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Herb induced liver injury by Xianling Gubao Tablets: A case assessed for causality using updated RUCAM and integrated evidence chain

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Chinese Herbal Medicines 2024年第2期16卷 301-309页

作者： Chunyu li Yingying li Zhaofang Bai jiabo Wang Guohui li Xiaohe Xiao National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Senior Department of Hepatology The Fifth Medical Center of PLA General HospitalBeijing 100039China School of Traditional Chinese Medicine Capital Medicinal UniversityBeijing 100069China

Objective:A typical case of Xianling Gubao(XLGB)Tablets-induced liver injury was systematically studied in the clinic and the ***:A patient with herb-induced liver injury(HIli)and a history of taking XLGB Tablets before disease onset was engaged as the study subject,and the case was diagnosed according to the updated Roussel Uclaf Causality Assessment Method(RUCAM)and the integrated evidence chain(iEC)method recommended by the Guidelines for Diagnosis and Treatment of Herb-induced liver Injury(HIli Guidelines).Results:Clinical history,biochemical indexes and imaging tests were used to exclude the influence of fundamental diseases and confusing liver diseases such as viral,alcoholic and autoimmune liver diseases on the *** on an investigation of the patient’s medication history,she was suspected to have HIli caused by XLGB Tablets,as the patient was only taking an oral preparation of XLGB Tablets,and the influence of other drugs on the diagnosis was *** patient with alanine aminotransferase(ALT)3 upper limit of normal(ULN)and a calculated R of 6 was diagnosed with possible acute drug-induced hepatocellular *** relationship was considered“highly probable”(score of 9)using the updated RUCAM of ***,the fingerprint similarity between the preparation taken by the patient and a commercially available preparation was 0.99,suggesting that the patient was consuming XLGB Tablets rather than another ***-MS technology and the Agilent Fake TCM-Drugs database were used to investigate the drug,and no chemical additions were *** of the drug for pesticide residues,heavy metals,aflatoxins and other exogenous substances indicated compliance with the content limits of the Chinese ***:In summary,the final diagnosis of XLGB-induced liver injury reached the clinical diagnosis of HIli and was acute severe hepatocellular injury type by the updated RUCAM and ***,this study provides scientif

关键词： chemical analysis compound preparations of traditional chinese medicines integrated evidence chain liver injury Roussel Uclaf Causality Assessment Method Xianling Gubao Tablets

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Histones of Neutrophil Extracellular Traps Induce CD11b Expression in Brain Pericytes Via Dectin-1 after Traumatic Brain Injury

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Neuroscience Bulletin 2022年第10期38卷 1199-1214页

作者： Yang-Wuyue liu Jingyu Zhang Wanda Bi Mi Zhou jiabo li Tiantian Xiong Nan Yang li Zhao Xing Chen Yuanguo Zhou Wenhui He Teng Yang Hao Wang Lunshan Xu Shuang-Shuang Dai Department of Biochemistry and Molecular Biology School of Basic MedicineArmy Medical UniversityChongqing400038China Department of Neurosurgery Daping HospitalArmy Medical UniversityChongqing400042China Molecular Biology Center State Key Laboratory of TraumaBurnand Combined InjuryDaping HospitalArmy Medical UniversityChongqing400042China Department of Pathophysiology College of High Altitude MedicineArmy Medical UniversityChongqing400038China Brigade 1 of Medical Undergraduates School of Basic MedicineArmy Medical UniversityBattalion 1Chongqing400038China

The brain pericyte is a unique and indispensable part of the blood-brain barrier(BBB),and contributes to several pathological processes in traumatic brain injury(TBI).However,the cellular and molecular mechanisms by which pericytes are regulated in the damaged brain are largely ***,we show that the formation of neutrophil extracellular traps(NETs)induces the appearance of CD11b^(+)pericytes after *** CD11b^(+)pericyte subsets are characterized by increased permeability and pro-inflammatory profiles compared to ***,histones from NETs by Dectin-1 facilitate CD11b induction in brain pericytes in PKC-c-Jun dependent manner,resulting in neuroinflammation and BBB dysfunction after *** data indicate that neutrophil-NET-pericyte and histone-Dectin-1-CD11b are possible mechanisms for the activation and dysfunction of *** NETs formation and Dectin-1 are promising means of treating TBI.

