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Evolving insights:how DNA repair pathways impact cancer evolution

Cancer Biology & Medicine 2020年第4期17卷 805-827页

作者： Jiadong Zhou Xiao Albert zhou Ning Zhang jiadong Wang Department of Radiation Medicine Institute of Systems BiomedicineSchool of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China Biomedical Pioneering Irmovation Center(BIOPIC)and Translational Cancer Research Center School of Life SciencesFirst HospitalPeking UniversityBeijing 100871China Laboratory of Cancer Cell Biology Tianjin Medical University Cancer Instituteand HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China

Viewing cancer as a large,evolving population of heterogeneous cells is a common perspective.Because genomic instability is one of the fundamental features of cancer,this intrinsic tendency of genomic variation leads to striking intratumor heterogeneity and functions during the process of cancer formation,development,metastasis,and relapse.With the increased mutation rate and abundant diversity of the gene pool,this heterogeneity leads to cancer evolution,which is the major obstacle in the clinical treatment of cancer.Cells rely on the integrity of DNA repair machineries to maintain genomic stability,but these machineries often do not function properly in cancer cells.The deficiency of DNA repair could contribute to the generation of cancer genomic instability,and ultimately promote cancer evolution.With the rapid advance of new technologies,such as single-cell sequencing in recent years,we have the opportunity to better understand the specific processes and mechanisms of cancer evolution,and让s relationship with DNA repair.Here,we review recent findings on how DNA repair affects cancer evolution,and discuss how these mechanisms provide the basis for critical clinical challenges and therapeutic applications.

关键词： DNA repair cancer evolution intratumor heterogeneity genomic instability drug resistance

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Ultrafast quasi-three-dimensional imaging

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International Journal of Extreme Manufacturing 2023年第4期5卷 501-512页

作者： Yiling Lian Lan Jiang Jingya Sun Jiadong Zhou Yao zhou Laser Micro/Nano Fabrication Laboratory School of Mechanical EngineeringBeijing Institute of TechnologyBeijing 100081People’s Republic of China Yangtze Delta Region Academy of Beijing Institute of Technology Jiaxing 314019People’s Republic of China Beijing Institute of Technology Chongqing Innovation Center Chongqing 401120People’s Republic of China Centre for Quantum Physics Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement(MOE)School of PhysicsBeijing Institute of TechnologyBeijing 100081People’s Republic of China Advanced Research Institute of Multidisciplinary Sciences Beijing Institute of TechnologyBeijing 100081People’s Republic of China

Understanding laser induced ultrafast processes with complex three-dimensional(3D)geometries and extreme property evolution offers a unique opportunity to explore novel physical phenomena and to overcome the manufacturing limitations.Ultrafast imaging offers exceptional spatiotemporal resolution and thus has been considered an effective tool.However,in conventional single-view imaging techniques,3D information is projected on a two-dimensional plane,which leads to significant information loss that is detrimental to understanding the full ultrafast process.Here,we propose a quasi-3D imaging method to describe the ultrafast process and further analyze spatial asymmetries of laser induced plasma.Orthogonally polarized laser pulses are adopted to illuminate reflection-transmission views,and binarization techniques are employed to extract contours,forming the corresponding two-dimensional matrix.By rotating and multiplying the two-dimensional contour matrices obtained from the dual views,a quasi-3D image can be reconstructed.This successfully reveals dual-phase transition mechanisms and elucidates the diffraction phenomena occurring outside the plasma.Furthermore,the quasi-3D image confirms the spatial asymmetries of the picosecond plasma,which is difficult to achieve with two-dimensional images.Our findings demonstrate that quasi-3D imaging not only offers a more comprehensive understanding of plasma dynamics than previous imaging methods,but also has wide potential in revealing various complex ultrafast phenomena in related fields including strong-field physics,fluid dynamics,and cutting-edge manufacturing.

关键词： ultrafast imaging extraction and reconstruction quasi-three-dimension plasma diffraction

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Regulating the dimensionality of diphosphaperylenediimide-based polymers by coordinating the out-of-plane anisotropic π-framework toward Ag^(+)

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Science China Chemistry 2022年第9期65卷 1741-1748页

作者： Zetong Ma Yujian Liu Shengdong Wang Jiadong Zhou Zhaohui Wang Wei Jiang Key Laboratory of Organic Optoelectronics and Molecular Engineering Department of ChemistryTsinghua UniversityBeijing 100084China Institute of Polymer Optoelectronic Materials and Devices State Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou 510640China

