抽动障碍对血清脑源性神经营养因子(BDNF)、中枢神经特异性蛋白(S-100β)水平的影响。方法选取2018-01—2022-06在潍坊医学院附属医院门诊就诊的120例抽动障碍患儿,依据随机数字表法分为高频组(1 Hz rTMS联合生物反馈治疗,60例)和低频组(0.5 Hz rTMS联合生物反馈治疗,60例)。比较2组患儿的耶鲁综合抽动严重程度量表(YGTSS)评分、注意力缺陷多动障碍筛查量表(SNAP-Ⅳ)评分、认知功能评分、血清BDNF和S-100β水平、平均血流速度(Vm)、收缩期最大血流速度(Vs)、血管阻力指数(RI)、治疗效果和不良反应。结果高频组总有效率显著高于低频组(P0.05)。结论高频rTMS联合生物反馈对难治性抽动障碍患儿血清BDNF、S-100β水平的改善效果优于低频rTMS联合生物反馈治疗。

关键词：难治性抽动障碍儿童重复经颅磁刺激生物反馈不同频率脑源性神经营养因子中枢神经特异性蛋白

V_r:A new index to represent the variation rate of geomagnetic activity

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Earthquake Science 2010年第4期23卷 343-348页

作者： Dongmei Yang Yufei He Chuanhua Chen jiadong Qian Institute of Geophysics China Earthquake Administration Beijing 10008 l China Tai'an Magnetic Observatory Earthquake Administration of Shandong Province Tai'an 271000 China Institute of Earthquake Science China Earthquake Administration Beo'ing 100036 China

By calculating the hourly standard deviation of the first-order differences of the horizontal geomagnetic com- ponent minute data, a new index Vr to represent the variation rate of the geomagnetic field was introduced. Vr-indices show similar trends in the temporal change at different observatories and have simultaneous peak values at the observatories cov- ering a large span geographically, which reveals that the source of geomagnetic disturbances represented by Vr is in the mag- netosphere. Based on the comparison among Vr, Kp and ap, it is found that generally Vr changes linearly with Kp and ap, which means that the rapid changes of magnetic field usually exist together with magnetic disturbances. But there are excep- tions. As Vr can be easily produced by individual observatory in quasi real time and is more sensitive to the variation rate of geomagnetic field rather than the field itself, it can be expected to serve for monitoring or predicting the geomagnetic-induced event in a quick and intuitive way.

关键词： Vr index first-order difference standard deviation variation rate of geomagnetic field geomagnetic-induced event

基于大数据技术的LNG加注站智能选址方案设计

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中国石油大学学报（社会科学版） 2024年第1期40卷 29-35页

作者：沙琦皓胡文娟江军许家栋中海石油气电集团有限责任公司北京100028

为实现“双碳”目标,国家大力推动交通清洁能源的使用,因此合理布局和建设LNG加注站就非常重要。基于交通车辆卫星定位数据的算法技术,运用机器学习模型和大数据架构等先进技术,实现对LNG加注站的智能识别,并对路段流量和LNG重卡加注行... 详细信息

为实现“双碳”目标,国家大力推动交通清洁能源的使用,因此合理布局和建设LNG加注站就非常重要。基于交通车辆卫星定位数据的算法技术,运用机器学习模型和大数据架构等先进技术,实现对LNG加注站的智能识别,并对路段流量和LNG重卡加注行为进行智能统计分析,搭建站点价值分析模型,进行LNG加注站的规划布局和建站选址。根据对交通大数据的分析,确定了全国6000余个LNG加注站的位置分布和其中的高价值站点,借助地图进行标注并打造加注站数据系统,大幅度提高了LNG加注站选址的科学性及效率。

关键词：液化天然气交通大数据数据算法 LNG加注站布局选址

基于网络平台调查的392例直肠癌患者治疗意愿影响因素分析

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肿瘤学杂志 2024年第6期30卷 486-491页

作者：彭昕和白明华褚嘉栋朱骥浙江省肿瘤医院中国科学院杭州医学研究所浙江杭州310022 温州医科大学浙江温州325035

[目的]调查分析直肠癌患者对治疗相关因素的选择及各因素优先等级的排序,希望能对肿瘤医生从患者角度出发进行治疗决策有所帮助,从而提升患者对治疗的满意度。[方法]设计一份包含15个直肠癌治疗相关因素的问卷。2023年12月19日至2024年1... 详细信息

