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Punicalagin prevents obesity-related cardiac dysfunction through promoting DNA demethylation in mice

Food Science and Human Wellness 2024年第3期13卷 1465-1474页

作者： Shengjie Pei Run Liu Qingqing Ma Peng Jiang Xin He Zhongshi Qi jiacheng fang Xu Yang Zirui Yao Xiaoqian Liu Xianfeng Jing Lei Chen Duo Li Institute of Nutrition&Health Qingdao UniversityQingdao 266071China School of Public Health Qingdao UniversityQingdao 266071China Central Laboratory Guizhou Aerospace HospitalZunyi 563000China Health Centers of Licha Town Qingdao 266071China College of Computer Science and Technology Qingdao UniversityQingdao 266071China

The aim of this study was to investigate whether punicalagin(PU)could prevent obesity-related cardiac dysfunction by promoting DNA demethy lation,and to explore its possible mechanism.C57BL/6J mice were fed with standard diet,high-fat diet(HFD),HFD supplemented with resveratrol,low-dose PU(LPU)and high-dose PU(HPU)for 8 *** with HFD group,body weight was significantly lower in PU treatment groups,number of cardionwocytes and the protein level of myosin heavy chain 7B were significantly higher in PU treatment *** of 5-hydroxymethylcytosine and 5-formylcytosine were significantly lower in HFD group than in other *** with the HFD group,the protein level of ten-eleven translocation enzyme(TET)2 was significantly higher in PU treatment groups,p-AMP-activated protein kinase(AMPK)was significantly higher in LPU *** of total antioxidant capacity and the protein levels of complexesⅡ/Ⅲ/Ⅴ,oxoglutarate dehydrogenase,succinate dehydrogenase B and fumarate hdrolase were significantly lower in HFD group than PU treatment *** ratio of(succinic acid+fumaric acid)/a-ketoglutarate was significantly higher in HFD group than other *** conclusion,PU up-regulated TETs enzyme activities and TET2 protein stability through alleviating mitochondrial dysfunction and activating AMPK,so as to promote DNA demethylation,thus preventing obesity-related cardiac dysfunction.

关键词： DNA demethylation Mitochondrial function Obesity-related cardiac dysfunction Punicalagin Ten-eleven translocation family enzymes

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区县教研员的角色冲突:表现与机理

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江苏第二师范学院学报 2024年第1期40卷 45-54页

作者：方佳诚徐小丽陕西师范大学教育学部陕西西安710062 常州市钟楼区教师发展中心江苏常州213002

中国的教研制度为保障基础教育质量做出了巨大的贡献,但其本身也存在一些问题,区县教研员的角色冲突是其中较为突出的问题之一。为探寻影响区县教研员角色冲突的主要因素,探寻这些因素相互作用的机理,对我国东部地区某区县级教师发展中... 详细信息

中国的教研制度为保障基础教育质量做出了巨大的贡献,但其本身也存在一些问题,区县教研员的角色冲突是其中较为突出的问题之一。为探寻影响区县教研员角色冲突的主要因素,探寻这些因素相互作用的机理,对我国东部地区某区县级教师发展中心教研员进行了半结构化访谈。结果显示,区县教研员日常工作中遇到的角色冲突主要可分为自我角色冲突、适应性角色冲突、角色超载及期望性角色冲突。影响这些冲突的因素主要有组织环境、人际互动和个体特征。有效的人际沟通及自我认同可以在一定程度上缓解角色压力,调适角色冲突;但要根本消解区县教研员的角色冲突,则需要明确的组织期望,适度的工作压力,合理的组织环境及区县教研员自身适应性共同作用。

关键词：教研员角色冲突角色互动

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基于硬件损伤和非完美CSI的IRS辅助NOMA网络鲁棒传输算法

