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Evolving insights:how DNA repair pathways impact cancer evolution

Cancer Biology & Medicine 2020年第4期17卷 805-827页

作者： jiadong Zhou Xiao Albert Zhou Ning Zhang jiadong wang Department of Radiation Medicine Institute of Systems BiomedicineSchool of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China Biomedical Pioneering Irmovation Center(BIOPIC)and Translational Cancer Research Center School of Life SciencesFirst HospitalPeking UniversityBeijing 100871China Laboratory of Cancer Cell Biology Tianjin Medical University Cancer Instituteand HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China

Viewing cancer as a large,evolving population of heterogeneous cells is a common *** genomic instability is one of the fundamental features of cancer,this intrinsic tendency of genomic variation leads to striking intratumor heterogeneity and functions during the process of cancer formation,development,metastasis,and *** the increased mutation rate and abundant diversity of the gene pool,this heterogeneity leads to cancer evolution,which is the major obstacle in the clinical treatment of *** rely on the integrity of DNA repair machineries to maintain genomic stability,but these machineries often do not function properly in cancer *** deficiency of DNA repair could contribute to the generation of cancer genomic instability,and ultimately promote cancer *** the rapid advance of new technologies,such as single-cell sequencing in recent years,we have the opportunity to better understand the specific processes and mechanisms of cancer evolution,and让s relationship with DNA ***,we review recent findings on how DNA repair affects cancer evolution,and discuss how these mechanisms provide the basis for critical clinical challenges and therapeutic applications.

关键词： DNA repair cancer evolution intratumor heterogeneity genomic instability drug resistance

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Study on coupled vibration characteristics of a cylindrical container with multiple elastic annular baffles

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Science China(Technological Sciences) 2012年第12期55卷 3292-3301页

作者： wang jiadong ZHOU Ding LIU WeiQing College of Civil Engineering Nanjing University of TechnologyNanjing 210009China

The coupled vibration characteristics of multiple elastic annular baffles of the same inner radius in a partially liquid-filled rigid cylindrical container were studied. The liquid domain was divided into several simple sub-domains so that the liquid velocity potential in each liquid sub-domain was of class C 1 with continuous boundary conditions. Based on the superposition principle, the general solution of the liquid velocity potential corresponding to each liquid sub-domain was obtained by means of the method of separation of variables. The coupled modes of the multiple elastic annular baffles were expressed in terms of dry-modal functions. The free surface condition, the interface conditions and coupled vibration conditions were expressed in terms of Fourier series along the liquid height and Bessel series in the radial direction, respectively. Stable and fast numerical computations were investigated by the convergence study. Excellent agreements have been achieved in the comparison of re- suits obtained by the proposed approach with those given by the finite element software ADINA. The natural frequencies and mode shapes versus the position, the inner radius and the number of the annular baffles were thoroughly discussed.

关键词： liquid-container interaction sub-domains multiple baffles sloshing mode bulging mode

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Maintenance of Genome Stability

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Genomics, Proteomics & Bioinformatics 2016年第3期14卷 119-121页

作者： jiadong wang Tomas Lindahl Institute of Systems Biomedicine Department of Radiation MedicineSchool of Basic Medical SciencesPeking University Cancer Research UK London Research Institute Clare Hall Laboratories

It was ever thought that genomic information is transmitted faithfully from generation to generation. But our current knowledge does not indicate that it is the case. For example, genomic variations can be generated from DNA replication infidelity and unequal chromosome segregation. Natural decay of DNA molecules is also a fundamental source of changing genomic information. In addition, cellular and organismal exposure to exogenous genotoxic agents such as ultraviolet （UV） light, oxidative stress, chemical mutagens, and radiation can lead to a variety of modifications on DNA constituents, resulting in genome alterations. Fortunately, cells have evolved several response systems to tackle numerous DNA lesions in order to maintain their genome integrity. Among them, check- point control is probably the most well-known one. For exam- ple, checkpoint responds to replication stress, replication fork stalling, double-strand DNA breaks, and various other types of DNA lesions. Increasing experimental evidence indicates that genomic instability is probably the fundamental reason for carcinogenesis. Genomic instability is also found to be a main etiological factor of neurodegenerative diseases, aging, immunodeficiency, etc. Thus, to understand how cells regulate to maintain their genomic stability is of fundamental importance.