The development of hetero-π-conjugated molecules is of significance for constructing diverse assembling superstructures based on heteroatom-related bonded or nonbonded interactions.Herein,we developed one-pot P-heteroannulation via palladiumcatalyzed dual P-C bonds formation and subsequent sulfidation to construct two isomeric diphosphaperylenediimides(cis-5 and trans-5).The unique out-of-plane anisotropic π-framework induced a cumulative anisotropy with a dipole moment of up to 8.82 D for cis-5,leading to distinct supramolecular packing arrangements.Optical and electrochemical characterizations demonstrated that they showed the largest redshifts extending to 574 nm and rather low-lying LUMO levels of −4.41 eV.Furthermore,the introduced P=S moieties endowed these diphosphaperylenediimides with prominent coordination ability towards Ag^(+),and thus the first example of perylene diimide(PDI)core-involved metal-organic coordination polymers(MOCPs)with tunable dimensionality varying from 1D,2D,to 3D was tactfully achieved.In view of easy accessibility and 2D layered porous structure,thus 2D(trans-5)·(AgOTf)based MOCP showed high crystallinity and good CO_(2) adsorption capacity with surface area of 112 m^(2)/g.The result opens a span-new avenue for exploring rylene imide-based MOCPs and related properties by integrating P functionality.

关键词： metal-organic coordination polymers perylene diimides phosphorous heteroannulation dimensionality gas adsorption

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Nonlinear semi-analytical modeling of liquid sloshing in rectangular container with horizontal baffles

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Applied Mathematics and Mechanics(English Edition) 2023年第11期44卷 1973-2004页

作者： Xun MENG Ying SUN jiadong WANG Ruili HUO Ding zhou College of Civil Engineering Nanjing Tech UniversityNanjing 211816China School of Transportation and Civil Engineering Nantong UniversityNantong 226019Jiangsu ProvinceChina Faculty of Civil Engineering and Mechanics Jiangsu UniversityZhenjiang 212013Jiangsu ProvinceChina

A nonlinear semi-analytical scheme is proposed for investigating the finiteamplitude nonlinear sloshing in a horizontally baffled rectangular liquid container under the seismic excitation.The sub-domain method is developed to analytically derive the modal behaviors of the baffled linear sloshing.The viscosity dissipation effects from the interior liquid and boundary layers are considered.With the introduction of the generalized time-dependent coordinates,the surface wave elevation and velocity potential are represented by a series of linear modal eigenfunctions.The infinite-dimensional modal system of the nonlinear sloshing is formulated based on the Bateman-Luke variational principle,which is further reduced to the finite-dimensional modal system by using the NarimanovMoiseev asymptotic ordering.The base force and overturning moment induced by the nonlinear sloshing are derived as the functions of the generalized time-dependent coordinates.The present results match well with the available analytical,numerical,and experimental results.The paper examines the surface wave elevation,base force,and overturning moment versus the baffle parameters and excitation amplitude in detail.

关键词： rectangular container nonlinear sloshing baffe sub-domain multi-modal method

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Recent progress in the synthesis of novel two-dimensional van der Waals materials

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National Science Review 2022年第5期9卷 57-76页

作者： Renji Bian Changcun Li Qing Liu Guiming Cao Qundong Fu Peng Meng Jiadong Zhou Fucai Liu Zheng Liu School of Optoelectronic Science and Engineering University of Electronic Science and Technology of China School of Electrical and Electronic Engineering Nanyang Technological University CNRS-International-NTU-Thales Research Alliance (CINTRA) Yangtze Delta Region Institute (Huzhou) University of Electronic Science and Technology of China Key Lab of Advanced Optoelectronic Quantum Architecture and Measurement(Ministry of Education) Beijing Key Lab of Nanophotonics and Ultrafine Optoelectronic Systems and School of Physics Beijing Institute of Technology School of Materials Science and Engineering Nanyang Technological University

The last decade has witnessed the significant progress of physical fundamental research and great success of practical application in two-dimensional(2D) van der Waals(vdW) materials since the discovery of graphene in 2004.To date,vdW materials is still a vibrant and fast-expanding field,where tremendous reports have been published covering topics from cutting-edge quantum technology to urgent green energy,and so on.Here,we briefly review the emerging hot physical topics and intriguing materials,such as 2D topological materials,piezoelectric materials,ferroelectric materials,magnetic materials and twistronic heterostructures.Then,various vdW material synthetic strategies are discussed in detail,concerning the growth mechanisms,preparation conditions and typical examples.Finally,prospects and further opportunities in the booming field of 2D materials are addressed.