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物联网学报 2024年第1期8卷 60-70页

作者：刘期烈方家成辛雅楠陈前斌重庆邮电大学通信与信息工程学院重庆400065

为提升非正交多址接入(NOMA,non-orthogonal multiple access)网络的鲁棒性并减少其能量消耗,考虑了收发器的硬件损伤(HWI,hardware impairment)和非完美的信道状态信息(CSI,channel state information),提出了智能反射面(IRS,intelligent reflecting surface)辅助的NOMA网络传输功率最小化算法。考虑了用户服务质量(QoS,quality of service)约束、串行干扰消除约束以及IRS的反射相移约束,基于HWI和非完美CSI建立了基站主动波束成形和IRS被动波束成形联合优化问题模型。为求解该非凸优化问题,首先利用线性近似和S-Procedure方法对QoS约束进行转换,然后将优化问题分解为两个子问题,并且利用逐次凸逼近(SCA,successive convex approximation)方法求解主动波束成形子问题,利用惩罚凸凹过程算法求解被动波束成形子问题,最后利用交替优化将子问题交替迭代得到最终解。仿真结果表明,在传输功率方面,所提算法比正交多址鲁棒算法降低了17.05%;在系统鲁棒性方面,所提算法相较于HWI鲁棒算法和CSI鲁棒算法,分别提升了20.69%和31.14%。

关键词：智能反射面非正交多址接入硬件损伤信道状态信息鲁棒性

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IRS辅助的全双工通感一体化波束成形设计

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电信科学 2024年第7期40卷 63-75页

作者：刘期烈王龙辛雅楠方家成陈前斌陶宇重庆邮电大学通信与信息工程学院重庆400065 重庆工业职业技术学院电子与物联网工程学院重庆401120

为了解决传统通感一体化(integrated sensing and communication,ISAC)场景中通信和感知系统收发信号的切换频率差异以及通信易受障碍物阻挡的问题,将全双工(full-duplex,FD)技术和智能反射面(intelligent reflecting surface,IRS)引入ISAC系统,研究ISAC场景下IRS辅助的FD波束成形设计。基于IRS相移约束、基站接收波束成形约束、基站最大发射功率约束、上行用户最大发射功率约束、雷达感知阈值约束,建立了上下行用户和速率最大化波束成形优化问题。利用交替优化、连续凸逼近、半正定松弛、变量替换、半正定规划将原非凸优化问题转换成凸优化问题进行求解。仿真结果表明,在所考虑的通信性能指标下,所提方案相比对应的半双工和随机IRS方案分别提升了89.02%和70.15%。

关键词：智能反射面通感一体化全双工波束成形

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“一带一路”背景下我国中药企业竞争力提升研究

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九江学院学报（自然科学版） 2024年第2期39卷 113-120页

作者：王珊李爱玉房佳成安徽中医药大学医药经济管理学院数据科学与中医药创新发展安徽省哲学社会科学重点实验室安徽合肥230012

中药企业竞争力的研究对推动中医药在“一带一路”建设中的海外传播和发展至关重要。该研究采用灰色关联度模型,运用8家中药企业公开数据,评估影响企业竞争力的关键要素。研究发现,企业运营效率和资本结构与中药企业竞争力最为相关。同... 详细信息

中药企业竞争力的研究对推动中医药在“一带一路”建设中的海外传播和发展至关重要。该研究采用灰色关联度模型,运用8家中药企业公开数据,评估影响企业竞争力的关键要素。研究发现,企业运营效率和资本结构与中药企业竞争力最为相关。同时,中药企业应提高资产运营效率,控制资产负债率,提升人力资源、增强营销和加大创新力度。该研究为判断中药企业核心竞争力提供了定量分析框架,也为其制定提升竞争力策略提供了参考。

关键词：中药企业企业竞争力灰色关联度资产运营效率

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基于层次分析法的平行多孔小净距隧道施工方案研究

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铁道勘察 2024年第2期50卷 133-139页

作者：杜世明杨佳运夏立锋方佳成李鹏飞宁波舜通集团有限公司浙江余姚315400 北京工业大学城市与工程安全减灾省部共建教育部重点实验室北京100124 宁波交通工程建设集团有限公司宁波315099

为解决平行多孔小净距隧道不同孔道数量施工方案比选的问题,针对隧道施工存在多种影响因素,采用层次分析法建立平行多孔小净距隧道施工评价体系,计算各影响因素权重值,并结合有限元软件数值模拟计算结果,对比分析平行多孔小净距隧道不... 详细信息