关键词： Pericyte Neutrophil TBI NET Dectin-1

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Force optimization of ionic polymer metal composite actuators by an orthogonal array method

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Chinese Science Bulletin 2011年第19期56卷 2061-2070页

作者： YU Min HE QingSong DING Yan GUO DongJie li jiabo DAI ZhenDong Institute of Bio-inspired Structure and Surface Engineering Nanjing University of Aeronautics & Astronautics Nanjing 210016 China College of Mechanical and Electrical Engineering Nanjing University of Aeronautics & Astronautics Nanjing 210016 China

Ionic polymer metal composites (IPMCs), a new kind of electro-active polymer, can be used for micro robotic actuators, artificial muscles and dynamic sensors. However, IPMC actuators have the major drawbacks of a low generative blocking force and dependence on a humid environment, which limit their further application. Multiple process parameters for the fabrication of IPMCs were optimized to produce a maximum blocking force; the parameters included reducing agent concentration, platinum salt concentration in the initial compositing process, and tetraethyl orthosilicate (TEOS) content. An orthogonal array method was designed and a series of fabrication experiments were carried out to identify the optimum process parameters. The results show that the platinum salt concentration in the initial compositing process plays the most significant role in improving the blocking force of IPMCs, the TEOS content plays an important role, and the reducing agent concentration has no apparent effect on the blocking force. In the optimized conditions, the IPMC actuator exhibited maximum blocking force of 50 mN, and the corresponding displacement was 14 mm. Compared with normal conditions, the blocking force improved 2.4-fold without sacrificing the displacement, and the effective air-operating life was prolonged 5.8-fold for the blocking force and 5-fold for the displacement. This study lays a solid foundation for further applications of IPMCs.

关键词：金属复合材料离子聚合物优化条件致动器正硅酸乙酯直交电活性聚合物 IPMC

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Ab initio/MBPT Studies of the Effective Exchange Integrals and Theoretical Models of Organic Ferromagnets

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Chemical Research in Chinese Universities 1991年第3期7卷 181-183页

作者： li jiabo (Department of Chemistry, Xiamen University, Xiamen)

Nowadays the studies of organize ferromagnets have been becoming a very attractive area of material science in both theoretical and experimental aspects. A major theoretical problem on design of OFM is to estimate the effective exchange integrals(J) between radical sites. However, most of theoretical work was on hypothetical hydrocarbons, which were impracticable in the synthesis. The recent breakthrough in the synthesis of OFM turns the theorist’s attention to some more realistic models such as those

关键词： Organic ferromagnet(OFM) Doping Curie temperature

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供应链视角下绿色物流发展路径研究

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物流科技 2023年第14期46卷 133-135,139页

作者：李嘉博哈尔滨商业大学会计学院黑龙江哈尔滨150028

近年来我国物流业得到了飞速发展,在“双碳”目标下绿色转型已然成为物流业的发展趋势。物流业传统运营模式下成本较高、上下游信息不对称、中小微企业获取转型资金困难等问题日益突出,对此,文章从供应链角度出发探讨现阶段绿色物流发... 详细信息

近年来我国物流业得到了飞速发展,在“双碳”目标下绿色转型已然成为物流业的发展趋势。物流业传统运营模式下成本较高、上下游信息不对称、中小微企业获取转型资金困难等问题日益突出,对此,文章从供应链角度出发探讨现阶段绿色物流发展存在的问题,并探究绿色发展路径,主张以绿色理念推动物流业绿色发展,利用数字信息技术打破信息壁垒,维护供应链平衡,加快物流智能基础设施建设,减少资源浪费与环境污染,提高企业绿色创新水平。

关键词：供应链物流绿色发展

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高校"课程思政"和"思政课程"协同育人路径研究

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哈尔滨职业技术学院学报 2022年第1期 55-57页

作者：李家波青岛港湾职业技术学院山东青岛266404

"课程思政"概念的提出,为职业院校思政课程教学和思政教育工作实施指明方向,有助于提高学生的整体思政素养,使其成长为一个全面发展的职业人才,为社会做出贡献."思政课程"与"课程思政"同向同行、同频共振协同育人是高校思想政治教育的... 详细信息

"课程思政"概念的提出,为职业院校思政课程教学和思政教育工作实施指明方向,有助于提高学生的整体思政素养,使其成长为一个全面发展的职业人才,为社会做出贡献."思政课程"与"课程思政"同向同行、同频共振协同育人是高校思想政治教育的战略考量.将"思政课程"与"课程思政"有机结合,以达到协同育人的目的,强化思政教育整体成效,满足学生的多元化发展需求,以体现职业教育的价值.阐述职业院校"课程思政"和"思政课程"协同育人的意义,分析协同育人中面临的问题,探索职业院校"课程思政"和"思政课程"协同育人的路径.