关键词： two-dimensional materials synthesis exfoliation chemical vapor deposition

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A spawning particle filter for defocused moving target detection in GNSS-based passive radar

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Journal of Systems Engineering and Electronics 2023年第5期34卷 1085-1100页

作者： ZENG Hongcheng DENG jiadong WANG Pengbo zhou Xinkai YANG Wei CHEN Jie School of Electronic and Information Engineering Beihang UniversityBeijing 100191China National Key Laboratory of Science and Technology on Space Microwave China Academy of Space TechnologyXi’an 710000China

Global Navigation Satellite System(GNSS)-based passive radar(GBPR)has been widely used in remote sensing applications.However,for moving target detection(MTD),the quadratic phase error(QPE)introduced by the non-cooperative target motion is usually difficult to be compensated,as the low power level of the GBPR echo signal renders the estimation of the Doppler rate less effective.Consequently,the moving target in GBPR image is usually defocused,which aggravates the difficulty of target detection even further.In this paper,a spawning particle filter(SPF)is proposed for defocused MTD.Firstly,the measurement model and the likelihood ratio function(LRF)of the defocused point-like target image are deduced.Then,a spawning particle set is generated for subsequent target detection,with reference to traditional particles in particle filter(PF)as their parent.After that,based on the PF estimator,the SPF algorithm and its sequential Monte Carlo(SMC)implementation are proposed with a novel amplitude estimation method to decrease the target state dimension.Finally,the effectiveness of the proposed SPF is demonstrated by numerical simulations and pre-liminary experimental results,showing that the target range and Doppler can be estimated accurately.

关键词： Global Navigation Satellite System(GNSS)-based passive radar(GBPR) defocused target moving target detec-tion(MTD) likelihood ratio function(LRF) spawning particle fil-ter(SPF)

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Two‑Dimensional Cr_(5)Te_(8)@Graphite Heterostructure for Efficient Electromagnetic Microwave Absorption

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Nano-Micro Letters 2024年第3期16卷 407-422页

作者： Liyuan Qin Ziyang Guo Shuai Zhao Denan Kong Wei Jiang Ruibin Liu Xijuan Lv Jiadong Zhou Qinghai Shu School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China Centre for Quantum Physics Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement(MOE)School of PhysicsBeijing Institute of TechnologyBeijing 100081People’s Republic of China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081People’s Republic of China Tangshan Research Institute Beijing Institute of TechnologyTangshan 063099People’s Republic of China

Two-dimensional(2D)transition metal chalcogenides(TMCs)hold great promise as novel microwave absorption materials owing to their interlayer interactions and unique magnetoelectric properties.However,overcoming the impedance mismatch at the low loading is still a challenge for TMCs due to the restricted loss pathways caused by their high-density characteristic.Here,an interface engineering based on the heterostructure of 2D Cr_(5)Te_(8) and graphite is in situ constructed via a one-step chemical vapor deposit to modulate impedance matching and introduce multiple attenuation mechanisms.Intriguingly,the Cr_(5)Te_(8)@EG(ECT)heterostructure exhibits a minimum reflection loss of up to−57.6 dB at 15.4 GHz with a thin thickness of only 1.4 mm under a low filling rate of 10%.The density functional theory calculations confirm that the splendid performance of ECT heterostructure primarily derives from charge redistribution at the abundant intimate interfaces,thereby reinforcing interfacial polarization loss.Furthermore,the ECT coating displays a remarkable radar cross section reduction of 31.9 dB m^(2),demonstrating a great radar microwave scattering ability.This work sheds light on the interfacial coupled stimulus response mechanism of TMC-based heterogeneous structures and provides a feasible strategy to manipulate high-quality TMCs for excellent microwave absorbers.

关键词： Chemical vapor deposition Interface polarization engineering Cr_(5)Te_(8)-graphite heterojunctions Microwave absorption

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Sub-nanopores-containing N,O-codoped porous carbon from molecular-scale networked polymer hydrogel for solid-state supercapacitor

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Chinese Chemical Letters 2021年第3期32卷 1111-1116页

作者： Meiling Wang Tianyuan Zhang Mingzhu Cui Weifeng Liu Xuguang Liu Jianwei Zhao Jiadong Zhou Institute of New Carbon Materials Taiyuan University of TechnologyTaiyuan 030024China College of Material and Textile Engineering Jiaxing UniversityJiaxing 314001China Department of Chemistry University of WashingtonSeattleWashington 98195United States School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore Institute of Crystalline Materials Shanxi UniversityTaiyuan 030006China

A template-free carbonization-activation route is developed to fabricate sub-nanopore-containing porous carbon by using a novel polypyrrole(PPy)hydrogel as a precursor.This design of PPy hydrogel precursor containing molecular-scale grids(diameter~2.0 nm)allows for homogeneous N,O-codoping into the porous carbon scaffold during the pyrolysis process.A subsequent activation step produces activated porous carbons(APCs)with tailored pore structures,which renders the APCs abundant subnanopores on their surface to increase the specific capacitance as extra capacitance sites.Coupled with large specific surface area and abundant heteroatoms,the optimized APC4/1 displays excellent specific capacitance of 379 F/g for liquid-state supercapacitor and 230 F/g for solid-state supercapacitor.The solid-state supercapacitor shows a high energy density of 22.99 Wh/kg at power density of 420 W/kg,which is higher than most reported porous carbon materials and satisfy the urgent requirements of elementary power source for electric vehicles.Moreover,this method can be easily modified to fabricate sub-nanopore-containing porous carbons with preferred structures and compositions for many applications.