[目的]调查分析直肠癌患者对治疗相关因素的选择及各因素优先等级的排序,希望能对肿瘤医生从患者角度出发进行治疗决策有所帮助,从而提升患者对治疗的满意度。[方法]设计一份包含15个直肠癌治疗相关因素的问卷。2023年12月19日至2024年1月12日期间,通过浙江省肿瘤医院平台进行问卷发放,以调查直肠癌患者对直肠癌治疗可能涉及疗效和生活质量相关因素的重要性选择及排序。运用Microsoft Excel、 SPSS 26.0软件进行统计分析。计数资料采用频数、构成比表示,亚组间分类变量的分析采用卡方检验。[结果]最终确定有效问卷392份。392例直肠癌患者认为对其整体健康和生活质量“非常重要”的5个影响因素依次为癌症得到治愈(n=376,95.9%)、无手术并发症(n=270,68.9%)、治疗后无永久性结肠造口(n=266,67.9%)、治疗后大便习惯和排便恢复正常(n=248,63.3%)、恢复正常的运动和体力活动(n=191,48.7%)。不同治疗状态、分期、年龄、学历的患者之间对影响因素的选择存在差异。[结论]对治疗后生活质量与器官功能保留的越来越重视是绝大多数患者的共同选择。手术治疗目前仍为患者选择的主要治疗模式,新辅助治疗后的观察等待策略作为一种有效的新兴治疗模式,需要进一步提升医患双方对其认知。

关键词：直肠癌患者网络平台影响因素分析

Discovery and Characterization of a Novel Method for Effective Improvement of Cyclodextrin Yield and Product Specificity

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Chemical Research in Chinese Universities 2019年第4期35卷 708-713页

作者： HUA Jinghan ZHANG Hongbin WU Hao WANG jiadong HU Xueqin YANG Jingwen Department of Pharmaceutical Science and Engineering School of Food and Biological Engineering Hefei University of Technology Hefei 230009 P. R. China

Cyclodextrins(CDs) are widely used in food,phamiaceuticals, drug delivery, and chemical industries and in agriculture and environmental engineering. To improve the yield and selectivity of CDs, this work presented a tacile, scalable and efficient enzymatic synthesis of β-CD from starch using β-cyclodextrin glycosyltransferase (CGTase, EC2.***.1.19) from Bacillus cereus. First, we found that the pretreatment of starch dramatically influenced CDs yield that was related to the structure and molecular weight of the substrate starch. Second, alcohol solvents influenced the yield and product selectivity of CDs;tertiary alcohols enhanced CDs yield(from 54.95% to 68.21%) and secondary alcohols increased the product selectivity(β-CD/γ-CD changed from 6.25 to 8.05). Fluorescence quenching analysis showed that the binding constants and entropy of the solvents influenced the yield and product selectivity, respectively. In conclusion, the results demonstrate that this study provides a promising method for the industrial production of β-CD.

关键词： β-Cyclodextrin glycosyltransferase Alcohol solvent Bacillus cereus Cyclodextrin

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三种水生植物对重金属的富集及净化能力研究

杭州师范大学学报（自然科学版） 2020年第1期19卷 57-63页

作者：周佳栋马丹丹刘敏洪小慧傅嘉辉蒋璐蔓吕丹丹方佳琪曹勇李伟东杭州师范大学钱江学院浙江杭州310018 浙江天川环保科技有限公司浙江杭州310015 浙江水美环保工程有限公司浙江杭州310036 浙江瑞启环境检测有限公司浙江杭州310021

以水芙蓉、凤眼莲和绿萝为实验植物,结合人工模拟废水试验和野外实际污染废水试验,测定植物生长状况及植株组织和水体中重金属Cu、Mn、Cd的含量,研究3种水生植物对水体中重金属的富集及净化能力,分析不同重金属对水生植物抗氧化酶系统... 详细信息

以水芙蓉、凤眼莲和绿萝为实验植物,结合人工模拟废水试验和野外实际污染废水试验,测定植物生长状况及植株组织和水体中重金属Cu、Mn、Cd的含量,研究3种水生植物对水体中重金属的富集及净化能力,分析不同重金属对水生植物抗氧化酶系统的影响.结果表明,3种植物对Cu、Mn、Cd均有不同程度的富集,其中,对Cu的富集能力以绿萝为最强,对Mn的富集能力以水芙蓉为最强,对Cd的富集能力以凤眼莲为最强.此外,不同植物由于丙二醛及抗氧化酶系统酶的含量不同,对不同重金属的富集能力有较大差异,适当的植物组合能在一定程度上增强植株对重金属的富集能力.优化组合试验表明,由水芙蓉和绿萝构成的多因素组合对污水中3种重金属的净化均有较高效率.

关键词：重金属污染水生植物修复富集净化