关键词： "课程思政" 思政课程协同育人高校

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植物多酚在反刍家畜中的研究进展

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中国饲料 2022年第19期 21-29页

作者：李家博王小琪段子渊宁夏大学农学院宁夏银川750000 中国科学院遗传发育与生物学研究所北京100101

植物多酚是自然界广泛存在的植物次生代谢物,具有较高的生物活性及应用价值。本文主要从植物多酚对反刍家畜生产性能、消化代谢与生化过程、瘤胃和肠道微生物的影响方面综述了国内外研究进展,以期为利用植物多酚提高反刍动物的生产性能... 详细信息

植物多酚是自然界广泛存在的植物次生代谢物,具有较高的生物活性及应用价值。本文主要从植物多酚对反刍家畜生产性能、消化代谢与生化过程、瘤胃和肠道微生物的影响方面综述了国内外研究进展,以期为利用植物多酚提高反刍动物的生产性能提供参考。

关键词：植物多酚反刍家畜生产性能消化代谢微生物

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常减压装置封油技术优化改造

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炼油技术与工程 2013年第11期43卷 25-28页

作者：李家博中国石油化工股份有限公司洛阳分公司河南省洛阳市471012

封油作为机泵密封的一种手段,在石化行业应用广泛。中国石油化工股份有限公司洛阳分公司常减压蒸馏装置原有封油系统存在问题,借装置大检修之际对封油系统实施了技术改造,将性质接近于常三线柴油的减一线油作为封油引入封油罐,将原有常... 详细信息

封油作为机泵密封的一种手段,在石化行业应用广泛。中国石油化工股份有限公司洛阳分公司常减压蒸馏装置原有封油系统存在问题,借装置大检修之际对封油系统实施了技术改造,将性质接近于常三线柴油的减一线油作为封油引入封油罐,将原有常三线柴油作为封油系统的补充封油;另一方面对高温机泵的封油系统进行改造,将一部分高温机泵改为双端面密封,并且引用白油作为大气侧密封介质,外端面密封共采用了PLAN52与PLAN53B两个方案,改造后运行效果良好。

关键词：常减压蒸馏装置封油机械密封双端面密封

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Design and Experiment of 1LFQ-325 Pneumatic Reversible Plough

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Asian Agricultural Research 2013年第1期5卷 76-78,82页

作者： Xuan ZHENG Xuefeng CHEN Chaomin QIN li jiabo JIA Machinery and Equipment Institute of Xinjiang Academy of Agricultural Reclamation Sciences Xinjiang Tianzhen Farm and Pasture Machinery Manufacturer

A pneumatic reversible plough is developed, which complements to the tractor of 25.7-36.8 *** plough adopts the cylinder as reversing mechanism between the right and left plough bodies, and the cylinder can substitute the mechanical reversing mechanism. The pneumatic turnover allows the plough to be operated easily and turned over flexibly. Field experiment results show that indicators of plough performance meet the requirements of the relevant national standards.

关键词： Pneumatic Reversible plough Design Experiment

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柠条对滩羊肉品质、胃肠道挥发性脂肪酸及其菌群的影响

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食品工业科技 2023年第9期44卷 96-103页

作者：李家博王小琪张志超陶金忠段子渊宁夏大学农学院宁夏银川750021 中国科学院遗传与发育生物学研究所北京100101

为探索日粮中添加柠条影响瘤胃、结肠内微生物生成的挥发性脂肪酸水平,进而调节滩羊肉品质、脂肪组织中主要脂肪酸含量的作用,本研究选取12只四月龄滩羊母羔随机分为两组,NC组饲喂30%精料及70%苜蓿颗粒,CK组为10%柠条替代等量苜蓿。预饲... 详细信息

为探索日粮中添加柠条影响瘤胃、结肠内微生物生成的挥发性脂肪酸水平,进而调节滩羊肉品质、脂肪组织中主要脂肪酸含量的作用,本研究选取12只四月龄滩羊母羔随机分为两组,NC组饲喂30%精料及70%苜蓿颗粒,CK组为10%柠条替代等量苜蓿。预饲期10 d,正试期60 d。饲喂期结束屠宰时取其背最长肌、股四头肌、皮下脂肪,瘤胃、结肠内容物,利用16S rRNA测序技术、气相色谱-质谱联用技术等对滩羊瘤胃、结肠内菌群、脂肪组织的脂肪酸含量及肌肉理化特性进行测定。结果表明,饲喂柠条可导致滩羊股四头肌的压榨损失有提高的趋势,系水力和熟肉率有所下降;但饱和脂肪酸有降低的趋势,不饱和脂肪酸有提高的趋势;皮下脂肪中的软脂酸含量显著降低(P<0.05);瘤胃内丁酸和结肠内乙酸的浓度显著降低(P<0.05),结肠内异丁酸和异戊酸等支链脂肪酸水平极显著提高(P<0.01)。斯皮尔曼相关性分析显示,瘤胃内5-7N15菌属和YRC22菌属均与丁酸含量趋向正相关,而结肠内密螺旋体属与乙酸含量趋向正相关,但与异丁酸含量趋向负相关(0.05

关键词：柠条微生物区系扩增子测序脂肪酸代谢滩羊

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