为解决平行多孔小净距隧道不同孔道数量施工方案比选的问题,针对隧道施工存在多种影响因素,采用层次分析法建立平行多孔小净距隧道施工评价体系,计算各影响因素权重值,并结合有限元软件数值模拟计算结果,对比分析平行多孔小净距隧道不同孔道施工方案。研究表明,在同一隧道的不同孔道数量施工方案影响因素排序中,位移控制为主要影响因素,所占权重为0.103 8;后续依次为爆破震动、运营维护因素、建设成本、断面尺寸、支护措施,计算权重依次分别为0.070 5、0.065 4、0.029 2、0.016 3、0.011 4。有限元计算结果表明,各观测点位的最终位移值,随围岩等级增大而增加;在同一围岩等级下,两孔隧道拱顶沉降、仰拱隆起值大于四孔隧道,两孔隧道左右边墙位移值小于四孔隧道。

关键词：公路隧道多孔隧道小净距层次分析法数值模拟

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Molecular Characterization and Antibacterial Activity of a G-Type Lysozyme in Yellow Drum(Nibea albiflora)

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Journal of Ocean University of China 2024年第2期23卷 477-486页

作者： XIAO Yao LI jiacheng TIAN Qianqian WU Baolan HAN fang State Key Laboratory of Mariculture Breeding Fisheries College of Jimei UniversityXiamen 361021China

Lysozyme(EC3.***.1.17)plays an important role in the immune response;as a nonspecific immune factor,it can resist causative *** can be divided into c-type and g-type in *** a previous study,through genome-wide association analysis,the g-type lysozyme gene,which is named NaLyg in yellow drum(Nibea albiflora),was found to be a key candidate gene for disease resistance in response to Vibrio harveyi *** cDNA of NaLyg was 1025 bp,including four exons and three introns,and its open reading frame(ORF)had a full-length of 582 bp,encoding 193 amino *** was found to be conserved during evolution through bioinformatic *** NaLyg protein possessed a sugar binding domain and three catalytic sites,including Glu71,Asp84 and *** qRT-PCR results confirmed that NaLyg gene mRNA was visibly increased after *** *** NaLyg protein purified by prokaryotic expression killed some gram-negative bacterial pathogens by inducing cell wall destruction,including ***,Aeromonas hydrophila and Edwardsiella ***,the NaLyg protein killed two gram-positive bacteria,Bacillus subtilis and Staphylococcus *** together,the experimental results suggested that the NaLyg protein of *** played an important role in fighting bacterial infections.

关键词： Nibea albiflora innate immunity Vibrio harveyi g-type lysozyme antibacterial activity

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The Mechanism of Morin Combined with Celastrol Induces Apoptosis and Inhibits the Growth of Lung Cancer

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Food Science and Human Wellness 2024年

作者： Jing Duan Jiayin Zhang jiacheng Sun Yulin fang College of Enology Northwest A&F University

Morin is a functional flavonoid commonly found in human diet. Compared to being used solely， it is evident that morin can be more effective as a drug adjuvant. However， research on the combined effect and its corresponding mechanism is limited. Here， we found that morin significantly potentiated the inhibitory effects of the natural compound celastrol on the proliferation of lung cancer cells. Morin and celastrol synergistically exhibit marked apoptosis induction in lung cancer cells， accompanied by changes in the abundance of apoptosis-related proteins. Transcriptome analyses revealed that the combination of morin and celastrol had a significant impact on the number of differentially expressed genes in lung cancer cells. Among these genes， BIRC3 was one of the most significantly different ones， which plays a crucial role in the process of tumor resistance to apoptosis. In addition， several genes identified are primarily associated with intracellular signal transduction pathways， specifically the NF-κB signaling pathway. Importantly， the treatment combining morin and celastrol in tumor-bearing mice results in a synergistic effect that significantly suppressed tumor growth. These findings indicate that morin could be a promising functional adjuvant， and the combination of morin and celastrol has potential for the treating lung cancer.