关键词： Hydrogel Sub-nanopores Carbonization-activation Porous carbon Heteroatomdoping Solid-state supercapacitor

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From surface loading to precise confinement of polyoxometalates for electrochemical energy storage

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Chinese Chemical Letters 2023年第12期34卷 29-41页

作者： Chongji Wang Yanhui Song Wenhua Cong Yuanyuan Yan Meiling Wang Jiadong Zhou College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Centre for Quantum Physics Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement(MOE)School of PhysicsBeijing Instituteof TechnologyBeijing100081China Instrumental Analysis Center Taiyuan University of TechnologyTaiyuan 030024China

Because of abundant redox activity,broad tunability,and specific atomic structure,polyoxometalates(POMs or POM)clusters have attracted burgeoning interests in electrochemical especially energy stor-age fields.Nevertheless,due to the high solubility and fully oxidized state,they often suffer from elec-trically insulation as well as chemical and electrochemical instability.Traditional noncovalent loading or covalent grafting of POMs on conductive substrates have been successfully performed to overcome this problem.However,severe shedding or agglomeration of POMs arising from weak interactions with substrates or excessive entrapment or weak destruction in conductive supports cause significantly re-duced availability and stability.To this end,precise confinement of POMs into conductive supports has been tried to improve their dispersibility and stability.Herein,recent progress of PoMs from surface loading to precise confinement in the electrochemistry energy storage field is reviewed.Firstly,we il-lustrate the typical non-confinement methods(viz.covalent and non-covalent)for supported POMs in energy storage applications.Secondly,different strategies for precise confinement of PoMs in organic and inorganic materials for related applications are also discussed.Finally,future research directions and opportunities for confined POMs,and derived ultrafine nanostructures are also proposed.This re-view seeks to point out future research directions of supported PoMs in the electrochemistry-related fields.

关键词： Polyoxometalates Non-confinement Confinement Electrochemical energy storage Supercapacitor Battery

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Sea-urchin-like ReS_(2) nanosheets with charge edge-collection effect as a novel cocatalyst for high-efficiency photocatalytic H_(2) evolution

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Chinese Chemical Letters 2022年第2期33卷 943-947页

作者： Bo Lin Bowen Ma Jiangang Chen Yao zhou Jiadong Zhou Xiaoqing Yan Chao Xue Xiao Luo Qing Liu Jinyong Wang Renji Bian Guidong Yang Fucai Liu School of Optoelectronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China School of Physical and Mathematical Sciences Nanyang Technological UniversitySingapore 637371Singapore Key Lab of Advanced Optoelectronic Quantum Architecture and Measurement(Ministry of Education) Beijing Key Lab of Nanophotonics&Ultraﬁne Optoelectronic Systemsand School of PhysicsBeijing Institute of TechnologyBeijing 100081China XJTU-Oxford International Joint Laboratory for Catalysis School of Chemical Engineering and TechnologyXi’an Jiaotong UniversityXi’an 710049China State Centre for International Cooperation on Designer Low-carbon and Environmental Materials(CDLCEM) School of Materials Science and EngineeringZhengzhou UniversityZhengzhou 450001China

The recombination of charge carriers arriving from the random charge movement in semiconductor pho-tocatalysts greatly limits the practical application of solar-driven H_(2)evolution.The design of photo-catalytic systems with spatially oriented charge-transfer is a promising route to achieve high charge-separation efficiency for photocatalysts.Herein,novel sea-urchin-like Re S_(2)nanosheet/TiO_(2)nanoparticle heterojunctions(SURTHs)are constructed.The unique sea-urchin-like structure endows the ReS_(2)cocat-alyst with an unusual charge edge-collection effect,which leads to a significant acceleration of charge separation and transfer,as evidenced by the well-designed selective photodeposition of Pt quantum dots in SURTHs.The markedly improved charge transfer capacity contributes to a high photocatalytic H_(2)evo-lution rate of 3.71 mmol h^(−1)g^(−1)for SURTHs(an apparent quantum efficiency(AQE)of 16.09%),up to 231.9 times by contrast with that of P25 TiO_(2).This work would provide a new platform for designing the high-efficiency cocatalyst/photocatalyst system with excellent charge transfer capacity.

关键词： Sea-urchin-like ReS_(2)nanosheets Charge edge-collection effect 2D planar edges/tips Charge transfer Photocatalytic H_(2)evolution

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