关键词： genomic Genome chromosome DNA segregation replication decay eukaryotic ultraviolet transmitted

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Nonlinear semi-analytical modeling of liquid sloshing in rectangular container with horizontal baffles

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Applied Mathematics and Mechanics(English Edition) 2023年第11期44卷 1973-2004页

作者： Xun MENG Ying SUN jiadong wang Ruili HUO Ding ZHOU College of Civil Engineering Nanjing Tech UniversityNanjing 211816China School of Transportation and Civil Engineering Nantong UniversityNantong 226019Jiangsu ProvinceChina Faculty of Civil Engineering and Mechanics Jiangsu UniversityZhenjiang 212013Jiangsu ProvinceChina

A nonlinear semi-analytical scheme is proposed for investigating the finiteamplitude nonlinear sloshing in a horizontally baffled rectangular liquid container under the seismic *** sub-domain method is developed to analytically derive the modal behaviors of the baffled linear *** viscosity dissipation effects from the interior liquid and boundary layers are *** the introduction of the generalized time-dependent coordinates,the surface wave elevation and velocity potential are represented by a series of linear modal *** infinite-dimensional modal system of the nonlinear sloshing is formulated based on the Bateman-Luke variational principle,which is further reduced to the finite-dimensional modal system by using the NarimanovMoiseev asymptotic *** base force and overturning moment induced by the nonlinear sloshing are derived as the functions of the generalized time-dependent *** present results match well with the available analytical,numerical,and experimental *** paper examines the surface wave elevation,base force,and overturning moment versus the baffle parameters and excitation amplitude in detail.

关键词： rectangular container nonlinear sloshing baffe sub-domain multi-modal method

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Discovery and Characterization of a Novel Method for Effective Improvement of Cyclodextrin Yield and Product Specificity

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Chemical Research in Chinese Universities 2019年第4期35卷 708-713页

作者： HUA Jinghan ZHANG Hongbin WU Hao wang jiadong HU Xueqin YANG Jingwen Department of Pharmaceutical Science and Engineering School of Food and Biological Engineering Hefei University of Technology Hefei 230009 P. R. China

Cyclodextrins(CDs) are widely used in food,phamiaceuticals, drug delivery, and chemical industries and in agriculture and environmental engineering. To improve the yield and selectivity of CDs, this work presented a tacile, scalable and efficient enzymatic synthesis of β-CD from starch using β-cyclodextrin glycosyltransferase (CGTase, EC2.***.1.19) from Bacillus cereus. First, we found that the pretreatment of starch dramatically influenced CDs yield that was related to the structure and molecular weight of the substrate starch. Second, alcohol solvents influenced the yield and product selectivity of CDs;tertiary alcohols enhanced CDs yield(from 54.95% to 68.21%) and secondary alcohols increased the product selectivity(β-CD/γ-CD changed from 6.25 to 8.05). Fluorescence quenching analysis showed that the binding constants and entropy of the solvents influenced the yield and product selectivity, respectively. In conclusion, the results demonstrate that this study provides a promising method for the industrial production of β-CD.

关键词： β-Cyclodextrin glycosyltransferase Alcohol solvent Bacillus cereus Cyclodextrin

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Inhibition of the toxic byproduct during photocatalytic NO oxidation via La doping in ZnO

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Chinese Chemical Letters 2020年第3期31卷 751-754页

作者： Chaowei Yuan Wen Cui Yanjuan Sun jiadong wang Ruimin Chen Jin Zhang Yuxin Zhang Fan Dong Chongqing Key Laboratory of Catalysis and New Environmental Materials College of Environment and ResourcesChongqing Technology and Business UniversityChongqing 400067China Research Center for Environmental Science&Technology Institute of Fundamental and Frontier SciencesUniversity of Electronic Science and Technology of ChinaChengdu 611731China The Center of New Energy Materials and Technology School of Materials Science and EngineeringSouthwest Petroleum UniversityChengdu 610500China College of Materials Science and Engineering Chongqing UniversityChongqing 400044China

It is of a great challenge to develop semiconductor photocatalysts with potential possibilities to simultaneously enhance photocatalytic efficiency and inhibit generation of toxic *** this study,we developed a facile method to induce the La doping and cationic vacancie(V(Zn))on ZnO for the highly efficient complete NO *** photocatalytic NO removal efficiency increases from 36.2%to 53,6%.Most importantly,a significant suppressed NO2 production also has been *** to the DFT calculations,ESR spectra and in situ FTIR spectra,the introduction of La^3+induce the redistribution of charge carriers in La-ZnO,which promote the production of·O2^- and lead to the formation of V(Zn)for the formation of·OH,contributing to the complete oxidation of NO to ***,the conversion pathway of photocatalytic NO oxidation has been elaborated,This work paves a new way to simultaneously realize the photocatalytic pollutants removal and the inhibition of toxic intermediates generation for efficient and safe air purification.