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Gigahertz-rate-switchable wavefront shaping through integration of metasurfaces with photonic integrated circuit

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Advanced Photonics 2024年第1期6卷 106-114页

作者： Haozong Zhong Yong Zheng jiacheng Sun Zhizhang Wang Rongbo Wu Ling-en Zhang Youting Liang Qinyi Hua Minghao Ning Jitao Ji Bin fang Lin Li Tao Li Ya Cheng Shining Zhu East China Normal University School of Physics and Electronic ScienceState Key Laboratory of Precision SpectroscopyShanghaiChina Nanjing University College of Engineering and Applied SciencesNational Laboratory of Solid State MicrostructuresNanjingChina China Jiliang University College of Optical and Electronic TechnologyHangzhouChina Shanxi University Collaborative Innovation Center of Extreme OpticsTaiyuanChina Chinese Academy of Sciences(CAS) Shanghai Institute of Optics and Fine Mechanics(SIOM)State Key Laboratory of High Field Laser Physics and CAS Center for Excellence in Ultra-Intense Laser ScienceShanghaiChina

Achieving spatiotemporal control of light at high speeds presents immense possibilities for various applications in communication,computation,metrology,and *** integration of subwavelength metasurfaces and optical waveguides offers a promising approach to manipulate light across multiple degrees of freedom at high speed in compact photonic integrated circuit(PIC)***,we demonstrate a gigahertz-rate-switchable wavefront shaping by integrating metasurface,lithium niobate on insulator photonic waveguides,and electrodes within a PIC *** proofs of concept,we showcase the generation of a focus beam with reconfigurable arbitrary polarizations,switchable focusing with lateral focal positions and focal length,orbital angular momentum light beams as well as Bessel *** measurements indicate modulation speeds of up to the gigahertz *** integrated platform offers a versatile and efficient means of controlling the light field at high speed within a compact system,paving the way for potential applications in optical communication,computation,sensing,and imaging.

关键词： metasurface photonic integrated circuit lithium niobate on insulator high-speed modulation

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Urine biomarkers discovery by metabolomics and machine learning for Parkinson’s disease diagnoses

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Chinese Chemical Letters 2023年第10期34卷 93-97页

作者： Xiaoxiao Wang Xinran Hao Jie Yan Ji Xu Dandan Hu Fenfen Ji Ting Zeng Fuyue Wang Bolun Wang jiacheng fang Jing Ji Hemi Luan Yanjun Hong Yanhao Zhang Jinyao Chen Min Li Zhu Yang Doudou Zhang Wenlan Liu Xiaodong Cai Zongwei Cai State Key Laboratory of Environmental and Biological Analysis Department of ChemistryHong Kong Baptist UniversityHong KongChina Department of Neurosurgery Shenzhen Key Laboratory of Neurosurgerythe First Affiliated Hospital of Shenzhen UniversityShenzhen Second People’s HospitalShenzhen 518035China The Central Laboratory the First Affiliated Hospital of Shenzhen UniversityShenzhen Second People’s HospitalShenzhen 518035China Department of Nutrition Food Safety and ToxicologyWest China School of Public HealthSichuan UniversityChengdu 610041China Mr.and Mrs.Ko Chi Ming Centre for Parkinson’s Disease Research School of Chinese MedicineHong Kong Baptist UniversityHong KongChina

Parkinson’s disease(PD)is a complex neurological disorder that typically worsens with age.A wide range of pathologies makes PD a very heterogeneous condition,and there are currently no reliable diagnostic tests for this *** application of metabolomics to the study of PD has the potential to identify disease biomarkers through the systematic evaluation of *** this study,urine metabolic profiles of 215 urine samples from 104 PD patients and 111 healthy individuals were assessed based on liquid chromatography-mass *** urine metabolic profile was first evaluated with partial leastsquares discriminant analysis,and then we integrated the metabolomic data with ensemble machine learning techniques using the voting strategy to achieve better predictive performance.A combination of 8-metabolite predictive panel performed well with an accuracy of over 90.7%.Compared to control subjects,PD patients had higher levels of 3-methoxytyramine,N-acetyl-l-tyrosine,orotic acid,uric acid,vanillic acid,and xanthine,and lower levels of 3,3-dimethylglutaric acid and imidazolelactic acid in their *** multi-metabolite prediction model developed in this study can serve as an initial point for future clinical studies.

关键词： Parkinson’s disease High-resolution mass spectrometry Biomarker Metabolomic Machine learning

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