关键词： Photocatalytic NO oxidation Toxic byproduct Reactive oxygen species ZnO Cationic vacancie

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Sheyang—A Coastal Window for Trade in Mid-northern Jiangsu

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China's Foreign Trade 1995年第9期 38-39页

作者： wang jiadong,Sheyang County Magistrate

To carry out internationalized economic strategy is one of the "Three Great Development Strategies" that Jiangsu Province faces in the 21st century, Being a coastal-open county, Sheyang will implement, an all-round outwardly oriented strategy to promote its coastal dominance and build a coastal window opening to the outside world in the middle part of northern Jiangsu. Sheyang is located at the middle of the 954-kilometer coastline of Jiangsu, looking towards Japan and Korea across the sea. Its own coastline is 109.6 kilometers in length, the first in the province, and it is in the forward position where the country, the province and the city implement coastal

关键词： Window Sheyang A Coastal Window for Trade in Mid-northern Jiangsu

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考虑换乘客流的城轨应急接运公交调度优化模型

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东南大学学报（自然科学版） 2021年第1期51卷 161-170页

作者：王佳冬袁振洲北京交通大学综合交通运输大数据应用技术交通运输行业重点实验室北京100044

针对突发运营中断下城市轨道交通与应急接运公交的换乘接续问题,考虑换乘客流的脉冲性特征,提出应急接运公交时刻表和行车计划综合优化模型.首先,分析城市轨道交通与应急接运公交的换乘接续关系,引入乘客容忍度判断接续是否有效.然后,... 详细信息

针对突发运营中断下城市轨道交通与应急接运公交的换乘接续问题,考虑换乘客流的脉冲性特征,提出应急接运公交时刻表和行车计划综合优化模型.首先,分析城市轨道交通与应急接运公交的换乘接续关系,引入乘客容忍度判断接续是否有效.然后,建立双层规划模型,上层为时刻表优化模型,以换乘等车时间和换乘失败人数最小为目标,下层为行车计划优化模型,以公交运营成本最小为目标,并设计改进的模拟退火算法进行求解.最后,以上海轨道交通10号线进行算例分析.结果表明:与等间隔时刻表相比,提出的模型使总成本减少13.7%,乘客等车时间减少14.1%,换乘失败人数减少54.9%.

关键词：城市轨道交通应急接运换乘客流模拟退火算法

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重组蛋白正确折叠与修饰的提高策略

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生物工程学报 2017年第4期33卷 591-600页

作者：李家冬王弘华南农业大学食品学院广东省食品质量与安全重点实验室畜禽产品精准加工与安全控制技术国家地方联合工程研究中心(广东) 广东广州510642

随着分子生物学的研究和不断发展,基因表达技术有了很大的进步。到目前为止,人们已经研究出多种表达系统用以生产重组蛋白,但没有一种表达系统能够完全满足当前需要,各种活性肽和蛋白质类药物的需求逐年攀升,不仅对表达量有要求,更需要... 详细信息

随着分子生物学的研究和不断发展,基因表达技术有了很大的进步。到目前为止,人们已经研究出多种表达系统用以生产重组蛋白,但没有一种表达系统能够完全满足当前需要,各种活性肽和蛋白质类药物的需求逐年攀升,不仅对表达量有要求,更需要正确的翻译后折叠、修饰,使表达蛋白和天然构象更加接近,具有更高的活性和稳定性。结合目前的研究工作从表达系统与宿主、分泌表达、共表达、融合表达和培养条件等方面综述了其对重组蛋白正确折叠以及翻译后修饰的影响,并提出可能改进的策略。

关键词：重组蛋白表达系统折叠翻译后修饰

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Novel perspective in transplantation therapy of mesenchymal stem cells:targeting the ferroptosis pathway

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第2期24卷 115-129页

作者： YUZHU XU PAN FAN LEI LIU XUANFEI XU LELE ZHANG jiadong wang YUAO TAO XIAOLONG LI XI LI YUNTAO wang Medical School of Southeast University Southeast UniversityNanjing 210009China Department of Spine Surgery Zhongda Hospital Affiliated to Southeast UniversitySchool of MedicineSoutheast UniversityNanjing 210009China

Ex vivo culture-amplified mesenchymal stem cells(MSCs)have been studied because of their capacity for healing tissue *** transplantation is a valid approach for promoting the repair of damaged tissues and replacement of lost cells or to safeguard surviving cells,but currently the efficiency of MSC transplantation is constrained by the extensive loss of MSCs during the short post-transplantation ***,strategies to increase the efficacy of MSC treatment are urgently *** overload,reactive oxygen species deposition,and decreased antioxidant capacity suppress the proliferation and regeneration of MSCs,thereby hastening cell ***,oxidative stress(OS)and deficient antioxidant defense induced by iron overload can result in *** may inhibit cell survival after MSC transplantation,thereby reducing clinical *** this review,we explore the role of ferroptosis in MSC *** that little research has focused on ferroptosis in transplanted MSCs,further study is urgently needed to enhance the in vivo implantation,function,and duration of MSCs.

关键词： Mesenchymal stem cells(MSCs) Ferroptosis Oxidative stress(OS) Iron metabolism Lipid peroxidation Glutathione peroxidase 4(GPX4)

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